LOCUS       NM_032015               2783 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ring finger protein 26 (RNF26), mRNA.
ACCESSION   NM_032015
VERSION     NM_032015.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Liu,X., Li,W., Yi,L., Wang,J., Liu,W., Cheng,H. and Ren,S.
  TITLE     CDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and
            increase the sensitivity of ccRCC to mTOR inhibitors
  JOURNAL   Br J Cancer 131 (3), 444-456 (2024)
   PUBMED   38890443
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Cremer,T., Voortman,L.M., Bos,E., Jongsma,M.L., Ter Haar,L.R.,
            Akkermans,J.J., Talavera Ormeno,C.M., Wijdeven,R.H., de Vries,J.,
            Kim,R.Q., Janssen,G.M., van Veelen,P.A., Koning,R.I., Neefjes,J.
            and Berlin,I.
  TITLE     RNF26 binds perinuclear vimentin filaments to integrate ER and
            endolysosomal responses to proteotoxic stress
  JOURNAL   EMBO J 42 (18), e111252 (2023)
   PUBMED   37519262
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Cremer,T., Jongsma,M.L.M., Trulsson,F., Vertegaal,A.C.O.,
            Neefjes,J. and Berlin,I.
  TITLE     The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts
            spatiotemporal control over the endolysosomal pathway
  JOURNAL   Cell Rep 34 (3), 108659 (2021)
   PUBMED   33472082
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Jongsma,M.L., Berlin,I., Wijdeven,R.H., Janssen,L., Janssen,G.M.,
            Garstka,M.A., Janssen,H., Mensink,M., van Veelen,P.A., Spaapen,R.M.
            and Neefjes,J.
  TITLE     An ER-Associated Pathway Defines Endosomal Architecture for
            Controlled Cargo Transport
  JOURNAL   Cell 166 (1), 152-166 (2016)
   PUBMED   27368102
  REMARK    GeneRIF: Study reveals the endoplasmic reticulum (ER)-located
            ubiquitin ligase Ring finger protein 26 (RNF26) as the global
            architect of the entire endosomal system, including the trans-Golgi
            network.
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Qin,Y., Zhou,M.T., Hu,M.M., Hu,Y.H., Zhang,J., Guo,L., Zhong,B. and
            Shu,H.B.
  TITLE     RNF26 temporally regulates virus-triggered type I interferon
            induction by two distinct mechanisms
  JOURNAL   PLoS Pathog 10 (9), e1004358 (2014)
   PUBMED   25254379
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Zhang,F., Baumer,N., Rode,M., Ji,P., Zhang,T., Berdel,W.E. and
            Muller-Tidow,C.
  TITLE     The inhibitor of growth protein 5 (ING5) depends on INCA1 as a
            co-factor for its antiproliferative effects
  JOURNAL   PLoS One 6 (7), e21505 (2011)
   PUBMED   21750715
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of RNF26 on human chromosome
            11q23 region, encoding a novel RING finger protein with leucine
            zipper
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1038-1044 (2001)
   PUBMED   11352657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003396.1.
            
            On May 17, 2019 this sequence version replaced NM_032015.4.
            
            Summary: The protein encoded by this intronless gene contains a
            C3HC5 type of RING finger, a motif known to be involved in
            protein-DNA and protein-protein interactions. The expression of
            this gene was found to be upregulated in cancer cell lines derived
            from different types of cancer. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7410570.492742.1,
                                        SRR3476690.1071667.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311413.5/ ENSP00000312439.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2783              AP003396.1         1060-3842
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..2783
                     /gene="RNF26"
                     /note="ring finger protein 26"
                     /db_xref="GeneID:79102"
                     /db_xref="HGNC:HGNC:14646"
                     /db_xref="MIM:606130"
     exon            1..2783
                     /gene="RNF26"
                     /inference="alignment:Splign:2.1.0"
     CDS             597..1898
                     /gene="RNF26"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein with leucine zipper"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF26"
                     /protein_id="NP_114404.1"
                     /db_xref="CCDS:CCDS8419.1"
                     /db_xref="GeneID:79102"
                     /db_xref="HGNC:HGNC:14646"
                     /db_xref="MIM:606130"
                     /translation="MEAVYLVVNGLGLVLDVLTLVLDLNFLLVSSLLASLAWLLAFVY
                     NLPHTVLTSLLHLGRGVLLSLLALIEAVVRFTCGGLQALCTLLYSCCSGLESLKLLGH
                     LASHGALRSREILHRGVLNVVSSGHALLRQACDICAIAMSLVAYVINSLVNICLIGTQ
                     NLFSLVLALWDAVTGPLWRMTDVVAAFLAHISSSAVAMAILLWTPCQLALELLASAAR
                     LLASFVLVNLTGLVLLACVLAVTVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMR
                     LSRLALGSEAWRRVWSRSLQLASWPNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRR
                     SEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLL
                     LPCRHLCLCQACTEILMRHPVYHRNCPLCRRGILQTLNVYL"
     regulatory      2762..2767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF26"
                     /note="hexamer: AATAAA"
     polyA_site      2783
                     /gene="RNF26"
                     /note="major polyA site"
ORIGIN      
        1 acacaagatg gcggcgccca gcggagtagg ggctgcgctt ggggtttgct gaagctggct
       61 gcctctccca ctcccctttt gggtgcaaag cgccgctagc gggaagacgg gggccgggcg
      121 gggacagggg cacctgcgta gctggactga gagcctgcgc ccagcttaca tcgaccccac
      181 ccggccccgg cccgacccga cgcgacccga tccgatccga tcccattcca tccgttcctc
      241 gtctcctccc ggtctgaccc gttgcccggc cgtggttcgc cacaccaggc atccaaagct
      301 gaggtcgctc ctacggcctg ggctcgcctt cgctttagag atgtttggcc tcttccctcc
      361 caaacagccc atcttcaaaa cctggactct tggactggca cctggccacc tttccctcta
      421 ccaagactcc acttccgtct tacccacttc ttcctcagat tcttggtacc ccctgggttg
      481 gagactgctc attttccttc caaattaatc ccagaccccc taaaatattg acaaccttga
      541 caacccccca accgaggagc cagactttgt tttggactaa cttccatagc cctatcatgg
      601 aggcagtgta cctggtagtg aatgggttgg gcctggtgct ggacgtgctg accttggtgt
      661 tggacctcaa cttcctgctg gtgtcctccc tcctggcttc cctggcctgg ctcctggcct
      721 tcgtctacaa cctgccgcac acggtactga ctagtcttct gcacttgggc cgcggagtct
      781 tgctttcatt gctggccttg atcgaagccg tggtccggtt cacatgtggg ggcttgcagg
      841 ccttgtgtac tctgctgtat agctgctgct ctggcctaga gagcctaaag ctcctggggc
      901 acctggcctc tcatggggca ctgcggagca gggagatact gcaccggggc gtcctcaatg
      961 tggtctccag tggccatgct ttgctgcgcc aggcctgtga catctgtgcc attgccatga
     1021 gcctggtggc ttatgtgatc aacagcctgg tcaacatctg cctcatcggc actcagaacc
     1081 tcttttccct ggtgctggcc ctgtgggatg cagtgaccgg gcctctgtgg aggatgacgg
     1141 acgtagtggc tgccttccta gcccacattt ccagcagtgc tgtggccatg gccatcctcc
     1201 tttggacacc ctgccaacta gccctggagc tgctggcctc agctgcccgc ctcctggcca
     1261 gctttgtgct tgtcaatctc actggcttgg tgttgctagc ttgtgtgctg gcagtgacgg
     1321 tgactgtgtt gcatccggac ttcaccctga ggctggctac ccaggcactc agccagctcc
     1381 atgcccggcc atcctaccac cgtcttcgag aggatgtcat gcggctctct cgcctagcac
     1441 tgggctcaga ggcctggcgc cgagtctgga gccgcagtct gcagctggcg agttggccaa
     1501 accggggagg ggcacctgga gctccccagg gtgaccctat gagggtattc tcagttagga
     1561 cccggagaca ggacactctt cctgaagcgg ggcgcagatc agaggcagaa gaggaggagg
     1621 ccaggaccat cagagtgaca cctgtcaggg gccgagagag gctcaatgag gaggagcctc
     1681 caggtgggca agacccttgg aaattgctga aggagcaaga ggagcggaag aagtgtgtca
     1741 tctgccagga ccagagcaag acagtgttgc tcctgccctg ccggcatctg tgcctgtgcc
     1801 aggcctgcac tgaaatcctg atgcgccacc ccgtctacca ccgcaattgc ccgctctgcc
     1861 gccggggcat cctgcagacc ctcaatgtct acctctgaag cctccttccc tgcctgccca
     1921 cccctccatg ctccacgcag gcactcacgc taggacagca ttaacacctc atctccgggt
     1981 cctggtctga atcccctcct acccctgtgg ccatcctgcc atacatccag gacattgagt
     2041 tggaagacta tgatctgggt gggggcagga taacatggct tctctttacc cagtgggtcc
     2101 cttcgatgct gagggtggtg agtatgtcac tatgcaaggg ccctgagact atttgctgtg
     2161 ggctctcctc cagcctgccc agggcccacc cagatgcctc tggggttacc cctgtctgct
     2221 tctggttttt ctgttggaga tctataggtc cttttcctgc ctccttcaca tttcctcccc
     2281 agcttttgcg gccacaacac atcagtgtca tttgggtgtt ttggcaactc aggggccttc
     2341 ggatgatctt aaacctttgt gttcagccag agcccctgtg ccctggtagg cgttggggtt
     2401 agtatctctc gggtgccctc agagccacct ctgcctgtga tcgtctgatg aggctccctc
     2461 ccaacctgat ccaaaagcca gtctcaggag tttacccctg ggatggggga tgcatctgca
     2521 cctgactttg gggccacgtg ccctgtggca ccccagctca ctgggagtct caggagggat
     2581 aaccggattt ctgctctttc ccctgtcact cccacatcac acagaaaaat ggcattcctc
     2641 tctgtctctc cctggcatgg agagggcaga ctgtgcacat ttcactaggg tccaaataca
     2701 gaagggccca gggcccaggg gcttgcagct tcgtgagggg tctctggccc agtttccaat
     2761 gaataaagtt ctcttgacag ctc
//
