LOCUS       NM_022453               1477 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ring finger protein 25 (RNF25), mRNA.
ACCESSION   NM_022453
VERSION     NM_022453.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1477)
  AUTHORS   Huang,Z., Zhou,L., Duan,J., Qin,S., Jiang,J., Chen,H., Wang,K.,
            Liu,R., Yuan,M., Tang,X., Nice,E.C., Wei,Y., Zhang,W. and Huang,C.
  TITLE     Oxidative Stress Promotes Liver Cancer Metastasis via
            RNF25-Mediated E-Cadherin Protein Degradation
  JOURNAL   Adv Sci (Weinh) 11 (13), e2306929 (2024)
   PUBMED   38286671
  REMARK    GeneRIF: Oxidative Stress Promotes Liver Cancer Metastasis via
            RNF25-Mediated E-Cadherin Protein Degradation.
REFERENCE   2  (bases 1 to 1477)
  AUTHORS   Zhao,S., Cordes,J., Caban,K.M., Gotz,M.J., Mackens-Kiani,T.,
            Veltri,A.J., Sinha,N.K., Weickert,P., Kaya,S., Hewitt,G.,
            Nedialkova,D.D., Frohlich,T., Beckmann,R., Buskirk,A.R., Green,R.
            and Stingele,J.
  TITLE     RNF14-dependent atypical ubiquitylation promotes
            translation-coupled resolution of RNA-protein crosslinks
  JOURNAL   Mol Cell 83 (23), 4290-4303 (2023)
   PUBMED   37951216
REFERENCE   3  (bases 1 to 1477)
  AUTHORS   Suryo Rahmanto,A., Blum,C.J., Scalera,C., Heidelberger,J.B.,
            Mesitov,M., Horn-Ghetko,D., Graf,J.F., Mikicic,I., Hobrecht,R.,
            Orekhova,A., Ostermaier,M., Ebersberger,S., Mockel,M.M.,
            Krapoth,N., Da Silva Fernandes,N., Mizi,A., Zhu,Y., Chen,J.X.,
            Choudhary,C., Papantonis,A., Ulrich,H.D., Schulman,B.A., Konig,J.
            and Beli,P.
  TITLE     K6-linked ubiquitylation marks formaldehyde-induced RNA-protein
            crosslinks for resolution
  JOURNAL   Mol Cell 83 (23), 4272-4289 (2023)
   PUBMED   37951215
REFERENCE   4  (bases 1 to 1477)
  AUTHORS   Gurzeler,L.A., Link,M., Ibig,Y., Schmidt,I., Galuba,O.,
            Schoenbett,J., Gasser-Didierlaurant,C., Parker,C.N., Mao,X.,
            Bitsch,F., Schirle,M., Couttet,P., Sigoillot,F., Ziegelmuller,J.,
            Uldry,A.C., Teodorowicz,W., Schmiedeberg,N., Muhlemann,O. and
            Reinhardt,J.
  TITLE     Drug-induced eRF1 degradation promotes readthrough and reveals a
            new branch of ribosome quality control
  JOURNAL   Cell Rep 42 (9), 113056 (2023)
   PUBMED   37651229
  REMARK    Erratum:[Cell Rep. 2023 Sep 26;42(9):113159. doi:
            10.1016/j.celrep.2023.113159.. PMID: 37708027]
REFERENCE   5  (bases 1 to 1477)
  AUTHORS   Oltion,K., Carelli,J.D., Yang,T., See,S.K., Wang,H.Y., Kampmann,M.
            and Taunton,J.
  TITLE     An E3 ligase network engages GCN1 to promote the degradation of
            translation factors on stalled ribosomes
  JOURNAL   Cell 186 (2), 346-362 (2023)
   PUBMED   36638793
REFERENCE   6  (bases 1 to 1477)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   7  (bases 1 to 1477)
  AUTHORS   van Wijk,S.J., de Vries,S.J., Kemmeren,P., Huang,A., Boelens,R.,
            Bonvin,A.M. and Timmers,H.T.
  TITLE     A comprehensive framework of E2-RING E3 interactions of the human
            ubiquitin-proteasome system
  JOURNAL   Mol Syst Biol 5, 295 (2009)
   PUBMED   19690564
  REMARK    Erratum:[Mol Syst Biol. 2009;5:317]
REFERENCE   8  (bases 1 to 1477)
  AUTHORS   Ding,W., Li,C., Hu,T., Graves-Deal,R., Fotia,A.B., Weissman,A.M.
            and Coffey,R.J.
  TITLE     EGF receptor-independent action of TGF-alpha protects Naked2 from
            AO7-mediated ubiquitylation and proteasomal degradation
  JOURNAL   Proc Natl Acad Sci U S A 105 (36), 13433-13438 (2008)
   PUBMED   18757723
REFERENCE   9  (bases 1 to 1477)
  AUTHORS   Asamitsu,K., Tetsuka,T., Kanazawa,S. and Okamoto,T.
  TITLE     RING finger protein AO7 supports NF-kappaB-mediated transcription
            by interacting with the transactivation domain of the p65 subunit
  JOURNAL   J Biol Chem 278 (29), 26879-26887 (2003)
   PUBMED   12748188
  REMARK    GeneRIF: RING finger protein AO7 supports NF-kappaB-mediated
            transcription by interacting with the transactivation domain of the
            p65 subunit.
REFERENCE   10 (bases 1 to 1477)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
  REMARK    GeneRIF: Functional studies of the mouse counterpart
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI831198.1, AK023968.1 and
            AW613024.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022453.2.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif. The mouse counterpart of this protein has been shown to
            interact with Rela, the p65 subunit of NF-kappaB (NFKB), and
            modulate NFKB-mediated transcription activity. The mouse protein
            also binds ubiquitin-conjugating enzymes (E2s) and is a substrate
            for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289501.1, SRR1660807.146979.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295704.7/ ENSP00000295704.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BI831198.1         57-82
            27-1348             AK023968.1         1-1322
            1349-1477           AW613024.1         34-162              c
FEATURES             Location/Qualifiers
     source          1..1477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1477
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /note="ring finger protein 25"
                     /db_xref="GeneID:64320"
                     /db_xref="HGNC:HGNC:14662"
                     /db_xref="MIM:616014"
     exon            1..73
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1412
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein AO7; RING-type E3 ubiquitin
                     transferase RNF25"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF25"
                     /protein_id="NP_071898.2"
                     /db_xref="CCDS:CCDS2420.1"
                     /db_xref="GeneID:64320"
                     /db_xref="HGNC:HGNC:14662"
                     /db_xref="MIM:616014"
                     /translation="MAASASAAAGEEDWVLPSEVEVLESIYLDELQVIKGNGRTSPWE
                     IYITLHPATAEDQDSQYVCFTLVLQVPAEYPHEVPQISIRNPRGLSDEQIHTILQVLG
                     HVAKAGLGTAMLYELIEKGKEILTDNNIPHGQCVICLYGFQEKEAFTKTPCYHYFHCH
                     CLARYIQHMEQELKAQGQEQEQERQHATTKQKAVGVQCPVCREPLVYDLASLKAAPEP
                     QQPMELYQPSAESLRQQEERKRLYQRQQERGGIIDLEAERNRYFISLQQPPAPAEPES
                     AVDVSKGSQPPSTLAAELSTSPAVQSTLPPPLPVATQHICEKIPGTRSNQQRLGETQK
                     AMLDPPKPSRGPWRQPERRHPKGGECHAPKGTRDTQELPPPEGPLKEPMDLKPEPHSQ
                     GVEGPPQEKGPGSWQGPPPRRTRDCVRWERSKGRTPGSSYPRLPRGQGAYRPGTRRES
                     LGLESKDGS"
     exon            74..148
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            149..251
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            252..319
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            320..389
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            390..461
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            462..605
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            606..698
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            699..833
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1477
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /note="hexamer: AATAAA"
     polyA_site      1477
                     /gene="RNF25"
                     /gene_synonym="AO7"
                     /note="major polyA site"
ORIGIN      
        1 atttccggtt ccggctgcgg gccggtgaag atatggcggc gtctgcgtct gcagctgcag
       61 gggaggagga ctgggtcctt ccctctgaag ttgaagtatt ggagtccatc tatctagatg
      121 aactacaggt gattaaagga aatggcagaa cttcaccatg ggagatctac atcactttgc
      181 atcctgccac tgcagaggac caggattcac agtatgtctg cttcactctg gtgcttcagg
      241 tcccagcaga gtatccccat gaggtgccac agatctctat ccgaaatccc cgaggacttt
      301 cagatgaaca gatccacacg atcttacagg tgctgggcca cgtggccaag gctgggctgg
      361 gcactgccat gctgtatgaa ctcattgaga aagggaagga aattctcaca gataacaaca
      421 tccctcatgg ccagtgtgtc atctgcctct atggtttcca ggagaaggag gcctttacca
      481 aaacaccctg ttaccactac ttccactgcc actgccttgc tcggtacatc cagcacatgg
      541 agcaagagct gaaggcacaa ggacaggagc aggaacagga acggcagcat gctacaacca
      601 aacagaaggc agtcggtgtg cagtgtccag tgtgcagaga gcccctcgtg tatgatcttg
      661 cctcactgaa agcagcccct gaaccccaac agcccatgga gctgtaccag cccagtgcag
      721 agagcttgcg ccagcaagaa gaacgcaagc ggctctacca gaggcagcag gagcgggggg
      781 gaatcattga ccttgaggct gagcgaaacc gatacttcat cagccttcag cagcctcctg
      841 cccctgcgga acctgagtca gctgtagatg tctccaaagg atcccaacca cccagcaccc
      901 ttgcagcaga actatccacc tcaccagccg tccaatccac tttgccacct cctctgcctg
      961 tggcgaccca gcacatatgt gagaagattc cagggaccag gtcaaatcag caaaggttgg
     1021 gcgaaaccca gaaagctatg ctagatcccc ccaagcccag tcgaggtccc tggcgacagc
     1081 ccgaacggag gcacccaaag ggaggggagt gccacgcccc taaaggtacc cgtgacaccc
     1141 aggaactgcc acctcctgag gggcccctca aggagcccat ggacctaaag ccagaacccc
     1201 atagccaagg agttgaaggt cctccacaag agaaggggcc tggcagctgg caggggcccc
     1261 caccccgcag gactcgggac tgtgttcgct gggagcgctc taaaggccgg acacccggtt
     1321 cttcctaccc tcgcctgcct cggggccagg gagcataccg gcctggtact cggagggagt
     1381 ccctgggcct ggaatctaag gatggttcct agcaggactt ggtgggggga acagggaatt
     1441 ggggatggga gggaggcaat aaagatattt ggccttc
//
