LOCUS       NM_001134337            7328 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ring finger protein 24 (RNF24), transcript variant 2,
            mRNA.
ACCESSION   NM_001134337
VERSION     NM_001134337.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7328)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7328)
  AUTHORS   Lussier,M.P., Lepage,P.K., Bousquet,S.M. and Boulay,G.
  TITLE     RNF24, a new TRPC interacting protein, causes the intracellular
            retention of TRPC
  JOURNAL   Cell Calcium 43 (5), 432-443 (2008)
   PUBMED   17850865
  REMARK    GeneRIF: Results indicate that RNF24 interacts with TRPC cation
            channels in the Golgi apparatus and affects TRPC intracellular
            trafficking without affecting their activity.
REFERENCE   3  (bases 1 to 7328)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY140488.1, BC039584.1,
            AL031670.6, CD367454.1 and BQ181223.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001134337.2.
            
            Summary: This gene encodes an integral membrane protein that
            contains a RING-type zinc finger. The encoded protein may interact
            with multiple transient receptor potential cation channel subfamily
            C (TRPC) proteins and regulate the trafficking and insertion of
            these proteins into the plasma membrane. [provided by RefSeq, Mar
            2016].
            
            Transcript Variant: This variant (2) uses a different segment for
            its 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the
            same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.485838.1,
                                           SRR3476690.674117.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358395.11/ ENSP00000351166.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                HY140488.1         35-82
            49-1575             BC039584.1         1-1527
            1576-2927           AL031670.6         114805-116156
            2928-3218           CD367454.1         16-306              c
            3219-6902           AL031670.6         116448-120131
            6903-7328           BQ181223.1         14-439              c
FEATURES             Location/Qualifiers
     source          1..7328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..7328
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /note="ring finger protein 24"
                     /db_xref="GeneID:11237"
                     /db_xref="HGNC:HGNC:13779"
                     /db_xref="MIM:612489"
     exon            1..122
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /inference="alignment:Splign:2.1.0"
     exon            123..272
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..576
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="RING finger protein 24 isoform 1"
                     /protein_id="NP_001127809.1"
                     /db_xref="CCDS:CCDS13074.1"
                     /db_xref="GeneID:11237"
                     /db_xref="HGNC:HGNC:13779"
                     /db_xref="MIM:612489"
                     /translation="MSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAIFVFILSLLFCC
                     YLIRLRHQAHKEFYAYKQVILKEKVKELNLHELCAVCLEDFKPRDELGICPCKHAFHR
                     KCLIKWLEVRKVCPLCNMPVLQLAQLHSKQDRGPPQGPLPGAENIV"
     exon            273..315
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /inference="alignment:Splign:2.1.0"
     exon            316..357
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /inference="alignment:Splign:2.1.0"
     exon            358..437
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /inference="alignment:Splign:2.1.0"
     exon            438..7328
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3191..3196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /note="hexamer: ATTAAA"
     polyA_site      3218
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /note="major polyA site"
     regulatory      7307..7312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /note="hexamer: AATAAA"
     polyA_site      7328
                     /gene="RNF24"
                     /gene_synonym="G1L"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcagcc gccgccacct ccgccgcgct ctgtccggac ggacgctcgc cgcccgcagc
       61 ctgccgcccg ccgcagggcg ctgacggtcc cgcacgtctg ccgctgccac cggcgcgccc
      121 gattcatcca tgagctcgga tttcccacat tacaacttca ggatgcctaa tattggattc
      181 cagaatctgc ctctcaacat atatattgtg gtttttggta ctgctatatt tgtcttcatc
      241 cttagtttac tcttctgttg ctacttgatt aggctaagac atcaagcaca caaagaattt
      301 tatgcctaca aacaggttat attaaaagag aaagtaaaag aattgaattt acatgagctc
      361 tgtgcagtgt gcctagaaga cttcaagcct cgagatgagt tggggatttg cccatgtaag
      421 cacgccttcc acagaaagtg ccttattaag tggctggagg ttcgtaaagt gtgtcccctg
      481 tgcaacatgc cagttctaca gctggcccag ttgcacagta agcaggaccg tggaccccct
      541 caggggcccc ttcctggggc agagaacatt gtatagctta ccgcaaggat cagactgttg
      601 ctggacacga cgtctgtgtg gagccaggag gaacacatgt ggtgtctgta tggctgctct
      661 ctacctagga caccagctgc cacttctttt gcctcatgaa gaactcttgg gccagccaaa
      721 ctgggaacct aggtgtctgg gtcttgtgac aaccaaagca ctttgacact accccctgcc
      781 gagagaagag gagtggatga gcctgcgggt ttgcctcaag aaacttcatg agggtctctt
      841 actaactcca ttacactctc tctcctggag cctcatctcc atgtcaagca ggagggtaaa
      901 gaagggaact aagagcaggt ctttcaagcc acacccccac ctgcggatgg atgggtttct
      961 ctgtaggcca tgcaggcctt tgtcgcagca aaccttccca gcagcccttg agccaagtaa
     1021 aaccagcaca accagccacc agtggttggt gaggcagtgc ccacaaggct catgttgtat
     1081 gcctttgata aggccatctt ggctttgagt agcagtgttc ctcgtcaccc atttccccct
     1141 caggattaca acacctgcta tcaaatcatc taagctgaaa acatgagatg cgcttggaaa
     1201 ggcctagtca gaagccattt cctcttatca tttccctctc ctatgcacca gtaaggcccg
     1261 tccagagccc cagcagggag tgggccctga gtccacactg tccctgagtg atccaggagg
     1321 ctgcccacat ccccacatgt gcactgtggt tccagtgtag ctgctgtgag cccactgcca
     1381 ctgcctcaga agggagccac tgtgaacctc tcgagtggct ccaaagagca gtggcttttt
     1441 gagaatggcc catacttctg gcccggctgg atgaagggaa tgccgaccct ttggcctctc
     1501 cccctccttc catctcttct ctctcttgcc ctatctctct ttctacttca gaaaaaaaaa
     1561 aaaaaaaaaa aaaaagcctg tcattcactt tttaacactt tatcccaaat aagatccctg
     1621 tgtaattctg aagctggtga tccacttgga attgtagata gtttcaggaa gctcctgcag
     1681 ggctgtccac cgttggtgtg tgcctcagta tttggacttc cgaaactgaa agtgaaagtg
     1741 tctttatagg agagaaacgc atgctgctct ttggctcttt ctgtccaact tttctagaaa
     1801 tgactcaaag tccattaaga tttgtgaata ttgtataaat tagctatgga aagtagcagg
     1861 tcagatggaa aattcttttc cacagccctg ctctccgcct ccctccatct taggagcgcc
     1921 tgcctcaatt cctcgtcaac tgctttgctc cactccatcc cacaggtgtg agtgggggaa
     1981 gtttttcatt aggaatacag tctgcgtgac atggagaatg gatggaggga gctttgctac
     2041 tctgctcttg gcatgactcc aggatttttt tctggaatcc aacctctgtc ctcttaggag
     2101 aaggaacctg tccttggttc agatggctgg gcatgaggag gaaaatttcc attagtgtag
     2161 aacagtgctg gacagaatcc ggtttggaaa attacaaatc cagttggtca aaataggcca
     2221 tttcctatgt gtgacctatt cgtggtatgc caactggact gcttcctaaa caggacgagg
     2281 aaagtgagga atatttttat atgaaagcct tagcctgtct ggcacccatg aaaaaaacta
     2341 tttatgcact cctactttca ccgtcttttt gcattctcta tttgtagcac aacagagttg
     2401 aatgccacaa aacaccccgt ttatagtgag ctgttttcag tgaccaatat cagaaggagg
     2461 cttgcttctg gactagcctc actaattgcc agcagccacc attttccatg gaatggcctt
     2521 gggacagatg tcacctctgt tatggggctc taataggaaa gagaatgttt tttcccttcc
     2581 tatgatcaat actgcaaatt attgctgctc acagctttta taggattctc ccaactgaaa
     2641 gttgcaggct ttttctgtcc ctgtgcatca gtactaacaa aagacagcct caccaagtct
     2701 gtatatttga acagaggcaa gttaattcat ccccccgtgt cagagccaca ggcatgttga
     2761 gggggttgat acgtagcact ggaccagggc gcaaagccca gatagttcca gccatgagag
     2821 gagagcacaa gaatgctctg cactctgcac tcagcaccac cttgggtctg ctttgcccag
     2881 atgagggacc actaacaacc ttctcagcac atgtgaatgt ggactggttt taaaatgcat
     2941 tcattctgct aggattgggc tggaagctgg aacagtgaga gtactttttc tgctcctagt
     3001 catctccctt tctcagcgtg acatcctcct gcagcaagcc tagtatcact agcagtagtt
     3061 cctgcgactc ttagcaacac aacccgaata tttgctccct gcatctgggt cctccaccag
     3121 gatgggcctg cgcatctgca ttgctgtaca gacaaacagg ccttttaatt tacatcctcc
     3181 tttaattctc attaaaatcg cagggttttt gtttgaaaga cagtcctttt tttatttatt
     3241 ttgaaaaagg aatgagttag ggaccccttt ataactctct tggctcagac tcgaacccca
     3301 tggtaaagtc accctttccg catctatctt caggagttgc tgggacttgt tactgtgtag
     3361 ctgcgtgggg attctggtct gctcttggac cactggctgg tatcctttgt gtgtttctta
     3421 agcagctcaa agatagaatg ttgctggtct gctatgggtt agtggagcat aactcagccc
     3481 caactggact ccacgggtgg ctgaaccatt agtagttgct aggggtacaa ctgaattcaa
     3541 ctgccttcag aaacagggaa caaaaccagc ctgacttgat tcctggttgg gtcagtatca
     3601 gacactagga agttgacatc tgctgctttt ctttgccacg tgtgatttgg ttaggcctgt
     3661 ccctggcaga taaggtcctt gaagcctatg cttgcctagc cagggaaggc aggacagaaa
     3721 tggccaaata ggggcaggtg gcccctggga aggtctgagc tgagggatac aggggacctc
     3781 ccaccattgc cggataccct gttcttgaca agaagatcct tttccccagt gccaagcccc
     3841 ttggatccat cagagaaata gcctcgggcc ttgtcctttt tcacaacccc acttcaaaat
     3901 catgtcatct ccctggcctg atcccgctct aagctacttt gaacaactag gaattatttt
     3961 tctcagaggc tttttgggca ttatgaaata catcctgata catccagggc agtataccca
     4021 gagctccagg cagagagtga tggaatcacc tcttgtcact cactagcctt aggcccttct
     4081 gcaggttagc ctctcagtct cttccttagc ttccttagct accacccagg gattgtagta
     4141 acgtccctgg cacctcttgt gggggttagc tggtgcccag agcctggtag gcagcaggcc
     4201 tggtgtcatg ggggctgctg ataccacata acatcatctg ggttacatgg gctcctctgc
     4261 catcatgatt gataggaaca gaacctcagc caaaaagctt cctgagctgt aggggctttc
     4321 cctgaggccc aggttcacct ggcccctttc ttccttggtc atctctgcct ttgcccacag
     4381 tgaactctga cttggttgtt cagtgctgaa tatttctttc ttaatgtttt gaataggtaa
     4441 tccattcatg tggttcacaa atcataaagt agttaaaagc ctttcttgag ttcctgatgc
     4501 ctagcaagct ccgctcctca ctccatgaat acctactatt ggtttgttcc ttgggtatcc
     4561 ttccagagat catttatgca tgtacacaca tgtgtatgtg tgtctatata atttttctcc
     4621 ttttctactc atgtgatacc agacaagtgt attcaaggaa cgctcctact aatgtgggaa
     4681 gagccatccc agaaatcaga atacaaaatg tgaacccaga attgggggat gtttttgcaa
     4741 tcacactcct gttgagtaag acatattttc attttattgc aacatactga aattttagtt
     4801 ttctgtacaa atcagaatct gcagtccctc ccttacccca aatgcccagc taatccaaga
     4861 gcacaaccag atttttctga ttgactttct atctgcgaca ggatgctcaa gatcaggctc
     4921 tgtagctgac agcagtggca caggcctctc ccagctctga gcagcctctg caggtgcctg
     4981 gacagctgct ggcccctccc ctaccttggc cagttccaag tgaggaccag tggtgatgtg
     5041 tggctgcaac tgttgtggtc acttaggcaa gctcttgtgt ctttgatgca ggagtttgag
     5101 cagcagcaac tgaaggcttc tattttgtgg ggcagacatc ttagctactg agcaagtgca
     5161 cagtgagtct catgtggata tgcctgaatg tccagcgtca gttcatggag ctactccctt
     5221 tccctcccaa cttttcgttg ttgttgagac agggtcttgt tacccagact ggagtgcagt
     5281 ggcaccattg tagctcactg cagcctcaac ttcctggact caagtgatcc tcccgcctca
     5341 gtctgtagct gcgtctacag gtgcacacca gcacacctgg ctaattttcg taattatttt
     5401 tttgtagaga caggtctcaa ctcactatgt tgcccaggct ggcctcctca ctctgtgcac
     5461 acactttgaa aagaaaatgc ttctggtcgg gcgcgatggc tcacgcctgt aatcccaaca
     5521 tcccagcact ttgggaggcc gaggcaggcg gatcacctta ggtcaagagt tcaagaccag
     5581 cctgaccaat atggtgaaac cccctctact aaaaatacaa aaatttgccg ggtgtggtga
     5641 cgcatgcctg taatcccagc cactcaggag gctgggacag gagaattgat tgaacccggg
     5701 agacagaagt tgcagtgagc caagatcccc actgcactcc agcctgggca acagagcgag
     5761 actccgtctc aaaaaaacac acaagaaaag aaaatgcttc ctacagaatt ttccctttat
     5821 gccttgtttt ccatttgaca acagaaatta ccccaacaat tttttttttt tttttttttt
     5881 tttttttttt tgagacggag tctcgctctg tcacccaggc tggaatgcag tggcacgatc
     5941 ttggcccact gcaagctccg cctcccaggt tcacgccatt ctcccgcctc gggagctggg
     6001 acaacaggtg cccgccacca cgctcggcta attttttgta tttttagtac agacggagtt
     6061 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatgcacct gccttgacct
     6121 cccaaagtgc tgggattaca ggcgtgagcc actgcgcccg gccaataatt tttttagttt
     6181 aagttcattt ttgtccccgc tgatgaaagt tagagctgct tcctccaggc agccctggga
     6241 gtaggggcac agacttgtgc ctcgcttccc agcagctgcc cagtgcctct gtccacaccc
     6301 acctccctgg tgtacttgcc ccctacagca gcagcccaga tcctcccctg gattaaaatt
     6361 gcaactggtg ccctaaccca aaacttgaga aaaaattctc tatcacatcc actcttctgg
     6421 catttgtaga atctctggcc ctgggtgtgt cttttcctgt agctgttaca gatttcttaa
     6481 gcagatttct taagcagatg gacatgtcca gattcatgcc taaatatcca gttgataact
     6541 ggaaaatgct ggttcacggt tctttagtaa agattaataa gggatcccca tgtgctgggg
     6601 agtgtgcttc catttgagtg gggatatcag aagaaaaaga ggggcttgtg tagtaaacct
     6661 tactttgcca attcagctgt agagcccaaa ttgttacaag atgcaaagat gtactccact
     6721 ttttgaccaa gcatcagcac ctttggctta ccatccagtc cttacttctg tgactgtaag
     6781 ggccccacca gtgtcagcag acttgtttgt gctttggggg aactctcttc tcagctccct
     6841 ttgccagtcc caagcctggt ggatctgcat ctcacgccca ctgcacaccg ttcctctcca
     6901 tctgcccttc cctcccaggc ccccggtcgg gggagcaggt gtggcaagtg ttaggaactc
     6961 ccttctggtg acagctggtc ttcctagagt gttgctggta actatcgcct cttggtcttc
     7021 tgacatcatt gccaggaacg gggcactttt tcgtcttgta gtttggccct cgggtttcct
     7081 cactaggtat tgtgtaactc cctcaaaaaa aggtttatga aatgctgaac ctcaggtttc
     7141 atagacgtct ttgtacacta aaaattctgc agcagaatat ttttaaacat tcgcagtttt
     7201 ttgtaagcta tatttttgta tatttaattg ctattttaaa attttaatgc attttgctaa
     7261 tcactcctca aaaataaaac atgcatgtaa ttgactcaaa cgtgtaaata aaagcaaatt
     7321 ttgaaaaa
//
