LOCUS       NM_001395871            6008 bp    mRNA    linear   PRI 07-AUG-2024
DEFINITION  Homo sapiens ring finger protein 228 (RNF228), mRNA.
ACCESSION   NM_001395871
VERSION     NM_001395871.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010980.8.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678139.2/ ENSP00000503543.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6008              AC010980.8         71302-77309         c
FEATURES             Location/Qualifiers
     source          1..6008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..6008
                     /gene="RNF228"
                     /note="ring finger protein 228"
                     /db_xref="GeneID:122319436"
                     /db_xref="HGNC:HGNC:55809"
     exon            1..6008
                     /gene="RNF228"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1128
                     /gene="RNF228"
                     /codon_start=1
                     /product="RING finger protein 228"
                     /protein_id="NP_001382800.1"
                     /db_xref="CCDS:CCDS92948.1"
                     /db_xref="GeneID:122319436"
                     /db_xref="HGNC:HGNC:55809"
                     /translation="MAAPASDSGGSQQSPSSSPGSREGAGVAAKGAPDCGDAGARDAA
                     ETVSGLPPLEDYECKICYNYFDADRRAPKLLACLHTFCQECLSQLQLRAAAAAAAAAA
                     PERPPRPPPWLCPPGAIACPVCRHRTPLPDSRVHGLPNNTKLAEAFPLALRAAHDPLP
                     QDRLPPLPARLPAPAAAPPPTPAPPPPPSPAPPQPPPPPPAEDAAPGPRARPGLRAPG
                     AYDSCQNCKRAALTAGCVCVVFSFLSMVVLLFTGLIFVNHYGGGGTPGGGAPPGEAPA
                     TGSPSPSPVGPICLSVASILALFSVVVTWVICWLKYRPEGAAAGSTGGSGGGGGPRAR
                     AAAGGARRSDT"
     regulatory      2892..2897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF228"
                     /note="hexamer: AACAAG"
     polyA_site      2912
                     /gene="RNF228"
                     /note="major polyA site"
     regulatory      3459..3464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF228"
                     /note="hexamer: AATATA"
     polyA_site      3480
                     /gene="RNF228"
     regulatory      3664..3669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF228"
                     /note="hexamer: AATACA"
     polyA_site      3692
                     /gene="RNF228"
     regulatory      5336..5341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF228"
                     /note="hexamer: ATTAAA"
     polyA_site      5358
                     /gene="RNF228"
     regulatory      5396..5401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF228"
                     /note="hexamer: AATAAA"
     polyA_site      5416
                     /gene="RNF228"
     regulatory      5985..5990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF228"
                     /note="hexamer: AATATA"
     polyA_site      6008
                     /gene="RNF228"
ORIGIN      
        1 agaagcgcct cctccccgcc cggagcccag gcggcggtgc agggggagga aggcacctca
       61 ccttgccccc gatgaggggc ggatcatgcc atggcagcgc cggcgagcga cagcggcggc
      121 agccagcaga gcccaagcag cagccccggg agccgggagg gagctggggt cgccgcgaag
      181 ggagccccgg actgcggaga cgcaggagcc cgggacgcag cggagacggt ctccggcctc
      241 cctccgcttg aggactacga gtgcaaaatc tgctacaact acttcgacgc ggaccggcgc
      301 gcgcccaagc tgctggcgtg cttgcacacc ttctgccagg agtgcctgag ccagctgcag
      361 ctccgcgccg ccgccgccgc cgccgctgcc gccgcgcctg agcgcccgcc gcgcccgccg
      421 ccctggctct gcccgcccgg cgccatcgcg tgcccggtgt gccgccaccg cacgccgctg
      481 cccgacagcc gcgtgcacgg cctgcccaac aacaccaagc tagccgaggc cttcccgctg
      541 gctttgcgcg cagcgcacga cccgctgccc caggaccgcc tcccgccgct gcccgcgcgc
      601 ctgcccgcgc ccgctgctgc cccgccgccc accccggccc cgccaccgcc gccctccccc
      661 gccccaccgc agccgccgcc gccgccgcct gccgaggacg cggcccccgg gcctcgagcc
      721 cgccccggcc tgcgcgcccc gggcgcctac gacagctgcc agaactgcaa gcgcgcggcg
      781 ctcaccgctg gctgcgtgtg cgtggtcttc tccttcctct ccatggtggt gctgctcttc
      841 accggcctca tcttcgtcaa ccactacggc ggcgggggaa cccccggagg cggggcgccc
      901 cctggcgagg caccggccac cgggtcgccc tcgccctcgc ccgtggggcc catctgcctg
      961 tcggtggcca gcatcctggc actcttctcg gtcgttgtca cctgggtcat ctgctggctc
     1021 aagtatcggc ccgagggtgc ggccgcgggc tcgacggggg gcagcggcgg cggcggcggc
     1081 ccgagggcac gggctgcggc gggcggcgcg cggaggagcg acacatagcc gggccacgcc
     1141 gcggaaccgg cgcctgcacc tccagccccg cgtggcggga gaagaggggg cctctggctc
     1201 ggtgcgctcg agcttctgca ccctctccct gctgcccccg ggctctcctg gactcacact
     1261 ctctcccaac tcggccactg aggagcctcg gttttctgtc cctcgggctt ctgtcgcccc
     1321 tcgcccttcg cgctgggcca gagagggaaa ctgaacagga agggatgttg gtgggggggg
     1381 ggggtctctt ttgcctggac tgtgcaaaat tgacctccgc gttatgcacc accctcgtcc
     1441 tcgtcagaat gtgcggccat ccctccctag agcacaaaga tctgcagaga cgaagcaagg
     1501 ggagggggag ccccaccgcc ccgcctgaaa gctggttttc tggccgccag gacttgagag
     1561 tttctttaaa ggtgcagctg cgcgcgtgca cacgtgcatc tgtggcggct gtgaatggac
     1621 ttgaattgcc cggaggaaga atgaatggga tgtaaacgtg agaggaaaag gatttcctgc
     1681 ttcctagcgg tcctggaaag ggagagatcc tgagcgctga gagtgacgga cactccccgc
     1741 cggcacagcg cgggcgtgcc cggagctcag gcagcagctg ggcgcgatgg ggcaggtgca
     1801 cggcgcgcgt gcgcgatcgg agccgactcg gagtggccga ggctgcggcg cgcccagggc
     1861 ggtgggccct gttgcccatg gccgggtgtt gtctggagca gagcctagaa gtctcatctc
     1921 ctggaagctt gtggttgttt tattcacggt gttactgcca ggaagtcttc tgtaactaga
     1981 ctcagggagc ttaaagagcc tgttctccct tctctcaaaa gtggcttacg gttgccccca
     2041 cctggaagat attgaaagct attcacacag aatataaact agattttctc cttcccctcg
     2101 cctttttttc ttaatttcat ttaacatata atttattttt gaatatataa atctggaaat
     2161 ttttgtgcat taagatttcc agaaaattgt ttgataagca gtgacattat tcccatacct
     2221 cgagtccaaa tacatttcga aattaggagc agaaaataaa agcctgttgg taattgattc
     2281 aatattttat actgtgaaat aactaatgac ttttaattat ctgataaaat ataaactagt
     2341 gcccaaacat gaaatcaact aactgaaggt ctttctgcct ttggctacaa aagatatata
     2401 tcgtatacac ttattagaaa gtattatatg attttgaatt tagctgtttg atattgttgg
     2461 aattactgaa atgttcacat acagtcacat gagatgaaaa agaatatata tctatctgat
     2521 tttgtaacta caaagatgaa ttgccagtat atgttgcaag tgggttagat gccttttttt
     2581 ttaagaagga aaactgttcc aaatgtattt tatatgaaaa cattctttat tccatctttt
     2641 gaaatttgga ataagacaaa gttttcatgc ttaaaaatca cagaatctac tgaaggtatg
     2701 ctattattcc tcgagtattt atgcaagctg tctgcatgat atcctgacac tattctatta
     2761 attgaacttg aatcgagcat ttgtatctat cataggagtg aagtaattta ttggccattg
     2821 ataagtggtt tggctgcaat gtagaaacta cagtatgaag tgttttatgt ctgcattgtc
     2881 ttaataataa aaacaagagg tatttataga aatatctatt ttcatgacat taatttcatg
     2941 gtaaaattgc tccattattt gtgtggcact tctcttcctt aaatacatgt ccccttctaa
     3001 atccaaattt cacattttta aatggggctg agagagaaat aactcacaca tggaaatgtg
     3061 cgttgctaag atgggcattt agtgggatta tttctaggaa taatgaccct ggaaggccca
     3121 gtgagatctg ttgtattctg aagagagaag taacttacat atttactacc acaatgtcca
     3181 ctaaaactaa actctgttgt cagactttgt tcttgccttc tatgaaatgt ttttaggttt
     3241 ctattactaa aagtcacttt tcagaactta gttttaattt atttataccc ccatgtcttg
     3301 tgttttactt ctatatccat ttttacctct tattcattct ttatttacct ccattactaa
     3361 gattctgttt gcactaaaaa ctgttgagtt gcacaagtgc agctacacat gtatatatgt
     3421 atgtattagg tttatgttta aagatatatt atgtataaaa tatatgcata ctggtaacaa
     3481 cttggctttg tggctgtaac cattgtacat gtgtacacac acatgagttt tttatgtgtg
     3541 ctaaactggc aacctagaag tctgtctaag gttactttgg gcaccaggtt tctttttaga
     3601 gtttatttgt gctccagaga agtatgccaa taatgtaacc taaaagattc ctcataactg
     3661 agaaatacat tcttgaatca cctcgatggc aacagaagcc acattttgct tctattatag
     3721 attgcacgtg taaatttcat gtaattgaaa tttgagttag aatactttga agtcaaagag
     3781 acacacttag cagatcagta tctaaacatg gagagagatt ttctgtggct taccatgctt
     3841 tattgctaat ttctgatttt gccatcagga actgagtggc aggatgtggt catggaaaat
     3901 atctgtctgg tttctagtgg ttatctggca ttcaggtctc tctcccctct ctccattcag
     3961 cagattgggt ttaatcattt atatttacgt ggaaacacct atacaccagc accttagaca
     4021 aagcaggagt ttaagaagta attgttgaaa tagcaagtaa gttgtctgga ggattcctgg
     4081 tgaaagtggt attttttttt cccttcccat ggcaactctt catcttggaa aagcttgatt
     4141 caatcctgga cacctctact accagtagag tcactacaaa aagccaggcc tggtctggtc
     4201 tctgtacctg cttggaaact cctggtcccc atgggccaca ttctgcctag gttctagggc
     4261 tacaggttag actcatcatc atgctttcat aggatctaca tttcaggtga aagaaactca
     4321 tgatgcaggt ggcgaattaa acattcagtc tctgaataca atatgattta gtgaacaaca
     4381 ggcacatcta gaaagcacat tggatttggg gtcagtatct gcaggcagga ggtgtaagcc
     4441 tgaacattgg ttctctcttt agtcggaaag accgttaaaa atcatttaac ctcctttgag
     4501 tctcaggctc cccatctata aaattagggg tggggagtat cagcgccccc tacctcatgg
     4561 agttggtgtg aagatttgta cacataagag ggtaaattca tgaaaattct ttggaaacta
     4621 aagccctata tggaccttgc ttttatttag gtctccaagt gtctaatatt acctccccag
     4681 agaggtctgc cctggccact ctattcccag tgggtatcta tcccagtttt actttcttaa
     4741 tgagatttac tttgtataat atgtgttata ctgtttgcag tagtcttagt tatcagttgc
     4801 atttttcatc actctcctgc agaatgtaaa gacataaaca ggaactttgt ctatctggtc
     4861 atccatttga tctgcaaagc cttaaccagt tctgggcaca tagtgagtgg ctgataaatg
     4921 ttctgttgag tctgctgaag ggacactctg gaattaatct taagtgactt ggctttccag
     4981 actcacactg accataactc ctgagatcct gggaggctta ggtaaatagt ttccttccct
     5041 acttcataag aatttttgaa aggcaaaaaa aaaaaaatac ttatggcaag cactttgagt
     5101 tttgagaaaa attagcacta taacagtgga actcttactg ttttatattc agcgatagga
     5161 accgctagag agactaaagg acatttggcc tccattttta atcagttctg cattgtgtga
     5221 cattttaagg tatctttgtg aacatgtcta cattgtcgcc tccaaggcta gcagcacctg
     5281 cgtaactggg aaaaaagcac attgcagtgg aatttccaac atgagaaaaa gatctattaa
     5341 atttcttact atttgttact ccctgttttc ttaagtattc aatctttgcc gttttaataa
     5401 atcgttattc atagaattgc taattttatg atcttaataa ctaagcaatt tcccagttat
     5461 tatgatctta ataactaagt aatcccccag ttattctgtg attcaactcg taccctcttt
     5521 aatcatttaa ttcctgttag ctatatttgt atttcacatt tctgctatta tacaaagatg
     5581 atgaaattca ctttatggac aatgaactgc atgcttgcta aatatgcatt acacgtcttc
     5641 ctttgaaatc atatgttttt tattgtattt gttatagtgc aagtttgttt gaggagcagc
     5701 taatatttac agtagtatct atttctgaaa tgaatgttag aaatgactgc agccagatct
     5761 tagtttgaag ttatgtgaat gaagaaagtg taagaaattg aatttatcct ctgctagaga
     5821 tctcttttga ttttccatat aagataagct ttgtaatata tattggcatt gtttcatcca
     5881 atcagttttg attctaagcc ttctgtactc ttaagcggac tgaaatatgc caaagaaaaa
     5941 caagtttgtt tctgtgatga attcacaata atttctgatt ataaaatata cttggagaag
     6001 taagaata
//
