LOCUS       NM_001358699            2850 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens ring finger protein 227 (RNF227), transcript variant
            1, mRNA.
ACCESSION   NM_001358699 NR_024349 XM_001715822 XM_001717540 XM_941810
VERSION     NM_001358699.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104581.22.
            
            On Jun 26, 2020 this sequence version replaced NM_001358699.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095766.1, SRR14038196.2938404.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324348.9/ ENSP00000490456.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-611               AC104581.22        78916-79526         c
            612-2850            AC104581.22        76576-78814         c
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2850
                     /gene="RNF227"
                     /gene_synonym="LINC02581"
                     /note="ring finger protein 227"
                     /db_xref="GeneID:284023"
                     /db_xref="HGNC:HGNC:27571"
     exon            1..611
                     /gene="RNF227"
                     /gene_synonym="LINC02581"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..667
                     /gene="RNF227"
                     /gene_synonym="LINC02581"
                     /note="long intergenic non-protein coding RNA 2581"
                     /codon_start=1
                     /product="RING finger protein 227"
                     /protein_id="NP_001345628.1"
                     /db_xref="CCDS:CCDS86570.1"
                     /db_xref="GeneID:284023"
                     /db_xref="HGNC:HGNC:27571"
                     /translation="MQLLVRVPSLPERGELDCNICYRPFNLGCRAPRRLPGTARARCG
                     HTICTACLRELAARGDGGGAAARVVRLRRVVTCPFCRAPSQLPRGGLTEMALDSDLWS
                     RLEEKARAKCERDEAGNPAKESSDADGEAEEEGESEKGAGPRSAGWRALRRLWDRVLG
                     PARRWRRPLPSNVLYCAEIKDIGHLTRCTL"
     exon            612..2850
                     /gene="RNF227"
                     /gene_synonym="LINC02581"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF227"
                     /gene_synonym="LINC02581"
                     /note="hexamer: AATAAA"
     polyA_site      2850
                     /gene="RNF227"
                     /gene_synonym="LINC02581"
                     /note="major polyA site"
ORIGIN      
        1 ggccccagga cccgacccgg ccccaggaga gtgtgctcgt tctgttcacg gagctggccg
       61 cgttagcgac gtcctcgagt ccgcggcggg cacgatgcag ctcttggtga gggtaccctc
      121 tcttccggag cggggcgagc tggactgcaa catctgctac cgtcctttca acctcgggtg
      181 ccgcgcgccc cgccgcctgc ccggaacggc gcgcgcccgc tgcggccaca cgatctgcac
      241 cgcctgcctc cgcgagctgg cggcgcgcgg ggacggcggc ggggcggccg cgcgcgtggt
      301 gcgcctgcgc cgcgtggtca cgtgcccctt ctgccgcgcg ccctcgcagc tccctcgcgg
      361 cggcctcacg gagatggctc ttgactcgga cttgtggtcg cgattggagg aaaaagcgcg
      421 ggccaagtgc gaacgagatg aggctgggaa cccggccaag gaaagcagcg acgctgacgg
      481 agaggcggag gaagaagggg agagcgagaa gggggcgggg cctaggagtg ctgggtggcg
      541 cgcgctccgg cggctctggg acagggtcct ggggcctgcg cggcgctggc ggcgtccgct
      601 gcctagcaac gtgctctact gtgcggagat caaggacatt ggccacctga cccgttgcac
      661 gttgtaaccg aggaactcgg aagctacagc cgaaggaagg tgggagctgc agcctcgcgg
      721 gggctgatgt caagactact ctctctcaga tcccaggatt ggcatgtgat gagagagatg
      781 agccgaaggc aggagggaac gccctgggag gtgttgatgc tgagttgggg aggctcctag
      841 acgaactcgc ccccatctac tgactgtgcc agtcttacat tttcaggatg gagtggccaa
      901 gggatgatat aaacaaagcc tacgttaccg tgggaagaag acagactgtt ttcttagctg
      961 ggacgttggc ttttgtccag ggtggctctg gtgtgtggga gcaacaggtc ccattttagc
     1021 aattctttgt caatggtttg aatttttttt ttttttaaga tggaacggga gagaagaggc
     1081 taattttcgc gtcatgttaa tctcacttct ctggcatgta agggtgctgg tatgcctgct
     1141 gtctccccac tcccagttct gtgttccaga aattgagatg gctccctgcc tgtgactatg
     1201 attaggagcc ttgcttcatt tcagaatctc ccttcaacct gctagggcag gtatcagaaa
     1261 ttccaaaggg catttatgtg aggcacctaa ttagagccta tcaaagtagg aagggagagc
     1321 catttgaaag gcatcatatt tcaaactttt gctattatct gtgttatctt tacagtcacg
     1381 ggaacacact agcgctactg aaaagatact tatacaattt taagtgtctt taaaatttgt
     1441 gtcccataat gggacatcac ctgttgtata tatgccatgt attctatttt agaatcctgt
     1501 atcttatgac cataaagtca tagtcaagga ccagcagtgt tggtgtactg tcaacggaag
     1561 tgcacagtct cactctagga tcccactcca gacttcctga atcagactct ggcagggttt
     1621 tttgtttttt tgtttttgtt ttgagccaga gtctcactgt gtcgcccagg ctggagtgca
     1681 gtggcgtgat ctcggctcac tgcagcctcc gcctcccagg ttcaagcgat tctcctgcct
     1741 catcctccgg agtagctggg attacaggcg cctgccacca cacctggcta atttttgtat
     1801 ttttagtaga gatggggttt cgccatgttt gtcaggctgg tctcaaaact cctgacctca
     1861 ggtgatggcg cccaccttgg cctcccaaag tgctgggatt ataggagtga gccaccgcgc
     1921 cgggccagac tctggcattt taacaatccc aggtgatgtg tgtgcatgtg aaaatttaag
     1981 taccattggt ctagatccta cactctttag gatatcacca tctgtaggta gaatatttaa
     2041 agcataatag gtatgactga tagattattt tatccaaagt tctttttttt tttttttgag
     2101 atggagtctt gctctgttgc ccagactgga gtgcagtggc gtgatctcgg ctcactgcaa
     2161 gctctgcctc ctgggttcac gccattctcc tgcctcagcc tcccaagtag ctggggctac
     2221 aggcacccac caccacgcct ggctaatttt tttgtatttt tagtagagat ggggtttcac
     2281 cgtgttagcc aggatggtct cgatctcctg acctcatgat ccgcctgcct cggcctccca
     2341 aagtgctagg attacaggcg tgagccacca cgcccggccc caaagttcta aagtaacatt
     2401 ctattgctaa agaaatccta acctactatg taacattttt ctcttagtta aaaatgtgaa
     2461 cttattatta acctcaattt tttagaggcc tccaatcttt ttaaaatata aatatttttg
     2521 attgacaaat cataattata cacttatggg ggtataaacc tcaatttttg taaccctatt
     2581 ttggcatttt cctgtcctta catctcagct taaatgctcc ctcttttggg aggccttttt
     2641 ctgccttcaa catagtagag ccttttcccc cacccctctg taacataatg ccctgtttta
     2701 tttttactgc ttttattttc atgctttgtg ggtgtcccca ctggagtgta agccctatgg
     2761 gagcaagggc tgacctgtga ctgttttatc tccagggcca acagcagtgt tactgtatag
     2821 tatgtactca ataaatattt gttggcttta
//
