LOCUS       NM_001146684            3070 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens ring finger protein 222 (RNF222), mRNA.
ACCESSION   NM_001146684 XM_001724946 XM_002343479 XM_002344982 XM_002347708
            XM_927169 XM_938348
VERSION     NM_001146684.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3070)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026130.15.
            
            On Jun 2, 2019 this sequence version replaced NM_001146684.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399398.3/ ENSP00000382330.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC026130.15        140775-140907
            134-285             AC026130.15        144273-144424
            286-3070            AC026130.15        145116-147900
FEATURES             Location/Qualifiers
     source          1..3070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3070
                     /gene="RNF222"
                     /note="ring finger protein 222"
                     /db_xref="GeneID:643904"
                     /db_xref="HGNC:HGNC:34517"
     exon            1..133
                     /gene="RNF222"
                     /inference="alignment:Splign:2.1.0"
     exon            134..285
                     /gene="RNF222"
                     /inference="alignment:Splign:2.1.0"
     exon            286..3070
                     /gene="RNF222"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..973
                     /gene="RNF222"
                     /note="RING finger protein LOC643904"
                     /codon_start=1
                     /product="RING finger protein 222"
                     /protein_id="NP_001140156.1"
                     /db_xref="CCDS:CCDS45608.1"
                     /db_xref="GeneID:643904"
                     /db_xref="HGNC:HGNC:34517"
                     /translation="MSEGESKDSSGSECPVCYEKFRDLEGASRTLSCGHVFCHDCLVK
                     YLLSTRVDGQVQRTLVCPICRYVTFLSKKSSRWPSMLDKSSQTLAVPVGLPSVPPLDS
                     LGHTNPLAASSPAWRPPPGQARPPGSPGQSAQLPLDLLPSLPRESQIFVISRHGMPLG
                     EQDSVLPRRSLAELSEASLAPRSARAFCCRSRALLLITLIAVVAVVAAILPWVLLVRK
                     QA"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF222"
                     /note="hexamer: AATAAA"
     polyA_site      2837
                     /gene="RNF222"
                     /note="major polyA site"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF222"
                     /note="hexamer: AATAAA"
     polyA_site      3070
                     /gene="RNF222"
                     /note="major polyA site"
ORIGIN      
        1 gtcattagga attgcctcgg cggtggcggt cacactaaca gcaacaggag gagatcgtgc
       61 tgctgctcag cacctcgggg tggctcagat ctgctggagg ccccaggagg gaaggtggat
      121 gctgctctct ccgacttggc taccagtgac ttctgggcat ttccaaagta tcagacatat
      181 tctcaaagga tgaaattctg tctccatcac ggttaatcag atgcttctct cactgcctca
      241 ggcagcccca taagaagaat ttggagaatg actgagctgt ggcagctgag cgtgccatct
      301 cccagtggcc atgtcagaag gggagagcaa ggacagctcg ggcagtgagt gccccgtgtg
      361 ctatgagaag ttccgggacc tggagggcgc cagccggacg ctgagctgtg gccatgtgtt
      421 ctgccatgac tgcctggtca agtacctgct gtccacccgc gtggatgggc aggtccagag
      481 gaccctggtc tgccccatct gccgctacgt cacattcctc agcaagaaga gctcccgctg
      541 gccctccatg ctggacaaga gctcccagac gctggctgtg cccgtgggcc tgccctccgt
      601 gcccccactg gacagcctgg gccacacaaa ccccctggcc gcctcctccc ctgcctggag
      661 gccacctcca ggccaggcca ggccgccagg cagcccgggc cagagcgccc agctccccct
      721 ggacctgctg cccagcctgc cccgggagtc acagatcttt gtcatcagcc gccacgggat
      781 gcccctgggg gagcaggaca gcgtgctgcc ccgccgcagc ctggcagagc tctcggaggc
      841 ctccctggcg ccccgctccg cccgcgcctt ctgctgccga tcgcgggccc tgctgctcat
      901 cacgctcatc gctgtggtgg ccgtggtggc cgccatcctg ccctgggtgc tgctggtgag
      961 gaagcaggcg tgagccgcac ctcagggagg ccgccgggct agccgtggcc tggggtggga
     1021 caggaggccc acggcagccc tggtgccacc aagctccgag gggcacgcgg gcaggcagag
     1081 gggaggacct gggcacagag agggccttgg gcttccccga cccccgcagg ggcttccgct
     1141 cgacagagag gctggagctg actccatgcg cgcggcgcgt gttccccacg tgaatcctca
     1201 gcagatgcgt tccccttcct ctaggctggg aagatgggtg gtcactgccc tcctgcaggc
     1261 tcaccagccc tgagcggcag accttacctg ccaggtgacc tgcccaaagc caggtgggcc
     1321 cctccaggga caagaaagtc ctgcaggcag acgtcctgct gggctggccg atggcaggat
     1381 cctccaggcc agaattccca cccaggattt gcggcttgcc ctcgggaaca gacagaaggg
     1441 gcgcccagaa tctcagcact cacccccgac ctccaccaca gcaccccatc ccctaaccct
     1501 ccctgtcccc aacctgccag cttagaaggg cttccctgaa ggagaagctg atctcagagg
     1561 ctgccccaga atttctggga gaatgaacag aaactgttct tcctgcagag ctgaggccag
     1621 atccagagac aggggttggt tgatagaggc caccccagca gagtgcccca cgaacggagc
     1681 cagaggtctc cctgagccct ccaggccaaa ggagggatcc aaactttgag tcctggggtt
     1741 ctcaagggtg gcagggagtg gaggggaagc ctgacaggcg agccttgagt cagctgagaa
     1801 ctatgtgggc aaacgaaccc ctgggggctc ccgcctccct cccagctagt cctcctcctc
     1861 atgacccagc cactcattta gaggccacac cagctgggcc agtttcctag gtggattgcc
     1921 aggctgggct gggtgaggaa gggtggggag gaaaacagct gtgcttgtca gggacgccgc
     1981 catctcaacc gagaaatgct gaggcccagg tgccctcagc tgctcctcaa ggtctctttg
     2041 cctggggccc ccacgttgga ctgtgaagag cctcaggttg ggtctagcct gagtcattcg
     2101 gggatagcta ttggctgttt attgaggtcc gtaagtcaac caacaccttt caatggaaaa
     2161 caacaaaaac ctccagcaat tatctcaact aagtggtggt ctgcacccag ctgtgcccac
     2221 agctgagccc ccaacctccc tcaacctata cccctctggg caatttgctg tcttggtggg
     2281 gagggaagaa atagcagtct acgttttatc tagttcctaa atgcctgcag tgctggtcat
     2341 ttggggaccg ctggggaatt gggccccact acaggggata tttgggacat agagagggct
     2401 gctttaaaag cacttgtggg cttctctgtg ctcatttcaa gattacagaa gtggccaggc
     2461 acggtggctc atgtctgtaa tcccagcact ttgggaggcc gaggtgggtg gatcacaagg
     2521 tcaggagttc gagaccagcc tggccaatat ggtgaaaccg cgtctctact aaaaatacaa
     2581 aaattagcca ggagtggtgg cacgtgcctg taatcccagc tacctgggag agacagaaga
     2641 ttcgcttgaa cccgggaggc ggaggttgca gtgagccgag atcgcgccac tgcactccag
     2701 cctgggtgac agagcgagac tctgtctaaa aaaaaaaaaa aattacagaa gagcacaggt
     2761 gctattggag gggagggata cagatggatt ccatggggaa aatatttatt ataggaataa
     2821 aaataatgtt aaatttgcaa agactccaat gagtctcttt taacctcagc caggctgttt
     2881 taaacagtgt catgaatttc tgggaacctg gttctagtct tttcagattc tgtcgtattt
     2941 gccaaaagtt tctttcaaca tactctcagt gtttttgtat gttcaatggt gacctgtagc
     3001 tgcaactcct tttattgtca gagaatgcca aaagctattt ttaaaataaa ggtatatatt
     3061 ttctcaaaga
//
