LOCUS       NM_001286398           11433 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ring finger protein 217 (RNF217), transcript variant
            1, mRNA.
ACCESSION   NM_001286398 XM_005266832
VERSION     NM_001286398.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11433)
  AUTHORS   Ho,S.R., Lee,Y.J. and Lin,W.C.
  TITLE     Regulation of RNF144A E3 Ubiquitin Ligase Activity by
            Self-association through Its Transmembrane Domain
  JOURNAL   J Biol Chem 290 (38), 23026-23038 (2015)
   PUBMED   26216882
REFERENCE   2  (bases 1 to 11433)
  AUTHORS   Fontanari Krause,L.M., Japp,A.S., Krause,A., Mooster,J., Chopra,M.,
            Muschen,M. and Bohlander,S.K.
  TITLE     Identification and characterization of OSTL (RNF217) encoding a
            RING-IBR-RING protein adjacent to a translocation breakpoint
            involving ETV6 in childhood ALL
  JOURNAL   Sci Rep 4, 6565 (2014)
   PUBMED   25298122
  REMARK    GeneRIF: The high expression of RNF217 in certain human leukemias
            suggests that the deregulation of this gene could be a more common
            mechanism in leukemogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11433)
  AUTHORS   Nakamura,N.
  TITLE     The Role of the Transmembrane RING Finger Proteins in Cellular and
            Organelle Function
  JOURNAL   Membranes (Basel) 1 (4), 354-393 (2011)
   PUBMED   24957874
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11433)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355296.12 and AL136128.9.
            
            On Sep 24, 2020 this sequence version replaced NM_001286398.2.
            
            Summary: This protein encoded by this gene is a member of the
            RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it
            belongs to a subfamily of these proteins that contain a
            transmembrane domain. This protein can interact with the HAX1
            anti-apoptotic protein via its C-terminal RING finger motif, which
            suggests a role in apoptosis signaling. It is thought that
            deregulation of this gene can be a mechanism in leukemogenesis.
            Mutations in the region encoding the protein GXXXG motif, which
            appears to be necessary for protein self-association, have been
            found in human cancers. Alternative splicing of this gene results
            in multiple transcript variants. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12921934.3841590.1,
                                           SRR14038196.2704554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521654.7/ ENSP00000428698.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-990               AL355296.12        94920-95909
            991-1224            AL136128.9         18684-18917
            1225-1389           AL136128.9         31415-31579
            1390-1591           AL136128.9         50130-50331
            1592-1663           AL136128.9         54909-54980
            1664-11433          AL136128.9         56337-66106
FEATURES             Location/Qualifiers
     source          1..11433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..11433
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /note="ring finger protein 217"
                     /db_xref="GeneID:154214"
                     /db_xref="HGNC:HGNC:21487"
                     /db_xref="MIM:618592"
     exon            1..990
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1737
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /EC_number="2.3.2.31"
                     /note="isoform a is encoded by transcript variant 1; IBR
                     domain containing 1; probable E3 ubiquitin-protein ligase
                     RNF217; opposite STL"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF217 isoform a"
                     /protein_id="NP_001273327.1"
                     /db_xref="CCDS:CCDS69191.1"
                     /db_xref="GeneID:154214"
                     /db_xref="HGNC:HGNC:21487"
                     /db_xref="MIM:618592"
                     /translation="MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLR
                     AASAEPSGGGCGSDWGCADTSAPEPARSLGPPGWSKSRAPAQPAGLALTGPLNPQTLP
                     LQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKR
                     QVFCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSP
                     DGGSIELEFYLAPEPFSMPSLLGAPPYSGLGGVGDPYVPLMVLMCRVCLEDKPIKPLP
                     CCKKAVCEECLKVYLSAQVQLGQVEIKCPITECFEFLEETTVVYNLTHEDSIKYKYFL
                     ELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHE
                     GVNCKEYKKGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCY
                     RCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLG
                     LALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW"
     exon            991..1224
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1389
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1591
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1663
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..11433
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /note="hexamer: ATTAAA"
     polyA_site      2519
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /note="major polyA site"
     regulatory      11410..11415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /note="hexamer: AATAAA"
     polyA_site      11433
                     /gene="RNF217"
                     /gene_synonym="C6orf172; dJ84N20.1; IBRDC1; OSTL"
                     /note="major polyA site"
ORIGIN      
        1 agaagcggag ccgcgagtcg agccgagcca ctgcccccgc tgcccgcggg cgccgggtgg
       61 gggtcccggc ggctggatgg gcagcggcgg cgcgggccgc gggcggcgat gggcgaggag
      121 cagagcacgg tgagcggcgg cggcgggccc caggagtcgc agaccctggc cagtggcact
      181 gcgggccacc ctgagccccc gaggcctcag ggggacagcg cccgggcgcc cccgctgcgc
      241 gccgcctccg cggagccgag cggcggtggc tgcggaagcg actggggctg cgcggacacc
      301 agcgccccag agcccgcgag gagcctgggg cccccgggct ggagtaagag ccgagcaccg
      361 gcgcagcctg cgggactggc actcaccggg cctctcaatc cccagacctt gccactgcag
      421 ttggagctgg aggaggaaga ggaggaagct ggggatcgaa aagagggagg ggatgaacag
      481 caggaggcgc cccccggcga agagctggag cccaggaccc gcgtgggggc cgccgacgga
      541 ctggtcctgg acgtgctggg tcagcggcgc ccgtccctcg ccaagagaca agtcttctgc
      601 tccgtgtact gcgtggagag cgacctgccc gaggcccccg cctcggagca gctctcgccg
      661 cccgcgtcgc cacctggggc tccgccagtg ttgaaccctc ccagcacccg ctcttccttc
      721 cccagccccc gactgtccct cccaacggat tccctctccc ccgacggcgg cagcatcgag
      781 ctggagttct acctggcgcc cgagccgttc tccatgccca gcctgttggg agctccaccc
      841 tactctggcc tgggcggtgt aggggatccc tatgtgcccc tcatggtgct gatgtgccgg
      901 gtgtgcctgg aagacaagcc catcaagccc ctgccttgct gcaagaaggc cgtgtgcgag
      961 gagtgcctca aagtctacct gagcgcccag gtacaacttg gccaagtaga aatcaaatgc
     1021 cccatcacag agtgttttga attcttggaa gaaacaactg ttgtctataa cttaacgcat
     1081 gaagactcca tcaagtataa gtacttcttg gaacttggcc gtattgattc cagcaccaag
     1141 ccatgtcctc agtgcaagca ctttacaacc ttcaagaaaa aaggacatat tcccacccct
     1201 tccagatcag aaagcaaata caaaatccag tgccctacct gccaattcgt ctggtgtttt
     1261 aagtgccact ctccttggca tgaaggtgtt aactgcaagg agtacaaaaa aggagacaaa
     1321 ttgttgcgtc actgggccag cgaaattgag catgggcaga ggaatgccca gaagtgtcca
     1381 aagtgcaaga tccacatcca gcgaactgaa ggatgtgacc atatgacctg ctcacaatgt
     1441 aacactaatt tttgttaccg atgtggtgag agataccgcc agctccgatt ttttggagac
     1501 cacacatcaa acctcagtat atttggatgc aaatatcgct acctcccaga gagacctcat
     1561 ttaaggagat tagtgcgagg gtcagtctgt gctggaaaat tattcattgc acctctaatt
     1621 atggttttgg gattggcact aggggccata gcggttgtaa tcggtttatt tgtatttcct
     1681 atctattgcc tttgtaaaaa acagagaaaa cgatcacgga caggtatgca ctggtaacat
     1741 gcagatgatt tcatccagct aagctggttg gagtaggagc gataccaaag ggtacaccca
     1801 tctgtgagtc acatcttgaa aaacactgag aggaaccttc taccatctca tctcccagtg
     1861 attctccgtg ggccacaatg cctctagcta tggtgcactc ccaacatggt atcctgtcct
     1921 ttccctaaac aaattgctgc tgcttttaaa aaatggtcac tttcataaac tataaacatc
     1981 tatatcataa ctctgacctt tgtggttctt ggaagaagat attttaagaa ccagttatcc
     2041 taagaattct gagcacgcct cttctgagaa ttgcttggac tgtctttgaa ctctgcacct
     2101 ccttccaggc catcttgtga gacttggtgt taatagctga agtcctatct gtaccaacaa
     2161 gcaaggccac ttttcagaag ataagagttc actgaatgca cctattataa tctgtggccc
     2221 cagcagtata attcttttat ctttcaaatg ttataattgc aaaaaatctc aatgtccaaa
     2281 agggaatgag tgaaactaaa ttaatgagaa gaatattaag ttactgaagt gtatatgcgt
     2341 aggggcgtga atgtgtgtgt atataaatat gtattaaaac taggcccagt aaccttgtac
     2401 ttacccagtt ccatgccgct acactatttt tccacatttt catagaccta ttgaaagatg
     2461 atggctcctt tgtggacata atttagcaat gtattaaatt aaagtcaatg tagacaacag
     2521 gccatttcga tactgaactt ttctatttct tgctctttct ttttgtcaca caaacacaga
     2581 aatttgtgca acgtcacccc aaggagtatt aagctttgta aactgacaaa actggctgct
     2641 tttaggaaat tctcaagaca caaatattca gtctttttaa aattcttaca ttttggaaaa
     2701 catgcttcac tctatagata gatccttcac attgggatta tttaatccca aaaacaagtt
     2761 tgctgtagac aactgcttaa gcctttaaaa aattcctatt ctgctaattt tttaaccaac
     2821 ttgtaattat agataattct gctttaggtc aaggtcttac atcatttaat atcctaacct
     2881 tgttatctct tgcctcctcc tctctgtttt tatttgtttt caaggttttt cataaaaaca
     2941 aatactagtt ttgaaggatt ttttcttaca tttaactgct caaacataat atttttgggg
     3001 acaccttctt atggaggagt ttgaaaactt tttatgttct tgagtttgtc caatatcagc
     3061 tgcttttggg aaaggaaaca aaaaagtgaa ggaaatattt tcaggaagtt tttctcaacc
     3121 tacaaaagct ttaaaaataa gaaattgaca agtaactaga ctatgatatg cctttgcttt
     3181 catcacaaaa gttcatcagc aaacaggaaa aaaaaagacc cctaaaaagc ctaaagcttt
     3241 aaattgtctc caaattctta aaattagtca tctgtcttag atgtacattt atttgtcagc
     3301 aaccttgtct gatttgaaat agatgatatg ataaaacatg cattaacatg agtagtttat
     3361 ttttgttggg ctccagagtg taagaatatt ttattttttg tttgacataa aaagtgaagt
     3421 tgacttgcgt gaataacaat ccagcatgct ttcattcttt ctgaataaca cagaataact
     3481 gtgctacagc ttctggatta gttgtctatt tccagttaga ggagtgtgtg acatttatgg
     3541 tttgggaata gcatatttct aaagcataat ataatacaag aaatagtgat gctctgtttt
     3601 cacaaattta tcttttcatt cacccatcca tccatttaac agatatttat tgagtgccta
     3661 tcttaggtgt aatagtattt aagactgaaa gaaggagaat ttctaacctg tcataagagt
     3721 aaggtttcgt aaattcatct ttcctgaact taggcattag tttggcaata tgtgaatatg
     3781 atgaactcta aacctagctg atctgtatat gtatgatgta tatatgtcat atgtatgata
     3841 tatatgaaat attcccataa ctgcatatga acacatatgc catatacata tataccaacg
     3901 ggctgaataa catactcttt tgtcttggat aatctgtttt ctgggttatg tatctgttgt
     3961 ctttggccta ctcagggatt tttatttctt taaataactt atcttttgga catattttta
     4021 tattatttgg aaaactttcc aatattcctg ttacaaagtg gtgtctgttt tcagtgatgg
     4081 ctatttcatc agtgcttgaa atagtgtgca ctgtgttgca caggtttttc atttttctat
     4141 tgagtagata tttttaaatt aacatacaca tttttctctt taaagggtca tatctattag
     4201 gcctttccct gctggtaact taaaatgatt atttgtgaat tttttactaa gtttcatcaa
     4261 gatcttaaaa agagagaaga aaataaaaag tattatttat atgtcagtgc caactttgaa
     4321 ggtaaaacag tagtagtaac ttttgggaga aattctaaaa actactttaa aaagaagcgt
     4381 gcacataaaa taaatatctt tctatccaag gcttgtcatt ttatatgctt ttattgtaaa
     4441 tttaatatat actactttaa aaaattgaac tatacagaat ttataaaata caactttctc
     4501 tacttacccc acctcttatt ttctaggggt aaccactgtt aatggtttgg tatgtgtcct
     4561 tccagacact ttctacaaat atacaaataa gtgtgtttgt gtatgtgtct gtgtgtgtat
     4621 tcattttata caaatagaaa aatattctta ctgtgctgtg actctttgtc attttattat
     4681 atattaatag atacctttcc ataagcgttt aaatagattt acctcattct tttataaatt
     4741 actgcataat ccattgtagg agtatacttt aacttattga attagtcccc tgttgaatgg
     4801 actacaagat tattttcact tctctattac aaagaaagca agagtgaaga cccttttgca
     4861 tatatttttg tcaccttgca tgaacatatc cataaggttg tacatttgtt ttttacaaga
     4921 tctttgtaat aaacatttta atgtaatttc aggagatgag gtcatagaga taatatgaga
     4981 cccttttttg gataaaaaga aagattgtac aggagtgcat aatttttaaa gaaaatcgtc
     5041 ttttgaaggg taatttcctt tctgcctgat tagccaaata aataccttgc caaaacttac
     5101 aataggaaat tttttttcaa taaaaataaa atttgaggag atgtgtgtca gataatgtga
     5161 gagagatgaa ttgacttttg gattgcctca ttttaaaact tgagggattt aaatcaaata
     5221 cccaagccaa attggtgata cttttcgcat ttttagtaac actatccact tttgtgtatg
     5281 ttgcttgaca gaggaactta attatgccat tgtgaaaagt aggaaagaat atgttggcaa
     5341 ttataaatgc ccacagcaat tcccagaaaa atacattaga ttatgtacga tttagtgatt
     5401 tggtgggata attataaatc gtggaataat ttatatatgt ggagtaagaa gagaggggtc
     5461 aaaccttttg gtacaagcaa catcttgttg ccaccacctt gattttctca taggtgctat
     5521 tgtgtcctaa gagtagaaca gacaagaaaa caaagataat taaacacaag tcaggttaca
     5581 acatgatatc tttaattgta ctttctctgc tgtggtatca agattcagtg gtgcttgtca
     5641 gaaaatacct tgttctgtga ctctgactat ctcttgagtc ccaaggctcc aattgagcct
     5701 ttatctttca accttaccac ccaagtatat gaccaactgt tctcctaaaa tacctatgaa
     5761 ccactgtaat catttccagt ccctgatgcc cctcttcaac ctcatttttc tccatacctc
     5821 tgctattcta actattcctc ttcactgaag gagaagagga gagacaggag gggcctaaaa
     5881 actcactctg gtatgtggga aacattagaa ttccttcctg acctttgtca aatgagggca
     5941 catctgccaa gacatcagtc cagcttctcc cttgttaaat gaaattgttt ttaacattac
     6001 acttttatac tggctgttac attagaatta caaaaaagtt agtggcctct ataaccttaa
     6061 ttggcatact ttactacaaa aataagaaaa tgtatgccaa aaaacgtttt tagattttaa
     6121 ttttataagc aacctgcaca taagccttaa tgtgagtctt cacattggat tatattttta
     6181 ttctcccata tttgtggctg aaatctctcc caactattga gagtgatctt tcccatggtc
     6241 tgctttattg ttttgtgtta atatctatta taaatatagc cttaaaattt tgtaatgcac
     6301 tttaaaatat ttgtgccatt taaataatga caaagcaatc aatgcataca tttcaatgga
     6361 gacagtatac aaagttaaag caactgatac atatatttca gtggagacag taggataaca
     6421 gtgttagcaa atatgtgtca tctctttaaa tttgggagga atcagaagct aaagatttaa
     6481 aacaaataaa acatacctga agaaaagtag caatttctga aattgtagta atcttggaat
     6541 ggttatcaaa cctagcaaat aatacttaat aagtgttacc taatatacct aattggaatg
     6601 tttgtttaaa atattaaatt aatttatact gaaagtttta actgcaattt cataattcat
     6661 gaattctata aaagaaatct ccctcactaa aaatatgatc aatcaaaact accagttttg
     6721 cacaccaatc ccaagtttaa gcatattttg tatttaaagt tataatttaa ttatgatact
     6781 gtccccctaa tatggaaaat aagttacaaa attctttttt tttttttttt ttttttgaga
     6841 cagaggttct ctcaatgttg cccaggctgg tctcaaactc ttgggctcaa gcgatcctcc
     6901 ctcctctgcc tctggagtag ctgggattac aagcacgtgc ctactatgcc tgtcttcaaa
     6961 atcacattgt taatttttat agccacaatt attaatttga taaaacaaat aattttatag
     7021 aagcattaaa gtattatcag aacaaaatca gagttccaaa atttggggag tattttaaga
     7081 ttgtgaaatg ttaccttttg gatgcaaacc aatgatacaa atctttaaga aagaattaca
     7141 gtgggactcc tttgaaactc tgattttgaa aatagaacaa atacacattt catagccaaa
     7201 ctttgtgtgg gacttctatt gttactaatt gtaaggctgt aactttggtt gacttcatcc
     7261 aaatccaaga aacagagtca cagtagtgag actattctca ttgcttcttt ggagcattag
     7321 ctgaagcttt accatatcac ataccttaca aaatccctat acatattgcc agttttaaaa
     7381 gaatgtaatt atgcatgtta caaactatat atatcttttt ggctagagaa gtgactattt
     7441 tagaataaca gtatgaatgt aaaaggcaat aatttttttt aaatacacaa aacattgcca
     7501 ttgccctttt ttgtcacttc cttttttctt ctaaaaattt tcatttggtg tatctaactt
     7561 tgtatcactt aaattattca gacttactaa gataaaaaat actttttttc agttctgtgc
     7621 tatattctgt cactctattc cattattaat actaaatgac tttccttgtg aaatgatacc
     7681 cacatactac aacatcaagc tcctttttct cttaaatttc ctaattatct tgatttttgc
     7741 ctctgcagtc ttcttcccat cttggccaag tgtgggataa attctgtctc gcccgtaact
     7801 cctttcactg taatgaaatg aattcaacac tgaacgcact ccagaattta gctctggtag
     7861 tgagcataat ttaccttggc ttattttatt tgtaaatgga aatgtatcag gagtgcctgg
     7921 aacacttttc cctcttgata ggagttggag aacactgcct agccctctgc caagaagtaa
     7981 gtcaagcaaa tgaagatacc agttggatca gagggcctaa taatagtcta aaaccaagct
     8041 tcagaaattg cttcgtgact gttgtaagat caatattgtg tttgcgtatt agttggacag
     8101 aaagcatgtg tggacattca tccaacctga ccccaggtca ttcattctcc atccaaaaag
     8161 ggttataggt atggtttatg gtctttgttt cagcaaaacg tcctacagct tggacttggg
     8221 gtggatttat atagtgtagc atttgtatat aagattcaat tatggattca tgctctgtga
     8281 acattgttag atttttaata atctaaagta ggtcacattg aatgtaactg atattaaccc
     8341 tattctagag aaaacatttg tcatttgcaa gtgtttgact tttttattga tatgatttag
     8401 atatgccaca ctcaatatat ttagtataga ttcagtacat aacaggaaag aaaaagggag
     8461 agacagactt gagtgttaaa ggaccccaga aattgctgaa atgtcctttt agattcttgt
     8521 ggctggcaag ctatgctgtc attggttctc tgcgaatctg tgatgtgttc acttcgccat
     8581 gccccagctt gggaaatatt cttagtaatc caatcaaatc cttaaaaaca gcatttttgt
     8641 gaatgtatta cttcttcaat atccccatat atttgtattg tttcaagcca ctagtatcta
     8701 aatttttgat ataaatatct aaattctttc attttataga aaattagcat gctttatgtt
     8761 tctttataat gaaaagtcta gataaagtat cataatttca ttatcagctg acaagaaacc
     8821 cttctaagac ccattttttt aagtgtcata tggcaactcc tcaatagctt acttttatta
     8881 tttgatcatt ttcatcacaa ttgcaatcct ctagagggta ttttaaaaag tagaccaacc
     8941 ttatgtttca cgtgaaacat agaataataa ttagtttgta tatatataaa accatttacc
     9001 ttgacaagga caatctgtta cagattttta atatgaaaat tgacaatttt gttgctttta
     9061 gaagcaatta acatagtaat tagtaaattc tgagagatga cagaaatgat tttctgtaga
     9121 aggaacacaa cagtgatgtt aaaatgttaa caaagaacca gttgttttga ttctatttta
     9181 aacaaaattg taaggcaatt ttatgaaaca aacatttata tcaatgtata tctatttcaa
     9241 aactgtggga caattattca ttcttttccc aaatagagta aaatattaaa gagaaaaaaa
     9301 ttcgagtgtt tatctgttat tactgtatat tcagaaatta cagttctaag gaattattgt
     9361 catcctctaa gtatcagaat gtattccatt ttaattatat tctccttaac aatagaaaat
     9421 tagaagaaat ttcttgatca taagatgaat agtaatttgt accagatctt gtccatcatt
     9481 tcattagatt gcatattttt agttttctat aaaatttgca gccattttcc aaataaagta
     9541 agttataata tttttcaagt ttaaaatgga ccgggttgaa aagagatttc attgattctt
     9601 tttaatgata ttggaaaata tttatgcaat tttatttttt aaccttttct ccatttcatt
     9661 agttatacta ttaactttga taatcacaaa actatgtgga agaaatcatt ctgattatat
     9721 tttatgaaag agaggggtag agtaaatttt ttaattagac aatgttgata tgcagaaatc
     9781 tctcaaaaga aattgcaaag gaaaaattac gttgagatga aatgttgaga aataaggagt
     9841 atcttaaaaa cctaatttct tacacttttt agagcaatca acttatttcc aaattattat
     9901 ttcatgctgt tgtttccatg aattgtgttt ttagcatagt atatactttt ctaccacgtt
     9961 agcatttaca ctctaattac tgaaaataaa ggaagaagtt ggtgaataaa agccagggaa
    10021 actgggttta ttctcatttt ccaatagcac taatgtataa tccctttaac cttccatatg
    10081 gtgctttgtg tgatgagtat ataacattca tatacgttat tagtgcctta tttttttcac
    10141 ttgactttat ttcttatcta aagagccata tattttttgt gagtgttctt tggtccctct
    10201 atttaaagtg ctaaggagaa agcatatctt tagggatgta tataggctgc gtttgctacc
    10261 ttaatctact gtattatctc taaaacaggt tagccaatgt atttttctta aattcattgt
    10321 tcatttttaa gctaacctat acaaatggat attaaacacc agaaattaaa gccattaaaa
    10381 ttgaattgta ctttaaaacc ataaaaaatg ctaattaagt ttagaacagg agttgaaatg
    10441 actctcagtt ttatctatag ctccaattag gacaaaatta ctttacaaaa agcattaaaa
    10501 ataaaagtaa ctgtatggta cttcaggaat ttgaccagtt ccttacaact tattcttggc
    10561 aatattttgt cagtaatata ctttcataca gatgctagag aaccatggtg tctgctattt
    10621 acatgttatt tgttcccagt gagctttatc aacatcaacc ctgtttatat aatatgttat
    10681 tttgctcttc ttgatctgtg ccttttgttt tagctttata caaaatgcta ggtttgttat
    10741 attctttatg tatcataata tataattcaa cttttcctga tgaatgtatg ctgaataatt
    10801 aaactaaacc atgtgcttag aaaagacaaa gacaggttgt atatgcagtt atgtgtaaat
    10861 atttgacaaa gaaaaaaaaa ggaaaagaat cttcctgcca acaggtaggt cctgctggac
    10921 aggacctgaa aattaagaga tttttttttt taagcagtga aatttaaaaa tctattacct
    10981 caagaatttt cagtcgatat gtcaatgtac tgttccttct cagtaagtac agtgtcacat
    11041 gctgctggcg gtaaaagcaa cccaagtgtc agatcacaca aattttaggg acaagtcttt
    11101 caaaagacgg acaccttgtg atattttgga gtctaatttc cgacttttcg taatgtccca
    11161 atgacctttt gttgtggttg ggcttttata aaaaattatt ttcggttggt tgttgtagaa
    11221 tggaagagta atcttaatta tgaaatcaga ttgcatggaa gaatataaag acactcactc
    11281 ggatgaaaac tataacggtt ttcaaactat tttgatggtc attgtacgag ctattgtatg
    11341 gattactgtg gagtgctgtt taccacatga tgtgtgcaat acatcatgca atgttattta
    11401 gcaatgcgta ataaaagttt ttaaaagaga aaa
//
