LOCUS       NM_207343               3477 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 214 (RNF214), transcript variant
            2, mRNA.
ACCESSION   NM_207343
VERSION     NM_207343.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3477)
  AUTHORS   Schurks,M., Buring,J.E., Ridker,P.M., Chasman,D.I. and Kurth,T.
  TITLE     Genetic determinants of cardiovascular events among women with
            migraine: a genome-wide association study
  JOURNAL   PLoS One 6 (7), e22106 (2011)
   PUBMED   21779381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC423629.1, AK298923.1, BX111206.1 and AP000892.4.
            
            On Nov 23, 2018 this sequence version replaced NM_207343.3.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.135675.1,
                                           SRR1660807.69395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300650.9/ ENSP00000300650.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DC423629.1         47-68
            23-2343             AK298923.1         1-2321
            2344-2711           BX111206.1         361-728
            2712-3477           AP000892.4         84172-84937
FEATURES             Location/Qualifiers
     source          1..3477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3477
                     /gene="RNF214"
                     /note="ring finger protein 214"
                     /db_xref="GeneID:257160"
                     /db_xref="HGNC:HGNC:25335"
     exon            1..56
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            57..169
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2174
                     /gene="RNF214"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="RING finger protein 214 isoform 1"
                     /protein_id="NP_997226.2"
                     /db_xref="CCDS:CCDS41720.1"
                     /db_xref="GeneID:257160"
                     /db_xref="HGNC:HGNC:25335"
                     /translation="MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLSTKDSAQKQ
                     KNSPLLSVSSQTITKENNRNVHLEHSEQNPGSSAGDTSAAHQVVLGENLIATALCLSG
                     SGSQSDLKDVASTAGEEGDTSLRESLHPVTRSLKAGCHTKQLASRNCSEEKSPQTSIL
                     KEGNRDTSLDFRPVVSPANGVEGVRVDQDDDQDSSSLKLSQNIAVQTDFKTADSEVNT
                     DQDIEKNLDKMMTERTLLKERYQEVLDKQRQVENQLQVQLKQLQQRREEEMKNHQEIL
                     KAIQDVTIKREETKKKIEKEKKEFLQKEQDLKAEIEKLCEKGRREVWEMELDRLKNQD
                     GEINRNIMEETERAWKAEILSLESRKELLVLKLEEAEKEAELHLTYLKSTPPTLETVR
                     SKQEWETRLNGVRIMKKNVRDQFNSHIQLVRNGAKLSSLPQIPTPTLPPPPSETDFML
                     QVFQPSPSLAPRMPFSIGQVTMPMVMPSADPRSLSFPILNPALSQPSQPSSPLPGSHG
                     RNSPGLGSLVSPHGPHMPPAASIPPPPGLGGVKASAETPRPQPVDKLEKILEKLLTRF
                     PQCNKAQMTNILQQIKTARTTMAGLTMEELIQLVAARLAEHERVAASTQPLGRIRALF
                     PAPLAQISTPMFLPSAQVSYPGRSSHAPATCKLCLMCQKLVQPSELHPMACTHVLHKE
                     CIKFWAQTNTNDTCPFCPTLK"
     exon            170..680
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            681..740
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            741..881
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1021
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1118
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1207
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1298
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1397
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1774
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1907
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2012
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2108
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..3477
                     /gene="RNF214"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF214"
                     /note="hexamer: AATGAA"
     polyA_site      2365
                     /gene="RNF214"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF214"
                     /note="hexamer: AATACA"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF214"
                     /note="hexamer: TATAAA"
     polyA_site      2492
                     /gene="RNF214"
                     /note="major polyA site"
     polyA_site      2505
                     /gene="RNF214"
                     /note="major polyA site"
     regulatory      3458..3463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF214"
                     /note="hexamer: ATTAAA"
     polyA_site      3477
                     /gene="RNF214"
ORIGIN      
        1 gctcgacccc tccccccgtg gctcggccgc cccctccccc cgctccgccc gctcagagca
       61 taatggcagc gtctgaggtt gctggtgttg tggccaatgc ccccagtcct ccggaatctt
      121 ctagtttatg tgcttccaaa tcagacgaag gtctcccaga tggtctaagc accaaagact
      181 ctgcacagaa gcagaagaac tcgcctctgt tgagtgtaag tagccaaaca ataaccaagg
      241 agaataacag aaatgtccat ttggagcact cagagcagaa tcctggttca tcagcaggtg
      301 acacctcagc agcgcaccag gtggttttag gagaaaactt gatagccaca gccctttgtc
      361 tttctggcag tgggtctcag tctgatttga aggatgtggc cagcacagca ggagaggagg
      421 gggacacaag ccttcgggag agcctccatc cagtcactcg gtctcttaag gcagggtgcc
      481 atactaagca gcttgcctcc aggaattgct ctgaagagaa atccccacaa acctccatcc
      541 taaaggaagg taacagggac acaagcttgg atttccgacc tgtagtgtct ccagcaaatg
      601 gggttgaagg agtccgagtg gatcaggatg atgatcaaga tagctcttcc ctgaagcttt
      661 ctcagaacat tgctgtacag actgacttta agacagctga ttcagaggta aacacagatc
      721 aagatattga aaagaatttg gataaaatga tgacagagag aaccctgttg aaagagcgtt
      781 accaggaggt cctggacaaa cagaggcaag tggagaatca gctccaagtg caattaaagc
      841 agcttcagca aaggagagaa gaggaaatga agaatcacca ggagatatta aaggctattc
      901 aggatgtgac aataaagcgg gaagaaacaa agaagaagat agagaaagag aagaaggagt
      961 ttttgcagaa ggagcaggat ctgaaagctg aaattgagaa gctttgtgag aagggcagaa
     1021 gagaggtgtg ggaaatggaa ctggatagac tcaagaatca ggatggcgaa ataaatagga
     1081 acattatgga agagactgaa cgggcctgga aggcagagat cttatcacta gagagccgga
     1141 aagagttact ggtactgaaa ctagaagaag cagaaaaaga ggcagaattg caccttactt
     1201 acctcaagtc aactccccca acactggaga cagttcgttc caaacaggag tgggagacga
     1261 gactgaatgg agttcggata atgaaaaaga atgttcgtga ccaatttaat agtcatatcc
     1321 agttagtgag gaacggagcc aagctgagca gccttcctca aatccctact cccactttac
     1381 ctccaccccc atcagagaca gacttcatgc ttcaggtgtt tcaacccagt ccctctctgg
     1441 ctcctcggat gcccttctcc attgggcagg tcacaatgcc catggttatg cccagtgcag
     1501 atccccgctc cttgtctttc ccaatcctga accctgccct ttcccagccc agccagcctt
     1561 cctcacccct tcctggctcc catggcagaa atagccctgg cttgggttcc cttgtcagcc
     1621 cccacggtcc acacatgccc cctgccgcct ccatcccacc tcccccaggc ttgggcggtg
     1681 ttaaggcttc tgctgaaact ccccggcccc aaccagtaga caaactggag aagatcctgg
     1741 agaagctgct gacccggttc ccacagtgca ataaggccca gatgaccaac attcttcagc
     1801 agatcaagac agcacgtacc accatggcag gcctgaccat ggaggaactt atccagttgg
     1861 ttgctgcacg actggcagaa catgagcggg tggcagcaag tactcagcca cttggtcgca
     1921 tccgggcctt gttccctgct ccactggccc aaatcagtac cccaatgttc ttgccttctg
     1981 cccaagtttc atatcctgga aggtcttcac atgctccagc cacctgtaag ctatgtctaa
     2041 tgtgccagaa actcgtccag cccagtgagc tgcatccaat ggcgtgtacc catgtattgc
     2101 acaaggagtg tatcaaattc tgggcccaga ccaacacaaa tgacacttgt cccttttgtc
     2161 caactcttaa atgacggacc tgactgggga ggaagaagaa gagaaactga tgtgaacagg
     2221 aagcgcgggt tcaagatttc taaaactcta tatttataca gtgacatata ctcatgccat
     2281 gtacattttt attatatagg taatgtgtgt atagaaagtc tgtattccaa tgttcgtaaa
     2341 tgaaactatg tatattatgc agaaacagtc tgttccccct catcttgcaa ttcctttggg
     2401 ggatgcagat tgtagggaag atgatgttta gtttggcctt gaaattatga tatccctgcc
     2461 cagggctgtt ttcaaataca atataaaaac cacctaggaa cctgctgttg ctctaaggcc
     2521 attctgcttt ggtttggctc agcctctagt ccatttcctt aaggctcatg tatgcagatt
     2581 taaagcctgg tgctcaccca ctgtccaacc agatgccttg cttaccgaaa gcctccagaa
     2641 gcctcagtat tgttttagcc actctactcc aaatggataa aatgagactc tgattgagga
     2701 aaaaaaagta accctagtag tttgacttct tattgaatat tttactgtgt taacgctcat
     2761 tatttataca gacattaggt ttacagaata ttctgtttta catcaccaaa attcacagtc
     2821 cgagaataac aacataacca ggtcccaatt cctccatgta ccccacaagc ttctgtccac
     2881 cctattttct ggacagaaat tagcacaacc cacaggtttt tcctgggcca agtcttcctt
     2941 tgctgccact gtcttggctt ctaatcaagc tctgacaggc caacattgtg aagtcctcac
     3001 cctttcccat tcacttctgg tctcctagtc tagctaatcc ccctccccca gaaggttaag
     3061 gcagttggtt cacaaccaag ttgtttggtg accttgggtg agctccagac aggcactggg
     3121 gtgaggagat gtctgtgcaa aattacttgt agaatgatct tgggatgctg gattttaatt
     3181 tttgaagcaa gaaagttagg gggggacata tttcctgtcc tgggaaaaat ggagaccaaa
     3241 gtgatattaa gaaagtagtt tggatttcaa atttataaat cacttgctct gtgggtagct
     3301 atcaggaact agatcatttt ccacctctgc ttattgtact tcttaatttt aggttttata
     3361 cctgggaaag ctgtgactct attagagctt tgaatctttt cctatccttt tatctttact
     3421 cctacaggga atggcctcag ctcccttctc ttttagaatt aaacaagtaa aaactaa
//
