LOCUS       NM_031297               1732 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens ring finger protein 208 (RNF208), transcript variant
            1, mRNA.
ACCESSION   NM_031297 XM_001125714
VERSION     NM_031297.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1732)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1732)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1732)
  AUTHORS   Pang,K., Park,J., Ahn,S.G., Lee,J., Park,Y., Ooshima,A., Mizuno,S.,
            Yamashita,S., Park,K.S., Lee,S.Y., Jeong,J., Ushijima,T., Yang,K.M.
            and Kim,S.J.
  TITLE     RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin
            to suppress metastasis in triple-negative breast cancers
  JOURNAL   Nat Commun 10 (1), 5805 (2019)
   PUBMED   31862882
  REMARK    GeneRIF: RING finger protein 208 (RNF208) decreases the stability
            of soluble Vimentin protein through a polyubiquitin-mediated
            proteasomal degradation pathway, thereby suppressing metastasis of
            triple-negative breast cancer (TNBC) cells. RNF208 was
            significantly lower in TNBC than the luminal type, and low
            expression of RNF208 was strongly associated with poor clinical
            outcomes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1732)
  AUTHORS   Lee,Y.I., Giovinazzo,D., Kang,H.C., Lee,Y., Jeong,J.S.,
            Doulias,P.T., Xie,Z., Hu,J., Ghasemi,M., Ischiropoulos,H., Qian,J.,
            Zhu,H., Blackshaw,S., Dawson,V.L. and Dawson,T.M.
  TITLE     Protein microarray characterization of the S-nitrosoproteome
  JOURNAL   Mol Cell Proteomics 13 (1), 63-72 (2014)
   PUBMED   24105792
REFERENCE   5  (bases 1 to 1732)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX255925.17.
            
            On Apr 8, 2021 this sequence version replaced NM_031297.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.3659042.1,
                                           SRR1163658.278557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391553.3/ ENSP00000375397.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               BX255925.17        17369-17620         c
            253-1732            BX255925.17        15639-17118         c
FEATURES             Location/Qualifiers
     source          1..1732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1732
                     /gene="RNF208"
                     /note="ring finger protein 208"
                     /db_xref="GeneID:727800"
                     /db_xref="HGNC:HGNC:25420"
                     /db_xref="MIM:618993"
     exon            1..252
                     /gene="RNF208"
                     /inference="alignment:Splign:2.1.0"
     exon            253..1732
                     /gene="RNF208"
                     /inference="alignment:Splign:2.1.0"
     CDS             779..1564
                     /gene="RNF208"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="RING finger protein 208 isoform 1"
                     /protein_id="NP_112587.2"
                     /db_xref="CCDS:CCDS7037.2"
                     /db_xref="GeneID:727800"
                     /db_xref="HGNC:HGNC:25420"
                     /db_xref="MIM:618993"
                     /translation="MPSDPGPEAGSGWPGLLMSCLKGPHVILKMEAMKIVHPEKFPEL
                     PAAPCFPPAPRPTPTLAPKRAWPSDTEIIVNQACGGDMPALEGAPHTPPLPRRPRKGS
                     SELGFPRVAPEDEVIVNQYVIRPGPSASAASSAAAGEPLECPTCGHSYNVTQRRPRVL
                     SCLHSVCEQCLQILYESCPKYKFISCPTCRRETVLFTDYGLAALAVNTSILSRLPPEA
                     LTAPSGGQWGAEPEGSCYQTFRQYCGAACTCHVRNPLSACSIM"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF208"
                     /note="hexamer: ATTAAA"
     polyA_site      1732
                     /gene="RNF208"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgcc acgctccgca cgcacctgcc gccgtcgccg ccgtgccgaa acccgcgccc
       61 cgcgccccac gcccgcgccc gcgcccctcg gtgccgcccg ggccccgcca tcgcctgagg
      121 tcgctgcggc cgccgccgga gccgccggag ccccccgagc tgccgggccg aggcgcgggc
      181 gccgcgtccg ggcctgcctt tgagacaacc tctgcggcgg cggcgcgcgg ccgggacgcc
      241 aggctggggc agctcaggcc tggcccaggc ctcgcctctg ctcctgccgc ggagcctgcc
      301 gccccggtcc tcctgcagcc agcgcttcgg ctagctgcct tccctgggcg ccctgtcctg
      361 gagccatggg gcccacccag cccctgcctg ccccgatgtc ccggcccgcg gcctgctgac
      421 ctcggctgca gggggagccc cccccgcgcc ccctcgccag cctcagcagc cagagaccct
      481 gggtgagacc ctgggccaga cccccagccc agggcagcct cccacccctc cctgcccccg
      541 cctgcctccc cctcccccac cccttcctcc tcctcccagg actggaccag agaagccact
      601 gtggccactg gggggggccc tgcaccccca actctcgccg gctgtcccta ggagtccacg
      661 ggccgtccgg ggcccccccc aggcctggcg ggaccaggat gctgccctgt cacctgcccc
      721 ccagccccac acaacgcccc cacccacccg aacatccagt ctgactggag acagccggat
      781 gccctctgac cccgggcccg aggcgggcag tggctggccg ggcctcctca tgtcctgcct
      841 gaagggtccc catgtcatcc tcaagatgga ggccatgaag attgtccacc ctgaaaagtt
      901 ccctgagcta ccggctgccc cctgcttccc gcctgctccc cggcccaccc caactctggc
      961 acccaagcgt gcctggccct cagacacaga gatcattgtc aaccaggcct gtggggggga
     1021 catgcctgcc ttggaagggg caccccatac cccgccactg ccacggcggc cccgtaaggg
     1081 aagctcggag ctgggctttc cccgcgtggc cccagaggat gaggtcattg tgaatcagta
     1141 cgtgattcgg cctggcccct cggcctcggc ggcttcttcg gcggcggcag gcgagcccct
     1201 ggagtgcccc acctgtgggc actcctacaa tgtcacccag cggaggcccc gcgtgctgtc
     1261 ctgcctgcac tctgtgtgtg agcagtgcct gcagattctc tacgagtcct gccccaagta
     1321 caagttcatc tcctgcccca cctgccgccg tgagactgtg ctcttcaccg actacggcct
     1381 ggccgcgctg gctgtcaaca cgtccatcct gagccgcctg ccgcctgagg cgctgacggc
     1441 cccatccggg ggtcagtggg gggctgagcc cgagggcagc tgctaccaga ccttccggca
     1501 gtactgtggg gccgcgtgca cctgccacgt gcggaaccca ctgtccgcct gctccatcat
     1561 gtagtagcgc ctgcctgccc gccactgccc gctgagcctc gctcgctgct tcttcaggga
     1621 cccggccctg ccctgccgcc cgctgaccct tccttcccca ccatggcttc cggccccacc
     1681 ccgagtggca ttgtcgctgc agccaacttt gccattaaaa ctctttgcca aa
//
