LOCUS       NM_019592               3938 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ring finger protein 20 (RNF20), mRNA.
ACCESSION   NM_019592
VERSION     NM_019592.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3938)
  AUTHORS   Lyu,Y., Yang,Y., Talwar,V., Lu,H., Chen,C., Salman,S., Wicks,E.E.,
            Huang,T.Y., Drehmer,D., Wang,Y., Zuo,Q., Datan,E., Jackson,W. 3rd,
            Dordai,D., Wang,R. and Semenza,G.L.
  TITLE     Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate
            histone ubiquitination and transcriptional activation of target
            genes
  JOURNAL   Cell Rep 43 (4), 113972 (2024)
   PUBMED   38517892
  REMARK    GeneRIF: Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to
            mediate histone ubiquitination and transcriptional activation of
            target genes.
REFERENCE   2  (bases 1 to 3938)
  AUTHORS   Wang,L., Liu,C., Li,L., Wei,H., Wei,W., Zhou,Q., Chen,Y.,
            Meng,T.G., Jiao,R., Wang,Z.B., Sun,Q.Y. and Li,W.
  TITLE     RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3
            to Centromeres and Spindle Poles
  JOURNAL   Adv Sci (Weinh) 11 (13), e2306986 (2024)
   PUBMED   38240347
  REMARK    GeneRIF: RNF20 Regulates Oocyte Meiotic Spindle Assembly by
            Recruiting TPM3 to Centromeres and Spindle Poles.
REFERENCE   3  (bases 1 to 3938)
  AUTHORS   Onishi,S., Uchiyama,K., Sato,K., Okada,C., Kobayashi,S., Hamada,K.,
            Nishizawa,T., Nureki,O., Ogata,K. and Sengoku,T.
  TITLE     Structure of the human Bre1 complex bound to the nucleosome
  JOURNAL   Nat Commun 15 (1), 2580 (2024)
   PUBMED   38519511
  REMARK    GeneRIF: Structure of the human Bre1 complex bound to the
            nucleosome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3938)
  AUTHORS   Dong,B., Wang,X., Song,X., Wang,J., Liu,X., Yu,Z., Zhou,Y., Deng,J.
            and Wu,Y.
  TITLE     RNF20 contributes to epigenetic immunosuppression through
            CDK9-dependent LSD1 stabilization
  JOURNAL   Proc Natl Acad Sci U S A 121 (7), e2307150121 (2024)
   PUBMED   38315842
  REMARK    GeneRIF: RNF20 contributes to epigenetic immunosuppression through
            CDK9-dependent LSD1 stabilization.
REFERENCE   5  (bases 1 to 3938)
  AUTHORS   Liu,D., Luo,R., Zhou,Q. and Li,M.
  TITLE     RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting
            NLRP3 Ubiquitination in Liver Cancer
  JOURNAL   J Environ Pathol Toxicol Oncol 43 (3), 69-80 (2024)
   PUBMED   38608146
  REMARK    GeneRIF: RNF20 Reduces Cell Proliferation and Warburg Effect by
            Promoting NLRP3 Ubiquitination in Liver Cancer.
REFERENCE   6  (bases 1 to 3938)
  AUTHORS   Hwang,W.W., Venkatasubrahmanyam,S., Ianculescu,A.G., Tong,A.,
            Boone,C. and Madhani,H.D.
  TITLE     A conserved RING finger protein required for histone H2B
            monoubiquitination and cell size control
  JOURNAL   Mol Cell 11 (1), 261-266 (2003)
   PUBMED   12535538
  REMARK    GeneRIF: Functional analysis of the yeast counterpart
REFERENCE   7  (bases 1 to 3938)
  AUTHORS   Rowley,A.H., Shulman,S.T., Spike,B.T., Mask,C.A. and Baker,S.C.
  TITLE     Oligoclonal IgA response in the vascular wall in acute Kawasaki
            disease
  JOURNAL   J Immunol 166 (2), 1334-1343 (2001)
   PUBMED   11145718
REFERENCE   8  (bases 1 to 3938)
  AUTHORS   Lee,J., Monson,N.L. and Lipsky,P.E.
  TITLE     The V lambda J lambda repertoire in human fetal spleen: evidence
            for positive selection and extensive receptor editing
  JOURNAL   J Immunol 165 (11), 6322-6333 (2000)
   PUBMED   11086069
REFERENCE   9  (bases 1 to 3938)
  AUTHORS   Slachta,C.A., Jeevanandam,V., Goldman,B., Lin,W.L. and
            Platsoucas,C.D.
  TITLE     Coronary arteries from human cardiac allografts with chronic
            rejection contain oligoclonal T cells: persistence of identical
            clonally expanded TCR transcripts from the early
            post-transplantation period (endomyocardial biopsies) to chronic
            rejection (coronary arteries)
  JOURNAL   J Immunol 165 (6), 3469-3483 (2000)
   PUBMED   10975868
REFERENCE   10 (bases 1 to 3938)
  AUTHORS   Lossos,I.S., Alizadeh,A.A., Eisen,M.B., Chan,W.C., Brown,P.O.,
            Botstein,D., Staudt,L.M. and Levy,R.
  TITLE     Ongoing immunoglobulin somatic mutation in germinal center B
            cell-like but not in activated B cell-like diffuse large cell
            lymphomas
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10209-10213 (2000)
   PUBMED   10954754
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF265230.1, BC110584.1 and
            AL832910.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_019592.6.
            
            Summary: The protein encoded by this gene shares similarity with
            BRE1 of S. cerevisiae. The protein encoded by this human gene is an
            E3 ubiquitin ligase that regulates chromosome structure by
            monoubiquitinating histone H2B. This protein acts as a putative
            tumor suppressor and positively regulates the p53 tumor suppressor
            as well as numerous histone H2A and H2B genes. In contrast, this
            protein also suppresses the expression of several protooncogenes
            and growth-related genes, including many genes that are induced by
            epidermal growth factor. This gene selectively suppresses the
            expression of some genes by interfering with chromatin recruitment
            of transcription elongation factor SII (TFIIS). [provided by
            RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022532.1, AF265230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389120.8/ ENSP00000373772.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-952               AF265230.1         3-954
            953-3513            BC110584.1         950-3510
            3514-3934           AF265230.1         3516-3936
            3935-3938           AL832910.1         1778-1781
FEATURES             Location/Qualifiers
     source          1..3938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..3938
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /note="ring finger protein 20"
                     /db_xref="GeneID:56254"
                     /db_xref="HGNC:HGNC:10062"
                     /db_xref="MIM:607699"
     exon            1..62
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..217
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..3016
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /EC_number="2.3.2.27"
                     /note="BRE1 E3 ubiquitin ligase homolog; homolog of S.
                     cerevisiae BRE1; RING-type E3 ubiquitin transferase BRE1A"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1A"
                     /protein_id="NP_062538.5"
                     /db_xref="CCDS:CCDS35084.1"
                     /db_xref="GeneID:56254"
                     /db_xref="HGNC:HGNC:10062"
                     /db_xref="MIM:607699"
                     /translation="MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTE
                     ELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDE
                     NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLA
                     TLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAV
                     QELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQW
                     DIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE
                     NKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLY
                     NESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRK
                     EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDL
                     NKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDE
                     EERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAE
                     IIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLK
                     DLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFE
                     DMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQ
                     LQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQK
                     KLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIK
                     DYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRI
                     YIG"
     exon            218..385
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..533
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..716
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..835
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..982
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1060
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1180
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1360
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1496
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1618
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1989
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2107
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2257
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2470
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2596
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2737
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2839
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3938
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3916..3921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /note="hexamer: ATTAAA"
     polyA_site      3938
                     /gene="RNF20"
                     /gene_synonym="BRE1; BRE1A; hBRE1"
                     /note="major polyA site"
ORIGIN      
        1 aagttctgcc ttgtctccgc cgcgggtcag gggtgagagc tggaatctct gcacgggcct
       61 tggaaaacga ctgtcttctt ctgccaaaat gtcaggaatt ggaaataaaa gagcagctgg
      121 agaacctggc acctccatgc ctcctgagaa gaaggcagct gttgaagatt cagggaccac
      181 agtggaaaca attaagctag gaggtgtctc ttcaacggag gaactagaca ttagaacact
      241 gcaaaccaaa aatcgcaagc tggcagaaat gttggatcag cggcaggcca ttgaagatga
      301 acttcgtgag cacattgaaa aactggaacg acgacaggcc actgatgatg cctcactatt
      361 gattgtcaac cgatactgga gtcagtttga tgaaaacatc cgtatcatcc ttaaacgtta
      421 tgatctggag cagggcttgg gagacctact cacagaacga aaagcccttg ttgtgcctga
      481 accagaacca gactctgata gcaatcagga gcgtaaagat gaccgagaga gaggggaagg
      541 gcaagagcca gctttctctt tccttgctac tttggccagc agttccagtg aagagatgga
      601 gtctcagctg caggaacgtg tggagtcttc ccgccgagcc gtgtcccaga ttgtgactgt
      661 ttatgataaa ttgcaagaaa aagtggagct cttatcccgg aagctaaaca gtggagataa
      721 tctgatagtg gaggaagcag tgcaggagct gaactctttc ctcgcacagg agaatatgag
      781 gctacaggaa ttgacagatc ttcttcagga aaagcatcgc accatgtctc aggagttctc
      841 caagttgcag agtaaagtgg agacagccga atcacgagtg tctgtcctgg agtccatgat
      901 tgatgacctg cagtgggata ttgacaaaat tcgaaagagg gaacagcgac tcaaccgaca
      961 cttagcagaa gtcctagaac gggtgaattc caaaggttat aaggtgtatg gagcggggag
     1021 cagtctgtat ggcggcacaa tcactatcaa tgctcggaag tttgaggaaa tgaatgcaga
     1081 gcttgaggag aacaaagagt tggctcagaa ccgtctctgt gagctggaga aacttcggca
     1141 agactttgag gaggtcacta cacaaaatga aaagctgaag gtggaattgc ggagtgcagt
     1201 ggagcaagtc gttaaggaaa ctccagaata tcgctgcatg cagtcacagt tctccgtctt
     1261 gtataatgag agcctacagt tgaaagcaca cttggatgag gctcggaccc tgcttcatgg
     1321 caccagagga acccaccagc accaggttga gcttattgag cgagatgagg ttagtcttca
     1381 taagaagctg aggactgaag taattcagct agaagataca ttggcccagg tccgcaagga
     1441 gtatgaaatg ctgaggatag aatttgagca gacccttgct gccaatgaac aagcaggccc
     1501 tataaacagg gagatgcgcc acctcatcag tagcctccag aatcacaatc accagctgaa
     1561 aggggaggtc ctgagatata agcggaaatt gagagaagcc cagtctgacc tgaacaagac
     1621 acgcctgcgt agtggtagtg ccctcctgca gtcccagtct agtactgagg acccgaagga
     1681 tgagcctgcg gagctaaaac cagattctga ggacttatcc tcccagtcct cagcttcaaa
     1741 ggcatctcag gaggatgcca atgaaatcaa gtctaaacgg gatgaagaag aacgagaacg
     1801 agaaaggagg gagaaggaga gggaacgaga aagagaacgg gagaaggaga aggagagaga
     1861 acgagagaag cagaagctaa aagagtcaga aaaagagaga gattctgcta aggataaaga
     1921 gaaaggcaaa catgatgatg gacggaaaaa ggaagcagaa attatcaaac aattgaagat
     1981 tgaactcaag aaggcacagg agagccaaaa ggagatgaaa ctattgctgg atatgtaccg
     2041 ttctgcccca aaggaacaga gagacaaagt tcagctgatg gcagctgaga agaagtctaa
     2101 ggcagagttg gaagatctaa ggcaaagact caaggatctg gaagataaag agaagaaaga
     2161 gaacaagaaa atggctgatg aggatgcctt gaggaagatc cgggcagtgg aggagcagat
     2221 agaataccta cagaagaagc tagccatggc caagcaggaa gaagaagcac tcctctctga
     2281 aatggatgtc acaggccagg cctttgaaga catgcaggag caaaatatcc gtttgatgca
     2341 gcaattgcgg gagaaggatg atgcaaattt caagctcatg tcagagcgta tcaagtccaa
     2401 tcagatccat aagttgctta aagaagagaa ggaggagctg gcagaccagg tgttgactct
     2461 gaagactcag gttgatgccc agctacaggt agtaaggaaa ctggaagaga aggagcatct
     2521 gttacagagc aacattggca caggggagaa agagctgggt cttaggaccc aagccttaga
     2581 gatgaataaa cgcaaggcaa tggaggcagc ccagcttgca gatgacctca aagcacaact
     2641 ggagttggct cagaagaagc tacatgattt tcaggatgag atcgtggaga acagtgttac
     2701 caaagaaaag gacatgttca atttcaaacg agcccaggag gacatctcta gacttcgcag
     2761 gaagctggag accacaaaga aaccagacaa tgtacccaag tgtgatgaga ttctgatgga
     2821 agagattaag gattacaagg cacgcttgac ctgtccgtgc tgtaacatgc gtaaaaagga
     2881 tgctgttctt actaagtgtt ttcatgtctt ctgctttgag tgtgtgaaga cacgctatga
     2941 cacccgccag cgcaaatgtc ccaagtgtaa tgctgctttt ggtgccaatg attttcatcg
     3001 catctacatt ggttgatcta agtcaagaga agaagaggag ctggctagtc aggaacttat
     3061 tcattaacca ccaaacctct acctcttctc tccttgactg tcacctgtag gacagtttat
     3121 cagtcaacta cctttcctcc agactttact tccaggctct cctcttcagt agctggatga
     3181 ctttagcaga aaggactggt aaatacaagc cttgggtttc agaatgaatt agaaacaaat
     3241 aactcttact gtcttccctc ccagctttgt ttattttgtg cttttagact tttcagtgtt
     3301 ttctttttcc agcccactgt ataaacttgg attgtccatt cctcctgaag aaatcaagtt
     3361 ggtatttttg atgtggaaaa gggaacaaaa gtggaaacat ggctactttt ggggagtgat
     3421 attttaaaaa ataagttgtc tatgggcaca aagttttctt catttgtgta gcaaacttct
     3481 tgtgaatgtg gattacaaaa tggtataatt gtgctactct cccctgggtg gtttgcagcc
     3541 ctaatgaaat tatgtctagg atgattcagt ctatttccca tttactagca gagtaacttg
     3601 ttaagatcag ctggctttct tgttaaagtt atttaagttt tgaatgctct actacttcaa
     3661 gtctttaaat ttcttgagac tagaataatt ttaaataata tgaccctttg tcttctaatg
     3721 aaataaagat tgaagaggtt gagtcaggac tgagctggtg aagaaatctt gtgggtattc
     3781 tggaaatttg atacggagag aacttggtga gctatgaatt actctcagtc tcctttttac
     3841 agggttgttg tgatccctct tttccagaaa attctgtgga atgtttctgt aggactttgt
     3901 tctccacaag cttgaattaa agcaggattc agtttgca
//
