LOCUS       NM_007212               3407 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens ring finger protein 2 (RNF2), mRNA.
ACCESSION   NM_007212
VERSION     NM_007212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Araujo-Abad,S., Rizzuti,B., Soto-Conde,L., Vidal,M., Abian,O.,
            Velazquez-Campoy,A., Neira,J.L. and de Juan Romero,C.
  TITLE     Citrullinating enzyme PADI4 and transcriptional repressor RING1B
            bind in cancer cells
  JOURNAL   Int J Biol Macromol 274 (Pt 1), 133163 (2024)
   PUBMED   38878927
  REMARK    GeneRIF: Citrullinating enzyme PADI4 and transcriptional repressor
            RING1B bind in cancer cells.
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Sera,Y., Imanaka,T. and Yamaguchi,M.
  TITLE     M phase-specific interaction between SBDS and RNF2 at the mitotic
            spindles regulates mitotic progression
  JOURNAL   Biochem Biophys Res Commun 682, 118-123 (2023)
   PUBMED   37806249
  REMARK    GeneRIF: M phase-specific interaction between SBDS and RNF2 at the
            mitotic spindles regulates mitotic progression.
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Seo,D.Y., Kim,D., Nguyen,K.T., Oh,J., Lee,J.S. and Hwang,C.S.
  TITLE     N-Terminally arginylated ubiquitin is attached to histone H2A by
            RING1B E3 ligase in human cells
  JOURNAL   Biochem Biophys Res Commun 666, 186-194 (2023)
   PUBMED   36932026
  REMARK    GeneRIF: N-Terminally arginylated ubiquitin is attached to histone
            H2A by RING1B E3 ligase in human cells.
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Yao,L., Li,J., Jiang,B., Zhang,Z., Li,X., Ouyang,X., Xiao,Y.,
            Liu,G., Wang,Z. and Zhang,G.
  TITLE     RNF2 inhibits E-Cadherin transcription to promote hepatocellular
            carcinoma metastasis via inducing histone mono-ubiquitination
  JOURNAL   Cell Death Dis 14 (4), 261 (2023)
   PUBMED   37037816
  REMARK    GeneRIF: RNF2 inhibits E-Cadherin transcription to promote
            hepatocellular carcinoma metastasis via inducing histone
            mono-ubiquitination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   Yuan,L., Li,X., Yang,H. and Li,H.
  TITLE     The ubiquitin ligase RNF2 stabilizes ERalpha and modulates breast
            cancer progression
  JOURNAL   Hum Cell 36 (1), 353-365 (2023)
   PUBMED   36271315
  REMARK    GeneRIF: The ubiquitin ligase RNF2 stabilizes ERalpha and modulates
            breast cancer progression.
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Suzuki,M., Mizutani-Koseki,Y., Fujimura,Y., Miyagishima,H.,
            Kaneko,T., Takada,Y., Akasaka,T., Tanzawa,H., Takihara,Y.,
            Nakano,M., Masumoto,H., Vidal,M., Isono,K. and Koseki,H.
  TITLE     Involvement of the Polycomb-group gene Ring1B in the specification
            of the anterior-posterior axis in mice
  JOURNAL   Development 129 (18), 4171-4183 (2002)
   PUBMED   12183370
REFERENCE   7  (bases 1 to 3407)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   8  (bases 1 to 3407)
  AUTHORS   Tuckfield,A., Clouston,D.R., Wilanowski,T.M., Zhao,L.L.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     Binding of the RING polycomb proteins to specific target genes in
            complex with the grainyhead-like family of developmental
            transcription factors
  JOURNAL   Mol Cell Biol 22 (6), 1936-1946 (2002)
   PUBMED   11865070
  REMARK    GeneRIF: The human PcG protein dinG interacts with CP2, a mammalian
            member of the grainyhead-like family of transcription factors, in
            vitro and in vivo. The functional consequence of this interaction
            is repression of CP2-dependent transcription.
REFERENCE   9  (bases 1 to 3407)
  AUTHORS   Lee,S.J., Choi,J.Y., Sung,Y.M., Park,H., Rhim,H. and Kang,S.
  TITLE     E3 ligase activity of RING finger proteins that interact with
            Hip-2, a human ubiquitin-conjugating enzyme
  JOURNAL   FEBS Lett 503 (1), 61-64 (2001)
   PUBMED   11513855
REFERENCE   10 (bases 1 to 3407)
  AUTHORS   Garcia,E., Marcos-Gutierrez,C., del Mar Lorente,M., Moreno,J.C. and
            Vidal,M.
  TITLE     RYBP, a new repressor protein that interacts with components of the
            mammalian Polycomb complex, and with the transcription factor YY1
  JOURNAL   EMBO J 18 (12), 3404-3418 (1999)
   PUBMED   10369680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF141327.1 and AL109865.36.
            
            On Nov 22, 2018 this sequence version replaced NM_007212.3.
            
            Summary: Polycomb group (PcG) of proteins form the multiprotein
            complexes that are important for the transcription repression of
            various genes involved in development and cell proliferation. The
            protein encoded by this gene is one of the PcG proteins. It has
            been shown to interact with, and suppress the activity of,
            transcription factor CP2 (TFCP2/CP2). Studies of the mouse
            counterpart suggested the involvement of this gene in the
            specification of anterior-posterior axis, as well as in cell
            proliferation in early development. This protein was also found to
            interact with huntingtin interacting protein 2 (HIP2), an
            ubiquitin-conjugating enzyme, and possess ubiquitin ligase
            activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012583.1, AF141327.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367510.8/ ENSP00000356480.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1189              AF141327.1         132-1320
            1190-3407           AL109865.36        160949-163166
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..3407
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /note="ring finger protein 2"
                     /db_xref="GeneID:6045"
                     /db_xref="HGNC:HGNC:10061"
                     /db_xref="MIM:608985"
     exon            1..92
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..181
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1105
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /EC_number="2.3.2.27"
                     /note="RING finger protein 1B; RING finger protein BAP-1;
                     HIP2-interacting protein 3; huntingtin-interacting protein
                     2-interacting protein 3; protein DinG; RING-type E3
                     ubiquitin transferase RING2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RING2"
                     /protein_id="NP_009143.1"
                     /db_xref="CCDS:CCDS1365.1"
                     /db_xref="GeneID:6045"
                     /db_xref="HGNC:HGNC:10061"
                     /db_xref="MIM:608985"
                     /translation="MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRS
                     LHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRP
                     DPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGK
                     KQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAMAIDP
                     VMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKG
                     ESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKE
                     HK"
     exon            182..342
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..558
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..831
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1003
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3407
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1937..1942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /note="hexamer: ATTAAA"
     polyA_site      1959
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /note="hexamer: TATAAA"
     polyA_site      2981
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /note="major polyA site"
     regulatory      3007..3012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /note="hexamer: AATATA"
     polyA_site      3027
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
     regulatory      3378..3383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
                     /note="hexamer: ATTAAA"
     polyA_site      3407
                     /gene="RNF2"
                     /gene_synonym="BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B;
                     RING2"
ORIGIN      
        1 atattgtgcg gcggcgccgg cgtccgcggc agctgatacc agagtcttgc tccggccgcg
       61 gccagcggag ccctgggctg gggcaggagc cgcaatgtct caggctgtgc agacaaacgg
      121 aactcaacca ttaagcaaaa catgggaact cagtttatat gagttacaac gaacacctca
      181 ggaggcaata acagatggct tagaaattgt ggtttcacct cgaagtctac acagtgaatt
      241 aatgtgccca atttgtttgg atatgttgaa gaacaccatg actacaaagg agtgtttaca
      301 tcgtttttgt gcagactgca tcatcacagc ccttagaagt ggcaacaaag aatgtcctac
      361 ctgtcggaaa aaactagttt ccaaaagatc actaaggcca gacccaaact ttgatgcact
      421 catcagcaaa atttatccaa gtcgtgatga gtatgaagct catcaagaga gagtattagc
      481 caggatcaac aagcacaata atcagcaagc actcagtcac agcattgagg aaggactgaa
      541 gatacaggcc atgaacagac tgcagcgagg caagaaacaa cagattgaaa atggtagtgg
      601 agcagaagat aatggtgaca gttcacactg cagtaatgca tccacacata gcaatcagga
      661 agcaggccct agtaacaaac ggaccaaaac atctgatgat tctgggctag agcttgataa
      721 taacaatgca gcaatggcaa ttgatccagt aatggatggt gctagtgaaa ttgaattagt
      781 attcaggcct catcccacac ttatggaaaa agatgacagt gcacagacga gatacataaa
      841 gacttctggt aacgccactg ttgatcactt atccaagtat ctggctgtga ggttagcttt
      901 agaagaactt cgaagcaaag gtgaatcaaa ccagatgaac cttgatacag ccagtgagaa
      961 gcagtatacc atttatatag caacagccag tggccagttc actgtattaa atggctcttt
     1021 ttctttggaa ttggtcagtg agaaatactg gaaagtgaac aaacccatgg aactttatta
     1081 cgcacctaca aaggagcaca aatgagcctt taaaaaccaa ttctgagact gaactttttt
     1141 atagcctatt tctttaatat taaagatgta ctggcattac ttttatggac agatcttgga
     1201 tatgttgttc aattttcttt ctgagccaga ctagtttacg ctattcaaat cttttcccct
     1261 ttatttaaga tttccttttt ggaagggact gcaattattc agtatttttt tctttccttt
     1321 aaaaaaatat atctgaagtt tcttgtgttt ttttttttcc ccacaaagtg tgtttccact
     1381 tggagcacca ttttgaccca ggaatttttc atagtttctg tattcttata agattcagtt
     1441 ggctgtcctt ttcctgctcc cctcaaaaga tttttagtca tacagaatgt taaatattat
     1501 gtattctgac tttttttttc ccccggagtc ttgtatattt atagttttct atataaactg
     1561 tagtatcttc atgaagaccc aaggctcaaa tttactgtcc ttaaaaacaa ttctcatagg
     1621 attattcttt tcatggtatt ttcttccata atatctcatt ttaaaaagaa gttctttatg
     1681 aacttagtgt ccattgtcat gcaatgtttt tttttttcca ttctttttcc ctgtaatttt
     1741 ggaatttctg gtcctgggaa gaatcaaaca aaatcttaag ttctatgaga acttggttca
     1801 ttgacatatt ctgctgaaga aagaaaaatt aaattggtag taaaatatag tcttcaagta
     1861 tacgtttgag agtgcttttt tttgtattag ttctgctgtc acttcatttc ctgtattata
     1921 tgtgatgttt ttccccatta aaataccaga gataatggag atattttgca ctttagcctt
     1981 gatgaaaagt acaagatatg ttcaaagctt ccctaatttt tttcttattt gtagccacat
     2041 aagtttcaag aataacatgg cacacagaac aatggaaaaa agtttgtttc cattggaaaa
     2101 ttatatcatt ttgggttgcc acatcagttt ataaatttgg cgctctttta attacactct
     2161 gtagaaggtt aatagagctt gagccctgct ttaatatgta gtgaaagata attctgtaga
     2221 aaaacgtcag ccagtagggt aaagtcattc tactgttctt aatttttata ttgaggaaca
     2281 atattgggtg tttgggagcc agaaagcttt gttgacagat cagaaataag attgacttgg
     2341 gtgttatatt tcatctctct ccagactcta ggtatatttc caactttata tatcacagta
     2401 tttaaaaaga catgtttgca ttgagaaatt aaccctaaag ggttttcaat agggtgtaga
     2461 cctccagtac ctttgtaact aaagtctgtc tagtcattgt aaatatttat ctgtcagttt
     2521 tgacagattg gggccagctt gatgttttaa atcttcagcc cggtatgaaa acttaaaggt
     2581 atatattcaa ttttttacca ttttatggaa aatatttaaa atctgttttt acagggtttt
     2641 tttttttttt ttttttttgt aatctgtgcc atgaaatttg aaaaccacca aaaatcaagg
     2701 gaacttttat atattcaatt ccttttctgg tgtaatgtta aagttgtata gattattaat
     2761 gcatgcccac tgaatataac cctggttttg tgataaaact gcttagattt tgttgatgac
     2821 attagattag tagttgcatt aaataactaa attcccattg tgattaattg aaattttgtc
     2881 tttaagcaga gagttatttg tgactataag ctttgtgctt agagaatgta tgtgttttta
     2941 tctgtcagta tgggaggata taaactgcat cattagtgaa attattggtt gtgtaatcct
     3001 ttgtgaaata taattctagg tatttgatag ggtattgagt gtattttgtg tgtgtgtgga
     3061 tgtgtgtttt ggggtacggg gagaggcgat gctattggcc atcactacca accagggttt
     3121 caaaaagtat tacctaagta atttctttta tcactatctc aactgaggaa gaaaaggctc
     3181 accacaagtg gtgtgaaggc tttgggtact tagttctaaa tttttttatg gtaacatata
     3241 catagccaca tttacagttt taaccatttt aaggcatgta attcagtggg gttaggtaca
     3301 ttcacaatgt tgtgtaatga tcaccgctgt ctacttgtaa aactttttca tcaccccaaa
     3361 cagaaactct gtgtgcaatt aaagtaatgc atttctcttc ttcttaa
//
