LOCUS       NM_001300826            2677 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ring finger protein 19B (RNF19B), transcript variant
            3, mRNA.
ACCESSION   NM_001300826 XM_005270460
VERSION     NM_001300826.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2677)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2677)
  AUTHORS   Lawrence,D.W., Willard,P.A., Cochran,A.M., Matchett,E.C. and
            Kornbluth,J.
  TITLE     Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin
            Ligase With an Integral Role in Innate Immunity
  JOURNAL   Front Physiol 11, 573372 (2020)
   PUBMED   33192571
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2677)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2677)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2677)
  AUTHORS   Lawrence,D.W. and Kornbluth,J.
  TITLE     E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively
            regulates STAT1-mediated transcriptional activity
  JOURNAL   Cell Signal 28 (12), 1833-1841 (2016)
   PUBMED   27570112
  REMARK    GeneRIF: NKLAM is a positive regulator of STAT1-mediated
            transcriptional activity and is an important component of the
            innate immune response.
REFERENCE   6  (bases 1 to 2677)
  AUTHORS   Hoover,R.G., Gullickson,G. and Kornbluth,J.
  TITLE     Impaired NK cytolytic activity and enhanced tumor growth in NK
            lytic-associated molecule-deficient mice
  JOURNAL   J Immunol 183 (11), 6913-6921 (2009)
   PUBMED   19915045
REFERENCE   7  (bases 1 to 2677)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 2677)
  AUTHORS   Fortier,J.M. and Kornbluth,J.
  TITLE     NK lytic-associated molecule, involved in NK cytotoxic function, is
            an E3 ligase
  JOURNAL   J Immunol 176 (11), 6454-6463 (2006)
   PUBMED   16709802
REFERENCE   9  (bases 1 to 2677)
  AUTHORS   Portis,T., Anderson,J., Esposito,A. and Kornbluth,J.
  TITLE     Gene structure of human and mouse NKLAM, a gene associated with
            cellular cytotoxicity
  JOURNAL   Immunogenetics 51 (7), 546-555 (2000)
   PUBMED   10912506
REFERENCE   10 (bases 1 to 2677)
  AUTHORS   Kozlowski,M., Schorey,J., Portis,T., Grigoriev,V. and Kornbluth,J.
  TITLE     NK lytic-associated molecule: a novel gene selectively expressed in
            cells with cytolytic function
  JOURNAL   J Immunol 163 (4), 1775-1785 (1999)
   PUBMED   10438909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA630289.1, AL031602.14,
            BC143687.1, BC113560.1 and AK074486.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001300826.1.
            
            Summary: This gene encodes a multi-pass membrane protein containing
            two RING-type and one IBR-type zinc finger motifs. The encoded
            protin is an E3 ubiquitin-protein ligase that plays a role in the
            cytotoxic effects of natural killer (NK) cells. Alternative
            splicing results in multiple transcript variants. There are
            pseudogenes for this gene on chromosomes X and Y in a possible
            pseudoautosomal region. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (c) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143687.1, SRR1163655.639970.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235150.5/ ENSP00000235150.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               DA630289.1         5-128
            125-629             AL031602.14        14306-14810
            630-1452            BC143687.1         1-823
            1453-2390           BC113560.1         827-1764
            2391-2392           AK074486.1         1698-1699
            2393-2677           AK074486.1         1701-1985
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..2677
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /note="ring finger protein 19B"
                     /db_xref="GeneID:127544"
                     /db_xref="HGNC:HGNC:26886"
                     /db_xref="MIM:610872"
     exon            1..759
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2320
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /EC_number="2.3.2.31"
                     /note="isoform c is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase RNF19B; IBR domain-containing
                     protein 3; natural killer lytic-associated molecule"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF19B isoform c"
                     /protein_id="NP_001287755.1"
                     /db_xref="CCDS:CCDS72754.1"
                     /db_xref="GeneID:127544"
                     /db_xref="HGNC:HGNC:26886"
                     /db_xref="MIM:610872"
                     /translation="MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASAR
                     GRRARAKPQAEPPPPAAQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFD
                     DEEAAEGGGPGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVP
                     ISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAY
                     GCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQ
                     ESGPDDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTF
                     WGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKT
                     SKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTA
                     NGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGP
                     YSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDNASTR
                     AMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEG
                     SGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSD
                     ECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV"
     exon            760..965
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1107
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1270
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1385
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1526
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1734
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1866
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2677
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /note="hexamer: AATAAA"
     polyA_site      2677
                     /gene="RNF19B"
                     /gene_synonym="IBRDC3; NKLAM"
                     /note="major polyA site"
ORIGIN      
        1 atcgccggga gggcggttga ggcggtggtg gcggcgtcgg cggcggccgg gcgctggctg
       61 aggggcgctg aggcgggagc tgtggcggcg ctgggcgccc ctggctcctc ggcctctgcc
      121 ggccatgggc tccgagaagg actccgagtc gccgcgctcc acatcgctac atgcggccgc
      181 acccgaccct aagtgccgca gcggcggccg gcgccggcgc ctcaccttgc acagcgtctt
      241 ctctgcctcg gcccgcggcc gccgcgcccg ggccaagccg caggccgagc cgccgccccc
      301 ggctgcgcag ccgccgcccg ccccggcccc tgccgcggcc cagggcccgc cgcccgaggc
      361 gctgcccgcc gagccggccg ccgaggccga ggcggaggcc gcggcggcgg cggcggagcc
      421 tgggttcgac gatgaggagg cggcggaggg cggtggcccg ggcgcggagg aggtggagtg
      481 tccgctgtgc ctggtgcggc tgccgcctga gcgggccccg cgcctcctca gctgtccgca
      541 ccgctcgtgc cgggactgcc tccgccacta cctgcgcctg gagataagcg agagcagggt
      601 gcccatcagc tgccccgagt gcagcgagcg actcaacccg cacgacatcc gcttgctgct
      661 cgccgacccg ccgcttatgc acaagtacga ggagttcatg ctgcgccgct acctagcctc
      721 ggaccccgac tgccgctggt gcccggcccc ggactgcggt tatgctgtta ttgcctatgg
      781 ctgtgccagc tgcccgaagc taacttgtga gagggaaggt tgccagactg agttctgcta
      841 ccactgcaag cagatatggc atccaaatca gacatgcgat atggcccgtc aacagagggc
      901 ccagacttta cgagttcgga ccaaacacac ttcaggtctc agttatgggc aagaatctgg
      961 accagatgac atcaagccat gcccacgatg cagtgcatac attatcaaga tgaatgatgg
     1021 aagctgtaat cacatgacct gtgcagtgtg tggctgtgaa ttctgttggc tttgtatgaa
     1081 agagatctca gacttgcatt acctcagccc ctctggctgt acattctggg gcaagaagcc
     1141 atggagccgt aagaagaaaa ttctttggca gctgggcacg ttgattggtg ctccagtggg
     1201 gatttctctc attgctggca ttgccattcc tgccatggtc attggcattc ctgtttatgt
     1261 tggaaggaag attcacagca ggtatgaggg aaggaaaacc tccaaacaca agaggaattt
     1321 ggctatcact ggaggagtga ctttgtcggt cattgcatcc ccagttattg ctgcagttag
     1381 tgttggtatt ggtgtcccca ttatgctggc atatgtttat ggggttgtgc ccatttctct
     1441 ttgtcgtgga ggcggctgtg gagttagcac agccaacgga aaaggagtga aaattgaatt
     1501 tgatgaagat gatggtccaa tcacagtggc agatgcctgg agagccctca agaatcccag
     1561 cattggggaa agcagcattg aaggcctgac tagtgtattg agcactagtg gaagccctac
     1621 agatggactt agtgttatgc aaggtcctta cagcgaaacg gccagctttg cagccctctc
     1681 agggggcacg ctgagtggcg gcattctctc cagtggcaag ggaaaatata gcaggttaga
     1741 agttcaagcc gatgtccaaa aggaaatttt ccccaaagac acagccagtc ttggtgcaat
     1801 tagtgacaac gcaagcactc gtgctatggc cggttccata atcagttcct acaacccaca
     1861 ggacagagaa tgcaacaata tggaaatcca agtggacatt gaagccaaac caagccacta
     1921 tcagctggtg agtggaagca gcacggagga ctcgctccat gttcatgctc agatggcaga
     1981 gaatgaagaa gaaggtagtg gtggcggagg cagtgaagag gatcccccct gcagacacca
     2041 aagctgtgaa cagaaagact gcctggccag caaaccttgg gacatcagcc tggcccagcc
     2101 tgaaagcatc cgcagtgacc tagagagttc tgatgcacag tcagacgatg tgccagacat
     2161 cacctcagat gagtgtggct ccccccgctc ccatactgca gcctgcccct cgacccccag
     2221 agcccaaggt gcaccgagcc caagtgccca tatgaacctc tctgccctag ccgagggaca
     2281 aactgtcttg aagccagaag gtggagaagc cagagtatga agtggaatga atgctcctgt
     2341 tctgagaagc acacttgtaa ctgcatcttt tggaattttt tttttttttt ttccaagggg
     2401 tagagattta tgtattttat ttcacagatt ctctggtcac aggtttttgc ccagggaaat
     2461 tctgagaaat tcacaatttc ttaccagata aaacatgaaa agtttgccgt tagttcccct
     2521 cccctcccct ccctcttttt agttttaatt tattggttaa actgatggca gcaatccatg
     2581 aggtgtgtca aagagtgtac atatgtatgt gtgtatattg aatgctaaac atattactga
     2641 aagacacatt ttaataaaga tttctgtcat aattcaa
//
