LOCUS       NM_183419               4186 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 19A, RBR E3 ubiquitin protein
            ligase (RNF19A), transcript variant 1, mRNA.
ACCESSION   NM_183419
VERSION     NM_183419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Yuan,H., Yu,J., Liu,C., Zhao,H., Xue,J., Liu,J. and Yang,Y.
  TITLE     LncRNA KCNQ10T1 shuttled by bone marrow mesenchymal stem
            cell-derived exosome inhibits sepsis via regulation of
            miR-154-3p/RNF19A axis
  JOURNAL   Cell Tissue Res 393 (3), 507-521 (2023)
   PUBMED   37326687
  REMARK    GeneRIF: LncRNA KCNQ10T1 shuttled by bone marrow mesenchymal stem
            cell-derived exosome inhibits sepsis via regulation of
            miR-154-3p/RNF19A axis.
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Zhang,N., Huang,D., Ruan,X., Ng,A.T., Tsu,J.H., Jiang,G., Huang,J.,
            Zhan,Y. and Na,R.
  TITLE     CRISPR screening reveals gleason score and castration resistance
            related oncodriver ring finger protein 19 A (RNF19A) in prostate
            cancer
  JOURNAL   Drug Resist Updat 67, 100912 (2023)
   PUBMED   36623445
  REMARK    GeneRIF: CRISPR screening reveals gleason score and castration
            resistance related oncodriver ring finger protein 19 A (RNF19A) in
            prostate cancer.
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Zhu,Q., Huang,J., Huang,H., Li,H., Yi,P., Kloeber,J.A., Yuan,J.,
            Chen,Y., Deng,M., Luo,K., Gao,M., Guo,G., Tu,X., Yin,P., Zhang,Y.,
            Su,J., Chen,J. and Lou,Z.
  TITLE     RNF19A-mediated ubiquitination of BARD1 prevents
            BRCA1/BARD1-dependent homologous recombination
  JOURNAL   Nat Commun 12 (1), 6653 (2021)
   PUBMED   34789768
  REMARK    GeneRIF: RNF19A-mediated ubiquitination of BARD1 prevents
            BRCA1/BARD1-dependent homologous recombination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Cheng,Y., Hu,Y., Wang,H., Zhao,Z., Jiang,X., Zhang,Y., Zhang,J.,
            Tong,Y. and Qiu,X.
  TITLE     Ring finger protein 19A is overexpressed in non-small cell lung
            cancer and mediates p53 ubiquitin-degradation to promote cancer
            growth
  JOURNAL   J Cell Mol Med 25 (16), 7796-7808 (2021)
   PUBMED   34184814
  REMARK    GeneRIF: Ring finger protein 19A is overexpressed in non-small cell
            lung cancer and mediates p53 ubiquitin-degradation to promote
            cancer growth.
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Ito,T., Niwa,J., Hishikawa,N., Ishigaki,S., Doyu,M. and Sobue,G.
  TITLE     Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
  JOURNAL   J Biol Chem 278 (31), 29106-29114 (2003)
   PUBMED   12750386
  REMARK    GeneRIF: results suggest that synphilin-1 has an important role in
            the formation of aggregates and cytotoxicity in Parkinson disease
            and that Dorfin may be involved in the pathogenic process by
            ubiquitylation of synphilin-1
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Hishikawa,N., Niwa,J., Doyu,M., Ito,T., Ishigaki,S., Hashizume,Y.
            and Sobue,G.
  TITLE     Dorfin localizes to the ubiquitylated inclusions in Parkinson's
            disease, dementia with Lewy bodies, multiple system atrophy, and
            amyotrophic lateral sclerosis
  JOURNAL   Am J Pathol 163 (2), 609-619 (2003)
   PUBMED   12875980
  REMARK    GeneRIF: These results suggest that Dorfin plays a crucial role in
            the formation of ubiquitylated inclusions of alpha-synucleinopathy
            and amyotrophic lateral sclerosis.
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Niwa,J., Ishigaki,S., Hishikawa,N., Yamamoto,M., Doyu,M.,
            Murata,S., Tanaka,K., Taniguchi,N. and Sobue,G.
  TITLE     Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated
            neurotoxicity
  JOURNAL   J Biol Chem 277 (39), 36793-36798 (2002)
   PUBMED   12145308
  REMARK    GeneRIF: Dorfin has a role in ubiquitylating mutant SOD1 proteins
            and targeting them for proteasomal degradation
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Niwa,J., Ishigaki,S., Doyu,M., Suzuki,T., Tanaka,K. and Sobue,G.
  TITLE     A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin
            ligase activity
  JOURNAL   Biochem Biophys Res Commun 281 (3), 706-713 (2001)
   PUBMED   11237715
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Gunther,M., Laithier,M. and Brison,O.
  TITLE     A set of proteins interacting with transcription factor Sp1
            identified in a two-hybrid screening
  JOURNAL   Mol Cell Biochem 210 (1-2), 131-142 (2000)
   PUBMED   10976766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB037264.1, BC093938.1,
            AL122096.1 and BQ003778.1.
            
            On Nov 22, 2018 this sequence version replaced NM_183419.3.
            
            Summary: This gene encodes a member of the ring between ring
            fingers (RBR) protein family, and the encoded protein contains two
            RING-finger motifs and an in between RING fingers motif. This
            protein is an E3 ubiquitin ligase that is localized to Lewy bodies,
            and ubiquitylates synphilin-1, which is an interacting protein of
            alpha synuclein in neurons. The encoded protein may be involved in
            amyotrophic lateral sclerosis and Parkinson's disease. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.209668.1,
                                           SRR1660809.91813.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341084.7/ ENSP00000342667.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DB037264.1         200-290
            92-2797             BC093938.1         1-2706
            2798-3954           AL122096.1         1051-2207
            3955-4186           BQ003778.1         27-258              c
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..4186
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /note="ring finger protein 19A, RBR E3 ubiquitin protein
                     ligase"
                     /db_xref="GeneID:25897"
                     /db_xref="HGNC:HGNC:13432"
                     /db_xref="MIM:607119"
     exon            1..87
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            88..854
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2697
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /EC_number="2.3.2.31"
                     /note="double ring-finger protein; protein p38 interacting
                     with transcription factor Sp1; ring-IBR-ring domain
                     containing protein Dorfin; ring finger protein 19A, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF19A"
                     /protein_id="NP_904355.1"
                     /db_xref="CCDS:CCDS6286.1"
                     /db_xref="GeneID:25897"
                     /db_xref="HGNC:HGNC:13432"
                     /db_xref="MIM:607119"
                     /translation="MQEQEIGFISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDL
                     QSSASSVSLPSVKKAPKKRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMC
                     TDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLR
                     QYLRIEISESRVNISCPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRW
                     CPAPDCGYAVIAFGCASCPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLR
                     LRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMK
                     EISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAMIIGIPV
                     YVGRKIHNRYEGKDVSKHKRNLAIAGGVTLSVIVSPVVAAVTVGIGVPIMLAYVYGVV
                     PISLCRSGGCGVSAGNGKGVRIEFDDENDINVGGTNTAVDTTSVAEARHNPSIGEGSV
                     GGLTGSLSASGSHMDRIGAIRDNLSETASTMALAGASITGSLSGSAMVNCFNRLEVQA
                     DVQKERYSLSGESGTVSLGTVSDNASTKAMAGSILNSYIPLDKEGNSMEVQVDIESKP
                     SKFRHNSGSSSVDDGSATRSHAGGSSSGLPEGKSSATKWSKEATAGKKSKSGKLRKKG
                     NMKINETREDMDAQLLEQQSTNSSEFEAPSLSDSMPSVADSHSSHFSEFSCSDLESMK
                     TSCSHGSSDYHTRFATVNILPEVENDRLENSPHQCSISVVTQTASCSEVSQLNHIAEE
                     HGNNGIKPNVDLYFGDALKETNNNHSHQTMELKVAIQTEI"
     exon            855..1063
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1208
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1371
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1486
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1648
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1862
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2006
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..4186
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4165..4170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /note="hexamer: AATAAA"
     polyA_site      4186
                     /gene="RNF19A"
                     /gene_synonym="RNF19"
                     /note="major polyA site"
ORIGIN      
        1 gcgcttcctc aggctgctgt cgccgctgct gggagatggg cctactcgcc cgccaccctg
       61 cgctgccgcc gctctgagga gttaaagaac atccatgata gcagtcttct gtaaatcgaa
      121 cttttcaaga attctctgaa ggaaccaagt aggatattct tacatcatga cttaatgtga
      181 atgcaagaac aagaaatagg ttttatctct aaatataatg aagggctgtg tgtaaacact
      241 gaccctgtct caattctaac aagcatttta gacatgagtt tacatcggca aatgggttca
      301 gatcgagatc ttcagtcctc tgcttcatct gtgagcttgc cttcagtcaa aaaggcaccc
      361 aaaaaaagaa gaatttcaat aggctccctg tttcggagga aaaaagataa caaacgtaaa
      421 tcaagggagc taaatggcgg ggtggatgga attgcaagta ttgaaagtat acattctgaa
      481 atgtgtactg ataagaactc cattttctct acaaatacct cttctgacaa tggattaact
      541 tccatcagca aacaaattgg agacttcata gagtgccctt tgtgcctttt gcggcattct
      601 aaagacagat ttcctgatat aatgacttgt catcacagat cttgtgtgga ttgcttacga
      661 caatatttaa ggatagaaat ctctgaaagc agagttaata ttagttgccc agaatgtact
      721 gaacggttta atccccatga tattcgcttg atattaagtg atgatgtctt gatggaaaaa
      781 tacgaagaat ttatgcttag acggtggctt gttgcagatc ctgattgtag gtggtgtcca
      841 gctccagact gtggatatgc tgtgatagca tttggatgtg ccagctgtcc aaaattaact
      901 tgtgggcgag agggctgtgg aacagagttt tgctaccact gtaaacagat ttggcacccc
      961 aaccagacct gtgatgctgc tcgacaagag agagcccaga gcttacgttt gagaactata
     1021 cgttcttcat ccattagtta tagtcaagag tctggagcag cagctgatga tataaagcca
     1081 tgtccacgat gtgctgctta tataataaag atgaatgatg ggagctgcaa tcacatgaca
     1141 tgtgctgttt gtggttgtga gttttgttgg ttgtgtatga aagaaatctc agatttgcat
     1201 tatctaagtc catcaggatg tactttttgg gggaagaaac cctggagccg aaagaagaaa
     1261 atattgtggc aactgggaac actggttggt gctcctgtcg gaatcgcttt aatagctggc
     1321 attgctattc ctgcaatgat tattggcatt cctgtgtatg tgggccgcaa gattcacaat
     1381 cgctatgaag gcaaggatgt ttcaaagcac aaacggaatt tggccatagc aggtggtgta
     1441 acgttgtctg taatcgtgtc tccagtagta gctgcagtga ctgtaggtat cggtgttcct
     1501 attatgttag cttatgtcta tggcgtagtt ccaatttctc tttgtcgaag cggaggttgt
     1561 ggagtctcag caggcaatgg aaaaggagtt aggattgaat ttgatgatga aaatgatata
     1621 aatgttggtg gaactaacac agctgtagac acaacatcag tagcagaagc aagacacaac
     1681 ccaagcatag gggagggaag tgttggtggg ctgactggca gtttgagtgc aagtggaagc
     1741 cacatggatc gaataggagc catccgagac aacctgagtg aaacggccag caccatggca
     1801 ctagctggag ccagtataac ggggagtctg tcaggaagtg ccatggtaaa ctgttttaac
     1861 aggttggaag tacaagcaga tgtacagaaa gaacggtaca gtctaagtgg agaatctggc
     1921 acagtcagct tgggaacagt tagtgataat gccagcacca aagcaatggc aggatccatt
     1981 ctgaattcct acatcccatt ggacaaagaa ggcaacagta tggaggtgca agtagatatt
     2041 gagtcaaagc catccaaatt caggcacaac agtggaagca gtagtgtgga tgatggcagt
     2101 gccacccgaa gtcatgctgg cggttcatcc agtggcttgc ctgaaggtaa atctagtgcc
     2161 accaagtggt ccaaagaagc aacagcaggg aaaaaatcaa aaagtggtaa actgaggaaa
     2221 aagggtaaca tgaagataaa tgagacgaga gaggacatgg atgcacagtt gttagaacaa
     2281 caaagcacga actcaagtga atttgaggct ccatccctca gtgacagtat gccttctgta
     2341 gcagattctc actctagtca tttttctgaa tttagttgtt ctgacctaga aagcatgaaa
     2401 acttcttgta gtcatggttc cagtgattat cacacccgct ttgctactgt taacattctt
     2461 cctgaggtag aaaatgaccg tctggaaaat tccccacatc agtgtagcat ttctgtggtt
     2521 acccaaactg cttcctgttc agaagtttca cagttgaatc atattgctga agaacatggt
     2581 aacaatggaa taaaacctaa tgttgattta tattttggcg atgcactaaa agaaacaaat
     2641 aacaaccact cacatcagac aatggaatta aaagttgcaa ttcagactga aatttaggcc
     2701 cataaatgct gcagaataat taccactgta caaccgtgtt tggagctggt tgaactacat
     2761 gtgactactt aagtttcagg ttaccagcaa aagccgggtt tcattatcat aatgcagata
     2821 cattttctgt gttcagcaag gcattgtgtg tcatgtggat cttagttacc aaactatgaa
     2881 gtgaaggctt taaaagtgca ttattttaag gataataaat ttgaagagca aagcatgttt
     2941 tgtgtgtttg ccacaaaaca ttgcttgaag cacatactta gatagaaatt ggtcttaatt
     3001 tatataatca atataaaata ctaatgcaat tctacagcat tcaaatgaag aaaacttgag
     3061 gctttaggga taagtggtta gtgatatttt attgaaacca ctaaagagat aagtttaaaa
     3121 gaactgcata ggttactctc agtatatgat actctgtaac atttctattt atatcggcat
     3181 aaatttcatt ttttttcttc atatgcaatg tggttatata aagcttaatg cagctcattt
     3241 gctaccattt ggatacttag acactttgag caagattgtg gcagtttttg cacaactttg
     3301 aaatagaaat acctggtact ctatcttgtt tattgttgat gccatcttag aggaaaaaat
     3361 gtaaaggtaa gtaattaagc atatgacagc aacaaataag atacataaaa ctacaaaata
     3421 aagtcccatt aggttataag tattacaaaa aatccacctt tctctaaggg gaagtttgta
     3481 ccccattgat tcttggtgcc tttgggatcg actgggtttt aatggcctag ttatttgagg
     3541 attttgctgt gttgttttcc atgtcttctc tggtcacctt ggattatata taaaaataca
     3601 ggaaatagat aaacatgaat gtgattaata atgctgaaaa agtattagcc taccaaagac
     3661 acactcaggc tttagtgaat aactttacat aacctcagtt tttaacacat gcatatcttc
     3721 tccaaccatg aaatcaaagc acggtgcaga acttgtacca agtacaaaag gtccatgtat
     3781 gattagcatt attttctttt gcttttgttt atggacaatg ttcagctgac ataagcagaa
     3841 gttggccaaa atactgcctg tactgttaat ttcctgtata attcacttaa ataaaagcag
     3901 gttaacctca atgatagcag ttaaaatgtt ctatcttatg tatttctttt aagtattacc
     3961 attatggtgc tactgagcgt tttcttttgg taaaaagaaa aatgccatgg gctgcagtct
     4021 tcttccatca cttttcccta ccaggtccat taatatgctt ataacactag tgccagttat
     4081 tttatttgat aatgcttatg gtatttgtat atttgtttgc attccaattt tgtttaataa
     4141 tgagtgtgta aactgcatac gttaaataaa tgtaaatact aatgta
//
