LOCUS       NM_001010858            3118 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 187 (RNF187), mRNA.
ACCESSION   NM_001010858 XM_001129309 XM_001715919 XM_928029
VERSION     NM_001010858.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Fan,X.T., Gao,B.F., Wang,X.F., Zhou,K., Zhao,Y. and Yuan,J.
  TITLE     Immune infiltration is associated with pan-cancer prognostic
            biomarker RING finger protein 187
  JOURNAL   J Mol Recognit 37 (2), e3071 (2024)
   PUBMED   38167828
  REMARK    GeneRIF: Immune infiltration is associated with pan-cancer
            prognostic biomarker RING finger protein 187.
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Li,X., Niu,Z., Sun,C., Zhuo,S., Yang,H., Yang,X., Liu,Y., Yan,C.,
            Li,Z., Cao,Q., Ji,G., Ding,Y., Zhuang,T. and Zhu,J.
  TITLE     Regulation of P53 signaling in breast cancer by the E3 ubiquitin
            ligase RNF187
  JOURNAL   Cell Death Dis 13 (2), 149 (2022)
   PUBMED   35165289
  REMARK    GeneRIF: Regulation of P53 signaling in breast cancer by the E3
            ubiquitin ligase RNF187.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Pang,D., Wang,W., Zhou,X., Lu,K., Zhang,J., Chen,Z., Wang,L.,
            Shen,F., Chen,Z., Wang,S., Hou,J., Zhang,A., Lv,B., Gao,C., Yan,Z.,
            Hu,Y., Chang,T., Wang,L. and Li,X.
  TITLE     RACO-1 modulates Hippo signalling in oesophageal squamous cell
            carcinoma
  JOURNAL   J Cell Mol Med 24 (20), 11912-11921 (2020)
   PUBMED   32896069
  REMARK    GeneRIF: RACO-1 modulates Hippo signalling in oesophageal squamous
            cell carcinoma.
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Chen,J., Chen,K., Zhou,Z., Huang,L., Cai,Y., Tu,H. and Zhang,X.
  TITLE     RING finger protein 187 as a novel potential biomarker for
            predicting the prognosis of ovarian carcinoma in 2 cancer centers
  JOURNAL   Curr Probl Cancer 44 (5), 100555 (2020)
   PUBMED   32057463
  REMARK    GeneRIF: RING finger protein 187 as a novel potential biomarker for
            predicting the prognosis of ovarian carcinoma in 2 cancer centers.
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Fu,Z., Yu,W., Wang,H. and Chen,X.
  TITLE     Overexpression of RNF187 induces cell EMT and apoptosis resistance
            in NSCLC
  JOURNAL   J Cell Physiol 234 (8), 14161-14169 (2019)
   PUBMED   30624778
  REMARK    GeneRIF: elevated RNF187 expression promotes NSCLC development by
            inducing cell EMT and apoptosis resistance, and RNF187 may be a
            novel prognostic indicator for NSCLC patients after curative
            resection
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Forster,L., Finlayson,J. and Ghassemifar,R.
  TITLE     RNF187 is Downregulated Following NF-kappaB Inhibition in Late
            Erythroblasts
  JOURNAL   Biochem Genet 54 (5), 714-721 (2016)
   PUBMED   27259582
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Chimusa,E.R., Zaitlen,N., Daya,M., Moller,M., van Helden,P.D.,
            Mulder,N.J., Price,A.L. and Hoal,E.G.
  TITLE     Genome-wide association study of ancestry-specific TB risk in the
            South African Coloured population
  JOURNAL   Hum Mol Genet 23 (3), 796-809 (2014)
   PUBMED   24057671
REFERENCE   9  (bases 1 to 3118)
  AUTHORS   Davies,C.C., Chakraborty,A., Diefenbacher,M.E., Skehel,M. and
            Behrens,A.
  TITLE     Arginine methylation of the c-Jun coactivator RACO-1 is required
            for c-Jun/AP-1 activation
  JOURNAL   EMBO J 32 (11), 1556-1567 (2013)
   PUBMED   23624934
  REMARK    GeneRIF: Arginine methylation of RACO-1 is required for efficient
            transcriptional activation by c-Jun/AP-1 and thus identify PRMT1 as
            an important regulator of c-Jun/AP-1 function.
REFERENCE   10 (bases 1 to 3118)
  AUTHORS   Davies,C.C., Chakraborty,A., Cipriani,F., Haigh,K., Haigh,J.J. and
            Behrens,A.
  TITLE     Identification of a co-activator that links growth factor
            signalling to c-Jun/AP-1 activation
  JOURNAL   Nat Cell Biol 12 (10), 963-972 (2010)
   PUBMED   20852630
  REMARK    GeneRIF: The RACO-1(RING domain AP-1 co-activator-1) is a
            co-activator that links c-Jun to growth factor signalling and is
            essential for AP-1 function in proliferation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI551408.1, BC012758.2 and AL139288.15.
            
            On Nov 23, 2018 this sequence version replaced NM_001010858.2.
            
            Sequence Note: The annotated protein is predicted to be translated
            from a non-AUG start codon based on cross-species sequence
            conservation, and includes a RING domain that would not be present
            if translation were to initiate from the first in-frame AUG. This
            RefSeq record was created from transcript and genomic sequence data
            to make the sequence consistent with the reference genome assembly.
            The genomic coordinates used for the transcript record were based
            on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279862.4775.1, BC012758.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000305943.9/ ENSP00000306396.9
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BI551408.1         21-31
            12-977              BC012758.2         1-966
            978-3118            AL139288.15        62177-64317         c
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..3118
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /note="ring finger protein 187"
                     /db_xref="GeneID:149603"
                     /db_xref="HGNC:HGNC:27146"
                     /db_xref="MIM:613754"
     exon            1..497
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..815
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /EC_number="2.3.2.27"
                     /note="non-AUG (CUG) translation initiation codon; protein
                     RNF187; RING domain AP1 coactivator 1; RING-type E3
                     ubiquitin transferase RNF187; ring domain AP-1
                     co-activator 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF187"
                     /protein_id="NP_001010858.2"
                     /db_xref="CCDS:CCDS76271.1"
                     /db_xref="GeneID:149603"
                     /db_xref="HGNC:HGNC:27146"
                     /db_xref="MIM:613754"
                     /translation="MALPAGPAEAACALCQRAPREPVRADCGHRFCRACVVRFWAEED
                     GPFPCPECADDCWQRAVEPGRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADAG
                     PLCAACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVW
                     KGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAV
                     SELEKKHRNLGLSMLLQ"
     exon            498..590
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..812
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..3118
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1880..1885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /note="hexamer: AATAAA"
     polyA_site      1899
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /note="major polyA site"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
                     /note="hexamer: TATAAA"
     polyA_site      3118
                     /gene="RNF187"
                     /gene_synonym="RACO-1; RACO1"
ORIGIN      
        1 gttggcgtct tcgtcctgtt gctggtctcc gtccggtcgc cggccgtcta ggtctccggc
       61 cctccccagc cgctcctgcg cccttgccgg ccccgccgcc cgcagccctg gcgctccctg
      121 cgggccccgc cgaggccgcc tgcgccctgt gccagcgcgc gccccgggaa ccggtgcgcg
      181 ccgactgcgg ccaccgcttc tgtcgggcgt gcgtggtgcg cttctgggcc gaggaggacg
      241 ggcccttccc gtgccccgag tgcgccgacg actgctggca gcgcgccgtg gagcccggca
      301 ggcccccgct cagccgccgc cttctggcgc tcgaggaggc ggccgcggcg cccgcgcgcg
      361 acggcccggc cagcgaggcc gcgctgcagc tgctgtgccg cgccgacgcc ggcccgctct
      421 gcgccgcctg ccgtatggct gcgggccccg agccgcccga gtgggaaccg cgctggagga
      481 aggcgctgcg cggcaaggag aacaaggggt ctgtggaaat catgagaaag gacttgaatg
      541 acgcccggga cctgcatggc caggcagagt cagcagctgc agtgtggaag ggacacgtga
      601 tggaccgtag gaagaaggca ctgaccgact acaagaagct gcgggccttc tttgtggagg
      661 aggaggagca tttcctgcag gaggctgaga aggaggaggg gctccctgag gacgagctgg
      721 ctgaccccac tgagcggttc aggtcactgc tgcaggcggt ctcggagctg gagaagaagc
      781 atcgcaacct gggcctcagc atgctgctgc agtgatggcg ccaacccgtg gcagtcccag
      841 agctggaggc aggaggatgg atcctcatct ccatgggaag tgtcagcgtg tggctgccag
      901 ggaagcgtgg caggcgcctg gccttgggtc catctacata gttgcgtgtt tcaacaatgt
      961 ccatttatcc ttcaccccga ggcgtgtttt gggggctgca aacacctccc ggtagaggct
     1021 ggacctgagg acccttccca cctgtgcccg tcccttcctg aagtcctagc cacagcccat
     1081 cctccatgag tcccggcagc tctgggtcat gcccttccct ggtcacccat ctgcccctca
     1141 cctcgtcatc cagggaccca gaccctgcac cttccatgtg ggcccacaga tccttggcag
     1201 gtacctgagg tgcaccattg agtgtcggat ttggggttag catccagaaa gaagaatgcg
     1261 catgacgctc tgtgaaggct ggaactcagg tcttcaggga gagaaaggaa gactggattg
     1321 caccttgatg cctcctgagg aggcggcccc cctcttgagg tgggcgtggg cccggcccag
     1381 ccttatccaa gtcgctctgt ccacctcccc cttcctggcc cccaccccac tcctgtgcct
     1441 cccaggagcc ctccctgtgc tccacctgcc tccgcagaag gaagcctctt tctctgtttc
     1501 cctgggtgag ggggctggca ggtggctaac cccatttagc atctccaggc cctgccatcg
     1561 tgtctcatct tgctgttatc tctagctctt tccctcctcc catttccttt agtagttgaa
     1621 ttttgcaaag cttgtagcag tagctcagtt gcctgcagca tccttgtgtg tagataaatt
     1681 agtcgacaga aactcagcac tggggacagg attgcaaagt cggggacata gatgcagaca
     1741 gttgttgaga tttggggata gccgggcttg tgagcggtgc ccatttccag atgaagcctt
     1801 tcagcccttc tgagtccccg gcccttggtg cgatgtctgt gagtttgacc tgcccagcgt
     1861 gtgggctggc tcaatgctga ataaagtggg tttgtgtcag ctcgtttgct tcgtctccgt
     1921 gtgtccacct ggcctcttcc ccctgccctg gccaccctcc agtgtcaaag gaaacttcct
     1981 cgtgacacgt gctaaagcat ggtgaggagg actttgattg ggaccattga gatgggtgtg
     2041 ggaccctttc cttggggcct ggggggagat ggggctccac cccgacgtag cagggcaggg
     2101 gttggaggag cgaggagcag tatagggtcc atgggtggga atgactgtga ggagacatca
     2161 gggctgaggg ggctctggct aaacccacct cacagagtcc ttgctgcagg caggcagggc
     2221 gatcagacat tggctgcaaa cggtcagaga ggaacccagt caggtaccat tgagggtggt
     2281 cagatattat ggttaaccaa attagggttc ttgctaaaac tggatttcat aagaaagggc
     2341 aaagagggcc ctaggagaag attccagagc ctggccagag tttggccaag tagagaatct
     2401 ttgtcagcac gccaacaaca tcccgaccct gagacctcca gtttgtcttt ctcactgtct
     2461 ccgcctgctg cagtctgctg tcatccctga gcatccctgc ccctgccctg cacacctgtg
     2521 atgcttgccc ggacaggtcc tgatggcaga gtctcccaca acatcagtgt ctccacatca
     2581 ccaggtccga cagtggcttc accatcctca cctaacctag ctgaccagca acatcccacc
     2641 ctgtcaatca caacctcttt ctatttaaga aaattatata tttatggggc acagtgtgat
     2701 gttttgatat ctatgtacat tgtggagtga cagattaatg tatccatctc atgttttttt
     2761 tggtggtgag aatatttgaa atctacactc agcaatttca aatacagtca tccctctgtg
     2821 cctaaggggg attggttcca ggaccccctc atggatacca aaatctgcag atactcaagt
     2881 accctgcagt cagccctccc tctgcacata tgtgggacag tcagatacag agggccaact
     2941 gcgtacagta cacggttatc agctgaagtc accatgctgt gcaatagacc ttgagtttat
     3001 tcttgtatag cagggactct gtaccctctg actagaattt ccccaaatcc tcttgtctca
     3061 gcccctgcta accaccgttc tactctctaa ttctataaat caacattttg attccaca
//
