LOCUS       NM_019062               1255 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ring finger protein 186 (RNF186), mRNA.
ACCESSION   NM_019062
VERSION     NM_019062.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1255)
  AUTHORS   Hu,Y., Jiang,N., Wang,X., Wu,X., Bo,J., Chen,Y., Zeng,Y., Wei,X.,
            Zhang,H. and Li,M.
  TITLE     Systematic pan-cancer analysis of RNF186 with potential
            implications in progression and prognosis in human cancer
  JOURNAL   Life Sci 338, 122389 (2024)
   PUBMED   38160786
  REMARK    GeneRIF: Systematic pan-cancer analysis of RNF186 with potential
            implications in progression and prognosis in human cancer.
REFERENCE   2  (bases 1 to 1255)
  AUTHORS   Zhang,H., Cui,Z., Cheng,D., Du,Y., Guo,X., Gao,R., Chen,J., Sun,W.,
            He,R., Ma,X., Peng,Q., Martin,B.N., Yan,W., Rong,Y. and Wang,C.
  TITLE     RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the
            colonic epithelial cells for the maintenance of intestinal
            homeostasis
  JOURNAL   Autophagy 17 (10), 3030-3047 (2021)
   PUBMED   33280498
REFERENCE   3  (bases 1 to 1255)
  AUTHORS   Ranjan,K., Hedl,M., Sinha,S., Zhang,X. and Abraham,C.
  TITLE     Ubiquitination of ATF6 by disease-associated RNF186 promotes the
            innate receptor-induced unfolded protein response
  JOURNAL   J Clin Invest 131 (17) (2021)
   PUBMED   34623328
  REMARK    GeneRIF: Ubiquitination of ATF6 by disease-associated RNF186
            promotes the innate receptor-induced unfolded protein response.
REFERENCE   4  (bases 1 to 1255)
  AUTHORS   Ranjan,K., Hedl,M. and Abraham,C.
  TITLE     The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate
            innate receptor-induced outcomes
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34353900
  REMARK    GeneRIF: The E3 ubiquitin ligase RNF186 and RNF186 risk variants
            regulate innate receptor-induced outcomes.
REFERENCE   5  (bases 1 to 1255)
  AUTHORS   Ji,Y., Tu,X., Hu,X., Wang,Z., Gao,S., Zhang,Q., Zhang,W., Zhang,H.
            and Chen,W.
  TITLE     The role and mechanism of action of RNF186 in colorectal cancer
            through negative regulation of NF-kappaB
  JOURNAL   Cell Signal 75, 109764 (2020)
   PUBMED   32882406
  REMARK    GeneRIF: The role and mechanism of action of RNF186 in colorectal
            cancer through negative regulation of NF-kappaB.
REFERENCE   6  (bases 1 to 1255)
  AUTHORS   Wang,P., Wu,Y., Li,Y., Zheng,J. and Tang,J.
  TITLE     A novel RING finger E3 ligase RNF186 regulate ER stress-mediated
            apoptosis through interaction with BNip1
  JOURNAL   Cell Signal 25 (11), 2320-2333 (2013)
   PUBMED   23896122
  REMARK    GeneRIF: BNip1 functions as a downstream modulator of RNF186 to
            direct endoplasmic reticulum stress-associated apoptotic signaling.
REFERENCE   7  (bases 1 to 1255)
  AUTHORS   Yang,S.K., Hong,M., Zhao,W., Jung,Y., Tayebi,N., Ye,B.D., Kim,K.J.,
            Park,S.H., Lee,I., Shin,H.D., Cheong,H.S., Kim,L.H., Kim,H.J.,
            Jung,S.A., Kang,D., Youn,H.S., Liu,J. and Song,K.
  TITLE     Genome-wide association study of ulcerative colitis in Koreans
            suggests extensive overlapping of genetic susceptibility with
            Caucasians
  JOURNAL   Inflamm Bowel Dis 19 (5), 954-966 (2013)
   PUBMED   23511034
  REMARK    GeneRIF: Single-nucleotide polymorphism in RNF186 gene is
            associated with ulcerative colitis.
REFERENCE   8  (bases 1 to 1255)
  AUTHORS   Beaudoin,M., Goyette,P., Boucher,G., Lo,K.S., Rivas,M.A.,
            Stevens,C., Alikashani,A., Ladouceur,M., Ellinghaus,D.,
            Torkvist,L., Goel,G., Lagace,C., Annese,V., Bitton,A., Begun,J.,
            Brant,S.R., Bresso,F., Cho,J.H., Duerr,R.H., Halfvarson,J.,
            McGovern,D.P., Radford-Smith,G., Schreiber,S., Schumm,P.L.,
            Sharma,Y., Silverberg,M.S., Weersma,R.K., D'Amato,M., Vermeire,S.,
            Franke,A., Lettre,G., Xavier,R.J., Daly,M.J. and Rioux,J.D.
  CONSRTM   Quebec IBD Genetics Consortium; NIDDK IBD Genetics Consortium;
            International IBD Genetics Consortium
  TITLE     Deep resequencing of GWAS loci identifies rare variants in CARD9,
            IL23R and RNF186 that are associated with ulcerative colitis
  JOURNAL   PLoS Genet 9 (9), e1003723 (2013)
   PUBMED   24068945
  REMARK    GeneRIF: Our results confirmed significant association to rare
            non-synonymous coding variants in both IL23R and CARD9, previously
            identified from sequencing of CD loci, as well as identified a
            novel association in RNF186
REFERENCE   9  (bases 1 to 1255)
  AUTHORS   McGovern,D.P., Gardet,A., Torkvist,L., Goyette,P., Essers,J.,
            Taylor,K.D., Neale,B.M., Ong,R.T., Lagace,C., Li,C., Green,T.,
            Stevens,C.R., Beauchamp,C., Fleshner,P.R., Carlson,M., D'Amato,M.,
            Halfvarson,J., Hibberd,M.L., Lordal,M., Padyukov,L., Andriulli,A.,
            Colombo,E., Latiano,A., Palmieri,O., Bernard,E.J., Deslandres,C.,
            Hommes,D.W., de Jong,D.J., Stokkers,P.C., Weersma,R.K., Sharma,Y.,
            Silverberg,M.S., Cho,J.H., Wu,J., Roeder,K., Brant,S.R.,
            Schumm,L.P., Duerr,R.H., Dubinsky,M.C., Glazer,N.L.,
            Haritunians,T., Ippoliti,A., Melmed,G.Y., Siscovick,D.S.,
            Vasiliauskas,E.A., Targan,S.R., Annese,V., Wijmenga,C.,
            Pettersson,S., Rotter,J.I., Xavier,R.J., Daly,M.J., Rioux,J.D. and
            Seielstad,M.
  CONSRTM   NIDDK IBD Genetics Consortium
  TITLE     Genome-wide association identifies multiple ulcerative colitis
            susceptibility loci
  JOURNAL   Nat Genet 42 (4), 332-337 (2010)
   PUBMED   20228799
  REMARK    Erratum:[Nat Genet. 2011 Apr;43(4):388]
REFERENCE   10 (bases 1 to 1255)
  AUTHORS   Silverberg,M.S., Cho,J.H., Rioux,J.D., McGovern,D.P., Wu,J.,
            Annese,V., Achkar,J.P., Goyette,P., Scott,R., Xu,W., Barmada,M.M.,
            Klei,L., Daly,M.J., Abraham,C., Bayless,T.M., Bossa,F.,
            Griffiths,A.M., Ippoliti,A.F., Lahaie,R.G., Latiano,A., Pare,P.,
            Proctor,D.D., Regueiro,M.D., Steinhart,A.H., Targan,S.R.,
            Schumm,L.P., Kistner,E.O., Lee,A.T., Gregersen,P.K., Rotter,J.I.,
            Brant,S.R., Taylor,K.D., Roeder,K. and Duerr,R.H.
  TITLE     Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by
            genome-wide association study
  JOURNAL   Nat Genet 41 (2), 216-220 (2009)
   PUBMED   19122664
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391883.17 and AK000232.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019062.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK000232.1, BC030960.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375121.4/ ENSP00000364263.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL391883.17        33102-33106         c
            6-1255              AK000232.1         1-1250
FEATURES             Location/Qualifiers
     source          1..1255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1255
                     /gene="RNF186"
                     /note="ring finger protein 186"
                     /db_xref="GeneID:54546"
                     /db_xref="HGNC:HGNC:25978"
                     /db_xref="MIM:617163"
     exon            1..1255
                     /gene="RNF186"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..866
                     /gene="RNF186"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF186"
                     /protein_id="NP_061935.1"
                     /db_xref="CCDS:CCDS199.1"
                     /db_xref="GeneID:54546"
                     /db_xref="HGNC:HGNC:25978"
                     /db_xref="MIM:617163"
                     /translation="MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCR
                     EPYSCPRLPKLLACQHAFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDH
                     EAVVGQLAQPCTEVSLCPQGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLL
                     LLALLIILIGPFIYPGVLRWVLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQ
                     KHSHISSIA"
     regulatory      1222..1227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF186"
                     /note="hexamer: AATAGA"
     polyA_site      1255
                     /gene="RNF186"
                     /note="major polyA site"
ORIGIN      
        1 aagccaagaa acaagctggg cagctctggg agagaggagt gtcagacagc tgttgtcaac
       61 aggcacctgg ccagagtgaa aaggaggggc agattccatc caagtcccag cggcgccagc
      121 tgacactctc tgccaatgcc caggtgctga gcgacagtgt cccaccggtc cctgtgccca
      181 gaatggcctg caccaagacc ctgcaacagt cccagcccat ctccgcagga gccaccacaa
      241 ccaccaccgc tgtggcccct gctgggggtc attctggctc cacagaatgt gacctggagt
      301 gtctggtgtg ccgggagccc tacagctgtc cccggttgcc caagctgctg gcctgccagc
      361 atgccttctg cgccatctgc ctgaagctcc tgctgtgcgt gcaggacaac acctggtcca
      421 tcacctgccc gctgtgccgc aaggtcaccg ccgtccccgg gggcctcatc tgcagcctgc
      481 gcgaccatga ggcggtggtg gggcagctgg cccagccatg cacagaggta tcgctctgtc
      541 ctcaggggct ggtggatcct gctgacttgg cagcaggaca ccccagcttg gtgggagagg
      601 atggacagga tgaagtaagt gcaaaccacg tggcagcccg gcgcctggcc gcgcacctac
      661 tcctgctggc cttgctcatt atcctcatcg ggcccttcat ctacccgggt gtcttacgat
      721 gggtgctcac cttcatcatc gccctggccc tgctgatgtc caccctcttc tgctgtctcc
      781 ccagcacccg gggcagctgc tggccctcct ccaggactct cttctgcaga gagcagaaac
      841 acagccacat ctcttccatt gcctgagtgc cctctgatga ggctatccct gcagcccttt
      901 ctgcccttgg gcccccggac ttccacaatg aacagggtaa ggggttacgg actaagactg
      961 gctcctttgg gaaatcacat gccagcggga cttgcaagcc acaaccgaga tggccagcct
     1021 gggtcaagaa ttacacgctt ggatgacagg cttgcacttg cccttgggat agcatagcta
     1081 aaactgttgg tggctagggg agcagacaca aactacttga acatgacaag atgggggaag
     1141 ctcctgttcc tcttattcca atgttcttgg tttttcttta tataacttga tgaaagtatt
     1201 gcagtattga tgccattgta gaatagaact ggaattccat tctttttgca attta
//
