LOCUS       NM_001371237            1853 bp    mRNA    linear   PRI 03-DEC-2024
DEFINITION  Homo sapiens ring finger protein 183 (RNF183), transcript variant
            5, mRNA.
ACCESSION   NM_001371237
VERSION     NM_001371237.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Yan,B., Li,X., Peng,M., Zuo,Y., Wang,Y., Liu,P., Ren,W. and Jin,X.
  TITLE     The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that
            modulates glucose metabolism and bladder cancer progression
  JOURNAL   Exp Mol Med 55 (6), 1145-1158 (2023)
   PUBMED   37258572
  REMARK    GeneRIF: The YTHDC1/GLUT3/RNF183 axis forms a positive feedback
            loop that modulates glucose metabolism and bladder cancer
            progression.
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Seo,S.U., Woo,S.M., Im,S.S., Jang,Y., Han,E., Kim,S.H., Lee,H.,
            Lee,H.S., Nam,J.O., Gabrielson,E., Min,K.J. and Kwon,T.K.
  TITLE     Cathepsin D as a potential therapeutic target to enhance anticancer
            drug-induced apoptosis via RNF183-mediated destabilization of
            Bcl-xL in cancer cells
  JOURNAL   Cell Death Dis 13 (2), 115 (2022)
   PUBMED   35121737
  REMARK    GeneRIF: Cathepsin D as a potential therapeutic target to enhance
            anticancer drug-induced apoptosis via RNF183-mediated
            destabilization of Bcl-xL in cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Okamoto,T., Imaizumi,K. and Kaneko,M.
  TITLE     The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186,
            RNF182 and RNF152, in Disease and Biological Function
  JOURNAL   Int J Mol Sci 21 (11), 3921 (2020)
   PUBMED   32486221
  REMARK    GeneRIF: The Role of Tissue-Specific Ubiquitin Ligases, RNF183,
            RNF186, RNF182 and RNF152, in Disease and Biological Function.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Wu,Y., Guo,X.P., Kanemoto,S., Maeoka,Y., Saito,A., Asada,R.,
            Matsuhisa,K., Ohtake,Y., Imaizumi,K. and Kaneko,M.
  TITLE     Sec16A, a key protein in COPII vesicle formation, regulates the
            stability and localization of the novel ubiquitin ligase RNF183
  JOURNAL   PLoS One 13 (1), e0190407 (2018)
   PUBMED   29300766
  REMARK    GeneRIF: Sec16A also stabilized the interacting ubiquitin ligase
            RNF152, which localizes to the lysosome and has structural
            similarity with RNF183
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Geng,R., Tan,X., Wu,J., Pan,Z., Yi,M., Shi,W., Liu,R., Yao,C.,
            Wang,G., Lin,J., Qiu,L., Huang,W. and Chen,S.
  TITLE     RNF183 promotes proliferation and metastasis of colorectal cancer
            cells via activation of NF-kappaB-IL-8 axis
  JOURNAL   Cell Death Dis 8 (8), e2994 (2017)
   PUBMED   28796265
  REMARK    GeneRIF: RNF183 promotes proliferation and metastasis of colorectal
            cancer cells via activation of NF-kappaB-IL-8 axis
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Geng,R., Tan,X., Zuo,Z., Wu,J., Pan,Z., Shi,W., Liu,R., Yao,C.,
            Wang,G., Lin,J., Qiu,L., Huang,W. and Chen,S.
  TITLE     Synthetic lethal short hairpin RNA screening reveals that ring
            finger protein 183 confers resistance to trametinib in colorectal
            cancer cells
  JOURNAL   Chin J Cancer 36 (1), 63 (2017)
   PUBMED   28756770
  REMARK    GeneRIF: The RNF183-IL-8 axis is responsible for the resistance of
            colorectal cancer (CRC)cells to the MEK1/2 inhibitor trametinib and
            may serve as a candidate target for combined therapy for CRC.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Yu,Q., Zhang,S., Chao,K., Feng,R., Wang,H., Li,M., Chen,B., He,Y.,
            Zeng,Z. and Chen,M.
  TITLE     E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory
            Bowel Disease
  JOURNAL   J Crohns Colitis 10 (6), 713-725 (2016)
   PUBMED   26818663
  REMARK    GeneRIF: RNF183, which is negatively regulated by miR-7, is a novel
            regulator promoting intestinal inflammation by increasing the
            ubiquitination and degradation of IkappaBalpha, thereby inducing
            NF-kappaB activation. The interaction between RNF183-mediated
            ubiquitination and miRNA may be an important novel epigenetic
            mechanism in the pathogenesis of inflammatory bowel disease.
REFERENCE   10 (bases 1 to 1853)
  AUTHORS   Maxfield,K.E., Taus,P.J., Corcoran,K., Wooten,J., Macion,J.,
            Zhou,Y., Borromeo,M., Kollipara,R.K., Yan,J., Xie,Y., Xie,X.J. and
            Whitehurst,A.W.
  TITLE     Comprehensive functional characterization of cancer-testis antigens
            defines obligate participation in multiple hallmarks of cancer
  JOURNAL   Nat Commun 6, 8840 (2015)
   PUBMED   26567849
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL449305.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138523.51603.1,
                                           SRR1803615.63385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489339.2/ ENSP00000508293.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AL449305.4         134382-134702       c
            322-440             AL449305.4         133521-133639       c
            441-520             AL449305.4         132998-133077       c
            521-724             AL449305.4         130898-131101       c
            725-1853            AL449305.4         128419-129547       c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1853
                     /gene="RNF183"
                     /note="ring finger protein 183"
                     /db_xref="GeneID:138065"
                     /db_xref="HGNC:HGNC:28721"
                     /db_xref="MIM:621029"
     exon            1..321
                     /gene="RNF183"
                     /inference="alignment:Splign:2.1.0"
     exon            322..440
                     /gene="RNF183"
                     /inference="alignment:Splign:2.1.0"
     exon            441..520
                     /gene="RNF183"
                     /inference="alignment:Splign:2.1.0"
     exon            521..724
                     /gene="RNF183"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1853
                     /gene="RNF183"
                     /inference="alignment:Splign:2.1.0"
     CDS             762..1340
                     /gene="RNF183"
                     /EC_number="2.3.2.27"
                     /note="probable E3 ubiquitin-protein ligase RNF183"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF183"
                     /protein_id="NP_001358166.1"
                     /db_xref="CCDS:CCDS43866.1"
                     /db_xref="GeneID:138065"
                     /db_xref="HGNC:HGNC:28721"
                     /db_xref="MIM:621029"
                     /translation="MAEQQGRELEAECPVCWNPFNNTFHTPKMLDCCHSFCVECLAHL
                     SLVTPARRRLLCPLCRQPTVLASGQPVTDLPTDTAMLALLRLEPHHVILEGHQLCLKD
                     QPKSRYFLRQPQVYTLDLGPQPGGQTGPPPDTASATVSTPILIPSHHSLRECFRNPQF
                     RIFAYLMAVILSVTLLLIFSIFWTKQFLWGVG"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF183"
                     /note="hexamer: AGTAAA"
     polyA_site      1853
                     /gene="RNF183"
                     /note="major polyA site"
ORIGIN      
        1 cgaggggatg gcaggagatc aatcggaccc agaacagagg cctgcaagga tgagcgcact
       61 tgatcccctc agagaaaaag ccagagtgac tcacaggaga aagacaaagc aaccaaagct
      121 tccagggtgt acaggaggtc caaagtcacc agaaggaaga agaaaacctg aaacagcgag
      181 agctggccaa acgctgctaa gacctatgca aataagaccc acccacgcta cctggaaatc
      241 gggcctggga agtcagaaaa caaagcacat gcgtgcaggg ctgcacgaac ggaggcggag
      301 gaggcggctc cgagggagca gctgatcctg aaacagcagt ggatccctgg gagagcagca
      361 cagataaaga tccaggcaat aatgatgctt cctcctcttg gacagccttt tacagttctg
      421 gccatggaac ttcagagaag aagtccttga tggtttccgt ggaatcgatt cccagtgggg
      481 gaaatgatga gtcaaggtta catacagttt acggcctctg cagatcaact cttcaaatta
      541 ttcgaatgac ccatatgaga aacagagaaa agccaagtat ttctggttga aacggagaag
      601 ctgggctgga gtgcgcctcc ctccaactcc ccgctttaac tccctaaggt tggtgggatg
      661 gccagctcta agatctcaga aggctgacca gctgtgtgct aagaacaaag cagaaggcag
      721 cgaggacgtc tcccgcgaag cctccccgtg tgtggctgag gatggctgag cagcagggcc
      781 gggagcttga ggctgagtgc cccgtctgct ggaacccctt caacaacacg ttccataccc
      841 ccaaaatgct ggattgctgc cactccttct gcgtggaatg tctggcccac ctcagccttg
      901 tgactccagc ccggcgccgc ctgctgtgcc cactctgtcg ccagcccaca gtgctggcct
      961 cagggcagcc tgtcactgac ttgcccacgg acactgccat gctcgccctg ctccgcctgg
     1021 agccccacca tgtcatcctg gaaggccatc agctgtgcct caaggaccag cccaagagcc
     1081 gctacttcct gcgccagcct caagtctaca cgctggacct tggcccccag cctgggggcc
     1141 agactgggcc gcccccagac acggcctctg ccaccgtgtc tacgcccatc ctcatcccca
     1201 gccaccactc tttgagggag tgtttccgca accctcagtt ccgcatcttt gcctacctga
     1261 tggccgtcat cctcagtgtc actctgttgc tcatattctc catcttttgg accaagcagt
     1321 tcctttgggg tgtggggtga gtgctgttcc cagacaagaa accaaacctt tttcggttgc
     1381 tgctgggtat ggtgactacg gagcctcatt tggtattgtc ttcctttgta gtgttgttta
     1441 ttttacaatc cagggattgt tcaggccatg tgtttgcttc tgggaacaat tttaaaaaaa
     1501 aacaaaaaaa cgaaaagctt gaaggactgg gagatgtgga gcgacctccg ggtgtgagtg
     1561 tggcgtcatg gaagggcaga gaagcggttc tgaccacaga gctccacagc aagttgtgcc
     1621 aaagggctgc acagtggtat ccaggaacct gactagccca aatagcaagt tgcatttctc
     1681 actggagctg cttcaaaatc agtgcatatt tttttgagtt gctcttttac tatgggttgc
     1741 taaaaaaaaa aaaaaaattg ggaagtgagc ttcaattctg tgggtaaatg tgtgtttgtt
     1801 tctctttgaa tgtcttgcca ctggttgcag taaaagtgtt ctgtattcat taa
//
