LOCUS       NM_152737               3629 bp    mRNA    linear   PRI 27-NOV-2024
DEFINITION  Homo sapiens ring finger protein 182 (RNF182), transcript variant
            2, mRNA.
ACCESSION   NM_152737
VERSION     NM_152737.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3629)
  AUTHORS   Zeng,X., Tang,X., Chen,X. and Wen,H.
  TITLE     RNF182 induces p65 ubiquitination to affect PDL1 transcription and
            suppress immune evasion in lung adenocarcinoma
  JOURNAL   Immun Inflamm Dis 11 (5), e864 (2023)
   PUBMED   37249301
  REMARK    GeneRIF: RNF182 induces p65 ubiquitination to affect PDL1
            transcription and suppress immune evasion in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 3629)
  AUTHORS   Okamoto,T., Imaizumi,K. and Kaneko,M.
  TITLE     The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186,
            RNF182 and RNF152, in Disease and Biological Function
  JOURNAL   Int J Mol Sci 21 (11), 3921 (2020)
   PUBMED   32486221
  REMARK    GeneRIF: The Role of Tissue-Specific Ubiquitin Ligases, RNF183,
            RNF186, RNF182 and RNF152, in Disease and Biological Function.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3629)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3629)
  AUTHORS   Cao,Y., Sun,Y., Chang,H., Sun,X. and Yang,S.
  TITLE     The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine
            production through promoting p65 ubiquitination and degradation
  JOURNAL   FEBS Lett 593 (22), 3210-3219 (2019)
   PUBMED   31432514
  REMARK    GeneRIF: E3 ubiquitin ligase RNF182 is highly expressed in
            macrophages and is specifically upregulated by Toll-like receptors
            (TLR) stimuli (TLR4, TLR3 and TLR9 agonists). Knockdown of RNF182
            selectively amplifies TLR signaling by promoting the production of
            proinflammatory cytokines but not type I interferons in
            macrophages.
REFERENCE   5  (bases 1 to 3629)
  AUTHORS   Wang,J.H., Wei,Z.F., Gao,Y.L., Liu,C.C. and Sun,J.H.
  TITLE     Activation of the mammalian target of rapamycin signaling pathway
            underlies a novel inhibitory role of ring finger protein 182 in
            ventricular remodeling after myocardial ischemia-reperfusion injury
  JOURNAL   J Cell Biochem 120 (5), 7635-7648 (2019)
   PUBMED   30450663
REFERENCE   6  (bases 1 to 3629)
  AUTHORS   Charlaftis,N., Suddason,T., Wu,X., Anwar,S., Karin,M. and
            Gallagher,E.
  TITLE     The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to
            cytokines
  JOURNAL   EMBO J 33 (21), 2581-2596 (2014)
   PUBMED   25260751
REFERENCE   7  (bases 1 to 3629)
  AUTHORS   Vijai,J., Kirchhoff,T., Schrader,K.A., Brown,J., Dutra-Clarke,A.V.,
            Manschreck,C., Hansen,N., Rau-Murthy,R., Sarrel,K., Przybylo,J.,
            Shah,S., Cheguri,S., Stadler,Z., Zhang,L., Paltiel,O.,
            Ben-Yehuda,D., Viale,A., Portlock,C., Straus,D., Lipkin,S.M.,
            Lacher,M., Robson,M., Klein,R.J., Zelenetz,A. and Offit,K.
  TITLE     Susceptibility loci associated with specific and shared subtypes of
            lymphoid malignancies
  JOURNAL   PLoS Genet 9 (1), e1003220 (2013)
   PUBMED   23349640
REFERENCE   8  (bases 1 to 3629)
  AUTHORS   van Wijk,S.J., de Vries,S.J., Kemmeren,P., Huang,A., Boelens,R.,
            Bonvin,A.M. and Timmers,H.T.
  TITLE     A comprehensive framework of E2-RING E3 interactions of the human
            ubiquitin-proteasome system
  JOURNAL   Mol Syst Biol 5, 295 (2009)
   PUBMED   19690564
  REMARK    Erratum:[Mol Syst Biol. 2009;5:317]
REFERENCE   9  (bases 1 to 3629)
  AUTHORS   Liu,Q.Y., Lei,J.X., Sikorska,M. and Liu,R.
  TITLE     A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated
            in the brains of Alzheimer's patients and targets ATP6V0C for
            degradation
  JOURNAL   Mol Neurodegener 3, 4 (2008)
   PUBMED   18298843
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315528.1, BC030666.1, BC050030.1, AW731636.1 and AL138718.17.
            
            On Nov 22, 2018 this sequence version replaced NM_152737.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB478884.1, SRR1803614.241613.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000488300.6/ ENSP00000420465.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AK315528.1         67-306
            241-1941            BC030666.1         226-1926
            1942-2010           BC050030.1         1748-1816
            2011-2613           BC030666.1         1996-2598
            2614-3324           BC050030.1         2420-3130
            3325-3328           AW731636.1         10-13               c
            3329-3629           AL138718.17        97972-98272
FEATURES             Location/Qualifiers
     source          1..3629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p23"
     gene            1..3629
                     /gene="RNF182"
                     /note="ring finger protein 182"
                     /db_xref="GeneID:221687"
                     /db_xref="HGNC:HGNC:28522"
                     /db_xref="MIM:621026"
     exon            1..72
                     /gene="RNF182"
                     /inference="alignment:Splign:2.1.0"
     exon            73..227
                     /gene="RNF182"
                     /inference="alignment:Splign:2.1.0"
     exon            228..3629
                     /gene="RNF182"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1182
                     /gene="RNF182"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF182"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF182"
                     /protein_id="NP_689950.1"
                     /db_xref="CCDS:CCDS4531.1"
                     /db_xref="GeneID:221687"
                     /db_xref="HGNC:HGNC:28522"
                     /db_xref="MIM:621026"
                     /translation="MASQPPEDTAESQASDELECKICYNRYNLKQRKPKVLECCHRVC
                     AKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGGKGKKCLP
                     ENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDS
                     VTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSL
                     VPSSLVILMVYGFCQCVCHEFLDCMAPPS"
     regulatory      3302..3307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF182"
                     /note="hexamer: ATTAAA"
     polyA_site      3324
                     /gene="RNF182"
                     /note="major polyA site"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF182"
                     /note="hexamer: AATAAA"
     polyA_site      3629
                     /gene="RNF182"
ORIGIN      
        1 gggaacctcc ctcccctccc aggcgccgcc gcagccggag cggctcccgg gccctgggcc
       61 gccgccggcc aggaagaaat acttgtgttg gctgcatttc cagggatgct accagagctc
      121 aaggctgtca cctggtcttg cccagaagag ccgttcttag aggcaggact tgatgaaggc
      181 tttcctgctg atggaatagg tttgctagag ctggccttgg aattagaacc cttcatgtgg
      241 cctttataaa tatgcgtttg agacagagtt atatgcagaa gttgaaaatg cctggaagat
      301 ttctggtttc tttcactact tatcctgcct ttttgcatcg ctgccagatt tggatgatat
      361 gatattcaga ggggcacctt aatcaaagcc attcttcaac aagacccacc tggcataaga
      421 ttgcacacat aattcaagat ggccagtcaa cctcctgaag acactgcgga gtctcaggcc
      481 tctgatgagc tggagtgcaa aatctgttac aatcgataca atctgaaaca gaggaaaccc
      541 aaagtgctgg agtgttgtca tagggtttgt gccaaatgcc tctacaagat catagacttt
      601 ggggactccc cacaaggtgt cattgtctgt cctttctgca ggtttgagac gtgcctgcca
      661 gatgatgaag ttagtagcct gcccgatgac aacaacatcc ttgtaaactt gacttgtgga
      721 ggcaaaggga agaagtgcct gccagagaac cctactgagc tgctgctcac ccccaagagg
      781 ctggcctctc tggtcagtcc ttctcacacg tcctccaact gcctggtcat aaccatcatg
      841 gaggtgcaga gagagagctc cccgtccctg agctccactc ctgtggtaga attttatagg
      901 cctgcgagtt tcgactctgt caccactgtg tcacacaact ggactgtgtg gaactgcacg
      961 tccctgctgt ttcagacatc catccgggtg ttagtgtggt tgctaggttt gctctacttc
     1021 agctccttac ccttaggaat ctacttactg gtgtctaaga aagtcaccct tggggtcgtc
     1081 tttgtcagcc tggtcccttc gagcctcgtt attcttatgg tgtatggttt ttgccagtgt
     1141 gtttgtcatg aatttctaga ctgtatggca cctccttctt aactgatatg caaaataaga
     1201 aattggacac acattgccct gtttgagtgt gaagttagat aatttataat ttattttctt
     1261 ttatgttctt tatgattagt atccatgaca ttaacaaaac ccttggccac atgttgactt
     1321 gattggtttt cctgtaggct ggaagtaaaa atgttcattt ctacttaggg gttagcaaaa
     1381 ttgtataagc tcacacttca tggagcactg acagcagtga gtcttcccag agaaaggaca
     1441 gggtttctct cagcactgcc agacagacgg caggggtgtg gtgtgttata ctatagggag
     1501 agcatggatc cctcctttcg tattcatgga tgttctatga tggcagttgg acacaagagg
     1561 aaagttgctc tgagacacaa agtgtgtact cctttcccac cccatacccc tggtattgga
     1621 acaccctaga attgtcttca ggtgttttct ctcttaagtc actctctgtg gtcggcgatc
     1681 ccattgagat acttgtttcc tctgcccatt ctcccttgcc aagaggaaac tcggttccat
     1741 tcccttgggt agtttcaact gaataccagt tttgccacat tactaaggag aatgaaaagc
     1801 actgaggaat ttgcatcaca gtcagcttca tggcagaatg tggccatttg tccttgagac
     1861 acactctttc ctccatgtct gttttcctct ctcctcagtc ttatctgaga agaatggagg
     1921 agaaggaact tctcatacag cggttattat tgatgaaaac cttcatttga gtctttcctt
     1981 ataacatctt agttttggtt tttttaaacc acattgccca atcagcctca ccccttgtcc
     2041 tgaaaaggtt ccatttaaat tagttgctat aaattcatca atactttttt tccctattat
     2101 atttttggtt ctattaggat ttacttaact gaatcttata acaattcgag gtgaactgtg
     2161 gcaatgaaaa ccagaaacag ttaatgagat gcttcagctc acagtttgaa gtgctgagaa
     2221 cctaagtatt ttgctgtacg gtactgagct gtaccaaaat atgatggttt aggtttatgt
     2281 gcaagacttt gtgttgtagt ctagacaaag gggtgggcaa gagacatgca aagctgaagc
     2341 cctgcttgaa aagacccttc aaggaagtaa aatggcaggg gcagagtgca gcttaacatg
     2401 ttgctatccc tgttgttttt gagttggttt tggaatggat tcaagttctt acacaattta
     2461 ttttgaatac aagcataatc taggtgattt gagttaatga acttcttttc atgatgtagg
     2521 gaaagttgaa tgtatatatt tctaagaaga atttgtttag cagattacaa gttggcaaaa
     2581 tagactgttc acagaaacta ggcaaaaatt taaaaaaaca ttctagtctc taaaacccat
     2641 tactaatgat taacattaaa atatttgtaa ctcttagaaa gggggcatta ctaagacgac
     2701 tttaacttgt tatgaaatct ttgttgtgtg atgcaggtac agtgcgccca ttccaactgg
     2761 aatagcagtt tgattttaat tgtaaaacta aacttcggga atatgtatgc ccaaagtaag
     2821 taggatgaga atagtataca tgggatatgg tccaatgaat ttaagcccca agatacagct
     2881 aaatacattt atgatttcat aaaatctagt ttagatagca ttgtgatgca atttccagaa
     2941 atccatttgt gtttagagta aataccatgt ttagaagatg ttttgtggtt tggatttata
     3001 tatttgtaag gtttttttaa aaaaatgttc gttttgtttg aaatgtaaca ttgagtaaat
     3061 tggtgagtta tataatgaga tttctagaaa gctctggaca tgggtacgat gtgttttgct
     3121 tctctgtata atgtctacag tgataaactt gtgtctccgt gtattgtggc agtctttttt
     3181 tctagttaat ttggctttag agagcaatct ttgtatgaca ccagaaaact cttcatgcta
     3241 ttgaatgata aaaagataat gctttaatat tttattcact gtgatactat tttgtttgtc
     3301 tattaaattg ttattatttc caaatttaga agtttgattt ctctgactta tggttaaaat
     3361 tcagttatga ctttgcacct ctgttagctt tagataacgg caaacatgaa cattcagaaa
     3421 cgttggttca gctaatgcct ttatcatgcc cgtgaagact tcagaacttt ccaacaaagg
     3481 ggacctaacc catcacactt ttaaaaggcc ttcatagttt ttttatttta ttttatttta
     3541 ttttatttta ttttatttta tttatttatt ttaaagcagg ggagaaaaat taggggagat
     3601 gaaataaaaa tatcgtcttt ataaataaa
//
