LOCUS       NM_001323292            7249 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens ring finger protein 180 (RNF180), transcript variant
            4, mRNA.
ACCESSION   NM_001323292
VERSION     NM_001323292.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7249)
  AUTHORS   Zhang,N., Gao,X., Yuan,Q., Fu,X., Wang,P., Cai,F., Liu,H.,
            Zhang,J., Liang,H., Nie,Y. and Deng,J.
  TITLE     E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to
            suppress the proliferation and metastasis of gastric cancer cells
            by promoting ubiquitination of DNMT1
  JOURNAL   Clin Epigenetics 15 (1), 77 (2023)
   PUBMED   37147733
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 prevents excessive PCDH10
            methylation to suppress the proliferation and metastasis of gastric
            cancer cells by promoting ubiquitination of DNMT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7249)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 7249)
  AUTHORS   Sun,W., Ma,G., Zhang,L., Wang,P., Zhang,N., Wu,Z., Dong,Y., Cai,F.,
            Chen,L., Liu,H., Liang,H. and Deng,J.
  TITLE     DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180
            to inhibit viability and motility in gastric cancer cells
  JOURNAL   Cell Death Dis 12 (5), 428 (2021)
   PUBMED   33931579
  REMARK    GeneRIF: DNMT3A-mediated silence in ADAMTS9 expression is restored
            by RNF180 to inhibit viability and motility in gastric cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7249)
  AUTHORS   Wu,Z., Liu,H., Sun,W., Du,Y., He,W., Guo,S., Chen,L., Zhao,Z.,
            Wang,P., Liang,H. and Deng,J.
  TITLE     RNF180 mediates STAT3 activity by regulating the expression of RhoC
            via the proteasomal pathway in gastric cancer cells
  JOURNAL   Cell Death Dis 11 (10), 881 (2020)
   PUBMED   33082325
  REMARK    GeneRIF: RNF180 mediates STAT3 activity by regulating the
            expression of RhoC via the proteasomal pathway in gastric cancer
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7249)
  AUTHORS   Deng,J., Guo,J., Guo,X., Hou,Y., Xie,X., Sun,C., Zhang,R., Yu,X.
            and Liang,H.
  TITLE     Mediation of the malignant biological characteristics of gastric
            cancer cells by the methylated CpG islands in RNF180 DNA promoter
  JOURNAL   Oncotarget 7 (28), 43461-43474 (2016)
   PUBMED   27223257
  REMARK    GeneRIF: The methylated status of the key CpG islands of RNF180 DNA
            promoter may be used to predict the variations of the malignant
            biological characteristics of gastric cancer cells.
REFERENCE   6  (bases 1 to 7249)
  AUTHORS   Deng,J., Liang,H., Zhang,R., Hou,Y., Liu,Y., Ying,G., Pan,Y. and
            Hao,X.
  TITLE     Clinical and experimental role of ring finger protein 180 on lymph
            node metastasis and survival in gastric cancer
  JOURNAL   Br J Surg 103 (4), 407-416 (2016)
   PUBMED   26805552
  REMARK    GeneRIF: RNF180 is capable of inhibiting lymph node metastasis of
            gastric cancer by suppressing the intracellular activation of
            malignant molecular signals.
REFERENCE   7  (bases 1 to 7249)
  AUTHORS   Xie,X.M., Deng,J.Y., Hou,Y.C., Cui,J.L., Wu,W.P., Ying,G.G.,
            Dong,Q.P., Hao,X.S. and Liang,H.
  TITLE     Evaluating the clinical feasibility: The direct bisulfite genomic
            sequencing for examination of methylated status of E3 ubiquitin
            ligase RNF180 DNA promoter to predict the survival of gastric
            cancer
  JOURNAL   Cancer Biomark 15 (3), 259-265 (2015)
   PUBMED   25769451
  REMARK    GeneRIF: hypermethylated CpG site count of E3 ubiquitin ligase Ring
            finger protein 180 promoter for evaluating the prognosis of gastric
            cancer was reasonable by using the direct bisulfite sequencing.
REFERENCE   8  (bases 1 to 7249)
  AUTHORS   Deng,J., Liang,H., Ying,G., Zhang,R., Wang,B., Yu,J., Fan,D. and
            Hao,X.
  TITLE     Methylation of CpG sites in RNF180 DNA promoter prediction poor
            survival of gastric cancer
  JOURNAL   Oncotarget 5 (10), 3173-3183 (2014)
   PUBMED   24833402
  REMARK    GeneRIF: We found that only few methylated CpG sites of RNF180
            promoter was appropriate to predict the survival of gastric cancer
REFERENCE   9  (bases 1 to 7249)
  AUTHORS   Cheung,K.F., Lam,C.N., Wu,K., Ng,E.K., Chong,W.W., Cheng,A.S.,
            To,K.F., Fan,D., Sung,J.J. and Yu,J.
  TITLE     Characterization of the gene structure, functional significance,
            and clinical application of RNF180, a novel gene in gastric cancer
  JOURNAL   Cancer 118 (4), 947-959 (2012)
   PUBMED   21717426
  REMARK    GeneRIF: RNF180 is a novel potential tumor suppressor in gastric
            carcinogenesis.
REFERENCE   10 (bases 1 to 7249)
  AUTHORS   Asad,S., Nikamo,P., Gyllenberg,A., Bennet,H., Hansson,O.,
            Wierup,N., Carlsson,A., Forsander,G., Ivarsson,S.A., Larsson,H.,
            Lernmark,A., Lindblad,B., Ludvigsson,J., Marcus,C., Ronningen,K.S.,
            Nerup,J., Pociot,F., Luthman,H., Fex,M. and Kockum,I.
  CONSRTM   Diabetes Incidence in Sweden Study Group
  TITLE     HTR1A a novel type 1 diabetes susceptibility gene on chromosome
            5p13-q13
  JOURNAL   PLoS One 7 (5), e35439 (2012)
   PUBMED   22563461
  REMARK    GeneRIF: Data indicate that the ring finger protein 180 (RNF180)
            and HTR1A showed association to T1D in the Swedish and Danish
            families.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA183707.1, AL832580.2, BC101397.2, DA809479.1 and AC016623.6.
            
            On Aug 14, 2020 this sequence version replaced NM_001323292.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.6600474.1,
                                           SRR1803611.269483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DA183707.1         1-39
            40-154              AL832580.2         2-116
            155-1338            BC101397.2         114-1297
            1339-1482           AL832580.2         1298-1441
            1483-1690           DA809479.1         224-431
            1691-7249           AC016623.6         39123-44681         c
FEATURES             Location/Qualifiers
     source          1..7249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..7249
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="ring finger protein 180"
                     /db_xref="GeneID:285671"
                     /db_xref="HGNC:HGNC:27752"
                     /db_xref="MIM:616015"
     exon            1..111
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1704
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /EC_number="2.3.2.27"
                     /note="isoform 4 is encoded by transcript variant 4; E3
                     ubiquitin-protein ligase RNF180; RING-type E3 ubiquitin
                     transferase RNF180"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF180 isoform 4"
                     /protein_id="NP_001310221.1"
                     /db_xref="GeneID:285671"
                     /db_xref="HGNC:HGNC:27752"
                     /db_xref="MIM:616015"
                     /translation="MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVI
                     KDKDDSVDAQNICHVWHMNVEALPEWISCLIQKAQWTVGKLNCPFCGARLGGFNFVST
                     PKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEALLTGGGSEN
                     RNHRLLNMARNNNDPGRLTEALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGR
                     CATRAFHRKSHSLDLNISEKLTLLPTLYEIHSKTTAYSRLNETQPIDLSGLPLQSSKN
                     SYSFQNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMD
                     LPSAGRSMPEASDQEEHLSPLDFLHSANFSLGSINQRLNKRERSKLKNLRRKQRRRER
                     WLQKQGKYSGVGLLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCHH
                     IFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKS
                     NSAKWPLPSCRKAFHLFGGKEI"
     exon            112..246
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            247..342
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1302
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1338
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1564
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..7249
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6431..6436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="hexamer: ATTAAA"
     polyA_site      6453
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="major polyA site"
     regulatory      7221..7226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="hexamer: AATAAA"
     polyA_site      7249
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="major polyA site"
ORIGIN      
        1 gaaccggcat cgccgccgcc ggagccgcag cgagtcctca gagcctggct gctggcggcc
       61 gggagcgccg ggacggggcg cgaagccgga ggctccggga cgtggataca gatgaaaaga
      121 agcaaagaat tgataactaa aaatcatagt caagaggaaa caagtattct tcgttgttgg
      181 aaatgtagaa aatgtatagc aagctctggt tgttttatgg agtatcttga gaatcaagtg
      241 attaaggata aagatgattc agttgatgct caaaatattt gtcatgtgtg gcacatgaat
      301 gtagaagccc ttccagaatg gataagctgc ctaatccaaa aagcccagtg gacagttgga
      361 aaactgaatt gtcctttctg tggggcccgt ttagggggct ttaattttgt cagcactcca
      421 aaatgttcct gtggccagct tgcagctgta catctctcca agagccggac tgattatcag
      481 ccaacacagg caggcagact aatgagacca tcagtgaaat acttgtcaca tcctagagtt
      541 cagtcaggtt gtgacaagga agctctgctg acaggtggtg gctctgaaaa cagaaatcac
      601 aggcttttaa acatggcccg aaataataat gaccctggaa gattaacaga agcactctgc
      661 ctggaggtgc gaccaacata ttttgagatg aagaacgaaa aactgctgtc caaagcatca
      721 gaaccaaaat accagctttt tgttccccag cttgtgactg gcagatgcgc tacaagagct
      781 tttcatagaa aatcacatag tttggatctg aacatcagtg agaaactgac tttattaccc
      841 actttatatg aaatacatag taagactact gcctattcca gactaaatga aacacagcct
      901 attgaccttt caggcttgcc tttacaatct agtaaaaata gctattcctt tcagaatcca
      961 tccagttttg atcctagtat gctgctgcaa agattttcag tggcccccca tgagacccag
     1021 acacaaagag gaggagaatt tcagtgtggt ctagaagctg cttcagtgta ttctgaccat
     1081 actaatacta acaatctgac tttcctgatg gacctgccct cagctggcag gagcatgccg
     1141 gaggcctcag accaggaaga gcacctctcc cctctggact tcctgcactc agccaatttt
     1201 tcattgggca gcattaatca gaggcttaat aagagagaaa ggagcaagtt gaagaatcta
     1261 agaaggaaac aacgaaggcg tgaaagatgg ctacagaagc agggtaaata ctcaggagtg
     1321 ggattgctgg atcatatgac tttgaataat gagatgagta cagatgaaga caatgaatat
     1381 gcagaagaaa aggatagcta catctgtgca gtgtgtctgg acgtttattt caacccttat
     1441 atgtgttacc cttgccatca catcttctgt gagccctgct tacggactct ggccaaagac
     1501 aatccttcaa gcactccatg cccattgtgt cggacaatta tttctagagt ctttttccaa
     1561 acagaattga acaatgccac aaaaactttc tttactaaag aatatttgaa aataaaacaa
     1621 agctttcaga aatccaactc tgcaaaatgg cccctaccaa gctgcagaaa agcatttcat
     1681 ctttttggag gtaaggaaat ctaacgccaa aaaaaaagtc tggtaatttt gtctaaggtc
     1741 tgttcttaaa agtaacttcc tgctgtctca gaaatattag gggaaacata tttctgtatt
     1801 aatcaatttt aaataaggat tttgctaagt atctccttgc tgaaaactac agatgtacaa
     1861 atgaagaaaa tgaagactat acaataagag caaatccgaa gactcatgac taaattgact
     1921 ttgccatgct atcactgttt agtacataga taatgaaaat acgtctcaaa agtatcagat
     1981 ttgacaaagt catatttatg gcagcggcag cccatctgga acagctgcta ctatgaagcc
     2041 agctgcagtc ggggaggcac aagccagggc tgcacattcc acagagctgg caggagccag
     2101 gaacaggtgg gagccctgcc cctttccaag ttagcagggt gggagccctg cctacccagg
     2161 caaagttgca gccacccagc catggcttcg gaccgagaca tccttgtact cttggggact
     2221 ggggaagccc ccttgcccct gcaggctcag aaatgcctac tcctgctgcc tggcctctcc
     2281 atgctcctgg cacccactcc aatttcacag caaagttgaa gccaagccca ggcactgtcg
     2341 caacccagcc aagtgtgtac actctcaggg cagtcctgac atgccagccc cctgctgcct
     2401 aggcccactc caaactctgg gtgctgacaa gcatgggagg aaggctgagg ggagctgagg
     2461 gcagctcagc gcaacctgca tacaccgctt ggcaagaata gcttgggcac tgtgggcacc
     2521 gtggatggca ggttgatggt ggcaggaggc agacaggctc ctgggcagaa aggggacagg
     2581 tccctggtaa agccccacct tcttcaaacc tgaagactgg gggctgggct gtcagttctg
     2641 tggaccagag tgagaactta cagtgctttt tccaggcctg cctatggcca cccatgaacc
     2701 agtcagcatg cacttcctcc cctctttagc ccataaaaac cctggactca gccagactca
     2761 ggcagacagt gggacaacct acctgacaat atgacctgtg agtctcctct ccactgaggg
     2821 ctgtagagac agcgggacaa cctgcctgtg aataggagat acccactgtg ggtctcctga
     2881 gaactgttct accactcagt gaagctcctc tccaccttgc ttaccctcca gttgtctgca
     2941 tacctcattc ctcctgaatg tgggacaaga actcaggacc tgctgagtgg caggactaaa
     3001 agaactgtaa cacaataagg gctgaaacac acccccgccc catgctcgcc acattgacgg
     3061 tgacaagaca agaagagctg cagccctttg aggagcccag atgtagagat ccctgagcca
     3121 gggctgtgac accctccttg gggttctgca gttcctggag tctccaagct tccaggcacc
     3181 actgcattta cctcgtcctg actcgggtgc ccacagcaga agccgcatga agtatatctc
     3241 atccagccac agccacacac agagccaaca cctggagctc cctgccccgc cacagcagcc
     3301 agcatgcctg gctgtgcaca gtggctggac ctcacgcttg ctcaaccaca caccccttgc
     3361 cattctgcac ctggcttgca cttggcagat gtgggatctg agccagtagt aagagccaag
     3421 cacagcctgc caggccaagt gggttgaact ggcccagcag gcacaagcag tactcaggca
     3481 gaagatgccg tcagctacag aggtttctgg ctggtgaagt gacaccctag ggatcctgtg
     3541 acaatagtta acaaaggcac cagtactctg tataaagatt cctaataatg cgttcattag
     3601 cagaagctct atttatttag ttttaatatt ttatagttgt cccacaagtt taaaacaaat
     3661 agaaagtaac agagccttgg tgtcagggtg tcttagagat gtgcagtggt caaggaatac
     3721 caatttctgg ctttaggtct aagttatcaa catgacttca gcgatatcat aggatctctg
     3781 ttttgatctg taaaatagga ataattatgt cttcctcacc taactaatat agtagtaaag
     3841 attaaatggg ctaatgtgaa agtacattgt aaattataac taattggaat ataaaaatat
     3901 aaggaatgaa ggtaatgcaa tatctaatac ctttttctgc tttgggaatt tgttactata
     3961 tgaacataca atatggacat aaaatataat ttcatctttt atgaaaccgt agtttatcaa
     4021 agcatgaact actgtgcagt tttcgttatt taacaattat gacattatgg gacctggtag
     4081 aaaagtccag atatgaggaa ctgtgatctt cagggaacag gaggaacttc tgcataagac
     4141 caacaaaatc agtacagcta ctacctacac caaaaggagg ttggtcttct gcgtaagacc
     4201 aacaagatca gtacagtact acctacacca aaaggagata gaagcagagc ccctatgatt
     4261 gtggcaaaag aaaaattggt gcatgaaatt ggtactctca aagaaagtaa cataagaata
     4321 taactttaca cagtgatttg aatgaagaaa atagtttaag gacattatat aagcacatac
     4381 tactttataa agtggtcagt aactgtaaaa atttaatatc tagagatttg gtatagatag
     4441 gttttatttt tattttttac tcatttattt tatttttttg agacaaagtc tggctctatc
     4501 gcccaggcta gagtgtagtg gcgcaatctc agctcactac aacctctgcc tcctgggttc
     4561 aagcagttct tctgcctcag cctcccaagt agctgggatt acaggtgcgt gctaccatgc
     4621 caagcttttt agtagagaag gagtttcgtc atgttggcca ggctggtctt gaataatgaa
     4681 tgacctcagg tgatccaccc gccttggcct cccaaaagtg ctgggattat aggcatgagc
     4741 cactgttcct ggccatagat aggttttaat aggtcacatt tagcccccaa aatatgaaat
     4801 caaatgtaag aaatcgagtc ttaaaggatt tcataccaaa gaaaagtaag tttattattt
     4861 taagagtgtt cttcaaaaca gtcccttgta ttctaccttc tatgctatac ccaaagttct
     4921 aaaagaatgg agtaccttct ggataactct acactttccc ttgtcttttt gtattctgag
     4981 gtagtacaga agctataatt taaagcagtt gcttccttgt gatttcttct tgtcttcccc
     5041 ataggagttc caaataactt aattttttaa gtgtgtgttt atgaaggagg ttcaaagtag
     5101 cattattaca ccacccaaca taagaaatat atatattcta tcaggagctc agctgagctg
     5161 ggaaagagct gagttatcag gtgtctggag tagccgatta aagtatcaag ccaaaaatga
     5221 aggagttaag cctttaatca tttactgcaa tagtataacc aagagtctaa aaccagagga
     5281 aatgctgtct cctcctgttc aattatctca tgcaacagtg cacactggtc cagggccaca
     5341 tagagcaggg cagaagtaag gattcactca ctgttgagaa tgtcccaaac aaaaggctcc
     5401 agcagttttt cagaccctga ggtcaggagg attggcaaag aggaaaggct aggagtagga
     5461 aagcaatggg cactgagtca gagtggagaa aagtgtttcc ccctccaacc tccataagaa
     5521 agcctttgta gagacacaga aggacctctg cccaagccgt cagatagata taagtagtaa
     5581 caaaggtgct gggaatatga atataaatac gtaaaagtgt atatgcagcc aggggagcct
     5641 gagaacttga ctgcagctcc cttcagagat tgtaatgcac tggttgtaca acaaatctgg
     5701 ctttttccca tgaatcctgc cagataaagc ctttgtaatg gtctgttgag gcctgaaaaa
     5761 aaatcgcaca taggatttta atcaggaact gtactcctca attaccaata ttattgaagc
     5821 accttctgta gttcttcttt gtttaccctg attcccctga attttgtatt tatcatttct
     5881 ttgtataagt atacatatgt atacttaatc atgttactta attttgcttg tcttttaact
     5941 tttataatgg tagcaatgta tatattctgc tttgctttgt cattcaatat ttttctcaaa
     6001 tccatttcag taagtgtggc cacattcttt ttactactac actgtagtca attatgtgaa
     6061 aatgccccaa cccaacttat ccattctctt gttgatgaac aattgagtgg tccaattttt
     6121 attataaaca gtgtttctat aaacactctt gtgatgtctc ctggaacata agagttactc
     6181 tagaataaat gccaggtaga aactggctgg gtcataggaa aagcacatct ttaacttcat
     6241 aacctaccca aaaccgtttt cctaaatggc tgtgatgatt tatcaccagc tttgtctacc
     6301 acatttggta ttttcagtct tttagatttt actgatttga taggtagaaa atgatatctc
     6361 attggggttt taatttccat tactgtgatt actgatgggg gttgaacata tctttatatg
     6421 tgtattgatc attaaatttc ttcatctgtg aaatgctttt ttacgatttt ctgttggttg
     6481 tatttttttg ttgtttaaga atgttaaaat attttctagt gacttttttt ctgttggtta
     6541 tatgaatggc agttattgtc tcccagtctg tgggttcttt ttactttgat atattttaat
     6601 gaattgtagt tcttcaattt cttcatcttt ctggtgtgta cttgcttaag aaattcttct
     6661 ctttccccaa ggtcataaag atattttctt atgtattttt caaataattt gaaagatctt
     6721 tgaaactgat ttgtgttaat ttttttttta ttgatttact ttctttgttg taggtagaga
     6781 cccagtttct ttggattttt ttcctaccac catttgttga aaataatgta tcatttcctc
     6841 actgatctac agtactaatc tgtcatattt taatttccac acttgggtct gttttgaggt
     6901 ctttgagtcc attggtataa ttttttattc ctatagcaat accatactgt ttcagtcact
     6961 aaaaacttag taagttttga tatcccccct tccaatttgt tttgctgcaa gagtgtcttg
     7021 gccatttttt ggccctttgc tcttccatat aaatttttaa atcacctggt caagctgcat
     7081 gaaaaactat gttctacttg ggaaatgggg tcctattaaa tgtataaatc aatttgggga
     7141 gtattgatac cttagagtaa aagtacttct atcagtgttg tttatctctt catttgttta
     7201 gatctccttt gatgtcctat aataaagttt tataatgttt ttataaata
//
