LOCUS       NM_001113561            4945 bp    mRNA    linear   PRI 05-JUN-2024
DEFINITION  Homo sapiens ring finger protein 180 (RNF180), transcript variant
            1, mRNA.
ACCESSION   NM_001113561
VERSION     NM_001113561.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4945)
  AUTHORS   Zhang,N., Gao,X., Yuan,Q., Fu,X., Wang,P., Cai,F., Liu,H.,
            Zhang,J., Liang,H., Nie,Y. and Deng,J.
  TITLE     E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to
            suppress the proliferation and metastasis of gastric cancer cells
            by promoting ubiquitination of DNMT1
  JOURNAL   Clin Epigenetics 15 (1), 77 (2023)
   PUBMED   37147733
  REMARK    GeneRIF: E3 ubiquitin ligase RNF180 prevents excessive PCDH10
            methylation to suppress the proliferation and metastasis of gastric
            cancer cells by promoting ubiquitination of DNMT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4945)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4945)
  AUTHORS   Sun,W., Ma,G., Zhang,L., Wang,P., Zhang,N., Wu,Z., Dong,Y., Cai,F.,
            Chen,L., Liu,H., Liang,H. and Deng,J.
  TITLE     DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180
            to inhibit viability and motility in gastric cancer cells
  JOURNAL   Cell Death Dis 12 (5), 428 (2021)
   PUBMED   33931579
  REMARK    GeneRIF: DNMT3A-mediated silence in ADAMTS9 expression is restored
            by RNF180 to inhibit viability and motility in gastric cancer
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4945)
  AUTHORS   Wu,Z., Liu,H., Sun,W., Du,Y., He,W., Guo,S., Chen,L., Zhao,Z.,
            Wang,P., Liang,H. and Deng,J.
  TITLE     RNF180 mediates STAT3 activity by regulating the expression of RhoC
            via the proteasomal pathway in gastric cancer cells
  JOURNAL   Cell Death Dis 11 (10), 881 (2020)
   PUBMED   33082325
  REMARK    GeneRIF: RNF180 mediates STAT3 activity by regulating the
            expression of RhoC via the proteasomal pathway in gastric cancer
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4945)
  AUTHORS   Deng,J., Guo,J., Guo,X., Hou,Y., Xie,X., Sun,C., Zhang,R., Yu,X.
            and Liang,H.
  TITLE     Mediation of the malignant biological characteristics of gastric
            cancer cells by the methylated CpG islands in RNF180 DNA promoter
  JOURNAL   Oncotarget 7 (28), 43461-43474 (2016)
   PUBMED   27223257
  REMARK    GeneRIF: The methylated status of the key CpG islands of RNF180 DNA
            promoter may be used to predict the variations of the malignant
            biological characteristics of gastric cancer cells.
REFERENCE   6  (bases 1 to 4945)
  AUTHORS   Deng,J., Liang,H., Zhang,R., Hou,Y., Liu,Y., Ying,G., Pan,Y. and
            Hao,X.
  TITLE     Clinical and experimental role of ring finger protein 180 on lymph
            node metastasis and survival in gastric cancer
  JOURNAL   Br J Surg 103 (4), 407-416 (2016)
   PUBMED   26805552
  REMARK    GeneRIF: RNF180 is capable of inhibiting lymph node metastasis of
            gastric cancer by suppressing the intracellular activation of
            malignant molecular signals.
REFERENCE   7  (bases 1 to 4945)
  AUTHORS   Xie,X.M., Deng,J.Y., Hou,Y.C., Cui,J.L., Wu,W.P., Ying,G.G.,
            Dong,Q.P., Hao,X.S. and Liang,H.
  TITLE     Evaluating the clinical feasibility: The direct bisulfite genomic
            sequencing for examination of methylated status of E3 ubiquitin
            ligase RNF180 DNA promoter to predict the survival of gastric
            cancer
  JOURNAL   Cancer Biomark 15 (3), 259-265 (2015)
   PUBMED   25769451
  REMARK    GeneRIF: hypermethylated CpG site count of E3 ubiquitin ligase Ring
            finger protein 180 promoter for evaluating the prognosis of gastric
            cancer was reasonable by using the direct bisulfite sequencing.
REFERENCE   8  (bases 1 to 4945)
  AUTHORS   Deng,J., Liang,H., Ying,G., Zhang,R., Wang,B., Yu,J., Fan,D. and
            Hao,X.
  TITLE     Methylation of CpG sites in RNF180 DNA promoter prediction poor
            survival of gastric cancer
  JOURNAL   Oncotarget 5 (10), 3173-3183 (2014)
   PUBMED   24833402
  REMARK    GeneRIF: We found that only few methylated CpG sites of RNF180
            promoter was appropriate to predict the survival of gastric cancer
REFERENCE   9  (bases 1 to 4945)
  AUTHORS   Cheung,K.F., Lam,C.N., Wu,K., Ng,E.K., Chong,W.W., Cheng,A.S.,
            To,K.F., Fan,D., Sung,J.J. and Yu,J.
  TITLE     Characterization of the gene structure, functional significance,
            and clinical application of RNF180, a novel gene in gastric cancer
  JOURNAL   Cancer 118 (4), 947-959 (2012)
   PUBMED   21717426
  REMARK    GeneRIF: RNF180 is a novel potential tumor suppressor in gastric
            carcinogenesis.
REFERENCE   10 (bases 1 to 4945)
  AUTHORS   Asad,S., Nikamo,P., Gyllenberg,A., Bennet,H., Hansson,O.,
            Wierup,N., Carlsson,A., Forsander,G., Ivarsson,S.A., Larsson,H.,
            Lernmark,A., Lindblad,B., Ludvigsson,J., Marcus,C., Ronningen,K.S.,
            Nerup,J., Pociot,F., Luthman,H., Fex,M. and Kockum,I.
  CONSRTM   Diabetes Incidence in Sweden Study Group
  TITLE     HTR1A a novel type 1 diabetes susceptibility gene on chromosome
            5p13-q13
  JOURNAL   PLoS One 7 (5), e35439 (2012)
   PUBMED   22563461
  REMARK    GeneRIF: Data indicate that the ring finger protein 180 (RNF180)
            and HTR1A showed association to T1D in the Swedish and Danish
            families.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA183707.1, AL832580.2 and DA809479.1.
            
            On Apr 19, 2016 this sequence version replaced NM_001113561.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832580.2, SRR1660807.58511.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389100.9/ ENSP00000373752.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               DA183707.1         1-469
            470-1482            AL832580.2         429-1441
            1483-1862           DA809479.1         224-603
            1863-4272           AL832580.2         1822-4231
            4273-4945           AL832580.2         4233-4905
FEATURES             Location/Qualifiers
     source          1..4945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..4945
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="ring finger protein 180"
                     /db_xref="GeneID:285671"
                     /db_xref="HGNC:HGNC:27752"
                     /db_xref="MIM:616015"
     exon            1..111
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1890
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF180; RING-type E3 ubiquitin
                     transferase RNF180"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF180 isoform 1"
                     /protein_id="NP_001107033.1"
                     /db_xref="CCDS:CCDS47219.1"
                     /db_xref="GeneID:285671"
                     /db_xref="HGNC:HGNC:27752"
                     /db_xref="MIM:616015"
                     /translation="MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVI
                     KDKDDSVDAQNICHVWHMNVEALPEWISCLIQKAQWTVGKLNCPFCGARLGGFNFVST
                     PKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEALLTGGGSEN
                     RNHRLLNMARNNNDPGRLTEALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGR
                     CATRAFHRKSHSLDLNISEKLTLLPTLYEIHSKTTAYSRLNETQPIDLSGLPLQSSKN
                     SYSFQNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMD
                     LPSAGRSMPEASDQEEHLSPLDFLHSANFSLGSINQRLNKRERSKLKNLRRKQRRRER
                     WLQKQGKYSGVGLLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCHH
                     IFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNATKTFFTKEYLKIKQSFQKS
                     NSAKWPLPSCRKAFHLFGGFRRHAAPVTRRQFPHGAHRMDYLHFEDDSRGWWFDMDMV
                     IIYIYSVNWVIGFIVFCFLCYFFFPF"
     exon            112..246
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            247..342
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1302
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1338
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1564
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1690
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..4945
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4921..4926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="hexamer: AATAAA"
     polyA_site      4945
                     /gene="RNF180"
                     /gene_synonym="RINES"
                     /note="major polyA site"
ORIGIN      
        1 gaaccggcat cgccgccgcc ggagccgcag cgagtcctca gagcctggct gctggcggcc
       61 gggagcgccg ggacggggcg cgaagccgga ggctccggga cgtggataca gatgaaaaga
      121 agcaaagaat tgataactaa aaatcatagt caagaggaaa caagtattct tcgttgttgg
      181 aaatgtagaa aatgtatagc aagctctggt tgttttatgg agtatcttga gaatcaagtg
      241 attaaggata aagatgattc agttgatgct caaaatattt gtcatgtgtg gcacatgaat
      301 gtagaagccc ttccagaatg gataagctgc ctaatccaaa aagcccagtg gacagttgga
      361 aaactgaatt gtcctttctg tggggcccgt ttagggggct ttaattttgt cagcactcca
      421 aaatgttcct gtggccagct tgcagctgta catctctcca agagccggac tgattatcag
      481 ccaacacagg caggcagact aatgagacca tcagtgaaat acttgtcaca tcctagagtt
      541 cagtcaggtt gtgacaagga agctctgctg acaggtggtg gctctgaaaa cagaaatcac
      601 aggcttttaa acatggcccg aaataataat gaccctggaa gattaacaga agcactctgc
      661 ctggaggtgc gaccaacata ttttgagatg aagaacgaaa aactgctgtc caaagcatca
      721 gaaccaaaat accagctttt tgttccccag cttgtgactg gcagatgcgc tacaagagct
      781 tttcatagaa aatcacatag tttggatctg aacatcagtg agaaactgac tttattaccc
      841 actttatatg aaatacatag taagactact gcctattcca gactaaatga aacacagcct
      901 attgaccttt caggcttgcc tttacaatct agtaaaaata gctattcctt tcagaatcca
      961 tccagttttg atcctagtat gctgctgcaa agattttcag tggcccccca tgagacccag
     1021 acacaaagag gaggagaatt tcagtgtggt ctagaagctg cttcagtgta ttctgaccat
     1081 actaatacta acaatctgac tttcctgatg gacctgccct cagctggcag gagcatgccg
     1141 gaggcctcag accaggaaga gcacctctcc cctctggact tcctgcactc agccaatttt
     1201 tcattgggca gcattaatca gaggcttaat aagagagaaa ggagcaagtt gaagaatcta
     1261 agaaggaaac aacgaaggcg tgaaagatgg ctacagaagc agggtaaata ctcaggagtg
     1321 ggattgctgg atcatatgac tttgaataat gagatgagta cagatgaaga caatgaatat
     1381 gcagaagaaa aggatagcta catctgtgca gtgtgtctgg acgtttattt caacccttat
     1441 atgtgttacc cttgccatca catcttctgt gagccctgct tacggactct ggccaaagac
     1501 aatccttcaa gcactccatg cccattgtgt cggacaatta tttctagagt ctttttccaa
     1561 acagaattga acaatgccac aaaaactttc tttactaaag aatatttgaa aataaaacaa
     1621 agctttcaga aatccaactc tgcaaaatgg cccctaccaa gctgcagaaa agcatttcat
     1681 ctttttggag gtttccgcag acatgcagct ccagttacaa gaaggcagtt cccacacggt
     1741 gcacacagga tggattacct gcactttgag gatgatagcc gtggatggtg gtttgacatg
     1801 gatatggtga tcatatatat ttattcagtg aactgggtca ttggattcat tgttttctgc
     1861 tttctttgct attttttctt tccgttttag gaatttcata ccttactaca attgaccaat
     1921 cataaatgat gtaaataaca attgcttaaa catttttaaa tgtgctttga agttttttta
     1981 atgttgcatt atacaaattg ttgatgttta tagaaagcct gagaataatg aatttattta
     2041 ttaatgtttt tcatgtaaca aactaaactt tattcaagag ctaacctacc cagcacttag
     2101 caacaatgca ctattaattt catagttgtt cttgggttag gatttggggc tctgatttta
     2161 taatatcact ttaatactta ttttgattgt aaaaaactga agttttctct ccacttaaaa
     2221 atagtaaaaa tacaaaaaga aatgataatc taggtagata ttatctttac tgataaaata
     2281 tttagtcaat caccacttat tctcaggcaa attatatgta ttaaagataa accatattct
     2341 ctgggaacta atctagcagg gtatattcag ttttggtttc taattgtcac tacttatatc
     2401 cctttctagt accaagaaaa ctgactattc tttttgtaca gatctaatta gtacaacatt
     2461 ttaaattatt ataaacagaa tactaaatac aaatcatgag actaatccct accaataaac
     2521 actttagcta gctataaaca ctttccagat tgaaggatta atcaccagaa gacatgaaaa
     2581 atttaccgac ttttagtagt ctaaaagagc aatgcatggt ccaaaatgta atttagtgat
     2641 tcatttaagt aggagatggt caaatatatt gtaaatgtgc aataaagagt ggcttttaat
     2701 ttttttaatg tctgaataaa gtattgttat aaataggctt atcgatttta gaaagaaaac
     2761 ctgacatttt taattacagt aatcattaat ttttttcatt attaaaattt aaaaataaga
     2821 gaactgaatc attagaacat ggaattgggg caggtaaccc aattcaaaaa aggaaaaact
     2881 ggagcagaga cttaagctta tttattcagt tattctggtg gtctttgtga aacctgggac
     2941 aaagttttta ttatgaatta ctaatccagt attactacac tatgatgtca tatatctggt
     3001 aattcaataa gcaaactttt acataaaata ggtgactctc tcgtggcact aaaaatacta
     3061 ccactatcca aaaacattgg gatcaactgg gctttaacag tttcaatcta tgaaaagcca
     3121 aaatttaagc taattgctac taactgtatt tcaataaaag cacttgactg ttggtatgtg
     3181 atgttctaag aaaactagaa gaatggtact gatttctatt ctaatgctgt tcttattatt
     3241 gtgttttaaa ttatatctat tacagaaaat agtatacact agacatcaaa tccagaaatc
     3301 agaacactaa gtacaattta gaaacacaga taaatttata cttataaatg gatatttata
     3361 attactaatt gctcaaagta aacataaggg aaaatatcag ctctcttaaa atatatagca
     3421 agattgaaaa cacacatatg aggagttgca ttattttaag aactttaaat tgcagccatt
     3481 tcctaggcaa cttctggttt atacactcta gaaaatatat cttgattcat tcctaaatca
     3541 caataaaggt tttaattatg tataaactaa ataagtatta ttatagatac agatctctca
     3601 taggaacaaa gttgattccc aatatatatt tgttaggtca gtgatacata tcagtttata
     3661 gatctcagtc tactaaatat ttatgatacc cttaaataaa catgaacctt taaatgaaga
     3721 aagcataatc tggaaaagca ttcaaaatgg attgagtata tttatcttga ctaataactt
     3781 gatctgaaaa ttatagaata ttaaaagaag taaattcata aaattataaa ttactaatct
     3841 ttaaaatatt cttaaatttt gtaaaagtgg agataaaaac tgctaaatat taagaagtat
     3901 agcatttcct agatctacca gcttataaga agccagataa aatctcagat ggaaagaaac
     3961 cagtttcttc tggtatgtag cacacagtag ccattcaaaa taaaatacat ggatgagctt
     4021 tagagtaaaa caaaaaatta taatgctctt cctaagcatc tctcacagta aaaactcact
     4081 gtccaataaa gagccaaaga aaggaaaaga agaaaaatgt taaagttaat gaagcatagt
     4141 acttgtccca agtaatatta tttaataagc ttaattttat gagttatcat tatcaataat
     4201 ttctatttct accaagctta attatggtaa aggttaattt taaacatgtt cacacattct
     4261 tttttaaaaa aatgccctaa ttgaggtata tttctgaata gtttcagcag gttatttttt
     4321 aattttaaaa aagcaaattc acaaacctag acccatttat tttatactca gcagaagaca
     4381 gggaaattta aattagacaa agttgaaaaa gaatcagaat ttatatttta caaagcttct
     4441 accactctga atcaacaaaa tcaggaatgg aaaaaaaaat ttctgtatct gctgaattat
     4501 taatgccact atagtattat atgctaaata tgaaagcagt gctgccatca gtttcacttc
     4561 tgccttggaa tcttgctcct aagttagctc tgtggcataa caaaattcca gttaataaaa
     4621 ttttcattta aatgtctttt gtatggctaa atgaatatac agattcttaa acatctaatt
     4681 tttatatgga tttctcaaag aatgccttac agaagagcat tctctgatta aatgcaatta
     4741 cagttggagt ctttgattct tcacagaatt ctgtagttga agccagaaaa cactgtcatt
     4801 taggaaagtg ttcctaaagg tttgaatgct ttaacatgct caactcttac ttcttgaagt
     4861 gtttgattgt cagtaaattt tcgaagaaca ttaaagttct accaatgtag aagcatgagg
     4921 aataaaagat ggtctggatc aagaa
//
