LOCUS       NM_173662               1358 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ring finger protein 175 (RNF175), mRNA.
ACCESSION   NM_173662
VERSION     NM_173662.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Postmus,I., Trompet,S., Deshmukh,H.A., Barnes,M.R., Li,X.,
            Warren,H.R., Chasman,D.I., Zhou,K., Arsenault,B.J., Donnelly,L.A.,
            Wiggins,K.L., Avery,C.L., Griffin,P., Feng,Q., Taylor,K.D., Li,G.,
            Evans,D.S., Smith,A.V., de Keyser,C.E., Johnson,A.D., de
            Craen,A.J., Stott,D.J., Buckley,B.M., Ford,I., Westendorp,R.G.,
            Slagboom,P.E., Sattar,N., Munroe,P.B., Sever,P., Poulter,N.,
            Stanton,A., Shields,D.C., O'Brien,E., Shaw-Hawkins,S., Chen,Y.D.,
            Nickerson,D.A., Smith,J.D., Dube,M.P., Boekholdt,S.M.,
            Hovingh,G.K., Kastelein,J.J., McKeigue,P.M., Betteridge,J.,
            Neil,A., Durrington,P.N., Doney,A., Carr,F., Morris,A.,
            McCarthy,M.I., Groop,L., Ahlqvist,E., Bis,J.C., Rice,K.,
            Smith,N.L., Lumley,T., Whitsel,E.A., Sturmer,T., Boerwinkle,E.,
            Ngwa,J.S., O'Donnell,C.J., Vasan,R.S., Wei,W.Q., Wilke,R.A.,
            Liu,C.T., Sun,F., Guo,X., Heckbert,S.R., Post,W., Sotoodehnia,N.,
            Arnold,A.M., Stafford,J.M., Ding,J., Herrington,D.M.,
            Kritchevsky,S.B., Eiriksdottir,G., Launer,L.J., Harris,T.B.,
            Chu,A.Y., Giulianini,F., MacFadyen,J.G., Barratt,B.J., Nyberg,F.,
            Stricker,B.H., Uitterlinden,A.G., Hofman,A., Rivadeneira,F.,
            Emilsson,V., Franco,O.H., Ridker,P.M., Gudnason,V., Liu,Y.,
            Denny,J.C., Ballantyne,C.M., Rotter,J.I., Adrienne Cupples,L.,
            Psaty,B.M., Palmer,C.N., Tardif,J.C., Colhoun,H.M., Hitman,G.,
            Krauss,R.M., Wouter Jukema,J. and Caulfield,M.J.
  CONSRTM   Welcome Trust Case Control Consortium
  TITLE     Pharmacogenetic meta-analysis of genome-wide association studies of
            LDL cholesterol response to statins
  JOURNAL   Nat Commun 5, 5068 (2014)
   PUBMED   25350695
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 1358)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 1358)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1358)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020703.7 and AC106865.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_173662.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034385.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347063.9/ ENSP00000340979.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AC020703.7         41956-42183         c
            229-266             AC020703.7         33597-33634         c
            267-408             AC020703.7         30804-30945         c
            409-563             AC020703.7         10366-10520         c
            564-671             AC020703.7         5510-5617           c
            672-792             AC020703.7         2343-2463           c
            793-926             AC106865.4         148201-148334       c
            927-1028            AC106865.4         145147-145248       c
            1029-1358           AC106865.4         142832-143161       c
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..1358
                     /gene="RNF175"
                     /note="ring finger protein 175"
                     /db_xref="GeneID:285533"
                     /db_xref="HGNC:HGNC:27735"
     exon            1..228
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1149
                     /gene="RNF175"
                     /codon_start=1
                     /product="RING finger protein 175"
                     /protein_id="NP_775933.2"
                     /db_xref="CCDS:CCDS47149.1"
                     /db_xref="GeneID:285533"
                     /db_xref="HGNC:HGNC:27735"
                     /translation="MAAGTAARKAAPVLEAPPQQEQLSHTKLSAEDTWNLQQERMYKM
                     HRGHDSMHVEMILIFLCVLVIAQIVLVQWRQRHGRSYNLVTLLQMWVVPLYFTIKLYW
                     WRFLSMWGMFSVITSYILFRATRKPLSGRTPRLVYKWFLLIYKLSYAFGVVGYLAIMF
                     TMCGFNLFFKIKARDSMDFGIVSLFYGLYYGVMGRDFAEICSDYMASTIGFYSVSRLP
                     TRSLSDNICAVCGQKIIVELDEEGLIENTYQLSCNHVFHEFCIRGWCIVGKKQTCPYC
                     KEKVDLKRMISNPWERTHFLYGQILDWLRYLVAWQPVVIGIVQGIIYSLGLE"
     exon            229..266
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            267..408
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            409..563
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            564..671
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            672..792
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            793..926
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1028
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1358
                     /gene="RNF175"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF175"
                     /note="hexamer: AGTAAA"
     polyA_site      1293
                     /gene="RNF175"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF175"
                     /note="hexamer: AATAAA"
     polyA_site      1358
                     /gene="RNF175"
                     /note="major polyA site"
ORIGIN      
        1 atctcccgcc ccgcacaacc cgggcagggc cgccgctccg ccgccgccgc agatccggct
       61 ctcaccctcg gctcccgagg ccccgcggcg cctccttctg cggactctgc gggaccctcc
      121 ccggcaggcg ctgtgccctg gagaaggcac agtggctcag gcatggccgc ggggacggcg
      181 gcgcggaagg cagcgccggt gctggaggcc cccccgcagc aggagcagct ctctcataca
      241 aagctttctg cagaagacac atggaacctg cagcaggaga ggatgtacaa gatgcaccgg
      301 ggccacgatt ccatgcacgt ggaaatgatc ttgatcttcc tctgcgttct ggtcattgcc
      361 cagatagtgc tggttcagtg gagacagagg catggccgat cctacaatct ggtgaccttg
      421 ttgcagatgt gggttgtccc cttatatttc acgataaaat tatactggtg gcggtttctg
      481 tctatgtggg ggatgttctc cgttattacc agttacatcc tcttcagagc tacccgaaaa
      541 cccctctcag gaaggacacc acgattggtc tacaaatggt ttcttttgat ctacaaactc
      601 agctatgcat ttggtgttgt gggttacttg gcgatcatgt ttacaatgtg tggattcaat
      661 ctgtttttca aaatcaaagc tagagattcc atggattttg gcattgtgtc tttgttctac
      721 ggcctctact atggagtaat ggggagagac tttgccgaga tctgctcaga ctacatggct
      781 tccactatag ggttctacag tgtcagccgg ttgcctacaa ggagcttatc ggacaatatc
      841 tgtgcagtct gtgggcagaa gatcattgtg gagcttgatg aagaagggct cattgaaaac
      901 acctaccagc tttcctgtaa tcatgtcttt catgaattct gcatccgagg ttggtgtatc
      961 gttgggaaaa agcagacttg cccttactgc aaagagaaag ttgatttgaa gaggatgatc
     1021 agtaatccct gggagcgcac acattttctg tatggacaaa tcctggattg gcttcgttat
     1081 ttggtggcct ggcaacctgt ggtgatagga atagttcaag gcattatcta ttcactaggg
     1141 ctggaatagg acagcagacc ccagaagcaa catactgcat ggttgaaatc cttggtccaa
     1201 catttaatat taattttttt aattttagag atgatcccaa gtgtttagaa aactaagtaa
     1261 actttgttgt caagcaattt gtccatgtgg aaagaattta aagagaagct gaacaatgga
     1321 ataaacaaat aaagcatgtt ttttcatctt tcccatta
//
