LOCUS       NM_031277               5102 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ring finger protein 17 (RNF17), transcript variant 1,
            mRNA.
ACCESSION   NM_031277 NM_019038
VERSION     NM_031277.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5102)
  AUTHORS   Guo,Y., An,L., Ng,H.M., Sy,S.M. and Huen,M.S.
  TITLE     An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator
            of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and
            Learning Difficulties (RIDDLE) Syndrome Protein RNF168
  JOURNAL   J Biol Chem 292 (3), 967-978 (2017)
   PUBMED   27903633
  REMARK    GeneRIF: Further mining of the UBE2U interactome uncovered its
            cognate E3 RNF17 as a novel factor that, via the radiosensitivity,
            immunodeficiency, dysmorphic features, and learning difficulties
            (RIDDLE) syndrome protein RNF168, enforces DNA damage responses.
REFERENCE   2  (bases 1 to 5102)
  AUTHORS   Seifi-Alan,M., Shamsi,R., Ghafouri-Fard,S., Mirfakhraie,R.,
            Zare-Abdollahi,D., Movafagh,A., Modarressi,M.H., Kazemi,G.,
            Geranpayeh,L. and Najafi-Ashtiani,M.
  TITLE     Expression analysis of two cancer-testis genes, FBXO39 and TDRD4,
            in breast cancer tissues and cell lines
  JOURNAL   Asian Pac J Cancer Prev 14 (11), 6625-6629 (2014)
   PUBMED   24377578
  REMARK    GeneRIF: TDRD4 showed significant up-regulation in invasive ductal
            breast carcinoma.
REFERENCE   3  (bases 1 to 5102)
  AUTHORS   Yoon,H., Lee,H., Kim,H.J., You,K.T., Park,Y.N., Kim,H. and Kim,H.
  TITLE     Tudor domain-containing protein 4 as a potential cancer/testis
            antigen in liver cancer
  JOURNAL   Tohoku J Exp Med 224 (1), 41-46 (2011)
   PUBMED   21515969
  REMARK    GeneRIF: TDRD4 mRNA is expressed in a subset of liver cancers, and
            TDRD4 is a candidate CT antigen for liver cancer.
REFERENCE   4  (bases 1 to 5102)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
REFERENCE   5  (bases 1 to 5102)
  AUTHORS   Janne,O.A., Moilanen,A.M., Poukka,H., Rouleau,N., Karvonen,U.,
            Kotaja,N., Hakli,M. and Palvimo,J.J.
  TITLE     Androgen-receptor-interacting nuclear proteins
  JOURNAL   Biochem Soc Trans 28 (4), 401-405 (2000)
   PUBMED   10961928
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC037275.1, CD358307.1,
            AK001907.1 and DB517763.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031277.2.
            
            Summary: This gene is similar to a mouse gene that encodes a
            testis-specific protein containing a RING finger domain.
            Alternatively spliced transcript variants encoding different
            isoforms have been found. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255324.10/ ENSP00000255324.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3006              BC037275.1         10-3015
            3007-3094           CD358307.1         716-803
            3095-3364           BC037275.1         3102-3371
            3365-3952           AK001907.1         592-1179
            3953-4712           BC037275.1         3960-4719
            4713-5099           DB517763.1         58-444
            5100-5102           BC037275.1         5107-5109
FEATURES             Location/Qualifiers
     source          1..5102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.12"
     gene            1..5102
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /note="ring finger protein 17"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
     exon            1..165
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..4907
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermatogenesis associated 23; tudor domain containing 4;
                     tudor domain-containing protein 4"
                     /codon_start=1
                     /product="RING finger protein 17 isoform 1"
                     /protein_id="NP_112567.2"
                     /db_xref="CCDS:CCDS9308.2"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
                     /translation="MAAEASKTGPSRSSYQRMGRKSQPWGAAEIQCTRCGRRVSRSSG
                     HHCELQCGHAFCELCLLMTEECTTIICPDCEVATAVNTRQRYYPMAGYIKEDSIMEKL
                     QPKTIKNCSQDFKKTADQLTTGLERSASTDKTLLNSSAVMLDTNTAEEIDEALNTAHH
                     SFEQLSIAGKALEHMQKQTIEERERVIEVVEKQFDQLLAFFDSRKKNLCEEFARTTDD
                     YLSNLIKAKSYIEEKKNNLNAAMNIARALQLSPSLRTYCDLNQIIRTLQLTSDSELAQ
                     VSSPQLRNPPRLSVNCSEIICMFNNMGKIEFRDSTKCYPQENEIRQNVQKKYNNKKEL
                     SCYDTYPPLEKKKVDMSVLTSEAPPPPLQPETNDVHLEAKNFQPQKDVATASPKTIAV
                     LPQMGSSPDVIIEEIIEDNVESSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNE
                     FCNRSSHLDPSDILELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVH
                     EVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHSAKQHIALNDLCLVLRKSEPYTEGLL
                     KDIQPLAQPCSLKDIVPQNSNEGWEEEAKVEFLKMVNNKAVSMKVFREEDGVLIVDLQ
                     KPPPNKISSDMPVSLRDALVFMELAKFKSQSLRSHFEKNTTLHYHPPILPKEMTDVSV
                     TVCHINSPGDFYLQLIEGLDILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDG
                     IWYRAKVIGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP
                     YKRTMQWSKEAKEKFEEKAQDKFMTCSVIKILEDNVLLVELFDSLGAPEMTTTSINDQ
                     LVKEGLASYEIGYILKDNSQKHIEVWDPSPEEIISNEVHNLNPVSAKSLPNENFQSLY
                     NKELPVHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKWENDMHCAVK
                     IQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL
                     VDIRPAGGSDKWTATACDCLSLYLTGAVATIILQVDSEENNTTWPLPVKIFCRDEKGE
                     RVDVSKYLIKKGLALRERRINNLDNSHSLSEKSLEVPLEQEDSVVTNCIKTNFDPDKK
                     TADIISEQKVSEFQEKILEPRTTRGYKPPAIPNMNVFEATVSCVGDDGTIFVVPKLSE
                     FELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYL
                     DHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQLLSKRQV
                     DIHIMELPKNPWEKLSIHLYFDGMSLSYFMAYYKYCTSEHTEEMLKEKPRSDHDKKYE
                     EEQWEIRFEELLSAETDTPLLPPYLSSSLPSPGELYAVQVKHVVSPNEVYICLDSIET
                     SNQSNQHSDTDDSGVSGESESESLDEALQRVNKKVEALPPLTDFRTEMPCLAEYDDGL
                     WYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFK
                     PPLRDLGETRIPYCPKWSMEALWAMIDCLQGKQLYAVSMAPAPEQIVTLYDDEQHPVH
                     MPLVEMGLADKDE"
     exon            166..260
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            261..352
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            353..464
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            465..545
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            546..646
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            647..818
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            819..895
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            896..970
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1275
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1434
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1624
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1793
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1984
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2126
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2280
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2396
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2517
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2638
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2866
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3017
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3136
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3239
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3355
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3645
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3809
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..3929
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4010
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4136
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4196
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4313
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4314..4482
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4618
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4808
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..4917
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..5102
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5083..5088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /note="hexamer: AATAAA"
     polyA_site      5102
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /note="major polyA site"
ORIGIN      
        1 gcactcggcg gttgttccag aagaaagaga cagcgatggc ggcagaggct tcgaagactg
       61 ggccttctag gtcttcctac cagcgaatgg ggaggaagag tcagccctgg ggtgccgctg
      121 aaatccagtg caccaggtgt ggaaggaggg tatccagatc atccggtcac cattgtgaac
      181 ttcaatgtgg acatgctttt tgtgaactat gcttgttaat gactgaagaa tgcaccacaa
      241 ttatatgccc tgattgtgag gttgctacag ctgtaaatac tagacaacgc tactacccaa
      301 tggctggata tattaaggaa gactccataa tggaaaaact gcagcctaag acgataaaga
      361 attgttctca ggactttaag aagactgctg atcagctaac tactggttta gaacgttcag
      421 cctccacaga caagactctt ttgaactcat cagctgtaat gttggacact aatactgcag
      481 aagaaattga tgaagcattg aatacagcac accatagttt cgaacagtta agcattgctg
      541 gaaaagcact tgaacacatg cagaagcaaa cgatagagga aagagaaaga gttatagaag
      601 ttgtggagaa acagtttgac caacttttgg ctttttttga ttccaggaaa aagaacctgt
      661 gtgaagaatt tgcaagaact actgatgatt atctatcaaa tttaataaag gctaaaagct
      721 acattgaaga gaaaaaaaat aatttgaatg cagctatgaa catagcaaga gcattacaat
      781 tatcgccttc tctaagaaca tactgtgacc tgaatcagat tatccggact ttgcagttaa
      841 cttcagatag tgaattagca caagttagtt ctccacaact aaggaaccct cccaggttga
      901 gtgtgaattg cagtgagatc atctgtatgt tcaacaatat gggaaagatt gaatttaggg
      961 actcaacaaa atgttatccc caagaaaatg aaattagaca gaatgttcaa aagaaatata
     1021 ataacaaaaa ggaactttct tgttacgata catacccacc gctagaaaag aaaaaggttg
     1081 acatgtctgt cctaaccagt gaagcaccac cacctccttt gcaacctgag acaaatgatg
     1141 tacatttaga agcaaaaaac ttccagccac agaaagacgt tgcaacagca tcccctaaaa
     1201 ccattgctgt gttacctcag atgggatcta gccctgatgt gataattgaa gaaattattg
     1261 aagacaacgt ggaaagttct gcagagctag tttttgtaag ccatgtaata gatccttgcc
     1321 atttctacat tcggaagtat tcacaaataa aagacgccaa agtactggag aagaaggtga
     1381 atgaattttg caataggagt tcacaccttg atccttcaga cattttggaa ctaggtgcaa
     1441 gaatatttgt cagcagtatt aaaaatggaa tgtggtgtcg aggaactatc acagaattaa
     1501 ttccaataga gggtagaaat accagaaaac cttgtagtcc aaccagatta tttgtccatg
     1561 aagttgcact aatacaaata ttcatggtag attttggaaa ttctgaagtc ctgattgtca
     1621 ctggagttgt tgatacccat gtgagaccag aacactctgc taagcaacat attgcactaa
     1681 atgatttatg tctggttcta aggaaatctg aaccatatac tgaagggctg ctaaaagaca
     1741 tccagccatt agcacaacca tgctcattga aagacattgt tccacagaat tcaaatgaag
     1801 gctgggaaga ggaagctaaa gtggaatttt tgaaaatggt aaataacaag gctgtttcaa
     1861 tgaaagtttt tagagaagaa gatggtgtgc ttattgtaga tctgcaaaaa ccaccaccga
     1921 ataaaataag cagtgatatg cctgtgtctc ttagagatgc gctagttttt atggaactag
     1981 caaagtttaa gtcacaatca ctaagaagtc actttgaaaa aaatactact ttacactatc
     2041 atccacctat tttgcctaaa gaaatgacag atgtttcagt aacggtttgt catataaata
     2101 gtcctggaga tttctatctt cagttgatag agggcctgga tattttattt ctattaaaga
     2161 caatcgagga attctataaa agtgaagatg gagaaaatct ggaaatcctc tgtccagttc
     2221 aagatcaagc ctgtgtagct aaatttgaag atggaatttg gtaccgagca aaagttatcg
     2281 gattgcctgg acatcaggaa gttgaagtta aatatgtgga ctttggtaat actgcaaaaa
     2341 taacaatcaa agacgtgcgt aaaataaagg atgagtttct gaatgcccca gagaaggcaa
     2401 ttaaatgtaa gttggcctat attgaaccat ataaaaggac aatgcagtgg tccaaagaag
     2461 ctaaagaaaa atttgaagaa aaggctcaag ataaatttat gacatgttca gttatcaaaa
     2521 ttctggaaga taatgtgctc ttagttgagc ttttcgattc tcttggtgct cctgaaatga
     2581 ctactactag tattaatgac cagctagtta aagagggcct agcatcttat gaaataggat
     2641 acatcctcaa agataattct caaaagcata ttgaagtttg ggatccttct ccagaagaaa
     2701 ttatttcaaa tgaagtacac aacttaaatc ctgtgtctgc aaaatctcta cctaatgaga
     2761 attttcagtc actttataat aaggaattgc ctgtgcatat ctgtaatgta atatctcctg
     2821 agaagattta tgttcagtgg ttgttaactg aaaacttact taatagttta gaagaaaaga
     2881 tgatagctgc ttatgaaaac tcaaaatggg aacctgttaa atgggaaaat gatatgcact
     2941 gtgctgttaa gatccaagat aaaaatcagt ggcgaagagg ccagatcatc agaatggtta
     3001 cagacacatt ggtagaggtc ttgctgtatg atgtgggtgt tgaactagta gtgaatgttg
     3061 actgtttaag aaaacttgaa gaaaatctaa agacaatggg aagactctct ttggaatgtt
     3121 ctctggttga cataagacca gctggtggga gtgacaagtg gacagcaaca gcttgtgact
     3181 gtctttcatt gtacctgact ggagctgtag caactataat cttacaggtg gatagtgagg
     3241 aaaacaacac aacatggcca ttacctgtga aaattttctg cagagatgaa aaaggagagc
     3301 gtgttgatgt ttctaaatat ttgattaaaa agggtttggc tttgagagaa aggagaatta
     3361 ataacttaga taacagccat tcattatctg agaagtctct ggaagtcccc ctggaacagg
     3421 aagattcagt agttactaac tgtattaaaa ctaactttga ccctgacaag aaaactgctg
     3481 acataatcag tgaacagaaa gtgtctgaat ttcaggagaa aattctagaa ccaagaacca
     3541 ctagagggta taagccacca gctattccta acatgaacgt atttgaggca acagtcagct
     3601 gtgttggtga tgatggaact atatttgtag tacctaaact atcagaattt gagctaataa
     3661 aaatgacaaa tgaaattcaa agtaatttaa aatgccttgg tcttttggag ccttatttct
     3721 ggaaaaaagg agaagcatgt gcagtaagag gatccgatac tctgtggtat cgtggcaagg
     3781 tgatggaggt tgtaggtggc gctgtcagag tacaatattt agatcatgga ttcactgaaa
     3841 agattccgca gtgccatctt taccctattt tgctgtatcc tgatataccc cagttttgta
     3901 ttccttgtca gctccataat accacacctg ttgggaatgt ctggcaacca gatgcaatag
     3961 aagttcttca acaactgctt tcaaagagac aggtggacat tcacattatg gagttaccta
     4021 aaaatccatg ggagaaattg tctattcacc tctattttga tggaatgtca ctttcttatt
     4081 ttatggcata ctataaatac tgtacttctg aacatactga ggagatgttg aaagaaaaac
     4141 caagatcaga tcatgataaa aagtatgaag aggaacaatg ggaaataagg tttgaggaat
     4201 tgctttcggc tgaaacagac actcctcttt taccaccata tttgtcttca tctctgcctt
     4261 ccccaggaga actctatgct gttcaagtta agcacgttgt ctcacctaat gaagtgtata
     4321 tttgccttga ttctatagaa acttctaacc agtctaacca gcatagtgac acagatgata
     4381 gtggagtcag cggggaatca gaatccgaga gccttgatga agcactgcag agggttaata
     4441 agaaggtaga ggcgcttcct cctctgacgg attttagaac agaaatgcct tgccttgcag
     4501 aatatgatga tggcttatgg tatagagcga agattgttgc cattaaagaa tttaatcctt
     4561 tatctatctt agtacaattt gttgattatg gatcaactgc aaagctgaca ttaaacagac
     4621 tgtgccaaat tccttctcat cttatgcggt atccagctcg agccataaag gttctcttgg
     4681 cagggtttaa acctccctta agggatctag gggagacaag aataccatat tgtcccaaat
     4741 ggagcatgga ggcactgtgg gctatgatag actgtcttca aggaaaacaa ctctatgctg
     4801 tgtccatggc tccagcacca gaacagatag tgacattata tgacgatgaa cagcatccag
     4861 ttcatatgcc gttggtagaa atggggcttg cagataaaga tgaataagtg cctaagtgta
     4921 tacagtgaga gcatctatag aagcctagaa gaattctgtt atgtttagac tatgtcttat
     4981 ctttagacta tttcaggctt aattttccta acttgttcag cactagtgct ttacctctca
     5041 tttttaattg aactgttagg aattgtgtgg ggaaaaaaag taaataaatg ttcgcttcca
     5101 aa
//
