LOCUS       NM_001098638            7842 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 169 (RNF169), mRNA.
ACCESSION   NM_001098638 XM_495886 XM_940188
VERSION     NM_001098638.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7842)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7842)
  AUTHORS   Roewenstrunk,J., Di Vona,C., Chen,J., Borras,E., Dong,C., Arato,K.,
            Sabido,E., Huen,M.S.Y. and de la Luna,S.
  TITLE     A comprehensive proteomics-based interaction screen that links
            DYRK1A to RNF169 and to the DNA damage response
  JOURNAL   Sci Rep 9 (1), 6014 (2019)
   PUBMED   30979931
  REMARK    GeneRIF: A comprehensive proteomics-based interaction screen that
            links DYRK1A to RNF169 and to the DNA damage response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7842)
  AUTHORS   An,L., Dong,C., Li,J., Chen,J., Yuan,J., Huang,J., Chan,K.M.,
            Yu,C.H. and Huen,M.S.Y.
  TITLE     RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand
            annealing repair
  JOURNAL   Proc Natl Acad Sci U S A 115 (35), E8286-E8295 (2018)
   PUBMED   30104380
  REMARK    GeneRIF: results highlight the interplay of RNF169 with 53BP1 in
            fine-tuning choice of DSB repair pathways.
REFERENCE   4  (bases 1 to 7842)
  AUTHORS   Hu,Q., Botuyan,M.V., Cui,G., Zhao,D. and Mer,G.
  TITLE     Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of
            53BP1 Chromatin Recruitment by RNF168/169 and RAD18
  JOURNAL   Mol Cell 66 (4), 473-487 (2017)
   PUBMED   28506460
  REMARK    GeneRIF: Ubiquitin ligases RNF168, RNF169, and RAD18 specifically
            bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1
            chromatin recruitment may be activated by RNF168 and blocked by
            RNF169 and RAD18.
REFERENCE   5  (bases 1 to 7842)
  AUTHORS   Kitevski-LeBlanc,J., Fradet-Turcotte,A., Kukic,P., Wilson,M.D.,
            Portella,G., Yuwen,T., Panier,S., Duan,S., Canny,M.D., van
            Ingen,H., Arrowsmith,C.H., Rubinstein,J.L., Vendruscolo,M.,
            Durocher,D. and Kay,L.E.
  TITLE     The RNF168 paralog RNF169 defines a new class of ubiquitylated
            histone reader involved in the response to DNA damage
  JOURNAL   Elife 6, e23872 (2017)
   PUBMED   28406400
  REMARK    GeneRIF: The authors establish that RNF169 binds to ubiquitylated
            histone H2A-Lys13/Lys15 in a manner that involves its canonical
            ubiquitin-binding helix and a pair of arginine-rich motifs that
            interact with the nucleosome acidic patch.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7842)
  AUTHORS   Poulsen,M., Lukas,C., Lukas,J., Bekker-Jensen,S. and Mailand,N.
  TITLE     Human RNF169 is a negative regulator of the ubiquitin-dependent
            response to DNA double-strand breaks
  JOURNAL   J Cell Biol 197 (2), 189-199 (2012)
   PUBMED   22492721
  REMARK    GeneRIF: results show that RNF169 functions in a noncanonical
            fashion to harness RNF168-mediated protein recruitment to
            DSB-containing chromatin, thereby contributing to regulation of DSB
            repair pathway utilization.
REFERENCE   7  (bases 1 to 7842)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 7842)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 7842)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 7842)
  AUTHORS   Ohara,O., Nagase,T., Mitsui,G., Kohga,H., Kikuno,R., Hiraoka,S.,
            Takahashi,Y., Kitajima,S., Saga,Y. and Koseki,H.
  TITLE     Characterization of size-fractionated cDNA libraries generated by
            the in vitro recombination-assisted method
  JOURNAL   DNA Res 9 (2), 47-57 (2002)
   PUBMED   12056414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000560.4, AB082522.1 and BU735906.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098638.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB082522.1, DRR138518.431516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299563.5/ ENSP00000299563.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AP000560.4         380-398
            20-974              AB082522.1         1-955
            975-7534            AP000560.4         87077-93636
            7535-7842           BU735906.1         18-325              c
FEATURES             Location/Qualifiers
     source          1..7842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..7842
                     /gene="RNF169"
                     /note="ring finger protein 169"
                     /db_xref="GeneID:254225"
                     /db_xref="HGNC:HGNC:26961"
                     /db_xref="MIM:618650"
     exon            1..534
                     /gene="RNF169"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2159
                     /gene="RNF169"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF169"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF169"
                     /protein_id="NP_001092108.1"
                     /db_xref="CCDS:CCDS41691.1"
                     /db_xref="GeneID:254225"
                     /db_xref="HGNC:HGNC:26961"
                     /db_xref="MIM:618650"
                     /translation="MAAAGPSTRASSAAAAAALSRRGRRGRCDETAAAKTGAPGPASG
                     PSLLVLSPPLLQPPLPPRPEESGCAGCLEPPGEAAALPCGHSLCRGCAQRAADAAGPG
                     CPRCRARGPGWARRRARDDGQADSEVLGECARRSQPERCRPRRDGGAAAAGPRPEQEP
                     RAAPAEPDFIFRAPIKLSKPGELREEYESLRKLREEKLQEEKPSEDQIHKLLPEDTET
                     GKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSL
                     AFLAGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPIIGVLLSTQN
                     NRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSPESNDSISEELNHFKPIVCSPCTP
                     PKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKA
                     TLTSLAPEMGEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPSVS
                     QTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFEGLGSTPDAKLDKTCISR
                     AMKITTVNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKR
                     HCKTKHLEQNGSLKKLRQTSGEVGLAPTDPVLREMEQKLQQEEEDRQLALQLQRMFDN
                     ERRTVSRRKGSVDQYLLRSSNMAGAK"
     exon            535..608
                     /gene="RNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            609..755
                     /gene="RNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            756..874
                     /gene="RNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            875..974
                     /gene="RNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            975..7842
                     /gene="RNF169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7818..7823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF169"
                     /note="hexamer: AGTAAA"
     polyA_site      7842
                     /gene="RNF169"
                     /note="major polyA site"
ORIGIN      
        1 gcaaccgact ctcccttcaa acgggaaaca agatggcggc tgcaggtccg agtactcggg
       61 cctcttccgc ggcggcagca gccgctctga gtcggcgggg ccggcggggc cgctgtgacg
      121 agacggcggc agctaagact ggggccccag gcccggcttc tggaccttcg ctgttggtgt
      181 tgtcgccgcc gttgctgcag ccgccgctgc cgccgcggcc ggaggaatcg ggctgcgccg
      241 ggtgcctgga gccccccgga gaagcagcgg ccctgccgtg cggccactcg ctttgccgag
      301 gctgcgccca acgcgccgcc gacgcggcgg gcccgggttg ccctcgctgc cgcgcccgcg
      361 gcccaggctg ggcccgccgt cgggcccgcg acgacggcca ggccgactca gaggtgctgg
      421 gcgagtgcgc ccgccgcagc caacccgagc gctgccgccc gcgccgggac gggggcgcgg
      481 ctgccgcggg gcccaggcca gagcaggagc cgcgtgccgc gcctgcggag ccagacttta
      541 tattcagagc accaatcaaa ttaagcaagc ctggggaact tcgtgaggaa tatgaaagct
      601 tgagaaagct gagagaagaa aagttacaag aggaaaaacc ctctgaagat caaatccaca
      661 agctgttacc agaggataca gaaacaggga aaaggaaaat ggatgaacag aaaaaaagag
      721 atgaaccatt agtactgaaa acaaatctgg aacgttgtcc tgcacgtctc tcagattcag
      781 agaatgaaga accttctcga ggccagatga cacagacaca tcgctcggca tttgtttcca
      841 agaacaactc ctactcctta gctttcctgg cagggaagct aaactccaag gtggaaagga
      901 gtcagagctg tagtgacaca gcccaggaaa gagcgaagag cagagtcaga gcagttccag
      961 gcaacaaagc caaggtcaca actatgactc cagcctccaa ccccatcatt ggtgtcctct
     1021 tgtcaactca aaacaaccgc tgcgtctcgg cccctgactt aaccatcgaa aagcgtctac
     1081 ccttcagctc cctttcatcc ttggcttccc tgcataagcc agagcgttct gtcagccctg
     1141 agagcaatga cagcatctcc gaagaactaa accatttcaa gcccattgtc tgctcaccat
     1201 gtactcctcc caagagactc cctgatggcc gtgtgctaag tcctctcatc atcaaatcaa
     1261 ctccacgcaa cctaaacaga agcctgcaga agcagacttc ttatgaggcc agtccacgga
     1321 tcctcaaaaa gtgggaacag atctttcagg agcggcagat caaaaagacc ctttcaaaag
     1381 ccactcttac ctctctggct cctgaaatgg gggaagagtt actaggctct gaaggtatcc
     1441 attctagcaa ggagaagcca cttgtggctg taaatacaag attatctggt gggcaggtcc
     1501 tctctgagta tactggaccc acctctgctg atcttgatca tttcccctct gttagccaaa
     1561 caaaagcaga acaggacagt gataataaaa gtagcactga gatcccactg gaaacctgct
     1621 gttcctcaga actcaaaggg ggaggcagtg ggacttcttt ggagagggag cagtttgagg
     1681 ggttagggtc aactccagat gccaagttag acaaaacctg tataagcaga gccatgaaaa
     1741 tcaccacagt taattcagtg ctaccccaaa acagtgtttt gggtggagtc ctcaaaacaa
     1801 agcaacaatt gaagacatta aatcattttg atctgactaa tggtgttcta gttgagagcc
     1861 taagtgaaga gccacttcct tctttgcgtc gaggccggaa aagacactgc aagaccaagc
     1921 acttagaaca aaatggctcc cttaaaaaac tgcgacaaac cagtggggag gtgggtctgg
     1981 ccccaacaga cccagtcctg cgagagatgg agcagaagct tcagcaagag gaagaagacc
     2041 gacagttggc tctgcagttg cagcgcatgt tcgacaatga gaggcggact gtgagccggc
     2101 gaaaaggaag tgtggatcag tatctcctac ggtccagcaa catggccggg gccaagtagc
     2161 acctaatgaa gtgttaccta tttttaaaag gtcttaggcc ttgatcattt atcctgaaga
     2221 gctgagtgtt ctcactttgg ttttatttta atggcaaaac actgtctaat atggttctga
     2281 gaggttccag ggcctttgta gtcaatatcc aagggaaaag catctccgtt tctctgtgac
     2341 ccaggccaga agcctgagtg acccatccct aagggcttct gggccaaacc tggcagcacc
     2401 cactgggaat gagatttgga acggcctcag gagcataatg gccacagtta gtaatggtaa
     2461 agaggggata ccttcttaaa ctgatagact tcctgacttc tttcagcagg gtattgtttt
     2521 aaatcagcct tgcagataaa aattaattcc atctttttca gacaagtgaa caatttagtt
     2581 ccttggcaga tccaaaatga tagatggtta tgttacgctt tctgctgtcc cttgccaaaa
     2641 ataagtaaat atatcagtta agattatgcc tttacaaaag ttaatttaca ttctctgttt
     2701 aaaaaataat atttggtgaa tgctatatag ttgacagagc acatttacag accttattaa
     2761 tttagtcttt ccaagagacc tctcatgtaa ctggcattag ccccattttt agatgatgaa
     2821 actgcagtgc agatgttctg gttctctcaa ctaccaagtg gcataaccca tggattttct
     2881 aaaggtttcc caaatagatc acaacctaag ggtgtgccag gggagcctag gggaagctag
     2941 gctgggcatt gaacactgat agtgcagaat ccacatgcaa acaagatcga cagggtggat
     3001 aaacatatat gtgcattatc cccatccccc acagtttaga gccttctgct tttctggggg
     3061 tttcagccta tgagacaaac tataatcagg cttcattatt acttttcaaa tggccaaggg
     3121 ttatctgcaa tgttgatcta aaatcctaaa aaatcaccct gaagtcaggc aaggaacaat
     3181 acttaaactc catactatgg aaacaaggta tctagctgga tgcagctggt aaattcagtc
     3241 ccatggacct ttgggggttt attttcctta gcagctgaca ccatgtgtct tttgcatccc
     3301 tggtggtgct tggtgcttct gcccatctgg gctcattgag aatagggatg aagatatgat
     3361 tttagggaat ttctgatggg ctggcatgcc ccatgtagta tgagttacta tataaagtca
     3421 tgtgactggc attttaacag accttccaga gcttatatat cccaatatat gttgtttcct
     3481 ttgagtagcc ccagcaggat actgcttagt ttttccagtg ccattggtga aagcatttct
     3541 ggaactgtct tcaaagacta gaaacactga ctcccaaaat gctagaactg gaagggacct
     3601 taatggttat ctattccagc ctcctcctaa ggtcctcctc agcttctaga cctagaagcc
     3661 aaagtccaga acagtgaccc attgatcaag gcagatagta taactccttt taagtgttct
     3721 cagatttgcc ttttctcagg gcaaatcttc agtgttttgt ggttatttgt ggttgagaga
     3781 gagagagaat gtaatgtctg agactagcca gcagctattt gaagcctctg ggaaagaagg
     3841 tggcttatca agtgggtttg tagtaatgag tgctgctgta aagcagagcc attttcttgt
     3901 gcagctcata gttcccaaac agttcccaaa cagaaattcc agagatgtct taaacattgt
     3961 ggtcatcatt gagataggtg gaatctcttt ggtgactacg ttggtgggga acatcactca
     4021 cctgaatgta tgcattctgt gttctctgtg tgtgtgcaca tatgcagatg tatgttttaa
     4081 aaacatttac caaactcatg attttgtagt cacaccactt cagttctggg ccctaccaac
     4141 aatttatgtc ctccaagagc tgctggaggg catgtttgtg cccaaaacag aagagctggc
     4201 tctggtttac agaagacagg gagggtgacc ttactataaa tgcccttaga ggaaacttat
     4261 cagttactgc catttcacgc atttcctttt tgatcttagt aaatattatt ggaaggctag
     4321 tcttgttggt aggagcaaag acacttattt ttccacttgc catctttctc tatatctcca
     4381 gtaatttgaa aaacactttt cagttggaat tgatttttgt ctttggtaaa aagaaatatt
     4441 tttaatagat aaaagatata tattttaaat atttccccaa attaatactt tcattttaag
     4501 aattgcatag cagttgtaac aagtgcagaa tgaagaacaa attcttgtta agcaaatagt
     4561 ccaaactcta ggtccagctt actgccttcc ccccttgtac ctacagtgat gcctaggatg
     4621 gtattgacag ttgttttcta aacttcctgc tgagcaacag tccttcaaat ataggtagag
     4681 tggtctaggt taaggaggga ggagggttga tctttaatca ggttggcttt ggaggaagga
     4741 aaaaccacta aggtattatc tgaattttaa gatgcttccc atccttaata actaaaacct
     4801 gaatgctttt ctttctgaaa aatctccctc tctccttcca tgattctgaa gttggttaaa
     4861 agtcgatatg ttgatgtgta ttatttgggg gaacagaaaa ggacaaggaa ggaaacagaa
     4921 cgatgggaag ggtttgtgag ctagaataag aggtgcagga tttcacaaaa caaattcctc
     4981 acaaatcatt gaagcccagt tcaccataca aattacccat gtcttactct gttccttgta
     5041 tatatgcatt ctgggttttt ttattattaa aggggaagtt aggggggagg gtgaaggtca
     5101 gtctgagggg aaatccagga aatgtggtgc ccttagaagg gggctgtcag ctcttttcca
     5161 tagagaggga aagaaacttt gagaaaatgt tcttgaccca ttgattgtat ctgctggaag
     5221 aagtcatctg ggcctgttgg gttggtatca gatcagggga ttatgcatcc agcccctggc
     5281 ccctttaatc tatttgcctc tttttaaaaa aggttaagtc ttcttgggtg aggcttgcca
     5341 gggaaactcc taagtggctt cacttatttt ttaaatttta atttaatttt taaatttttg
     5401 cttggaagca gcactggtaa taaatgtttt attttttgtt cattttccct aaaggaaaaa
     5461 tgtccttaag agattaaagc tcttaattga ttactgtctg gttacaaact ggcaaactga
     5521 ctaaaatggg aagctgccac cgtgcctgac tcatgtagct gatgaccgaa ggctcatcct
     5581 ttcttttcta tttgacagac atttactgag cttcagactt gagccaaccc tgagctggac
     5641 tgtggagata aagcagttcc tgctcttgag gagctcaatg tctaatggaa tgcatttgaa
     5701 tgtatgtgtg gctggagagt tcatttatgg tcttaggaaa gccatttctg gtcccattta
     5761 gaaaactgac cagcacccag caagctgcat tctacatttt agagacccca ttggtatttg
     5821 tgaatttgat tgcaccaccg cttttccttt actaagtaat gttatggaag gagaatgaat
     5881 tttctcctct agtgattaca ggacattaac atctcttcag aagctgcttt tagcttaagc
     5941 cccaagaagt gaggtgggtt gtggatcact gacatggtca ggggaggccc acacctcaat
     6001 tcagtaacca cctaatctct cccccaacct gatctctcat cagagctggc agcaacttgg
     6061 gattcctttc ctttttcctg cctaactttt cattgaaatg tctagtagga gagtgagaaa
     6121 agagaacaaa ggctgggtca cagtcataga atgttacagc tggaatgggc atggaaatca
     6181 tccaagttaa acttcttctc tgccccccgc ccccactttt tttttttttt ttttttaacc
     6241 aaacgaactt gtgatccagt gccctatttt atagtgtggt tttccagggt ctgaataaat
     6301 aatcattaaa gtttgacaca cgcagacaca cgcaccaatg atggggatac ccccaaatga
     6361 tttaggaggt tattttattt taatagtttt ttcttcctga tttttttcag ttagttagag
     6421 ttaaatgtac ctatagcccc tgaatacatg ctcaggtaga gaaagtctcc atagtataag
     6481 taagtaatat gaatgtggaa tcttggaaag tgatatattt tgattggaat aattttaatt
     6541 aaatttaatg attttaatta agaattaaaa gccagctagc caaattttct ttaaaaattg
     6601 gaaactcatt atggtcttaa attgtcctca ggcagccttt tcctcatcaa cccatagagt
     6661 ggtcttttga actggtatct aaacatacct ggttatgaat tctcaaaaga gaaagcaggt
     6721 ctggggcggg gtggtcagga gacagattct agggaaagtg ctgaagagat tttcttctga
     6781 agatgatcta ggaaatgcat ctttatacat gattgttagc tgctgtagct ttctgaagaa
     6841 gattgtagaa aagagactaa gatatatgca agggtcacca gtttagagat cagtcaaatt
     6901 ggaaaaagtg ccaagactgg atgtgcagat tgttctatgt attatcagta tttttttcct
     6961 cttaagaaaa aaatttactc tctctccttt gtgagtaaat gcctccttaa tgccttttaa
     7021 gtaaggtggc aacttttaac tgtcatcttg tgagaggcaa cctcaaactc taagcagact
     7081 ccctctctcc ctttctggtg tcttaaatca agaactagtt tgaagccaag gcaaagcaag
     7141 gtttgttcat cttcctttcc tgtcatttaa ggtaaaacag gcaatgaact cgctcttcaa
     7201 ataccatagt tcaagagtag ctgttggccc tggttccaga ttaatatagc agcaggcaga
     7261 ttgccccttc ttggggccac caccctccaa agctgtgcca ccaatgagag cattgggttc
     7321 aagtttgcat caaacatggt attaccaacg ctgagcctcc agcagagcac ttaaaagtcc
     7381 tagtgagaga atagatacta tgcaagggaa aaaaatttaa atgccaacga atagtttttt
     7441 tttttttgaa cctgatacac tgtttgttta ctctcaactc tttgtacaaa tattattgtc
     7501 ctaagggcct tttcccctcc tgcctagaaa ataggttgtg tattggtttt attcaacctg
     7561 ctgtctgctt taggattgga gaaggtacct ggatccttgt ggactgccac tgctggctgc
     7621 ctcctctcca actcatcaga agagcatttt gacaaagaca gaggacttgg accagggcat
     7681 gccctgttgg ggatgtttct gtcagcaagg acatggcatg gaatcaagtg ggctgatgtg
     7741 ttgttattta aacagtacca aagtgcattc ttcaatgtat gtttgcctgc ttgaagcaag
     7801 gcccaagttg agaatacagt aaaggaaact catgaaagtg ga
//
