LOCUS       NM_015528               1775 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 167 (RNF167), transcript variant
            1, mRNA.
ACCESSION   NM_015528
VERSION     NM_015528.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1775)
  AUTHORS   Wang,D., Xu,C., Yang,W., Chen,J., Ou,Y., Guan,Y., Guan,J. and
            Liu,Y.
  TITLE     E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and
            cancer progression
  JOURNAL   Mol Cell 82 (4), 770-784 (2022)
   PUBMED   35114100
  REMARK    GeneRIF: E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR
            and cancer progression.
REFERENCE   2  (bases 1 to 1775)
  AUTHORS   Ghilarducci,K., Cabana,V.C., Desroches,C., Chabi,K., Bourgault,S.,
            Cappadocia,L. and Lussier,M.P.
  TITLE     Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and
            UBE2N promotes ubiquitination of AMPA receptor
  JOURNAL   FEBS J 288 (16), 4849-4868 (2021)
   PUBMED   33650289
  REMARK    GeneRIF: Functional interaction of ubiquitin ligase RNF167 with
            UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.
REFERENCE   3  (bases 1 to 1775)
  AUTHORS   Li,T., Wang,X., Ju,E., da Silva,S.R., Chen,L., Zhang,X., Wei,S. and
            Gao,S.J.
  TITLE     RNF167 activates mTORC1 and promotes tumorigenesis by targeting
            CASTOR1 for ubiquitination and degradation
  JOURNAL   Nat Commun 12 (1), 1055 (2021)
   PUBMED   33594058
  REMARK    GeneRIF: RNF167 activates mTORC1 and promotes tumorigenesis by
            targeting CASTOR1 for ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1775)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1775)
  AUTHORS   Nair,S.V., Narendradev,N.D., Nambiar,R.P., Kumar,R. and
            Srinivasula,S.M.
  TITLE     Naturally occurring and tumor-associated variants of RNF167 promote
            lysosomal exocytosis and plasma membrane resealing
  JOURNAL   J Cell Sci 133 (11) (2020)
   PUBMED   32409562
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1775)
  AUTHORS   Lussier,M.P., Herring,B.E., Nasu-Nishimura,Y., Neutzner,A.,
            Karbowski,M., Youle,R.J., Nicoll,R.A. and Roche,K.W.
  TITLE     Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic
            transmission
  JOURNAL   Proc Natl Acad Sci U S A 109 (47), 19426-19431 (2012)
   PUBMED   23129617
  REMARK    GeneRIF: RNF167 is a selective regulator of AMPAR-mediated
            neurotransmission.
REFERENCE   7  (bases 1 to 1775)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 1775)
  AUTHORS   Yamada,H.Y. and Gorbsky,G.J.
  TITLE     Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel
            ubiquitin ligase RING105
  JOURNAL   Oncogene 25 (9), 1330-1339 (2006)
   PUBMED   16314844
REFERENCE   9  (bases 1 to 1775)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 1775)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004771.1.
            
            On May 4, 2019 this sequence version replaced NM_015528.2.
            
            Summary: RNF167 is an E3 ubiquitin ligase that interacts with TSSC5
            (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM
            602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky,
            2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.360103.1, AK025329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262482.11/ ENSP00000262482.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC004771.1         9930-10022
            94-600              AC004771.1         10149-10655
            601-681             AC004771.1         10739-10819
            682-807             AC004771.1         12003-12128
            808-895             AC004771.1         12239-12326
            896-986             AC004771.1         12513-12603
            987-1092            AC004771.1         12841-12946
            1093-1186           AC004771.1         13088-13181
            1187-1267           AC004771.1         14220-14300
            1268-1775           AC004771.1         14377-14884
FEATURES             Location/Qualifiers
     source          1..1775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1775
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /note="ring finger protein 167"
                     /db_xref="GeneID:26001"
                     /db_xref="HGNC:HGNC:24544"
                     /db_xref="MIM:610431"
     exon            1..93
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            94..600
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..1569
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /EC_number="2.3.2.27"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; E3 ubiquitin-protein ligase RNF167; RING-type
                     E3 ubiquitin transferase RNF167"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF167 isoform a
                     precursor"
                     /protein_id="NP_056343.1"
                     /db_xref="CCDS:CCDS11060.1"
                     /db_xref="GeneID:26001"
                     /db_xref="HGNC:HGNC:24544"
                     /db_xref="MIM:610431"
                     /translation="MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPAL
                     FGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQ
                     KAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARV
                     LLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPT
                     HDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVH
                     RGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGP
                     STDPPLSPPSSPVILV"
     exon            601..681
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            682..807
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            808..895
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            896..986
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1092
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1186
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1267
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1775
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1750..1755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="RNF167"
                     /gene_synonym="5730408C10Rik; LP2254; RING105"
                     /note="major polyA site"
ORIGIN      
        1 agacacagca actattcagc tgcgagggga cgggagaggt ggtgagcact ctcgcgagat
       61 ttgaaggagc ggcggaggcc agagggagga gaggaccgga agtccttcat ctcaagcatc
      121 caatgctgaa agcggcctga ttttctctac cggaagccct tttccagagg ctgggaacac
      181 ggcccaccta gcaggaagtc ccacctcctt gagctccgcc acccttcccg aagtttttct
      241 gtcacctgtg ttaggctccg tcccctttcc gcgttttatc cccgtaccag aaaaggatac
      301 atttagtgcc tcccacccag ctccactaaa cgggttggat atctcattct ttgagttggt
      361 gttccttccc cggcgccccc atgtagctgg gaagtgggac ctgggggtgg ttggacccct
      421 gggatcctaa aggaggggca gggagggcgc agaactccgc ttctgctcct tgctaccagg
      481 acgcgcggcc tcctcagcct ctttcctccc gctgccatgc accctgcagc cttcccgctt
      541 cctgtggttg tggccgctgt gctgtgggga gcggccccga cccgggggct cattcgagcg
      601 acctcggacc acaatgccag catggacttt gcagaccttc cagctctgtt tggggctacc
      661 ttgagccagg agggcctcca ggggttcctt gtggaggctc acccagacaa tgcctgcagc
      721 cccattgccc caccaccccc agccccggtc aatgggtcag tctttattgc gctgcttcga
      781 agattcgact gcaactttga cctcaaggtc ctaaatgccc agaaggctgg atatggtgcc
      841 gctgtagtac acaatgtgaa ttccaatgaa cttctgaaca tggtgtggaa tagtgaggaa
      901 atccagcagc agatctggat cccgtctgta tttattgggg agagaagctc cgagtacctg
      961 cgtgccctct ttgtctacga gaagggggct cgggtgcttc tggttccaga caataccttc
     1021 cccttgggct attacctcat ccctttcaca gggattgtgg gactgctggt tttggccatg
     1081 ggagcagtaa tgatagctcg ttgtatccag caccggaaac ggctccagcg gaatcgactt
     1141 accaaagagc aactgaaaca gattcctaca catgactatc agaagggaga ccagtatgat
     1201 gtctgtgcca tttgcctgga tgaatatgag gatggggaca agctgcgggt actcccctgt
     1261 gctcatgcct accacagccg ctgcgtggac ccctggctca ctcagacccg gaagacctgc
     1321 cccatttgca agcagcctgt tcatcggggt cctggggacg aagaccaaga ggaagaaact
     1381 caagggcaag aggagggtga tgaaggggag ccaagggacc accctgcctc agaaaggacc
     1441 ccacttttgg gttctagccc cactcttccc acctcctttg gttccttagc cccagctccc
     1501 cttgtttttc ctgggccttc aacagatccc ccactgtccc ctccctcttc ccctgttatc
     1561 ctggtctaat aaccccccac acatacacct ctggtgacct atttgcacag accgtcgtct
     1621 tccctccagt cttctgaggg ataggggaca ttccatccca agcttctccc ttacccacac
     1681 ctatcctttt gaggggcttt ggggtggagc tggggcaagc agagggactg ggtcttcact
     1741 tcttgggcta ataaaattgt ttctttgtgg actaa
//
