LOCUS       NM_178841               1864 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ring finger protein 166 (RNF166), transcript variant
            1, mRNA.
ACCESSION   NM_178841
VERSION     NM_178841.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1864)
  AUTHORS   Li,Y., Zhang,X., Liu,N., Liu,R., Zhang,W., Chen,L. and Chen,Y.
  TITLE     RNF166 promotes colorectal cancer progression by recognizing and
            destabilizing poly-ADP-ribosylated angiomotins
  JOURNAL   Cell Death Dis 15 (3), 211 (2024)
   PUBMED   38480683
  REMARK    GeneRIF: RNF166 promotes colorectal cancer progression by
            recognizing and destabilizing poly-ADP-ribosylated angiomotins.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1864)
  AUTHORS   Hwang,I.Y., Oh,C.K., Choi,Y.K., Yun,N. and Oh,Y.J.
  TITLE     RNF166 plays a dual role for Lys63-linked ubiquitination and
            sumoylation of its target proteins
  JOURNAL   J Neural Transm (Vienna) 129 (5-6), 463-475 (2022)
   PUBMED   34837535
  REMARK    GeneRIF: RNF166 plays a dual role for Lys63-linked ubiquitination
            and sumoylation of its target proteins.
REFERENCE   3  (bases 1 to 1864)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1864)
  AUTHORS   Hongbo,M., Yanjiao,D., Shuo,W., Kun,S., Yanjie,L. and Mengmeng,L.
  TITLE     Podocyte RNF166 deficiency alleviates diabetic nephropathy by
            mitigating mitochondria impairment and apoptosis via regulation of
            CYLD signal
  JOURNAL   Biochem Biophys Res Commun 545, 46-53 (2021)
   PUBMED   33545631
  REMARK    GeneRIF: Podocyte RNF166 deficiency alleviates diabetic nephropathy
            by mitigating mitochondria impairment and apoptosis via regulation
            of CYLD signal.
REFERENCE   5  (bases 1 to 1864)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1864)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1864)
  AUTHORS   Heath,R.J., Goel,G., Baxt,L.A., Rush,J.S., Mohanan,V.,
            Paulus,G.L.C., Jani,V., Lassen,K.G. and Xavier,R.J.
  TITLE     RNF166 Determines Recruitment of Adaptor Proteins during
            Antibacterial Autophagy
  JOURNAL   Cell Rep 17 (9), 2183-2194 (2016)
   PUBMED   27880896
  REMARK    GeneRIF: An unbiased informatics approach pinpointed RNF166 as a
            key gene that interacts with the autophagy network and controls the
            recruitment of ubiquitin as well as the autophagy adaptors p62 and
            NDP52 to bacteria.
REFERENCE   8  (bases 1 to 1864)
  AUTHORS   Chen,H.W., Yang,Y.K., Xu,H., Yang,W.W., Zhai,Z.H. and Chen,D.Y.
  TITLE     Ring finger protein 166 potentiates RNA virus-induced
            interferon-beta production via enhancing the ubiquitination of
            TRAF3 and TRAF6
  JOURNAL   Sci Rep 5, 14770 (2015)
   PUBMED   26456228
  REMARK    GeneRIF: These findings suggest that RNF166 positively regulates
            RNA virus-triggered IFN-beta production by enhancing the
            ubiquitination of TRAF3 and TRAF6.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1864)
  AUTHORS   Chaste,P., Klei,L., Sanders,S.J., Hus,V., Murtha,M.T., Lowe,J.K.,
            Willsey,A.J., Moreno-De-Luca,D., Yu,T.W., Fombonne,E.,
            Geschwind,D., Grice,D.E., Ledbetter,D.H., Mane,S.M., Martin,D.M.,
            Morrow,E.M., Walsh,C.A., Sutcliffe,J.S., Lese Martin,C.,
            Beaudet,A.L., Lord,C., State,M.W., Cook,E.H. Jr. and Devlin,B.
  TITLE     A genome-wide association study of autism using the Simons Simplex
            Collection: Does reducing phenotypic heterogeneity in autism
            increase genetic homogeneity?
  JOURNAL   Biol Psychiatry 77 (9), 775-784 (2015)
   PUBMED   25534755
REFERENCE   10 (bases 1 to 1864)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138028.1.
            
            On May 17, 2019 this sequence version replaced NM_178841.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017226.1, SRR1163655.483202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312838.9/ ENSP00000326095.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC138028.1         72271-72508
            239-395             AC138028.1         77261-77417
            396-508             AC138028.1         78947-79059
            509-623             AC138028.1         79594-79708
            624-731             AC138028.1         80070-80177
            732-1864            AC138028.1         81046-82178
FEATURES             Location/Qualifiers
     source          1..1864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2-q24.3"
     gene            1..1864
                     /gene="RNF166"
                     /note="ring finger protein 166"
                     /db_xref="GeneID:115992"
                     /db_xref="HGNC:HGNC:28856"
                     /db_xref="MIM:617178"
     exon            1..238
                     /gene="RNF166"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..797
                     /gene="RNF166"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RING-type E3 ubiquitin transferase RNF166; E3
                     ubiquitin-protein ligase RNF166"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF166 isoform 1"
                     /protein_id="NP_849163.1"
                     /db_xref="CCDS:CCDS10969.1"
                     /db_xref="GeneID:115992"
                     /db_xref="HGNC:HGNC:28856"
                     /db_xref="MIM:617178"
                     /translation="MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPV
                     AIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCN
                     KKVTLAKMRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNL
                     DQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDY
                     SIDEEAAFQAALALSLSEN"
     exon            239..395
                     /gene="RNF166"
                     /inference="alignment:Splign:2.1.0"
     exon            396..508
                     /gene="RNF166"
                     /inference="alignment:Splign:2.1.0"
     exon            509..623
                     /gene="RNF166"
                     /inference="alignment:Splign:2.1.0"
     exon            624..731
                     /gene="RNF166"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1864
                     /gene="RNF166"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF166"
                     /note="hexamer: AATAAA"
     polyA_site      1864
                     /gene="RNF166"
                     /note="major polyA site"
ORIGIN      
        1 agcgcggcgc agtagcggct gtgactagcg ggccggcccg ggccaggaca gcgggcggcg
       61 ggcggcgcgg gcctggcccc gggatggcta tgttccgcag cctggtggcc tcggctcagc
      121 agcggcagcc gccggccggg ccggcgggcg gcgacagcgg cctggaggcg cagtacacct
      181 gccccatctg cctggaggtc tatcaccggc ccgtggccat cggcagctgc ggccacacgt
      241 tctgcgggga gtgtctccag ccctgcctgc aggtgccatc cccgctgtgc ccactctgcc
      301 gcctgccctt cgaccccaag aaggtggaca aggccaccca cgtggagaag cagctctcat
      361 cctacaaagc gccctgtcga ggctgcaaca aaaaggtgac cctggcaaag atgagagtgc
      421 acatttcgtc ctgcctgaag gtccaggagc agatggccaa ctgccccaag ttcgtccccg
      481 tggtgcccac atcacagcct atccccagca acatccccaa caggtccacc ttcgcctgcc
      541 cgtactgtgg tgcccgcaac ctggaccagc aggagctggt gaagcactgt gtggaaagcc
      601 accgcagcga ccccaaccgc gtggtgtgcc ccatctgctc ggcaatgccc tggggggacc
      661 ccagctacaa gagcgccaac ttcctgcagc acctgcttca ccgacacaag ttctcctacg
      721 acacctttgt ggactacagt attgacgagg aggccgcctt ccaggctgct ctggccctgt
      781 ctctctctga gaactgaagg gaagcgcagc cacccgcctg cgtctggggt cagggatgtc
      841 cccgctcctg tgtcgcacct ggcacctgct cgggagcgca cctcaccgga ctgagctcac
      901 aggaggagcc tgcacccgcg cagaagggga gccggggccg agcctccggg cctgaatacg
      961 ggccagccgc cgaggccgcc agagcagggc cgcctggtcc caccggcgtc gctgggttct
     1021 tcggtgcttc tggccgagca ggcggcctac ttgggcaggg ctggacgctg ggacctggag
     1081 ctgccgccgt ctcttcaaag ccatgatacc ccctcgtggg aagaagggac cgacgcgcga
     1141 gtcgcgctcc gcagtcgagc cgggaggaac ccaggctgct gccctgccca gcccgaccct
     1201 gccccggccc cacttccacc ttgcgcattt ggtactggct tttgtgatac ttaggaaccc
     1261 tggcatcttt tctatattat ccagtgtgat aatcttttca cgttttatag agcaaagaca
     1321 gagcagttac tcttcatatt gcaatatctg tgtttgacta ggaataatag tatttttatg
     1381 gaacatttac aaaattatat tttttaagaa aacaatcaaa acaagcattg ggggattggg
     1441 gcaaggatgg aaggagcagt ggggcagctg ccagagctca ggcgagccat ggggtctgct
     1501 gtggggtctg ccctggccac ccactgtgtg tctgggtcct tgaggtttgt acgtttctct
     1561 ttgatgacca ggaagaaatc ccagcacccc agccacaggc tgtggctgct cccagcagag
     1621 gcggggccgg cagagaaggg gcctcctcca cccagagtcc tggccttggc ccgctgtcac
     1681 cttcaaagct gactgtgccc cgctgcggga ggggacggca ccccagtggt ggcagagctt
     1741 gggggcctgg gcaggggccc gcttggcggg ccgggcaaca cgtcaacatt cttttctgtt
     1801 cttggcatta attattgctg tctttttttt aaaaaaaaaa gtttaaataa aatgtctcag
     1861 agca
//
