LOCUS       NM_052916               5054 bp    mRNA    linear   PRI 18-DEC-2024
DEFINITION  Homo sapiens ring finger protein 157 (RNF157), transcript variant
            1, mRNA.
ACCESSION   NM_052916 XM_290732
VERSION     NM_052916.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5054)
  AUTHORS   Dogan,T., Gnad,F., Chan,J., Phu,L., Young,A., Chen,M.J., Doll,S.,
            Stokes,M.P., Belvin,M., Friedman,L.S., Kirkpatrick,D.S.,
            Hoeflich,K.P. and Hatzivassiliou,G.
  TITLE     Role of the E3 ubiquitin ligase RNF157 as a novel downstream
            effector linking PI3K and MAPK signaling pathways to the cell cycle
  JOURNAL   J Biol Chem 292 (35), 14311-14324 (2017)
   PUBMED   28655764
  REMARK    GeneRIF: Data suggest that RNF157 plays role as downstream effector
            of both PI3K signaling and MAPK signaling in melanoma cell line;
            regulation of RNF157 expression is cell-cycle-dependent in melanoma
            cell line; both CDH1 and CDK2 are involved in modulation of RNF157
            stability during melanoma cell proliferation. (PI3K =
            phosphatidylinositol 3-kinase; CDH1 = E-cadherin; CDK2 =
            cyclin-dependent kinase 2)
REFERENCE   2  (bases 1 to 5054)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 5054)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 5054)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015801.25, AB067504.2, AK091467.1, AK055949.1, CX872674.1,
            BM474134.1, BI857136.1 and AA932192.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052916.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067504.2, ERR4368410.341250.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269391.11/ ENSP00000269391.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC015801.25        64155-64338
            185-606             AB067504.2         1-422
            607-1951            AK091467.1         306-1650
            1952-3753           AK055949.1         848-2649
            3754-4101           CX872674.1         380-727
            4102-4654           BM474134.1         183-735
            4655-5052           BI857136.1         230-627
            5053-5054           AA932192.1         46-47               c
FEATURES             Location/Qualifiers
     source          1..5054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..5054
                     /gene="RNF157"
                     /note="ring finger protein 157"
                     /db_xref="GeneID:114804"
                     /db_xref="HGNC:HGNC:29402"
                     /db_xref="MIM:621044"
     exon            1..341
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2293
                     /gene="RNF157"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RING-type E3 ubiquitin transferase RNF157; E3 ubiquitin
                     ligase RNF157"
                     /codon_start=1
                     /product="E3 ubiquitin ligase RNF157 isoform 1"
                     /protein_id="NP_443148.1"
                     /db_xref="CCDS:CCDS32740.1"
                     /db_xref="GeneID:114804"
                     /db_xref="HGNC:HGNC:29402"
                     /db_xref="MIM:621044"
                     /translation="MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKF
                     DSTHPEGYLFGENSDLNFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAE
                     EVKSPGEEASKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSET
                     VQYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVL
                     LGTFEKHTDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAE
                     CVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGP
                     LSPTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDG
                     HLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDE
                     HSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPE
                     GPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGE
                     GLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAFLGMECDNNNDFDIA
                     SVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETRPCVWGPLAV"
     exon            342..460
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            461..549
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            550..696
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            697..814
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            815..881
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            882..925
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            926..973
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1045
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1205
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1318
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1557
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1666
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1778
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1951
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2017
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2063
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2174
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..5054
                     /gene="RNF157"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5033..5038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF157"
                     /note="hexamer: AATAAA"
     polyA_site      5054
                     /gene="RNF157"
                     /note="major polyA site"
ORIGIN      
        1 acgcggcctg aggcggcggc ggcgcccccg gcccagaccc gcagccccct tggcagaggc
       61 gccgccgcgg tgcccggcgg aggatggtgc gcggcgcgcc gggggctccc cgccgccaga
      121 gccgcagcgc cgcagcggag ccggccgcgg cgggcagtcg gcccccgcac cgggcgcggg
      181 gcgggcggcc gcggtgaagc gcggagggcg gcgcgggcac cggggccggg ccggggctgc
      241 agccgcagcg gccatggggg ccctgacgag ccggcagcac gcgggcgtgg aggaggtgga
      301 catcccgtct aattccgtgt accgctaccc gcccaagtcc ggaagctatt ttgccagcca
      361 cttcattatg ggaggagaga agtttgactc aactcatcct gaaggttacc tgtttggaga
      421 gaacagcgat ctgaactttc tggggaacag accagttgtg tttccttacg ccgccccacc
      481 tccccaagaa cccgtgaaga ctctgagaag cctggtcaat atccgaaagg acacactgag
      541 gctcgtcaaa tgtgctgagg aagtgaagag ccctggagaa gaggccagta aagctaaagt
      601 ccactacaat gttgagttca cctttgacac agatgctcgg gtagccatca ccatctatta
      661 ccaggccacg gaagagttcc agaatggtat tgccagctac attcccaaag acaacagcct
      721 ccagtcggag actgtgcagt acaagcgagg agtgtgtcag cagttctgcc tgccctccca
      781 caccgtggat ccctccgagt gggccgaaga ggagcttggc tttgatttag accgagaagt
      841 ttaccctcta gtggtacatg ccgtggtgga tgaaggagac gagtattttg gccattgcca
      901 tgtactgctg ggtacttttg agaagcacac agatggaact ttctgtgtca agcccctcaa
      961 acagaaacaa gtagtagacg gggtcagcta cctccttcag gagatctatg gaattgaaaa
     1021 caagtacaac acacaagatt ctaaggtggc tgaagacgaa gtgagtgata acagtgccga
     1081 gtgtgtggtg tgtctctcgg atgtccggga caccttgatt ctgccctgtc gccacctctg
     1141 cctctgtaac acctgtgcag acacgctgcg ctaccaggcc aacaactgcc ccatctgccg
     1201 actgcccttc cgggcactgc ttcagatccg agccatgagg aaaaaattgg gccccttgtc
     1261 cccaaccagc tttaacccca tcatctcatc ccagacatct gactctgaag agcatccatc
     1321 ctcagagaat attccaccag gctatgaagt agtatctctt ctggaggccc tcaacgggcc
     1381 cctcaccccg tccccagcag ttcctccact tcacgtgctt ggagatggcc acctctcagg
     1441 aatgctccct tcatatggca gtgatggcca cctgcccccc gtcaggacga tctcgcctct
     1501 tgaccgcctg tctgacagca gcagtcaggg actcaaactc aaaaagagtc tctccaaatc
     1561 cacttcccaa aactcttccg tgctgcatga agaggaagat gagcattcct gcagcgagtc
     1621 ggagacacag ctctctcaga gaccgtcggt tcagcatctc ggagaggaat gtggtgtgac
     1681 tccagaaagt gagaatctca ccttgtcgtc atctggagct attgaccagt cgtcttgcac
     1741 agggacgcct ctgtcatcca ctatttcctc cccagaaggc cctgccagca gcagcttggc
     1801 ccagtctgtc atgtccatgg catcctccca gatcagcact gacaccgtct cctccatgtc
     1861 tggctcctac atcgcccctg gcactgaaga ggagggagag gctctctctt ccccccagcc
     1921 tgccagcagg gccccctcag aagaaggaga ggggctgcca gcggagtctc cagacagcaa
     1981 ctttgctggc ctcccagctg gagagcagga tgcagaggga aatgatgtta tagaggaaga
     2041 ggatggatca cccacgcagg aaggccagag gacgtgcgca tttctaggta tggagtgtga
     2101 caataacaat gactttgaca tcgcaagcgt gaaagcactg gacaataagc tgtgctctga
     2161 ggtctgctta cctggtgcct ggcaggctga tgacaatgcc gtcagtcgga atgcccagcg
     2221 ccggcgcttg tcatccagca gcctggagga ctctgagacg aggccctgtg tgtggggccc
     2281 tttggctgtc tgagccccag cctctgcact tgggctcccc tcctgccctg cattccatcc
     2341 atcctcactc agctgctgcc tactgggcat cctcagcaag atgctggaga ctttttaccc
     2401 tcctgtgaca gctgttacaa cctgtaacca caatccctca cctctcagag ggaactggaa
     2461 ccctcctttc tccgtgtgac ctaaagccac tcaatgaact gcagctcacg agaccttttg
     2521 cagggactct ggaatgtcct cacggtatat tgatgttcag gtggagctgg ggtccatggg
     2581 ctaatttctt acacatcttt tttctcctta gggggtagaa caagaaggct tagagtttgg
     2641 cagctttgtt acaaacatcc ctctggcatt tcctggtctc tggcacatca taaccaattg
     2701 gaaacctgca gtttggggta gggctggagg atcgctcctg tggaaaggga gagccatact
     2761 gcacggacgt agcgtttccc tctacaagca ctaggagcac ctttctcaag gacaagaaat
     2821 ggtagcaacc aaaaggttgg ttgaaggaaa caatccttcc ttctggtggc agagccagtc
     2881 ttctgggcct cacatgcctg tgcggttaag aaggagctct tggccgggcg cggtggctca
     2941 cgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcatgagat caggagatcg
     3001 agaccatcct ggctaacacg gcgaaacccc gtctctacta aaaatacaaa aaattagctg
     3061 ggcatggttg caggcgcctg tagtcccagc tacttgggag gctgaggcag gagaatggcc
     3121 tgaacccggg aggcggagct tgcagtgagc cgagatcgcg ccaatgcact ccagcctggg
     3181 cgacagagaa aaaaaaaaaa aaagaaggag cccttgaatc tgagaatccc ccagttaaga
     3241 tgatttccct taaggagcat ttctcctgat caggtgcatt cagggaggcc tgcaactcca
     3301 tcctaaggtg acatttcaag aaacacatgt gttgaccacc tctgtgtgcc aagcactggg
     3361 tgaggagtgg tcgtatatta ccataattca tcctcactca attgggaggt ggcattcttg
     3421 tccctgttgc ccccatctct accccctttt gttaatggtt gagagaaatg tggaccagtg
     3481 attctcagtt tggtgcccag gtccccaaag gaagtgatgg agagccttga gctaagttca
     3541 ggcagcagca tgtggccagc agcagtgtgc tgggagcaga ggttggaatc agggctcagg
     3601 gccttcactt caagggccct ccccagctac tcgggaggct gaggcaggag aatcgcttga
     3661 actcaggagg tggaggttgc ggtgagccaa gatcgtgcca ctgcactcca gcctgggcta
     3721 caagattgaa aagatcgaaa ctctgtctca aacaaaaaaa aaaaaattca aggctgtttc
     3781 caaggcagcc tcaaaaagag cctggtgccc agggggtcct tcgtttctgt gtggctgcag
     3841 aggccaggag tgcagtgact gtctcactgc ctagtggttg tggctcacat cctgccctga
     3901 tggagagggg ggcctgtcgt ccaaccctct ctgaaaaact gcagtagact ttaccatttc
     3961 aggccccacc taatgttctt tccttccttc cccctacatt cttcccgccc ctttcatagt
     4021 taagatgcat aagctgagca ataaccccac ttcctgattt ccctgaaata tgagcccaga
     4081 agcagcaggt gacagggagc ttcccttacc ctggggtggt ggcacacaga ccacctcctg
     4141 tcctgtcccc tgcaggtagt attcacagtg tggtgttacc tgggaggagg gaggaaggag
     4201 ctgagatgaa ggagattcag gtaaacagta gccacagtgg ccaggacccc cttcctgagg
     4261 atccctgtcc ttcctcgcag caggtgctta gtcctctcct agggagaagc acggaaagat
     4321 tcctcaaggc ctcagtccca tgtccaaggc atacctaggt tagaaatgtc ctttacttgt
     4381 ttctcagtta ctatttctcc tcttcctccc tccccctgcc ttctcttggc tgtcatttag
     4441 ctctctggcc cacagaaata ctccatccaa ggagctggtc ctcagtcagc ctgatgagga
     4501 caggtcagtg gccaaccctt ttgccccagt ccttcatctg gagacagtca catagtcacg
     4561 tcaacagttc acccaaagag aagaggtggg gcctggcttc tcccacaggg cacagcctaa
     4621 ctatggagac ccagggctcc ttcctgctgc actaggcctg tgctctccct attgccttca
     4681 ggtggtgtga tcccggcttc ctcacagagc ccttttttcc ttctgcccag ctccatccca
     4741 ccagagtttc tacccccgct gaggcatctc ctgggcacag accaccacac tctaagccgg
     4801 ctggcctggg agttagggtc ctgcccacct cacctgggag ttggggtcct gcccacctgg
     4861 agtttagcac gctggtcgct cactttgctt tggtctgcac acctggtgtg tgcatgtgta
     4921 tactgcttgt gccatctgtg tacccctctc cctggagtac acttgtggtc acactacagt
     4981 ggggacatca agaatgcaat atttatggat tgctgcatga ttcttaaaaa tgaataaaac
     5041 tgtttacaag ggaa
//
