LOCUS       NM_173557               8745 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ring finger protein 152 (RNF152), mRNA.
ACCESSION   NM_173557
VERSION     NM_173557.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8745)
  AUTHORS   Zhu,D., Nie,Y., Zhao,Y., Chen,X., Yang,Z. and Yang,Y.
  TITLE     RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung
            Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression
  JOURNAL   Am J Pathol 193 (10), 1603-1617 (2023)
   PUBMED   37717980
  REMARK    GeneRIF: RNF152 Suppresses Fatty Acid Oxidation and Metastasis of
            Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10
            Expression.
REFERENCE   2  (bases 1 to 8745)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 8745)
  AUTHORS   Okamoto,T., Imaizumi,K. and Kaneko,M.
  TITLE     The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186,
            RNF182 and RNF152, in Disease and Biological Function
  JOURNAL   Int J Mol Sci 21 (11), 3921 (2020)
   PUBMED   32486221
  REMARK    GeneRIF: The Role of Tissue-Specific Ubiquitin Ligases, RNF183,
            RNF186, RNF182 and RNF152, in Disease and Biological Function.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8745)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 8745)
  AUTHORS   Deng,L., Chen,L., Zhao,L., Xu,Y., Peng,X., Wang,X., Ding,L.,
            Jin,J., Teng,H., Wang,Y., Pan,W., Yu,F., Liao,L., Li,L., Ge,X. and
            Wang,P.
  TITLE     Ubiquitination of Rheb governs growth factor-induced mTORC1
            activation
  JOURNAL   Cell Res 29 (2), 136-150 (2019)
   PUBMED   30514904
REFERENCE   6  (bases 1 to 8745)
  AUTHORS   Deng,L., Jiang,C., Chen,L., Jin,J., Wei,J., Zhao,L., Chen,M.,
            Pan,W., Xu,Y., Chu,H., Wang,X., Ge,X., Li,D., Liao,L., Liu,M.,
            Li,L. and Wang,P.
  TITLE     The ubiquitination of rag A GTPase by RNF152 negatively regulates
            mTORC1 activation
  JOURNAL   Mol Cell 58 (5), 804-818 (2015)
   PUBMED   25936802
  REMARK    GeneRIF: A mechanism for regulation of mTORC1 signaling by
            RNF152-mediated K63-linked polyubiquitination of RagA.
REFERENCE   7  (bases 1 to 8745)
  AUTHORS   Zhang,S., Wu,W., Wu,Y., Zheng,J., Suo,T., Tang,H. and Tang,J.
  TITLE     RNF152, a novel lysosome localized E3 ligase with pro-apoptotic
            activities
  JOURNAL   Protein Cell 1 (7), 656-663 (2010)
   PUBMED   21203937
  REMARK    GeneRIF: RNF152 is a lysosome localized E3 ligase with
            pro-apoptotic activities
REFERENCE   8  (bases 1 to 8745)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122758.1 and AC105094.6.
            
            On Nov 23, 2018 this sequence version replaced NM_173557.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB227448.1, SRR1803612.152601.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312828.4/ ENSP00000316628.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AK122758.1         753-1134
            383-1179            AC105094.6         37858-38654
            1180-1741           AK122758.1         1932-2493
            1742-8745           AC105094.6         39217-46220
FEATURES             Location/Qualifiers
     source          1..8745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..8745
                     /gene="RNF152"
                     /note="ring finger protein 152"
                     /db_xref="GeneID:220441"
                     /db_xref="HGNC:HGNC:26811"
                     /db_xref="MIM:616512"
     exon            1..213
                     /gene="RNF152"
                     /inference="alignment:Splign:2.1.0"
     exon            214..8745
                     /gene="RNF152"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..960
                     /gene="RNF152"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF152"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF152"
                     /protein_id="NP_775828.1"
                     /db_xref="CCDS:CCDS11978.1"
                     /db_xref="GeneID:220441"
                     /db_xref="HGNC:HGNC:26811"
                     /db_xref="MIM:616512"
                     /translation="METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRT
                     SQKDVRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYML
                     PLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGV
                     VKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG"
     regulatory      8720..8725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF152"
                     /note="hexamer: ATTAAA"
     regulatory      8729..8734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF152"
                     /note="hexamer: CATAAA"
     polyA_site      8738
                     /gene="RNF152"
     polyA_site      8745
                     /gene="RNF152"
                     /note="major polyA site"
ORIGIN      
        1 acccgctcca gccccgtctg cccaggaggg cgcttggatt tccttctccg cggcgcgtat
       61 ctaacccttc ctgcatgtat ttcactgcag gctgaagaaa gctcagtctc aattgtgttt
      121 cctgcctgtc agcctcttgc ctcctaaacg tgtaccattt ccacttgatg tcatcacgca
      181 gaaggggtga aagagactcg gtgacagata cagaaatgaa cacacctgtg agtactggat
      241 gcctgtgagc ttgccattac ctgcactgca aagacacagg gcggtggcct ctgagaagca
      301 gctccttccc cttcaccttg gccttgccct tcctgctcac ggtccaccat ggagacgctg
      361 tcccaggact ctctgctgga atgtcagatc tgtttcaatt actacagccc ccggcgcagg
      421 cccaagttgc tggactgcaa gcacacctgc tgttcagtgt gcctgcagca gatgaggacc
      481 agccagaagg atgtgcggtg cccctggtgc cgcggtgtca ccaagctgcc tcccggcttc
      541 tccgtgtcgc agctcccgga cgacccggag gtcctggctg tcatcgccat tccacacact
      601 tccgaacaca ccccggtctt catcaaactt cccagcaatg ggtgctacat gctgcccctg
      661 cccatctcca aggagcgtgc gctgctgccc ggagacatgg gctgccgcct gctgcccggg
      721 agccagcaga agtccgtcac cgtggtgacc atccctgctg aacagcagcc tctgcaaggt
      781 ggggctcccc aggaggcggt ggaggaggag caggacaggc ggggcgtggt gaaaagctcc
      841 acctggtcgg gggtgtgcac tgtcatcttg gtggcttgcg tcttggtctt cctcctcggc
      901 atcgtgcttc acaacatgtc ttgcatttct aagcgcttca ctgtgatatc ctgtggctga
      961 agagggctgc agggaagtct cttgtgggtg ccaacttagg ggttgagcag gttgatgatg
     1021 agatcccagt gagaagatgg ggggcaacac tgaccatttg gtgctgagcg ctggcctctg
     1081 ggttgcctct tgattacccc aagacagaca caaagggcag aaggtgcggt ctcaacaaga
     1141 taccaggtga attgttctga gtgttgatgg caacagcttg gaagatgatt gcatgcatcc
     1201 tcataatcat gtattcaatg gactgtaatt tatgattttt caaaatcatg ttacaagata
     1261 gacatattct acttagacgt taaactgtac aagtgcgtac aatgtgacct tctctaaatg
     1321 cggtagattc aaacaaagat gctctgtaga caagtagaat taaacctgcg aatccgtgta
     1381 aaaattcagt gaagacatgc actgctggct tctttatttt ttttttcttt ttattgaaac
     1441 ccagtcttca tttagttgct aaggctttta atacattttg aatggcacca aaacaaaata
     1501 agtcaaaatg gacagtcatt ttatttggag gaaatatttg aacaagtgtc tccaatgtgt
     1561 tgtgttttgt catgaacctt cattttcttc acttgtaatt agagcttgct acgtgtttat
     1621 ggaactgaaa gctcaacagg ggagcaataa accgagaaat catgagaaat gtctaatccc
     1681 atgggaaaac ctgtatgccg attttcctca agccatctca caaaataaga atttcaaatg
     1741 taaatattgt gtatttgtgt gtgtatgtgt gtgtgtctaa tttgatttac ctcaggtgtt
     1801 tgagtctttg ctgaagaatc ctgggatgaa gacttcattg ggcatgaatg agtcaagtct
     1861 ctgaagcggt ggccacttct tggacatctt gacccagcga gtggtctcct acacgtcacc
     1921 tgcaacactc gctcctcttc tgtgtattta agtcctgcat tttgtaagag gcaaatggag
     1981 agtaacagaa gagtgtcttt tctcctggtt ttggagtctt gcactggcca tgagtgttgt
     2041 gactgatggt caacccaggc gggcatttta ataaatggcc tgtgattctt ttttgaaaga
     2101 tgctcttcca caagagttaa gccagttaga attcctgttt cctcttgttg atatgagaga
     2161 agatctcctg tattttaaca cgtttttacc aagaaaggtg gcaaggtaaa ctaacagctc
     2221 aaattcccaa tataagtgga ccagttcctc ataaactgtc aaatgttctt aaatgtgtaa
     2281 tgatctatag atgctcatga agaaagatct gctacaagta cgtgataaat tcctatccct
     2341 gggtgcatgt gcattcagaa atagctgtga gctttacagc tctcatctaa cttcttttat
     2401 ggaattcatg aagcaagtgg tatgtgacaa ggactccact tataaatata actgttttta
     2461 tgttccactg aatccctgaa aatggtgagg agggtggggg gaagtgaagg aaagacaagc
     2521 agggctaatt ccaaaaagca aggctagaaa atagccctgt gaggtcaaga caatttaatt
     2581 tatttacatg ctgtctgtta tcttcaagca gcacaaaata tgcatataaa agtgatggaa
     2641 ttaatgtgaa ataaaacaaa aatataatgg ctagaataca aagctaatac tgctaattgg
     2701 catgagaatt caacataaaa ttgtgagctc tgatttttca aattgatcat aaaaccttta
     2761 ggaaatgtat ttgaaagctc aaaatagaaa ttaggttaaa atgccatttt attgtgtaag
     2821 ctcttgggca ttatacaaca aataatctag gatttatttg gtattaataa tttaggtgtc
     2881 atattagctg aatactatcc tctattacat aacataatat actgttgggt tagtgtcaat
     2941 ttctcaaact ctcccaggct gccataatgc atgtctgacc taatttctat ttctcttgga
     3001 ggaaaataca cacacacaca caccacagaa gtgttgcatt aagaatgcta catttcgaat
     3061 agactttgcc cttgcaattt taagctatgc catattcaga ttaattttgt gagtgatatc
     3121 tgcatatgtt tctgtacagt gtgaaatgac tgaccctgta gtatagtacg tgatagagtt
     3181 ctacttgtta aagtaggtta gatatagaca ctaatgtgtg tgatgatagt gtcctgtgtt
     3241 tcttagtgca aatctgtaga gtaaaaatgt ccatagaact tttacttaaa aacaatccca
     3301 tgctagagtt gccattaagc agtgcaaaat taatcggctg tatggtagat tcttgacctt
     3361 aaatttaaca acaacaacca aaatcagatt ttttttgtga gtcttactga cctaagaaac
     3421 attgtttaaa ttgtttaaat ggatctgctt gcagttattt gtgtacctgt ttgttggggt
     3481 gtgcattctt gtgtatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgagagaga
     3541 gagagagaga gagaatctca gtctcccaga tagaatttta taggcttaat gatgttttaa
     3601 tgttgcttgg catcccattg ctctggcctc ttctggcatt taccaatgac ccttaacaaa
     3661 cacatctacc catgtgacca aagtccactg acacaagagg ccaggattca tacttgcaca
     3721 ttaatgaaaa gtcacaactg gaaagcacag aaagagctga aagcagcctc cggtggcttc
     3781 attttgtaga tgagtccgtt ttgtaattct gcagaaaggg ggggatatga acttcgcact
     3841 gcagtgtctt cttgctccat cctaggtctg tctatatctc tatctggcta tgatcctttc
     3901 tagggttgat gaataccctt tactgagtca actattgctt taaagaattt tttttgtagg
     3961 tttatgtact cattttagtt agcatctacc tctctgggaa aatgaaagga gggttgactt
     4021 agggatgagt atagatgttg aaagacaact atcaaaccat gtggtttgaa tttttaaaat
     4081 tgtaaaacat tggtgtccaa acctcccacc ccacttgtat gtaaaggaca gtgagtgttg
     4141 tataaatagt aaactataag aagcatgaat tttcatcttt attaatgatc ttgaaataag
     4201 gaagagaatg cttaatatgt taagtagagc caagaatgct actaagaagc attgtctttg
     4261 gaaaaatttt gtataatgac ttggggcata agttgtgatg aaaaggcaac ttggtttttg
     4321 gttccagtca tacttaatga tcagaaagct ctaagatgtt ttctttaaaa atagaattaa
     4381 gtttaatttt ttgcatggct tacagattgg gtcccttgaa ggttaaacca tgtgatggta
     4441 taacctgtga gatcttctag attggcactg ttcaataggg ctttctgtga tgatggaaat
     4501 gctcgaaaac ctgtgccgtc tggtacggta gccaccaggc acattgactt ttaggcagtt
     4561 aaaatggggt tactacaagg gaagaactgg atttcaaatt ttatttaatt ttaattagct
     4621 taaatttaaa tagccctatg tgtctagtgg ctgccatatt gaacgatgca gttctgggtg
     4681 atagcgcttg gggatccagc atcaaggtat taatggagta acagtgaggc taaggtgaga
     4741 gtttgtgggc tagtgacatg cagttggcaa aaggcaaaac attcctttct gggcttaaaa
     4801 agtatgtgat ctcaagtatg acagtaaaaa ttcattgttg ccctttggaa ctgttgctta
     4861 tagattttag gccaaggaat gatcagtgaa gcttaaagaa tgctttatta agcccctttt
     4921 ctgggatcat tagctgcatg ttaacctatt gtccaaaaat agtagttaga cagtacctgt
     4981 aaaacgtttg acttgcaagc tatgcatgat ctgtactgtg aaattgtgtc tagggtcttg
     5041 tggccaaaaa gtaaatgtta caggaaaaaa aaagcctaat gaaatccctg ttcacttcca
     5101 gtatcctatc caaacttcat tgctgtatta gtaaggtgca aatataagag caagcatgtt
     5161 ttgcagtgtt cagactggtt ttgtttgccc ttgaagttgg ccagcttgtc gttgtatttg
     5221 gtgtgggcat atgtgggcat catttttcag atgccaaact aaaatgtagg tagtattttt
     5281 agaatgagat ttgacattgt tttagtgtct ttctttttta agcaaaaatt tcagttatcc
     5341 ctgaaagagt tgaagatttg aagctttgca caaaagcact ttttttaaca gtaaaaaata
     5401 ctgcccatga aatttaaaga cttgaagttt actaaagcta caataattac tttttagcta
     5461 aataaaagga agcagaaaat tcagtttgag atatatttcc tataaagacc agattcttac
     5521 tgataatctg gtatttattc cagtctagat tttgatttta agagttccca tccctttatt
     5581 tgaaaactta tgttgtttca aaattggtta gtctgctttt cattgttttc caaatggaat
     5641 atatacaaaa tacatttact tcattttagc agaaatgggt tgattttttt tttctagaac
     5701 tcatcaatgt gcaagacttt ccttcttagc ttgcctttaa aaatcattta attttttttt
     5761 ttttgccaag atactaatct ttctttagcc ttaataggaa gatagaagtt caaaagttat
     5821 cggtgcaaaa ggagtgatac acaaaagact tcaatttcta tcttttctca gaaaagtgat
     5881 gctgcccacc agtcagcatt ttgtttccac ataagaagtg tcaggtagtc agtctgtcat
     5941 ccctgactta gatagagaag ctgttccttg acatttccat cattctcagt aaattgtcac
     6001 ctacaaggta attcttacca aaacagaaac tattgagaat aataagatag tcgagataat
     6061 tcagtagctg ttttgaaagt agtagtctat ttaaaaagca acgatgttca gttgctggat
     6121 tttgttcaac atgagacact tatttattta tttatttatt tatgagatgg agttttgctc
     6181 ttggtgccca ggccagagtg caatggcatg atctcagctc actgcaacct ccgcctccca
     6241 ggttcaagct attctcctgc ctcagcctcc tgagtagctg ggattatagg catgcgcctc
     6301 catgcccagc taattttgta ttttttaaag tagagacggg gtttctccat gttggtcagg
     6361 ctggtctcca acttctgact tcaggcgatc cacccgcctc ggcctcccaa agtgctggga
     6421 ttacaggcat gggccactgc acccagccaa catgaaacac ttctaaaaga taagtggaaa
     6481 ttcaagccat tgatttttct gacacaactg acttactaca cacacacaca cacacacacc
     6541 acgatttagc tgtaattgga gttaaaattc agtaaaaaac tgttattagt catgttttcc
     6601 aatttgtgag ttatacaata ttggattaga tgctaatttc ttaactgttg ctatgggctg
     6661 catacattat gtcaaactaa ctacctttgg gagtgtctat ataaacactt gaaacttttc
     6721 aaatatatga agaggtaggt tctactgtat acattttatt ggaaagccat taatcattga
     6781 agaacttaag caggtggggc atttaatttc ttccaaatac cttatttttt ggatctgctc
     6841 aagtggttag ggcgagtgca ccattattcc cgaatccctg caatttggtt cccatttttc
     6901 tgcacaaatt ttcttgctca gtcgagccaa tgactttttt tttttttttt tttttcagga
     6961 ttcactgcct ggggtatccc actatatata tctcacctat gatgtagtgg tgcttgaaat
     7021 actcatctca ttagctcgat tttattattc taatctaagg ttttttatat tattcatact
     7081 atgatatttt tagggacaat cagtaatatt tggggcagag tactgaggga cctcttgaag
     7141 tctgcaacag catgcatttt ctttgttttt gtgggagtgc ttccctgtag ctgtctttgt
     7201 tctagaacac tgctccaaat ttatttccat gggatgtagg gctagtagcc catgtgaaag
     7261 tcttctgtaa tctccttggg gtgtgagtta ttgggttatt ctaacaggag ttttccaaag
     7321 ggatggccca tttttaattc aacatttgct ttttgaaaat ccagaagtag acagttggat
     7381 ataatagtgg tggaagagca tgggctgtaa gcagaaggaa atagagatga caaatgcctc
     7441 ttaaagggga tctagttgat acctctgtta aatagtggga gaacacagta gctggtacct
     7501 tacactgtgc tttaggaaaa tcctatgagg atttcattta caaatcctca taggattttc
     7561 tgggttgagg gacaatgcaa ctattaagta gagggagagg gagagggaaa gggagacatg
     7621 aagcactggg tctatgtgaa gggacaggca gatataccca aagagggaga aaatacttaa
     7681 taaaggaaga gtatagctgc aaaacaagac atataggagc tgaaggccag atatggcaga
     7741 aaccagctgg agaaagaagc acaggacaac taggacaact tagtcaagca caatctgtca
     7801 ttccagtacg gactaccaag ttcaattcag gatgcttcag ttgaagacat gtggggtaat
     7861 gtgctcagct catgagggtc caaggagtcc ccattttccc tatcacccta tcctatgctc
     7921 gtggtttgga ttgttagcac actaggcaat ttcagagtcc gctctagagt tggttgccac
     7981 gtcagtgcag acagactcta gaatcctctt aaccatggaa tgcaaggcct gttcctgtgg
     8041 atctatcctg acttgagtat gtcagtactg ttgggaaaat gagttcaaga atatttcagt
     8101 ttatatatcc tggttgccgt catatatttt ttcatttcac cacttgtttg tgtttgcctc
     8161 actcaacagt catgggtgta gaagctggtt tcagcttggg gctgttacaa actccctaca
     8221 taagccatgt agctgcaatc cagggttcct cccaccctac ggctttagcg gtgggttctc
     8281 tggccctctt gataacaaat actccagtct aatggctata ttaatgctgc tcagaggcta
     8341 ttaactcaaa tccttgatgt gtttcattta caattatgtg gattatttat tttaggagct
     8401 tttttttttt tttttttttt ttttaagggc caaatagccc tacagataaa tgagctgctg
     8461 ggctgtgtag aaaatattgt ccaaatgttg ccaaatattg acttcgtaaa ggggatatca
     8521 agctgctgtt tataaatctg aatgtcttaa aagcattctt gcttgctctc tctgttatag
     8581 atggtgtctt agccagtcct gagttttcca atgaacccaa ttttaatata tggtattttt
     8641 gtatgccaaa ctggtgtctt gtcctttgta tatgtggtaa tgttgatttt atgactaccg
     8701 taaaaacaca tttgctatga ttaaagttca taaaatgatt tcaaa
//
