LOCUS       NM_173647               2953 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 149 (RNF149), mRNA.
ACCESSION   NM_173647
VERSION     NM_173647.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2953)
  AUTHORS   Hong,S.W., Jin,D.H., Shin,J.S., Moon,J.H., Na,Y.S., Jung,K.A.,
            Kim,S.M., Kim,J.C., Kim,K.P., Hong,Y.S., Lee,J.L., Choi,E.K.,
            Lee,J.S. and Kim,T.W.
  TITLE     Ring finger protein 149 is an E3 ubiquitin ligase active on
            wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF)
  JOURNAL   J Biol Chem 287 (28), 24017-24025 (2012)
   PUBMED   22628551
  REMARK    GeneRIF: Data show that RNF149 (RING finger protein 149) interacts
            with wild-type BRAF.
REFERENCE   2  (bases 1 to 2953)
  AUTHORS   Low,S.K., Kuchiba,A., Zembutsu,H., Saito,A., Takahashi,A., Kubo,M.,
            Daigo,Y., Kamatani,N., Chiku,S., Totsuka,H., Ohnami,S., Hirose,H.,
            Shimada,K., Okusaka,T., Yoshida,T., Nakamura,Y. and Sakamoto,H.
  TITLE     Genome-wide association study of pancreatic cancer in Japanese
            population
  JOURNAL   PLoS One 5 (7), e11824 (2010)
   PUBMED   20686608
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2953)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA383672.1, AC073643.3 and AC013722.8.
            
            On May 17, 2019 this sequence version replaced NM_173647.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.68921.1,
                                           SRR1803617.105687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751, SAMN03267764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295317.4/ ENSP00000295317.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               DA383672.1         16-628
            614-824             AC073643.3         339-549             c
            825-893             AC013722.8         204998-205066       c
            894-976             AC013722.8         199957-200039       c
            977-1073            AC013722.8         197065-197161       c
            1074-1272           AC013722.8         192843-193041       c
            1273-2953           AC013722.8         186585-188265       c
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2953
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /note="ring finger protein 149"
                     /db_xref="GeneID:284996"
                     /db_xref="HGNC:HGNC:23137"
     exon            1..573
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1316
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase RNF149; DNA
                     polymerase-transactivated protein 2; RING-type E3
                     ubiquitin transferase RNF149"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF149 precursor"
                     /protein_id="NP_775918.2"
                     /db_xref="CCDS:CCDS2051.1"
                     /db_xref="GeneID:284996"
                     /db_xref="HGNC:HGNC:23137"
                     /translation="MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNI
                     EYVDPQTNLTVWSVSESGRFGDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPG
                     GRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVV
                     IMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAW
                     LIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENF
                     KVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGDVQEMPAPES
                     PPGRDPAANLSLALPDDDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLEAGRSD
                     SRHGGPIS"
     exon            574..824
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..893
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..976
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1073
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1272
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..2953
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1991..1996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /note="major polyA site"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /note="hexamer: AATAAA"
     polyA_site      2465
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /note="hexamer: AATAAA"
     polyA_site      2616
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
     regulatory      2752..2757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
                     /note="hexamer: AATACA"
     polyA_site      2774
                     /gene="RNF149"
                     /gene_synonym="DNAPTP2"
ORIGIN      
        1 gaccccgcct cagtcttcca gggcggcggt gggtgtccgc ttctctctgc tcttcgactg
       61 caccgcactc gcgcgtgacc ctgactcccc ctagtcagct cagcggtgct gccatggcgt
      121 ggcggcggcg cgaagccagc gtcggggctc gcggcgtgtt ggctctggcg ttgctcgccc
      181 tggccctgtg cgtgcccggg gcccggggcc gggctctcga gtggttctcg gccgtggtaa
      241 acatcgagta cgtggacccg cagaccaacc tgacggtgtg gagcgtctcg gagagtggcc
      301 gcttcggcga cagctcgccc aaggagggcg cgcatggcct ggtgggcgtc ccgtgggcgc
      361 ccggcggaga cctcgagggc tgcgcgcccg acacgcgctt cttcgtgccc gagcccggcg
      421 gccgaggggc cgcgccctgg gtcgccctgg tggctcgtgg gggctgcacc ttcaaggaca
      481 aggtgctggt ggcggcgcgg aggaacgcct cggccgtcgt cctctacaat gaggagcgct
      541 acgggaacat caccttgccc atgtctcacg cgggaacagg aaatatagtg gtcattatga
      601 ttagctatcc aaaaggaaga gaaattttgg agctggtgca aaaaggaatt ccagtaacga
      661 tgaccatagg ggttggcacc cggcatgtac aggagttcat cagcggtcag tctgtggtgt
      721 ttgtggccat tgccttcatc accatgatga ttatctcgtt agcctggcta atattttact
      781 atatacagcg tttcctatat actggctctc agattggaag tcagagccat agaaaagaaa
      841 ctaagaaagt tattggccag cttctacttc atactgtaaa gcatggagaa aagggaattg
      901 atgttgatgc tgaaaattgt gcagtgtgta ttgaaaattt caaagtaaag gatattatta
      961 gaattctgcc atgcaagcat atttttcata gaatatgcat tgacccatgg cttttggatc
     1021 accgaacatg tccaatgtgt aaacttgatg tcatcaaagc cctaggatat tggggagagc
     1081 ctggggatgt acaggagatg cctgctccag aatctcctcc tggaagggat ccagctgcaa
     1141 atttgagtct agctttacca gatgatgacg gaagtgatga cagcagtcca ccatcagcct
     1201 cccctgctga atctgagcca cagtgtgatc ccagctttaa aggagatgca ggagaaaata
     1261 cggcattgct agaagccggc aggagtgact ctcggcatgg aggacccatc tcctagcaca
     1321 cgtgcccact gaagtggcac caacagaagt ttggcttgaa ctaaaggaca ttttattttt
     1381 tttactttag cacataattt gtatatttga aaataatgta tattatttta cctattagat
     1441 tctgatttga tatacaaagg actaagatat tttcttcttg aagagacttt tcgattagtc
     1501 ctcatatatt tatctactaa aatagagtgt ttaccatgaa cagtgtgttg cttcagacta
     1561 ttacaaagac aactggggca ggtactctaa tataaaggac aggtggtgtt tctaaataat
     1621 tggctgctat ggttctgtaa aaaccagtta attctatttt tcaaggtttt tggcaaagca
     1681 catcaatgtt agactagttg aagtggaatt gtataattca attcgataat tgatctcatg
     1741 ggctttccct ggaggaaagg ttttttttgt tgtttttttt ttaagaactt gaaacttgta
     1801 aactgagatg tctgtagctt ttttgcccat ctgtagtgta tgtgaagatt tcaaaacctg
     1861 agagcacttt ttctttgttt agaattatga gaaaggcact agatgacttt aggatttgca
     1921 tttttccctt tattgcctca tttcttgtga cgccttgttg gggagggaaa tctgtttatt
     1981 ttttcctaca aataaaaagc taagattcta tatcgcacat gagcattaag ttcttcattg
     2041 ccttgttaag gaaaatgagt aggcagactc agaatctgtt atattgattt cagttacaat
     2101 ttaatcttta caattaaaag ggcgaaagat gtagaatttt agtttttgtt gttgactcga
     2161 aataaccagt tttcttgatt agagtttaag cagatttaat accatgacct tgcttaaccg
     2221 tttcttcttt tttacttgct tgctgttctt ttgggtcaaa ggagcaggct aatgcaaagc
     2281 ttttggagac tgctaagtgt taaaaagtga ttaaacacac actctgctat tttttcactt
     2341 cttggaggta gaagtcgagt atgaggcagt tattttttag agtgtggaat tatagtcttt
     2401 ccttgctcct agttattctg tatatcttta ctttgtaggt aaaaataaat gtttatttaa
     2461 aacaattttt aaaattataa atttattttt atagccatat gtaggatata aagatttata
     2521 tagattattt tctcaagcta cttaatgctt taattctagc tactcatcat gaaatagtaa
     2581 acagttttac tgaaataaac tctacagaca gatgcagtat gaggagctat tgaagtagaa
     2641 aatgtatttc gctttgcaca ctgagttggt tttagcagac aacctcaagt aggtttccat
     2701 aacagccatt acctttgaaa tctaccttct gtagtttatt ataaatagga aaatacatcc
     2761 tgattctgta gcaagtagat tgtttgctct ttgtctttaa gaaatactag gagggccggg
     2821 cgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc ggatcacgag
     2881 gtcaggagat cgagaccatc ccggctaaaa cggtgaaacc ccgtctctac taaaaataca
     2941 aaaaattagc cgg
//
