LOCUS       NM_198085               1255 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens ring finger protein 148 (RNF148), mRNA.
ACCESSION   NM_198085
VERSION     NM_198085.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1255)
  AUTHORS   Liu,S., Zhuo,L., Chen,L., He,Y., Chen,X., Zhang,H., Zhou,Y., Ni,Z.,
            Zhao,S. and Hu,X.
  TITLE     E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal
            cancer by ubiquitination-mediated degradation of CHAC2
  JOURNAL   Carcinogenesis 45 (4), 247-261 (2024)
   PUBMED   38190483
  REMARK    GeneRIF: E3 ubiquitin ligase RNF148 functions as an oncogene in
            colorectal cancer by ubiquitination-mediated degradation of CHAC2.
REFERENCE   2  (bases 1 to 1255)
  AUTHORS   Liu,Y.Q., Tao,D.C., Liao,S.Y., Yang,Y., Ma,Y.X. and Zhang,S.Z.
  TITLE     Identification of a novel human testicular interstitial gene,
            RNF148, and its expression regulated by histone deacetylases
  JOURNAL   Genet Mol Res 12 (3), 4060-4069 (2013)
   PUBMED   24089095
  REMARK    GeneRIF: We identified a novel human testicular interstitial gene
            and observed that histone deacetylases regulate RNF148 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1255)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029264.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198085.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189667.152867.1, BC029264.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434824.2/ ENSP00000388207.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1255              BC029264.1         46-1300
FEATURES             Location/Qualifiers
     source          1..1255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..1255
                     /gene="RNF148"
                     /note="ring finger protein 148"
                     /db_xref="GeneID:378925"
                     /db_xref="HGNC:HGNC:22411"
     exon            1..1255
                     /gene="RNF148"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1090
                     /gene="RNF148"
                     /codon_start=1
                     /product="RING finger protein 148 precursor"
                     /protein_id="NP_932351.1"
                     /db_xref="CCDS:CCDS47692.1"
                     /db_xref="GeneID:378925"
                     /db_xref="HGNC:HGNC:22411"
                     /translation="MSFLRITPSTHSSVSSGLLRLSIFLLLSFPDSNGKAIWTAHLNI
                     TFQVGNEITSELGESGVFGNHSPLERVSGVVALPEGWNQNACHPLTNFSRPKQADSWL
                     ALIERGGCTFTHKINVAAEKGANGVIIYNYQGTGSKVFPMSHQGTENIVAVMISNLKG
                     MEILHSIQKGVYVTVIIEVGRMHMQWVSHYIMYLFTFLAATIAYFYLDCVWRLTPRVP
                     NSFTRRRSQIKTDVKKAIDQLQLRVLKEGDEELDLNEDNCVVCFDTYKPQDVVRILTC
                     KHFFHKACIDPWLLAHRTCPMCKCDILKT"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF148"
                     /note="hexamer: AATAAA"
     polyA_site      1255
                     /gene="RNF148"
                     /note="major polyA site"
ORIGIN      
        1 aatctactaa atattaaaat actggaagga gcaagatagc tttgatccag ggagaccttt
       61 tccatttatg tgctttagta atctgccgcc aacaagctat cttctttatg ttcttctaca
      121 actgatgttg ttttgttttc tcatgtttgt ctcttaatag acaaatggag gcatgagctt
      181 ccttagaatt accccttcga cgcatagttc tgtttcatct ggacttttga ggcttagtat
      241 ctttctacta cttagctttc ctgactcaaa cggaaaagcc atttggacag ctcacctgaa
      301 tataacattt caggttggaa atgagatcac atcggaatta ggagagagtg gagtgttcgg
      361 gaatcattct cctctggaaa gggtgtctgg tgtggtggca cttcctgaag gatggaatca
      421 gaatgcctgt catcctttga ccaatttcag caggcccaaa caggcagact catggctggc
      481 cctcatcgaa cgtggaggct gtacttttac acataaaatc aacgtggcag cagagaaggg
      541 agcaaatggg gtgatcatct acaactatca aggtacgggc agtaaagtat ttcccatgtc
      601 tcaccagggg acggaaaata tagtcgcggt gatgataagc aacctgaaag gcatggaaat
      661 tttgcactcg attcagaaag gagtctatgt gacagtcatc attgaagtgg ggagaatgca
      721 catgcagtgg gtgagccatt acatcatgta tctatttacc ttcctggctg ccacaattgc
      781 ctacttttac ttagattgcg tctggagact tacacctaga gtgcccaatt ctttcaccag
      841 gaggcgaagt caaataaaga cagatgtgaa gaaagctatt gaccagcttc aactgcgagt
      901 tctcaaagaa ggggatgagg aattagacct aaatgaagac aactgtgttg tttgctttga
      961 cacatacaaa ccccaagatg tagtacgcat tttaacttgc aaacattttt tccataaggc
     1021 atgcattgac ccctggcttt tagcccatag gacatgtccc atgtgcaagt gtgacatcct
     1081 gaaaacttaa gaaatctgga gaattttctg aagatgtaac cagatctttc caaatacaaa
     1141 gattagataa attgtcttat tgtactttat gtagagagaa aatttcagct tctctaccca
     1201 agtatgaaca agggtgaaat ttgtgtttta aaaataaaac tccttatcat gccca
//
