LOCUS       NM_001242850            2119 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ring finger protein 146 (RNF146), transcript variant
            9, mRNA.
ACCESSION   NM_001242850
VERSION     NM_001242850.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Li,W., Han,Q., Zhu,Y., Zhou,Y., Zhang,J., Wu,W., Li,Y., Liu,L.,
            Qiu,Y., Hu,K. and Yin,D.
  TITLE     SUMOylation of RNF146 results in Axin degradation and activation of
            Wnt/beta-catenin signaling to promote the progression of
            hepatocellular carcinoma
  JOURNAL   Oncogene 42 (21), 1728-1740 (2023)
   PUBMED   37029301
  REMARK    GeneRIF: SUMOylation of RNF146 results in Axin degradation and
            activation of Wnt/beta-catenin signaling to promote the progression
            of hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Xu,Y.R., Shi,M.L., Zhang,Y., Kong,N., Wang,C., Xiao,Y.F., Du,S.S.,
            Zhu,Q.Y. and Lei,C.Q.
  TITLE     Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2122805119 (2022)
   PUBMED   35733260
  REMARK    GeneRIF: Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation.
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Chandrakumar,A.A., Coyaud,E., Marshall,C.B., Ikura,M., Raught,B.
            and Rottapel,R.
  TITLE     Tankyrase regulates epithelial lumen formation via suppression of
            Rab11 GEFs
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   34128958
  REMARK    GeneRIF: Tankyrase regulates epithelial lumen formation via
            suppression of Rab11 GEFs.
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Nie,L., Wang,C., Li,N., Feng,X., Lee,N., Su,D., Tang,M., Yao,F. and
            Chen,J.
  TITLE     Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146
            Targeted for Degradation
  JOURNAL   Mol Cell Proteomics 19 (12), 2015-2030 (2020)
   PUBMED   32958691
  REMARK    GeneRIF: Proteome-wide Analysis Reveals Substrates of E3 Ligase
            RNF146 Targeted for Degradation.
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Zhang,Y., Liu,S., Mickanin,C., Feng,Y., Charlat,O., Michaud,G.A.,
            Schirle,M., Shi,X., Hild,M., Bauer,A., Myer,V.E., Finan,P.M.,
            Porter,J.A., Huang,S.M. and Cong,F.
  TITLE     RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin
            degradation and Wnt signalling
  JOURNAL   Nat Cell Biol 13 (5), 623-629 (2011)
   PUBMED   21478859
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Menachem,T.D., Laitman,Y., Kaufman,B. and Friedman,E.
  TITLE     The RNF146 and ECHDC1 genes as candidates for inherited breast and
            ovarian cancer in Jewish Ashkenazi women
  JOURNAL   Fam Cancer 8 (4), 399-402 (2009)
   PUBMED   19517271
  REMARK    GeneRIF: Mutations in the coding regions of the RNF146 and ECHDC1
            genes do not contribute to the burden of inherited predisposition
            of breast cancer in Ashkenazi high risk women.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Gold,B., Kirchhoff,T., Stefanov,S., Lautenberger,J., Viale,A.,
            Garber,J., Friedman,E., Narod,S., Olshen,A.B., Gregersen,P.,
            Kosarin,K., Olsh,A., Bergeron,J., Ellis,N.A., Klein,R.J.,
            Clark,A.G., Norton,L., Dean,M., Boyd,J. and Offit,K.
  TITLE     Genome-wide association study provides evidence for a breast cancer
            risk locus at 6q22.33
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4340-4345 (2008)
   PUBMED   18326623
  REMARK    GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   von Rotz,R.C., Kins,S., Hipfel,R., von der Kammer,H. and
            Nitsch,R.M.
  TITLE     The novel cytosolic RING finger protein dactylidin is up-regulated
            in brains of patients with Alzheimer's disease
  JOURNAL   Eur J Neurosci 21 (5), 1289-1298 (2005)
   PUBMED   15813938
  REMARK    GeneRIF: Dactylidin may function early in the progression of
            Alzheimer's disease.
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027558.1 and AJ420549.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001242850.1.
            
            Transcript Variant: This variant (9) lacks two alternate internal
            exons, which results in the use of an upstream start codon,
            compared to variant 1. The encoded isoform (b) has a longer
            N-terminus than isoform a. Variants 8-10 encode the same isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027558.1, SRR14038192.1739080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368314.6/ ENSP00000357297.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2115              AK027558.1         16-2130
            2116-2119           AJ420549.1         2014-2017
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..2119
                     /gene="RNF146"
                     /note="ring finger protein 146"
                     /db_xref="GeneID:81847"
                     /db_xref="HGNC:HGNC:21336"
                     /db_xref="MIM:612137"
     exon            1..62
                     /gene="RNF146"
                     /inference="alignment:Splign:2.1.0"
     exon            63..172
                     /gene="RNF146"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1250
                     /gene="RNF146"
                     /EC_number="2.3.2.27"
                     /note="isoform b is encoded by transcript variant 9;
                     dactylidin; RING-type E3 ubiquitin transferase RNF146; E3
                     ubiquitin-protein ligase RNF146; iduna"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF146 isoform b"
                     /protein_id="NP_001229779.1"
                     /db_xref="CCDS:CCDS56449.1"
                     /db_xref="GeneID:81847"
                     /db_xref="HGNC:HGNC:21336"
                     /db_xref="MIM:612137"
                     /translation="MMAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTC
                     VHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNG
                     EYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEH
                     GRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSS
                     VRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSG
                     RVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRS
                     VAGGGTVSVSVRSRRPDGQCTVTEV"
     exon            173..2119
                     /gene="RNF146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1895..1900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF146"
                     /note="hexamer: AATAAA"
     polyA_site      1919
                     /gene="RNF146"
                     /note="major polyA site"
     regulatory      2097..2102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF146"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="RNF146"
ORIGIN      
        1 agctgcgggc tccgaggcca gagagaaaag actgcgaggt ggccgcagct gtggccggag
       61 agcacaaaga atgaaccagc agtggaagag aaaatactgt aagctggctg actgctggtg
      121 aagaaaatgc tttatttttg tggcaggcat ctgtgggatc tgtaatagaa atgatggctg
      181 gctgtggtga aattgatcat tcaataaaca tgcttcctac aaacaggaaa gcgaacgagt
      241 cctgttctaa tactgcacct tctttaaccg tccctgaatg tgccatttgt ctgcaaacat
      301 gtgttcatcc agtcagtctg ccctgtaagc acgttttctg ctatctatgt gtaaaaggag
      361 cttcatggct tggaaagcgg tgtgctcttt gtcgacaaga aattcccgag gatttccttg
      421 acaagccaac cttgttgtca ccagaagaac tcaaggcagc aagtagagga aatggtgaat
      481 atgcatggta ttatgaagga agaaatgggt ggtggcagta cgatgagcgc actagtagag
      541 agctggaaga tgctttttcc aaaggtaaaa agaacactga aatgttaatt gctggctttc
      601 tgtatgtcgc tgatcttgaa aacatggttc aatataggag aaatgaacat ggacgtcgca
      661 ggaagattaa gcgagatata atagatatac caaagaaggg agtagctgga cttaggctag
      721 actgtgatgc taataccgta aacctagcaa gagagagctc tgctgacgga gcggacagtg
      781 tatcagcaca gagtggagct tctgttcagc ccctagtgtc ttctgtaagg cccctaacat
      841 cagtagatgg tcagttaaca agccctgcaa caccatcccc tgatgcaagc acttctctgg
      901 aagactcttt tgctcattta caactcagtg gagacaacac agctgaaagg agtcataggg
      961 gagaaggaga agaagatcat gaatcaccat cttcaggcag ggtaccagca ccagacacct
     1021 ccattgaaga aactgaatca gatgccagta gtgatagtga ggatgtatct gcagttgttg
     1081 cacagcactc cttgacccaa cagagacttt tggtttctaa tgcaaaccag acagtacccg
     1141 atcgatcaga tcgatcggga actgatcgat cagtagcagg gggtggaaca gtgagtgtca
     1201 gtgtcagatc tagaaggcct gatggacagt gcacagtaac tgaagtttaa ataaaaatgt
     1261 cttcagctcc atgctcaagg ttgaaagggt tacctgtaaa tttctgccca cataacatta
     1321 tactcatccc tagtagtgca ttttgggagt tggggtggga aggggtatgg gaaggataga
     1381 ctcataatta aaatgtctaa catgtctctg ttgagaaatt tatttaatgt aaggaacttg
     1441 ggtgttaata gttgagagct gtttagtaat aacccagttt tcttgaggtc tgtttacttt
     1501 atacttttta aaaacttctg tagttctttt ggccagtgtg tttgtattat ctgtgcatta
     1561 atggtcctca tctgactcct gcattgtgtc ttatttttct gcatggattg gcataagacc
     1621 attactaaaa tttggcacct gtgagatgtt tgatattatg aacaggaaac ataatttaat
     1681 gtatgaatag atgtgaattt gggatttcaa aatagatgaa taacaactat tttatagtaa
     1741 agttattgaa atggaaatga aaacagccag taacttatgt ttcagaatgt ttgtaacaca
     1801 cttcatggtg ttcccatagg ctttgctgtc tagtcttata gtttgaggtt tttttggtct
     1861 gcatttttct ttttgattac aaaatttata atttaataaa tactagagtt tatcaaaaac
     1921 agtttgtctc ttgtttgagg gtggaaaggg tgtggaaaca ttttgacatt tgtgaccaaa
     1981 ggtcacttaa aaagtggtgg ttttaattgg ttgttttcag cttaatcacc tgctcagaaa
     2041 agtttgattt ttttcttaga gattatttaa acagaatcta taggcagtgt gtatataata
     2101 aacatgtatg gaaataaaa
//
