LOCUS       NM_144726               3364 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ring finger protein 145 (RNF145), transcript variant
            2, mRNA.
ACCESSION   NM_144726
VERSION     NM_144726.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Rong,L., Chen,B., Liu,K., Liu,B., He,X., Liu,J., Li,J., He,M.,
            Zhu,L., Liu,K., Shi,X., Shuai,Y. and Jin,L.
  TITLE     CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to
            accelerate oral squamous cell carcinoma progression via NFkappaB
            signaling pathway
  JOURNAL   J Transl Med 20 (1), 148 (2022)
   PUBMED   35365168
  REMARK    GeneRIF: CircZDBF2 up-regulates RNF145 by ceRNA model and recruits
            CEBPB to accelerate oral squamous cell carcinoma progression via
            NFkappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Ming,J., Wei,X., Han,M., Adi,D., Abuzhalihan,J., Wang,Y.T.,
            Yang,Y.N., Li,X.M., Xie,X., Fu,Z.Y., Gai,M.T. and Ma,Y.T.
  TITLE     Genetic variation of RNF145 gene and blood lipid levels in Xinjiang
            population, China
  JOURNAL   Sci Rep 11 (1), 5969 (2021)
   PUBMED   33727652
  REMARK    GeneRIF: Genetic variation of RNF145 gene and blood lipid levels in
            Xinjiang population, China.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Gieger,C., Radhakrishnan,A., Cvejic,A., Tang,W., Porcu,E.,
            Pistis,G., Serbanovic-Canic,J., Elling,U., Goodall,A.H.,
            Labrune,Y., Lopez,L.M., Magi,R., Meacham,S., Okada,Y., Pirastu,N.,
            Sorice,R., Teumer,A., Voss,K., Zhang,W., Ramirez-Solis,R.,
            Bis,J.C., Ellinghaus,D., Gogele,M., Hottenga,J.J., Langenberg,C.,
            Kovacs,P., O'Reilly,P.F., Shin,S.Y., Esko,T., Hartiala,J.,
            Kanoni,S., Murgia,F., Parsa,A., Stephens,J., van der Harst,P.,
            Ellen van der Schoot,C., Allayee,H., Attwood,A., Balkau,B.,
            Bastardot,F., Basu,S., Baumeister,S.E., Biino,G., Bomba,L.,
            Bonnefond,A., Cambien,F., Chambers,J.C., Cucca,F., D'Adamo,P.,
            Davies,G., de Boer,R.A., de Geus,E.J., Doring,A., Elliott,P.,
            Erdmann,J., Evans,D.M., Falchi,M., Feng,W., Folsom,A.R.,
            Frazer,I.H., Gibson,Q.D., Glazer,N.L., Hammond,C.,
            Hartikainen,A.L., Heckbert,S.R., Hengstenberg,C., Hersch,M.,
            Illig,T., Loos,R.J., Jolley,J., Khaw,K.T., Kuhnel,B.,
            Kyrtsonis,M.C., Lagou,V., Lloyd-Jones,H., Lumley,T., Mangino,M.,
            Maschio,A., Mateo Leach,I., McKnight,B., Memari,Y., Mitchell,B.D.,
            Montgomery,G.W., Nakamura,Y., Nauck,M., Navis,G., Nothlings,U.,
            Nolte,I.M., Porteous,D.J., Pouta,A., Pramstaller,P.P., Pullat,J.,
            Ring,S.M., Rotter,J.I., Ruggiero,D., Ruokonen,A., Sala,C.,
            Samani,N.J., Sambrook,J., Schlessinger,D., Schreiber,S.,
            Schunkert,H., Scott,J., Smith,N.L., Snieder,H., Starr,J.M.,
            Stumvoll,M., Takahashi,A., Tang,W.H., Taylor,K., Tenesa,A., Lay
            Thein,S., Tonjes,A., Uda,M., Ulivi,S., van Veldhuisen,D.J.,
            Visscher,P.M., Volker,U., Wichmann,H.E., Wiggins,K.L.,
            Willemsen,G., Yang,T.P., Hua Zhao,J., Zitting,P., Bradley,J.R.,
            Dedoussis,G.V., Gasparini,P., Hazen,S.L., Metspalu,A., Pirastu,M.,
            Shuldiner,A.R., Joost van Pelt,L., Zwaginga,J.J., Boomsma,D.I.,
            Deary,I.J., Franke,A., Froguel,P., Ganesh,S.K., Jarvelin,M.R.,
            Martin,N.G., Meisinger,C., Psaty,B.M., Spector,T.D., Wareham,N.J.,
            Akkerman,J.W., Ciullo,M., Deloukas,P., Greinacher,A., Jupe,S.,
            Kamatani,N., Khadake,J., Kooner,J.S., Penninger,J., Prokopenko,I.,
            Stemple,D., Toniolo,D., Wernisch,L., Sanna,S., Hicks,A.A.,
            Rendon,A., Ferreira,M.A., Ouwehand,W.H. and Soranzo,N.
  TITLE     New gene functions in megakaryopoiesis and platelet formation
  JOURNAL   Nature 480 (7376), 201-208 (2011)
   PUBMED   22139419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Soranzo,N., Spector,T.D., Mangino,M., Kuhnel,B., Rendon,A.,
            Teumer,A., Willenborg,C., Wright,B., Chen,L., Li,M., Salo,P.,
            Voight,B.F., Burns,P., Laskowski,R.A., Xue,Y., Menzel,S.,
            Altshuler,D., Bradley,J.R., Bumpstead,S., Burnett,M.S., Devaney,J.,
            Doring,A., Elosua,R., Epstein,S.E., Erber,W., Falchi,M.,
            Garner,S.F., Ghori,M.J., Goodall,A.H., Gwilliam,R.,
            Hakonarson,H.H., Hall,A.S., Hammond,N., Hengstenberg,C., Illig,T.,
            Konig,I.R., Knouff,C.W., McPherson,R., Melander,O., Mooser,V.,
            Nauck,M., Nieminen,M.S., O'Donnell,C.J., Peltonen,L., Potter,S.C.,
            Prokisch,H., Rader,D.J., Rice,C.M., Roberts,R., Salomaa,V.,
            Sambrook,J., Schreiber,S., Schunkert,H., Schwartz,S.M.,
            Serbanovic-Canic,J., Sinisalo,J., Siscovick,D.S., Stark,K.,
            Surakka,I., Stephens,J., Thompson,J.R., Volker,U., Volzke,H.,
            Watkins,N.A., Wells,G.A., Wichmann,H.E., Van Heel,D.A.,
            Tyler-Smith,C., Thein,S.L., Kathiresan,S., Perola,M., Reilly,M.P.,
            Stewart,A.F., Erdmann,J., Samani,N.J., Meisinger,C., Greinacher,A.,
            Deloukas,P., Ouwehand,W.H. and Gieger,C.
  TITLE     A genome-wide meta-analysis identifies 22 loci associated with
            eight hematological parameters in the HaemGen consortium
  JOURNAL   Nat Genet 41 (11), 1182-1190 (2009)
   PUBMED   19820697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056513.1, BC042684.1 and AL831829.1.
            
            On Aug 13, 2020 this sequence version replaced NM_144726.2.
            
            Transcript Variant: This variant (2) has an alternate 5' exon, as
            compared to variant 1. The resulting isoform (2) has a shorter and
            distinct N-terminus, as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056513.1, SRR18074967.2256401.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2144333,
                                           SAMEA2155550 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2671              AK056513.1         1-2671
            2672-2789           BC042684.1         2937-3054
            2790-3364           AL831829.1         1054-1628
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..3364
                     /gene="RNF145"
                     /note="ring finger protein 145"
                     /db_xref="GeneID:153830"
                     /db_xref="HGNC:HGNC:20853"
                     /db_xref="MIM:620640"
     exon            1..72
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2103
                     /gene="RNF145"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="RING finger protein 145 isoform 2"
                     /protein_id="NP_653327.1"
                     /db_xref="CCDS:CCDS4344.1"
                     /db_xref="GeneID:153830"
                     /db_xref="HGNC:HGNC:20853"
                     /db_xref="MIM:620640"
                     /translation="MMRNHRIASSLCGDQVFSKKKKKKKKNNMAAKEKLEAVLNVALR
                     VPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPR
                     QHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQLV
                     VCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSN
                     LLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFS
                     TRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFM
                     NDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPI
                     VLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSL
                     QVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFG
                     EWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICA
                     ICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGTEPVLQPH
                     AGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAK
                     DEAHPVESA"
     exon            73..295
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            296..404
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            405..496
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            497..732
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            733..908
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1049
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1232
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1380
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1737
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..3364
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF145"
                     /note="hexamer: AATAAA"
     polyA_site      3364
                     /gene="RNF145"
                     /note="major polyA site"
ORIGIN      
        1 agactccctg tctttgcggt ttgggagatg atgagaaacc acagaattgc tagtagttta
       61 tgtggagatc aggtcttctc caagaaaaaa aaaaagaaaa aaaaaaacaa catggctgca
      121 aaggagaaac tggaggcagt gttaaatgtg gccctgaggg tgccaagcat catgctgttg
      181 gatgtcctgt acagatggga tgtcagctcc tttttccagc agatccaaag aagtagcctt
      241 agtaataacc ctcttttcca gtataagtat ttggctctta atatgcatta tgtaggttat
      301 atcttaagtg tggtgctgct aacattgccc aggcagcatc tggttcagct ttatctatat
      361 tttttgactg ctctgctcct ctatgctgga catcaaattt ccagggacta tgttcggagt
      421 gaactggagt ttgcctatga gggaccaatg tatttagaac ctctctctat gaatcggttt
      481 accacagcct taataggtca gttggtggtg tgtactttat gctcctgtgt catgaaaaca
      541 aagcagattt ggctgttttc agctcacatg cttcctctgc tagcacgact ctgccttgtt
      601 cctttggaga caattgttat catcaataaa tttgctatga tttttactgg attggaagtt
      661 ctctattttc ttgggtctaa tcttttggta ccttataacc ttgctaaatc tgcatacaga
      721 gaattggttc aggtagtgga ggtatatggc cttctcgcct tgggaatgtc cctgtggaat
      781 caactggtag tccctgttct tttcatggtt ttctggctcg tcttatttgc tcttcagatt
      841 tactcctatt tcagtactcg agatcagcct gcatcacgtg agaggcttct tttccttttt
      901 ctgacaagta ttgcggaatg ctgcagcact ccttactctc ttttgggttt ggtcttcacg
      961 gtttcttttg ttgccttggg tgttctcaca ctctgcaagt tttacttgca gggttatcga
     1021 gctttcatga atgatcctgc catgaatcgg ggcatgacag aaggagtaac gctgttaatc
     1081 ctggcagtgc agactgggct gatagaactg caggttgttc atcgggcatt cttgctcagt
     1141 attatccttt tcattgtcgt agcttctatc ctacagtcta tgttagaaat tgcagatcct
     1201 attgttttgg cactgggagc atctagagac aagagcttgt ggaaacactt ccgtgctgta
     1261 agcctttgtt tatttttatt ggtattccct gcttatatgg cttatatgat ttgccagttt
     1321 ttccacatgg atttttggct tcttatcatt atttccagca gcattcttac ctctcttcag
     1381 gttctgggaa cactttttat ttatgtctta tttatggttg aggaattcag aaaagagcca
     1441 gtggaaaaca tggatgatgt catctactat gtgaatggca cttaccgcct gctggagttt
     1501 cttgtggccc tctgtgtggt ggcctatggc gtctcagaga ccatctttgg agaatggaca
     1561 gtgatgggct caatgatcat cttcattcat tcctactata acgtgtggct tcgggcccag
     1621 ctggggtgga agagctttct tctccgcagg gatgctgtga ataagattaa atcgttaccc
     1681 attgctacga aagagcagct tgagaaacac aatgatattt gtgccatctg ttatcaggac
     1741 atgaaatctg ctgtgatcac gccttgcagt cattttttcc atgcaggctg tcttaagaaa
     1801 tggctgtatg tccaggagac ctgccctctg tgccactgcc atctgaaaaa ctcctcccag
     1861 cttccaggat taggaactga gccagttcta cagcctcatg ctggagctga gcaaaacgtc
     1921 atgtttcagg aaggtactga acccccaggc caggagcata ctccagggac caggatacag
     1981 gaaggttcca gggacaataa tgagtacatt gccagacgac cagataacca ggaaggggct
     2041 tttgacccca aagaatatcc tcacagtgcg aaagatgaag cacatcctgt tgaatcagcc
     2101 tagaggagaa gcagcaggaa tgatgctttg atactctgga ggagaagtta actcaagatg
     2161 gaattcatgt tctgatttga ggaatgaaaa tgagatgatc aggcaggaaa ctgacattcc
     2221 aaggatctaa tccaggaagt actctcagtg gggaccacct gctttcatcc cctgacattg
     2281 tgggagaaat tttgcaatgt atgctaatca aaatgtattt atatgttctc tgctgatgtt
     2341 ttatagaggt ttgtgaagaa aattcaacct cagcaacttc agaaactgcc cctgatacgt
     2401 gtgagagaga aataaaatca gattttgagt gttgaaggga ctgaggaagt gaggataaag
     2461 agcatgagga cagcatggaa agaaggaggc agaagtggaa ctgaactttc actctccatg
     2521 ggacagatca atctcattat caagtctgaa tagcaaccag ccctctcctc caccccgttt
     2581 ctcctcagtt aattggagct cagtcaggtg attattgagt cttgtacagc actgaaatga
     2641 aatcaaagat gaagaagcat tgattgtatt caaagattga agcacgctca tactttgtat
     2701 gtgctttagg gaaggggtgg gtgggcactt gggccttgcg ggtgcattca tgtaatctga
     2761 gactcttgaa ctttatgacg gagtcttcag tattttgatg tatatgaaac ttttgttaaa
     2821 tatgttgtat acttcgctgg ctgtgtgaag taaactaaaa ctctgatgaa cactttggag
     2881 tctgctttag tgaaggagac caaagtggga agggctttag ggcactgata gaggccctgg
     2941 gtgtactttt caatcctgtg taatgtttaa ttcttgcaac tgaatcaaaa cagtgttaaa
     3001 ttatggcaat atttgcactt tgggaatgag tacataactg tatgatcaca ctctgcaaat
     3061 gccactttta aagctgttaa tagactttgc accttttctt tgacaaggat gtgtcatatt
     3121 taaattttta cattcatcat ggctacaggt agaactgggg aggggggaat gtaatttttt
     3181 atgggaattt tgatatgaaa agaaactagt catttattta tacaataggc ttggctcaaa
     3241 aagtgttttt cagacctcgg tattcctaat gtgggatgtg actttatttt atttttagta
     3301 gcaaatttgg atgtagactg acagacatag ctgaatgtct taataaattt aaatttgaag
     3361 ataa
//
