LOCUS       NM_001199383            3615 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ring finger protein 145 (RNF145), transcript variant
            5, mRNA.
ACCESSION   NM_001199383
VERSION     NM_001199383.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3615)
  AUTHORS   Rong,L., Chen,B., Liu,K., Liu,B., He,X., Liu,J., Li,J., He,M.,
            Zhu,L., Liu,K., Shi,X., Shuai,Y. and Jin,L.
  TITLE     CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to
            accelerate oral squamous cell carcinoma progression via NFkappaB
            signaling pathway
  JOURNAL   J Transl Med 20 (1), 148 (2022)
   PUBMED   35365168
  REMARK    GeneRIF: CircZDBF2 up-regulates RNF145 by ceRNA model and recruits
            CEBPB to accelerate oral squamous cell carcinoma progression via
            NFkappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3615)
  AUTHORS   Ming,J., Wei,X., Han,M., Adi,D., Abuzhalihan,J., Wang,Y.T.,
            Yang,Y.N., Li,X.M., Xie,X., Fu,Z.Y., Gai,M.T. and Ma,Y.T.
  TITLE     Genetic variation of RNF145 gene and blood lipid levels in Xinjiang
            population, China
  JOURNAL   Sci Rep 11 (1), 5969 (2021)
   PUBMED   33727652
  REMARK    GeneRIF: Genetic variation of RNF145 gene and blood lipid levels in
            Xinjiang population, China.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3615)
  AUTHORS   Gieger,C., Radhakrishnan,A., Cvejic,A., Tang,W., Porcu,E.,
            Pistis,G., Serbanovic-Canic,J., Elling,U., Goodall,A.H.,
            Labrune,Y., Lopez,L.M., Magi,R., Meacham,S., Okada,Y., Pirastu,N.,
            Sorice,R., Teumer,A., Voss,K., Zhang,W., Ramirez-Solis,R.,
            Bis,J.C., Ellinghaus,D., Gogele,M., Hottenga,J.J., Langenberg,C.,
            Kovacs,P., O'Reilly,P.F., Shin,S.Y., Esko,T., Hartiala,J.,
            Kanoni,S., Murgia,F., Parsa,A., Stephens,J., van der Harst,P.,
            Ellen van der Schoot,C., Allayee,H., Attwood,A., Balkau,B.,
            Bastardot,F., Basu,S., Baumeister,S.E., Biino,G., Bomba,L.,
            Bonnefond,A., Cambien,F., Chambers,J.C., Cucca,F., D'Adamo,P.,
            Davies,G., de Boer,R.A., de Geus,E.J., Doring,A., Elliott,P.,
            Erdmann,J., Evans,D.M., Falchi,M., Feng,W., Folsom,A.R.,
            Frazer,I.H., Gibson,Q.D., Glazer,N.L., Hammond,C.,
            Hartikainen,A.L., Heckbert,S.R., Hengstenberg,C., Hersch,M.,
            Illig,T., Loos,R.J., Jolley,J., Khaw,K.T., Kuhnel,B.,
            Kyrtsonis,M.C., Lagou,V., Lloyd-Jones,H., Lumley,T., Mangino,M.,
            Maschio,A., Mateo Leach,I., McKnight,B., Memari,Y., Mitchell,B.D.,
            Montgomery,G.W., Nakamura,Y., Nauck,M., Navis,G., Nothlings,U.,
            Nolte,I.M., Porteous,D.J., Pouta,A., Pramstaller,P.P., Pullat,J.,
            Ring,S.M., Rotter,J.I., Ruggiero,D., Ruokonen,A., Sala,C.,
            Samani,N.J., Sambrook,J., Schlessinger,D., Schreiber,S.,
            Schunkert,H., Scott,J., Smith,N.L., Snieder,H., Starr,J.M.,
            Stumvoll,M., Takahashi,A., Tang,W.H., Taylor,K., Tenesa,A., Lay
            Thein,S., Tonjes,A., Uda,M., Ulivi,S., van Veldhuisen,D.J.,
            Visscher,P.M., Volker,U., Wichmann,H.E., Wiggins,K.L.,
            Willemsen,G., Yang,T.P., Hua Zhao,J., Zitting,P., Bradley,J.R.,
            Dedoussis,G.V., Gasparini,P., Hazen,S.L., Metspalu,A., Pirastu,M.,
            Shuldiner,A.R., Joost van Pelt,L., Zwaginga,J.J., Boomsma,D.I.,
            Deary,I.J., Franke,A., Froguel,P., Ganesh,S.K., Jarvelin,M.R.,
            Martin,N.G., Meisinger,C., Psaty,B.M., Spector,T.D., Wareham,N.J.,
            Akkerman,J.W., Ciullo,M., Deloukas,P., Greinacher,A., Jupe,S.,
            Kamatani,N., Khadake,J., Kooner,J.S., Penninger,J., Prokopenko,I.,
            Stemple,D., Toniolo,D., Wernisch,L., Sanna,S., Hicks,A.A.,
            Rendon,A., Ferreira,M.A., Ouwehand,W.H. and Soranzo,N.
  TITLE     New gene functions in megakaryopoiesis and platelet formation
  JOURNAL   Nature 480 (7376), 201-208 (2011)
   PUBMED   22139419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3615)
  AUTHORS   Soranzo,N., Spector,T.D., Mangino,M., Kuhnel,B., Rendon,A.,
            Teumer,A., Willenborg,C., Wright,B., Chen,L., Li,M., Salo,P.,
            Voight,B.F., Burns,P., Laskowski,R.A., Xue,Y., Menzel,S.,
            Altshuler,D., Bradley,J.R., Bumpstead,S., Burnett,M.S., Devaney,J.,
            Doring,A., Elosua,R., Epstein,S.E., Erber,W., Falchi,M.,
            Garner,S.F., Ghori,M.J., Goodall,A.H., Gwilliam,R.,
            Hakonarson,H.H., Hall,A.S., Hammond,N., Hengstenberg,C., Illig,T.,
            Konig,I.R., Knouff,C.W., McPherson,R., Melander,O., Mooser,V.,
            Nauck,M., Nieminen,M.S., O'Donnell,C.J., Peltonen,L., Potter,S.C.,
            Prokisch,H., Rader,D.J., Rice,C.M., Roberts,R., Salomaa,V.,
            Sambrook,J., Schreiber,S., Schunkert,H., Schwartz,S.M.,
            Serbanovic-Canic,J., Sinisalo,J., Siscovick,D.S., Stark,K.,
            Surakka,I., Stephens,J., Thompson,J.R., Volker,U., Volzke,H.,
            Watkins,N.A., Wells,G.A., Wichmann,H.E., Van Heel,D.A.,
            Tyler-Smith,C., Thein,S.L., Kathiresan,S., Perola,M., Reilly,M.P.,
            Stewart,A.F., Erdmann,J., Samani,N.J., Meisinger,C., Greinacher,A.,
            Deloukas,P., Ouwehand,W.H. and Gieger,C.
  TITLE     A genome-wide meta-analysis identifies 22 loci associated with
            eight hematological parameters in the HaemGen consortium
  JOURNAL   Nat Genet 41 (11), 1182-1190 (2009)
   PUBMED   19820697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK821118.1, AK292854.1 and AL831829.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001199383.1.
            
            Transcript Variant: This variant (5) has an alternate 5' exon,
            resulting in a downstream AUG start codon, as compared to variant
            1. The resulting isoform (5) has a shorter N-terminus, as compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044767.1, DRR138524.300268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2155550
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424310.7/ ENSP00000409064.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CK821118.1         3-51
            50-579              CK821118.1         67-596
            580-2647            AK292854.1         571-2638
            2648-3615           AL831829.1         661-1628
FEATURES             Location/Qualifiers
     source          1..3615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..3615
                     /gene="RNF145"
                     /note="ring finger protein 145"
                     /db_xref="GeneID:153830"
                     /db_xref="HGNC:HGNC:20853"
                     /db_xref="MIM:620640"
     exon            1..323
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            324..546
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..2354
                     /gene="RNF145"
                     /EC_number="2.3.2.27"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="RING finger protein 145 isoform 5"
                     /protein_id="NP_001186312.1"
                     /db_xref="CCDS:CCDS56390.1"
                     /db_xref="GeneID:153830"
                     /db_xref="HGNC:HGNC:20853"
                     /db_xref="MIM:620640"
                     /translation="MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLS
                     NNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVR
                     SELEFAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARL
                     CLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALG
                     MSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYS
                     LLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQ
                     VVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVF
                     PAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDV
                     IYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKS
                     FLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLY
                     VQETCPLCHCHLKNSSQLPGLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQE
                     GSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHPVESA"
     exon            547..655
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            656..747
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            748..983
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1159
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1300
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1483
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1631
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1988
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..3615
                     /gene="RNF145"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF145"
                     /note="hexamer: AATAAA"
     polyA_site      3615
                     /gene="RNF145"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcgcc gggggcggga ggagcaaacg caggaggcca tggccgccga cgccggcgcc
       61 ggctgctaag gggctcggcc cgcgagcgcc tgctgccgcg gacgatggtg accgtacggg
      121 ccgggccgct gccgctgccg ctgcctccgc ctccccagaa gcaacatccg aggctcggcg
      181 cagaagagcc gccgctgtga gccgtgccgt accggccccc gccgccgccc gaggagaacg
      241 ggagggcggg cgagagagcc ggggagttgc ggagcccgcc cgccggcagc gccgctcccc
      301 agggagggag tccgcagcct gaggtcttct ccaagaaaaa aaaaaagaaa aaaaaaaaca
      361 acatggctgc aaaggagaaa ctggaggcag tgttaaatgt ggccctgagg gtgccaagca
      421 tcatgctgtt ggatgtcctg tacagatggg atgtcagctc ctttttccag cagatccaaa
      481 gaagtagcct tagtaataac cctcttttcc agtataagta tttggctctt aatatgcatt
      541 atgtaggtta tatcttaagt gtggtgctgc taacattgcc caggcagcat ctggttcagc
      601 tttatctata ttttttgact gctctgctcc tctatgctgg acatcaaatt tccagggact
      661 atgttcggag tgaactggag tttgcctatg agggaccaat gtatttagaa cctctctcta
      721 tgaatcggtt taccacagcc ttaataggtc agttggtggt gtgtacttta tgctcctgtg
      781 tcatgaaaac aaagcagatt tggctgtttt cagctcacat gcttcctctg ctagcacgac
      841 tctgccttgt tcctttggag acaattgtta tcatcaataa atttgctatg atttttactg
      901 gattggaagt tctctatttt cttgggtcta atcttttggt accttataac cttgctaaat
      961 ctgcatacag agaattggtt caggtagtgg aggtatatgg ccttctcgcc ttgggaatgt
     1021 ccctgtggaa tcaactggta gtccctgttc ttttcatggt tttctggctc gtcttatttg
     1081 ctcttcagat ttactcctat ttcagtactc gagatcagcc tgcatcacgt gagaggcttc
     1141 ttttcctttt tctgacaagt attgcggaat gctgcagcac tccttactct cttttgggtt
     1201 tggtcttcac ggtttctttt gttgccttgg gtgttctcac actctgcaag ttttacttgc
     1261 agggttatcg agctttcatg aatgatcctg ccatgaatcg gggcatgaca gaaggagtaa
     1321 cgctgttaat cctggcagtg cagactgggc tgatagaact gcaggttgtt catcgggcat
     1381 tcttgctcag tattatcctt ttcattgtcg tagcttctat cctacagtct atgttagaaa
     1441 ttgcagatcc tattgttttg gcactgggag catctagaga caagagcttg tggaaacact
     1501 tccgtgctgt aagcctttgt ttatttttat tggtattccc tgcttatatg gcttatatga
     1561 tttgccagtt tttccacatg gatttttggc ttcttatcat tatttccagc agcattctta
     1621 cctctcttca ggttctggga acacttttta tttatgtctt atttatggtt gaggaattca
     1681 gaaaagagcc agtggaaaac atggatgatg tcatctacta tgtgaatggc acttaccgcc
     1741 tgctggagtt tcttgtggcc ctctgtgtgg tggcctatgg cgtctcagag accatctttg
     1801 gagaatggac agtgatgggc tcaatgatca tcttcattca ttcctactat aacgtgtggc
     1861 ttcgggccca gctggggtgg aagagctttc ttctccgcag ggatgctgtg aataagatta
     1921 aatcgttacc cattgctacg aaagagcagc ttgagaaaca caatgatatt tgtgccatct
     1981 gttatcagga catgaaatct gctgtgatca cgccttgcag tcattttttc catgcaggct
     2041 gtcttaagaa atggctgtat gtccaggaga cctgccctct gtgccactgc catctgaaaa
     2101 actcctccca gcttccagga ttaggaactg agccagttct acagcctcat gctggagctg
     2161 agcaaaacgt catgtttcag gaaggtactg aacccccagg ccaggagcat actccaggga
     2221 ccaggataca ggaaggttcc agggacaata atgagtacat tgccagacga ccagataacc
     2281 aggaaggggc ttttgacccc aaagaatatc ctcacagtgc gaaagatgaa gcacatcctg
     2341 ttgaatcagc ctagaggaga agcagcagga atgatgcttt gatactctgg aggagaagtt
     2401 aactcaagat ggaattcatg ttctgatttg aggaatgaaa atgagatgat caggcaggaa
     2461 actgacattc caaggatcta atccaggaag tactctcagt ggggaccacc tgctttcatc
     2521 ccctgacatt gtgggagaaa ttttgcaatg tatgctaatc aaaatgtatt tatatgttct
     2581 ctgctgatgt tttatagagg tttgtgaaga aaattcaacc tcagcaactt cagaaactgc
     2641 ccctgatacg tgtgagagag aaataaaatc agattttgag tgttgaaggg actgaggaag
     2701 tgaggataaa gagcatgagg acagcatgga aagaaggagg cagaagtgga actgaacttt
     2761 cactctccat gggacagatc aatctcatta tcaagtctga atagcaacca gccctctcct
     2821 ccaccccgtt tctcctcagt taattggagc tcagtcaggt gattattgag tcttgtacag
     2881 cactgaaatg aaatcaaaga tgaagaagca ttgattgtat tcaaagattg aagcacgctc
     2941 atactttgta tgtgctttag ggaaggggtg ggtgggcact tgggccttgc gggtgcattc
     3001 atgtaatctg agactcttga actttatgac ggagtcttca gtattttgat gtatatgaaa
     3061 cttttgttaa atatgttgta tacttcgctg gctgtgtgaa gtaaactaaa actctgatga
     3121 acactttgga gtctgcttta gtgaaggaga ccaaagtggg aagggcttta gggcactgat
     3181 agaggccctg ggtgtacttt tcaatcctgt gtaatgttta attcttgcaa ctgaatcaaa
     3241 acagtgttaa attatggcaa tatttgcact ttgggaatga gtacataact gtatgatcac
     3301 actctgcaaa tgccactttt aaagctgtta atagactttg caccttttct ttgacaagga
     3361 tgtgtcatat ttaaattttt acattcatca tggctacagg tagaactggg gaggggggaa
     3421 tgtaattttt tatgggaatt ttgatatgaa aagaaactag tcatttattt atacaatagg
     3481 cttggctcaa aaagtgtttt tcagacctcg gtattcctaa tgtgggatgt gactttattt
     3541 tatttttagt agcaaatttg gatgtagact gacagacata gctgaatgtc ttaataaatt
     3601 taaatttgaa gataa
//
