LOCUS       NM_182757               5032 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens ring finger protein 144B (RNF144B), mRNA.
ACCESSION   NM_182757 XM_172581
VERSION     NM_182757.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5032)
  AUTHORS   Abad,E., Sandoz,J., Romero,G., Zadra,I., Urgel-Solas,J.,
            Borredat,P., Kourtis,S., Ortet,L., Martinez,C.M., Weghorn,D.,
            Sdelci,S. and Janic,A.
  TITLE     The TP53-activated E3 ligase RNF144B is a tumour suppressor that
            prevents genomic instability
  JOURNAL   J Exp Clin Cancer Res 43 (1), 127 (2024)
   PUBMED   38685100
  REMARK    GeneRIF: The TP53-activated E3 ligase RNF144B is a tumour
            suppressor that prevents genomic instability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5032)
  AUTHORS   Du,L., Chen,W., Li,C., Cui,Y. and He,Z.
  TITLE     RNF144B stimulates the proliferation and inhibits the apoptosis of
            human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway
            and its abnormality is associated with azoospermia
  JOURNAL   J Cell Physiol 237 (9), 3565-3577 (2022)
   PUBMED   35699595
  REMARK    GeneRIF: RNF144B stimulates the proliferation and inhibits the
            apoptosis of human spermatogonial stem cells via the
            FCER2/NOTCH2/HES1 pathway and its abnormality is associated with
            azoospermia.
REFERENCE   3  (bases 1 to 5032)
  AUTHORS   Zhang,Z., Zhang,L., Wang,B., Zhu,X., Zhao,L., Chu,C., Guo,Q.,
            Wei,R., Yin,X., Zhang,Y. and Li,X.
  TITLE     RNF144B inhibits LPS-induced inflammatory responses via binding
            TBK1
  JOURNAL   J Leukoc Biol 106 (6), 1303-1311 (2019)
   PUBMED   31509299
  REMARK    GeneRIF: Our study identifies that RNF144B interaction with TBK1 is
            sufficient to inactivate TBK1 and delineates a previously
            unrecognized role for RNF144B in innate immune responses.
REFERENCE   4  (bases 1 to 5032)
  AUTHORS   Zhou,Q., Eldakhakhny,S., Conforti,F., Crosbie,E.J., Melino,G. and
            Sayan,B.S.
  TITLE     Pir2/Rnf144b is a potential endometrial cancer biomarker that
            promotes cell proliferation
  JOURNAL   Cell Death Dis 9 (5), 504 (2018)
   PUBMED   29724995
  REMARK    GeneRIF: Inactivation of GSK3beta activity is associated with loss
            of PIR2 protein and consequent inhibition of cell proliferation in
            endometrial cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5032)
  AUTHORS   Yang,G., Gong,Y., Wang,Q., Wang,L. and Zhang,X.
  TITLE     miR-100 antagonism triggers apoptosis by inhibiting
            ubiquitination-mediated p53 degradation
  JOURNAL   Oncogene 36 (8), 1023-1037 (2017)
   PUBMED   27524417
  REMARK    GeneRIF: Low RNF144B expression is associated with gastric cancer.
REFERENCE   6  (bases 1 to 5032)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   7  (bases 1 to 5032)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 5032)
  AUTHORS   van Wijk,S.J., de Vries,S.J., Kemmeren,P., Huang,A., Boelens,R.,
            Bonvin,A.M. and Timmers,H.T.
  TITLE     A comprehensive framework of E2-RING E3 interactions of the human
            ubiquitin-proteasome system
  JOURNAL   Mol Syst Biol 5, 295 (2009)
   PUBMED   19690564
  REMARK    Erratum:[Mol Syst Biol. 2009;5:317]
REFERENCE   9  (bases 1 to 5032)
  AUTHORS   Huang,J., Xu,L.G., Liu,T., Zhai,Z. and Shu,H.B.
  TITLE     The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent
            apoptosis
  JOURNAL   FEBS Lett 580 (3), 940-947 (2006)
   PUBMED   16427630
REFERENCE   10 (bases 1 to 5032)
  AUTHORS   Ng,C.C., Arakawa,H., Fukuda,S., Kondoh,H. and Nakamura,Y.
  TITLE     p53RFP, a p53-inducible RING-finger protein, regulates the
            stability of p21WAF1
  JOURNAL   Oncogene 22 (28), 4449-4458 (2003)
   PUBMED   12853982
  REMARK    GeneRIF: p53RFP, a p53-inducible RING-finger protein, regulates the
            stability of p21WAF1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096832.1 and AL138725.19.
            
            On Nov 30, 2019 this sequence version replaced NM_182757.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2038266.1, AK096832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259939.4/ ENSP00000259939.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AK096832.1         1-111
            112-112             AL138725.19        66338-66338
            113-301             AK096832.1         113-301
            302-302             AL138725.19        78396-78396
            303-1725            AK096832.1         303-1725
            1726-5032           AL138725.19        144441-147747
FEATURES             Location/Qualifiers
     source          1..5032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..5032
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /note="ring finger protein 144B"
                     /db_xref="GeneID:255488"
                     /db_xref="HGNC:HGNC:21578"
                     /db_xref="MIM:618869"
     exon            1..281
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..482
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1229
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /EC_number="2.3.2.31"
                     /note="IBR domain containing 2; p53-inducible RING finger
                     protein; IBR domain-containing protein 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF144B"
                     /protein_id="NP_877434.2"
                     /db_xref="CCDS:CCDS34345.1"
                     /db_xref="GeneID:255488"
                     /db_xref="HGNC:HGNC:21578"
                     /db_xref="MIM:618869"
                     /translation="MGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTT
                     LQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHGTLQEAEIACLVPVDQFQL
                     YQRLKFEREVHLDPYRTWCPVADCQTVCPVASSDPGQPVLVECPSCHLKFCSCCKDAW
                     HAEVSCRDSQPIVLPTEHRALFGTDAEAPIKQCPVCRVYIERNEGCAQMMCKNCKHTF
                     CWYCLQNLDNDIFLRHYDKGPCRNKLGHSRASVMWNRTQVVGILVGLGIIALVTSPLL
                     LLASPCIICCVCKSCRGKKKKHDPSTT"
     exon            483..587
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..648
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..853
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..998
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1088
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..5032
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /note="hexamer: AATAAA"
     polyA_site      4781
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /note="major polyA site"
     regulatory      5014..5019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
                     /note="hexamer: AATAAA"
     polyA_site      5032
                     /gene="RNF144B"
                     /gene_synonym="bA528A10.3; IBRDC2; p53RFP; PIR2"
ORIGIN      
        1 gagctgtgcc ccacgctccc gctgcaacag tcccgggcat cgcagctgcc agtcaaggct
       61 aggaggcggt cggggactcc gcctcctccc gacccgtagg tctgggagcg caagtcctgt
      121 tgcagtcttg caaagtgtaa agctgtcagc cgcagagcac ggaggaaaga cggagagaat
      181 ggaagagctc ctgtccggtg tgccagcagc ccggactggc ggtgagcgcg agggaggcta
      241 ctgagaagcc cggcgacgga ggaacgcagg tctgctgcca gggattgagg agactgaaga
      301 atgctgaaga caggctgatg ggctcagctg gtaggctcca ctatctcgcc atgactgctg
      361 aaaatcccac tcctggagac ctggctccgg cccccctcat cacttgcaaa ctctgcctgt
      421 gtgagcagtc tctggacaag atgaccacac tccaggaatg ccagtgcatc ttttgcacag
      481 cttgcctgaa acagtacatg cagctggcaa tccgagaagg atgtgggtct cccatcactt
      541 gccctgacat ggtgtgccta aaccacggga ccctgcagga agctgagatt gcctgtttgg
      601 tacctgtgga ccagtttcaa ctttatcaga ggttaaaatt tgaaagagaa gttcatctgg
      661 acccctaccg aacatggtgt cctgttgcag actgtcagac agtgtgccct gttgcctcga
      721 gtgacccagg acagcctgtg ctggtggaat gcccttcttg ccacctgaaa ttctgctcgt
      781 gttgcaagga tgcttggcat gcagaggtct cctgtagaga cagtcagcct attgtcctgc
      841 caacagagca ccgagccctc tttgggacag atgcagaagc ccccattaag cagtgcccag
      901 tttgccgggt ttatatcgaa cgcaatgaag gctgcgctca gatgatgtgc aaaaactgca
      961 agcatacatt ttgctggtac tgcctccaga acttggataa tgacattttc ctcagacatt
     1021 atgacaaagg gccatgcagg aataaacttg gccactcaag agcatcagtg atgtggaacc
     1081 gaacacaggt ggtggggatt ctcgtaggct tgggcatcat tgccttggtt acttcaccct
     1141 tgttactcct ggcctcccca tgtataatct gttgtgtctg caagtcctgt cggggcaaga
     1201 agaaaaagca cgacccatcc acaacctaaa gatctctgtg ttcatacgcc ccagatatgt
     1261 gagttacatg agatggcaca gtgataaagc cccatttagt gaccttgcct ccttctcctt
     1321 gccaactttg aaagtgcctc cgtgtccaga ctttgaactt gcctgccagc cttcagcatc
     1381 aggaaaggcc aagtcctggg tgtgagtgtt cctgtgtaac aagaactggg ctcaacggtc
     1441 cagctgtttc tatggagctt tggggttcct tgagatgaat gaacatatca ttttatcatc
     1501 caaaggatct cactggactg ttcaacttcc agccaaattc aaggagcttg cgggaacatt
     1561 tgatataaca aatgtgttgt cattgttggc aacatacaag ataaccaaga agctggagtc
     1621 tgttctgtgt tgatttgact gccatgagaa acacagggga aacctgatga ggagaaggat
     1681 aagactgcgt aaggagaaat cctcatagga gctataaagc aggctgctga tctcagcagt
     1741 tgatatggtg gttgtgcctc tgctggctac tgggtgtgct gtccccatgt tcccgctgtg
     1801 atttggcaga aacacaatag gcttctcctt gtgtgatctc agcttcaagc aggtgaaact
     1861 gctgtgcaga gggagttgcc ccttcccagt aaaagagttg cagcctgtta aacaatgtgg
     1921 tctaatttag tgtctctccc ttggcaaatg taagttttct aagttggcca acttgtctct
     1981 tacagccagt ggctgtggtc tacagaattg tttcatataa aatacgggta gagtggtaga
     2041 gtttcaaaac tttcgtcata gatatctggg acctttctca ggatctgtgt tcacacagcc
     2101 aatagatttg gaatcaggcc taagagtaca catggagggt aaatattaaa gtgcgtatta
     2161 tgtacatcta gaatccatgt gacttgcagc ctacctgtaa tttctatcca ttgagcatgc
     2221 atggatatac ccaatagtac acacaaaata aatgtttact taagagccat tctatccttt
     2281 tgtgactgaa atggtttatt gtaaatctgc ctaaagattt tttgcatatt atatatgtga
     2341 attttggttg taagttcata acttacccaa gggtatagac tcataactct tttaaaacag
     2401 tgcttagtac aatatcctgc catctctgta aaaacgctaa ttgataaccg agtcatttac
     2461 atgttttcga acacagaata gctcttttct cagcatcatt attgctcttt cagcatctgt
     2521 taggacagtc tgaatacttt ctgtttcaag gcactgataa aaccgcaaca aaaacatgta
     2581 agaaataaaa tagaaatgct ttatataatt tagtttaaat ttatgtatca cctcattgtg
     2641 acttattttt tccattatac cattagtcag atttgaataa cgaggttttg aaaggataaa
     2701 accttttctc caatgacagg attatataat tgctattggc aatgtagcct ggtgcttcat
     2761 gagacctatg ctaaatgtta ctggagagtt cttgaagcca gggataccat atcaggaact
     2821 attcaggatc tatgatattt tctgaggtaa ctgggtaata gaatatcaaa ttgctgctat
     2881 ctcggaccta ttgttaaagg atgatgcttt gcctatgtaa taggatatat cctaagtggg
     2941 gatgtgtata tttcaggaac tttaattcac aagtatatat tgatatctga tgtgtgtata
     3001 gtacatctgt tggttatgta cattttaatt tacatgttgt gtagaacata gatgagaact
     3061 ctgggaaaac ttgggaatgg caaccaacca aaatcatttt taatcattta ttagaaattt
     3121 ctcaatattg tgtctttttc ttttgaaact ctaaacactt cagaaaaaaa cactatcagt
     3181 gtagttcatg ttagtataat tatagattta catatatttg aatagttaat ttgctttgtt
     3241 ttacacgtag cccactgcct cattataggt aaaaggcatt tataactgct caggggatta
     3301 cgagaactca actgaaactg aatttttgta acaagaatgt taatagtggc aaagtcctct
     3361 gtcagtaaac tctttaagct tggtgctgca aagagtcttt aaatgggggc tgatttcaag
     3421 taacctaaaa gactgtgtta tcagaggaag aggtcccaaa tttggagtaa agatgggaga
     3481 aaataaatat gtgctatttc cttggcgagt tgagggaatt tgccacctta cagagtttgt
     3541 atcactgaat tagctgcttt tgtttttttt tttttttttt tgccagggct atggagtggg
     3601 ggttgtttgt caaactgatt ttcaataatt ggatttaatt ttttttaaca ttgaaaagtg
     3661 cctgaaaaat ggtaaattct taaatgtgtg tgagattgtc agaatcaaca aaactaggtt
     3721 ggttaaacat atctctggta catcaagggg catgatacaa accagtctaa agactgttta
     3781 taaaggagag agctggcgac ttatttttat ttttattttt tggacagagt ctccctttgt
     3841 cacccaggcc ggagtgcagt ggcatgatca tggttcactt caacccctac ctcctgggct
     3901 caagtgttcc tctcacctta tcctcctgag cagctgggac tacaggcaca caccaccaca
     3961 cctggctaag ttttgtattt tttgtagaga tggggtttct ctgtgttgcc cagtcttgtc
     4021 tcaaactcct gggctcaagc gatccaccca ccttgggctc ccaaagtgtt gggattacag
     4081 gtgtgtgtca ctgtgcctga cagctgacag ttttaactga caactttgat aacagaggct
     4141 gctatttttg ttttagataa ttggccagtg acagagttta cccttgcctc ctttcttggt
     4201 ctgccagctt tgtcctttct gagtgattct ctttctgtat tgagaggaag tgtgggtcta
     4261 catagggatg tttggatgct atggcaagaa tctttttgtg tttggagtgt agtccatttg
     4321 caatagaaat aaaaaaatcc gtcaccaaat tgtaacctgg atgttatagc ccagcatcta
     4381 gaaatcctat gaaacgtatt agcacaatat cttgccattg tcccatctag gaaatttttt
     4441 cttgttgtga ggtagggaag tgaggaggaa agccatgccg aagcaaatgt tagaatctta
     4501 ggcatcctat ttgttcatgc catgggtatt tgctttggac ttggagtctg tactttgaaa
     4561 gaggcctttg aaaaacaaat aattctgtgt gaattttctt gtagcgtgct tcatgaaaat
     4621 atctacttat ccaggtttgc aaatgtacat gttcatttga atgtaaatca ccatttcttg
     4681 gaaccccacg ttttttctta aaaattattc tgaattaaat gtatatttct ttagccttcc
     4741 ctacacagta ctaataaaag acttttcttt ctgttcatga atggatgcct ttatgtgata
     4801 tagagtcatg tgtgtatgtg tagctttaag ggcaatttca gaaatgcatt agatgaatga
     4861 cattttataa agcgatcaca attgatatct acaggctatt atgtctcatg ttgattcatg
     4921 atccaggaag ttttatgtat ttaaaaaatt gctatcgtgt tatatttttc caatttttgg
     4981 agaagaaaat agctgtttag gctctctagc cacaataaat gtaagcagga aa
//
