LOCUS       NM_014746               5720 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens ring finger protein 144A (RNF144A), transcript variant
            2, mRNA.
ACCESSION   NM_014746
VERSION     NM_014746.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5720)
  AUTHORS   Yang,B., Pei,J., Lu,C., Wang,Y., Shen,M., Qin,X., Huang,Y.,
            Yang,X., Zhao,X., Ma,S., Song,Z., Liang,Y., Wang,H. and Wang,J.
  TITLE     RNF144A promotes antiviral responses by modulating STING
            ubiquitination
  JOURNAL   EMBO Rep 24 (12), e57528 (2023)
   PUBMED   37955227
REFERENCE   2  (bases 1 to 5720)
  AUTHORS   Zhang,Y.L., Cao,J.L., Zhang,Y., Liao,L., Deng,L., Yang,S.Y.,
            Hu,S.Y., Ning,Y., Zhang,F.L. and Li,D.Q.
  TITLE     RNF144A exerts tumor suppressor function in breast cancer through
            targeting YY1 for proteasomal degradation to downregulate GMFG
            expression
  JOURNAL   Med Oncol 39 (4), 48 (2022)
   PUBMED   35103856
  REMARK    GeneRIF: RNF144A exerts tumor suppressor function in breast cancer
            through targeting YY1 for proteasomal degradation to downregulate
            GMFG expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5720)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5720)
  AUTHORS   Han,S.H. and Kim,K.T.
  TITLE     RNF144a induces ERK-dependent cell death under oxidative stress via
            downregulation of vaccinia-related kinase 3
  JOURNAL   J Cell Sci 133 (21) (2020)
   PUBMED   33067254
  REMARK    GeneRIF: RNF144a induces ERK-dependent cell death under oxidative
            stress via downregulation of vaccinia-related kinase 3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5720)
  AUTHORS   Miyamoto,K., Migita,K. and Saito,K.
  TITLE     Solution structure of the zinc finger domain of human RNF144A
            ubiquitin ligase
  JOURNAL   Protein Sci 29 (8), 1836-1842 (2020)
   PUBMED   32557973
  REMARK    GeneRIF: Solution structure of the zinc finger domain of human
            RNF144A ubiquitin ligase.
REFERENCE   6  (bases 1 to 5720)
  AUTHORS   Ho,S.R., Mahanic,C.S., Lee,Y.J. and Lin,W.C.
  TITLE     RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis
            during DNA damage
  JOURNAL   Proc Natl Acad Sci U S A 111 (26), E2646-E2655 (2014)
   PUBMED   24979766
  REMARK    GeneRIF: The regulation of DNA-PKcs by RNF144A is important for
            proper apoptotic response during DNA damage, suggesting a tumor
            suppressor function for RNF144A.
REFERENCE   7  (bases 1 to 5720)
  AUTHORS   Adkins,D.E., Aberg,K., McClay,J.L., Bukszar,J., Zhao,Z., Jia,P.,
            Stroup,T.S., Perkins,D., McEvoy,J.P., Lieberman,J.A., Sullivan,P.F.
            and van den Oord,E.J.
  TITLE     Genomewide pharmacogenomic study of metabolic side effects to
            antipsychotic drugs
  JOURNAL   Mol Psychiatry 16 (3), 321-332 (2011)
   PUBMED   20195266
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 5720)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   9  (bases 1 to 5720)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 5720)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
  REMARK    GeneRIF: Functional analysis of the mouse counterpart.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC017076.14, BC050373.1 and
            AC068481.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014746.5.
            
            Summary: This gene encodes a member of a family of RING finger
            domain-containing E3 ubiquitin ligases that also includes parkin
            and parc. The expression of this gene is induced by DNA damage. The
            encoded protein interacts with the cytoplasmic DNA-dependent
            protein kinase, catalytic subunit (DNA-PKcs) and promotes its
            degradation through ubiquitination. The orthologous mouse protein
            has been shown to interact with a ubiquitin-conjugating enzyme
            involved in embryonic development. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR compared to variant 1. The encoded isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            Variants 2-5 encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.230551.1,
                                           SRR1803611.227324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320892.11/ ENSP00000321330.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC017076.14        116845-116884
            41-431              BC050373.1         1-391
            432-432             AC068481.2         77761-77761
            433-1793            BC050373.1         393-1753
            1794-5720           AC068481.2         121078-125004
FEATURES             Location/Qualifiers
     source          1..5720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..5720
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /note="ring finger protein 144A"
                     /db_xref="GeneID:9781"
                     /db_xref="HGNC:HGNC:20457"
                     /db_xref="MIM:619454"
     exon            1..211
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            212..411
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            412..557
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1301
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /EC_number="2.3.2.31"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UbcM4-interacting protein 4; ring finger protein 144; E3
                     ubiquitin-protein ligase RNF144A; ubiquitin conjugating
                     enzyme 7 interacting protein 4; probable E3
                     ubiquitin-protein ligase RNF144A"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF144A isoform 2"
                     /protein_id="NP_055561.2"
                     /db_xref="CCDS:CCDS1657.1"
                     /db_xref="GeneID:9781"
                     /db_xref="HGNC:HGNC:20457"
                     /db_xref="MIM:619454"
                     /translation="MTTTRYRPTWDLALDPLVSCKLCLGEYPVEQMTTIAQCQCIFCT
                     LCLKQYVELLIKEGLETAISCPDAACPKQGHLQENEIECMVAAEIMQRYKKLQFEREV
                     LFDPCRTWCPASTCQAVCQLQDVGLQTPQPVQCKACRMEFCSTCKASWHPGQGCPETM
                     PITFLPGETSAAFKMEEDDAPIKRCPKCKVYIERDEGCAQMMCKNCKHAFCWYCLESL
                     DDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVL
                     CCKCKCSKGDDDPLPT"
     exon            558..662
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            663..723
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            724..931
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1079
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1169
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..5720
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5617..5622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /note="hexamer: AATACA"
     polyA_site      5635
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /note="major polyA site"
     regulatory      5700..5705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /note="hexamer: AATACA"
     polyA_site      5720
                     /gene="RNF144A"
                     /gene_synonym="hUIP4; RNF144; UBCE7IP4; UIP4"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtgcgc gctcgcgccc cgcccgcgca gccgcttctc cccgcgcggg ctctcggcag
       61 gcgggaggcg gcagggctgg cattgcagtg cgggccgtgc gggctgcgcg ggcgcgggga
      121 ggcgcgggcg gcaaactgcg ggcacccggc accccgcagc cagtaccggg cggaggcgtc
      181 agagccgcgc accgcggacg agcaggccca ggcatccagt accctgctga ctctgacatg
      241 cccccagcct cccccagctc tgcagggagc cctggtgcca gagaccttct cccatttctc
      301 cctatgggtg cctgacctga gggcagagac atctgagtgt gtataagcac agcaggacac
      361 caggacctgg cctgaagaca tttcctctcc tcccctctgg atttctcaga gactgttctg
      421 cgatgaccac aacaaggtac cggcccacct gggacctggc cctcgacccg ctggtgtctt
      481 gcaagctctg tcttggggag tacccagtgg agcagatgac aaccatagcc cagtgccaat
      541 gcatcttctg tactctgtgc ctgaaacagt atgttgagct cttgatcaaa gaaggattag
      601 aaaccgcaat tagctgccca gatgctgcct gccctaaaca gggccaccta caggagaacg
      661 agattgagtg catggttgca gctgaaatta tgcaaagata taaaaagcta caatttgaaa
      721 gagaggtgct gtttgatccc tgtcggactt ggtgcccggc gtccacctgc caagctgtgt
      781 gtcagctcca ggacgtgggg ctgcagaccc cccagccagt gcagtgcaaa gcctgccgta
      841 tggaattctg ctccacctgc aaagccagct ggcaccctgg ccagggctgc ccggagacca
      901 tgccgatcac cttcctcccc ggggagacca gtgctgcttt caaaatggaa gaagatgacg
      961 cgcccatcaa gcgctgcccc aagtgcaaag tctacatcga gcgagacgaa ggctgcgcgc
     1021 agatgatgtg caagaactgc aagcacgcct tctgctggta ctgcctggag tctctggacg
     1081 atgatttcct tctgatacac tacgataagg gaccctgccg gaacaagctg ggccactccc
     1141 gggcatctgt gatctggcat cggacacagg ttgtgggcat ttttgcagga tttgggctgc
     1201 tgctcttggt ggcctcacct ttcctactcc tggccactcc ctttgtactt tgctgcaagt
     1261 gcaagtgcag taaaggtgac gacgacccgt tacccaccta gaggaagcgc gatgctggaa
     1321 cacatccctg cctccgggaa gtgtggctct cccccaaccc tccccaccgt ccccccttca
     1381 ctaaacatct ttcttgcctt atgtgcccca ttgagcttca cagtgtcagg ctggacgccg
     1441 tgatttcagg gacctatgtc acaatgttcg ctgaggcccc aggtgtggtg gggaggggag
     1501 gcaggtgtgg gtagcgcaca tccccacaga tcaatctctg cagatgacag ggaggtgctg
     1561 tgagaagtgc accaggcagc tttctctctg tggtagacta ggcatgtctg gggatggcct
     1621 aagagacttt ctgctccttg gcttctagat ggcaccatgt tgtcagagaa gtcttttaag
     1681 gactgccact ctcttcagac agaatctgat tattccagct tgagagaagc actctgttta
     1741 tgacaactgt ttttattact aatggcattt agtaaaatcc tttttagaag gtattttttt
     1801 tccaactgag tagtgaaaat caacaaggtg catataaacc atcctatgcc tttcttgaaa
     1861 tgtgcatttt aagaagttat agttaaacga cttttcagga gatttagaaa gccttatgca
     1921 ctctttgtgt ttttcttgaa acttgctgta gtaacttttt gaacgctgta agctgtgtac
     1981 tgttataagt gtgcttccta tattgttgca tttccttgat aatattgacg tgtttaaagg
     2041 aacatctcat ctccattaga tttgcctttt gttgttttct ctctttggtg attcagctca
     2101 gctcatgggc ctcatccctt ctctcccagg tagcagaaaa cgctttttat tgtattcaat
     2161 cccactgctt tgctcggcaa tggttctcct ccgaattgct gccgtctggc ctctggcctc
     2221 agtcttcaga tagacagtaa gaagaaagca gcctcattga tccgcagatg taggggcctc
     2281 ttggcagagg ctggaggact ctgggggcta gggaagagcc tgccagattt tcacattttt
     2341 aaaatgttct agtcattttg agaaatcata tatcttacac agttccaagt cctgttgcta
     2401 accgttttgc tcttgttggg gaaaagaacc tcccatttca cttcgtttta acgtggggat
     2461 tttaccactt gatcttttac agggctgtct gtgaccattt ccatggcagc aggatgcagg
     2521 gattaataag gacacataca cattattcca ccaattgact ttgaaaagtg gagaaagtgt
     2581 attctttaaa gagaatttac ttctaaaagc cacaggtgct tttacaaagc aaactgcatt
     2641 gaatttaaaa cttctaaaaa taacaggcaa atattgtagc tatattacag tgggatttta
     2701 aaaatcttgt taaacattct ataaagaagt aaaacaaaat ccttttatct cagttatttg
     2761 cccatcacaa gcacattttt aaaatgttgc tttgtgtgtg tttgacttct gcatttgagt
     2821 atcagtctca ggtcctagtt tactttccct ggttggaaat ttatttctta tttcctaaca
     2881 ttgaattcgt tagaaaaaac agcgtcacct cactcttcac ctgtcatgtt gattttcctt
     2941 atgaacccga agccatttag aaaatccctg tgtgtcaaaa ttacattcaa aaagctctcc
     3001 ttgtaattgc aagtttagta actcagtaag aacatgcctg cgactccctt tctggatgga
     3061 acctgggctg tggctctctg tcgtttgtgg tgctgtgatg gtgtctactg ttagaatagc
     3121 ttttctggag gtgggtggca actccacgcg ggagtcattg gctgggcttg agccctcagc
     3181 ctgtgatatg tggatgcagc tgtccagcca ctgcccttta acatgcccag cacacatggg
     3241 aggcctgtgg ccctgtgtcc agtggcccac aggacacgcc tccaccatat gctcatcctt
     3301 cctgcctgaa attgctgctg cccatcgcat gagcccacac agtagcaccc ccgtccttag
     3361 gatgagagtc agagcctttg gaaaggctgc atccccaggg ctagagctca gatgacctta
     3421 tttctagagg gacaggctgt tctgttggaa gagtctctgg cccagtcatg cacatctgta
     3481 gccccagcca tccttgtgcc ttcacctctg atgtgtttca caagcacgta gttcaaccca
     3541 gatagggacc acagagattc tggggccagc caggggcagt caaattggca cctactggct
     3601 ctgacttttt gtatgaagca tgcctcagtt tcctcatttt gatctagata taaaattaaa
     3661 attgtccatt tcctatataa ataccagcaa gatcactctg agatacataa actcgcattt
     3721 ccttctgttt tagtaaggag tgccagactt atctttgatg ggaatacagt atgaaccctg
     3781 cttgatgtaa aatggaaata gcacacaggc agatggccct gggtttggac tttgatcttg
     3841 ccatcattcc ccagtaaaac ctggggagtt ctgcgttgag tggacggact tattcctgtg
     3901 aagcggcata atttgtctcc attgaaaaat ggcattcact cttacagatg gtgttcactg
     3961 caagccccag aagcatatgg catgtgttca ctaagaggcc tttaatcctg gggagtaagg
     4021 ggcgaaggcc cttagacaac catggctgct gtactgccgc ccagggtggg tggccagtga
     4081 ggactggcct tagcccagtg gacctgtggc ttctctgagg cccttgagta actgaccaca
     4141 tttggaggtt ttgctggaaa tgcctgacct ctcagtctgg ctctgctgtg tagtccatag
     4201 cccagccaga tgagcttgca gcctcatagg aggtcagcac cttgcaaaga tgcagtcacc
     4261 atagatgtcc acgtagcaga gactgactta ggatctgaga taaagcatcg gattgcagga
     4321 ataactgtcc aaattagttc ttcctcctca actcatagga gtagctgtgg acagaggaac
     4381 caacatctgc cacctctggc attttctttc tttttttttc tttttgagac ggagtttcgc
     4441 ttttgtcccc caagctggag tacaatgaca ggatctcggc tcactgcaag ctctgcctcc
     4501 cgggttcaag cgattctcct gcctcagcct cccaagtagc tgggattaca ggcacccacc
     4561 acctcaccca gctaattttt gtattttcag tagagacggg gtttcaccat gttggccagg
     4621 ctactctcaa actcctgacc tcaggtgatc tgcccacctc ggcttcccaa agtgctggaa
     4681 ttacaggcct gagccacccc acccggccta ttttcttaaa ggggaacaaa tgatcttgac
     4741 aacatattat tccataaaac cagtttaggg cacaggccag ttcctgatta gaacacagga
     4801 cctgtgggag ggactatcag agatgcaaaa attacttcaa gatgagttta ttgttttcat
     4861 ttgtattgca aaagttagaa gtcattttac aaattaaaaa aacatttttt tcttggtagt
     4921 ctttaaaaat taggggattg aaaggatcca ggatgggctt tgtgtgtgtg tctcagattc
     4981 tcatttatta gtgagcacac ctgtgtatat atataaatca caaggagatc atcaagggaa
     5041 aacattttgc atgtgtaaag cttcatgaag ttctctttaa aaaataccaa agcttgttta
     5101 tttctgataa ttaacctaag cccttatgaa aataaacaaa atgaagggat tatgacaggt
     5161 attaccaaaa acaccaaaag gaacaaaggg gcctgcgtta aaacctaatt gctaatgctt
     5221 cacaactagg agagcatgcc gtcttgatgt ttaaaaaacc cagggtctcc acccttcctt
     5281 tgatttgtgc aattctgtct tccacagttc cggagccttc agtgaggggt agctacatgc
     5341 cccatgcctg ccctttcttt ccttctttgc tcactttact atgggtgtat tttaatcttg
     5401 tataaaaata tgcatgaatg agtcatgcac atgtatacgt tatgtatttg acaagtggtg
     5461 gtgaaacaaa atcaaaacag atttgatttg tgtttttgaa atgtcagtac attttgtgcc
     5521 actaacactg tgatgtataa aagagctgtt tgaatgcctt ttaatgttgt gttttgtact
     5581 ctggaatcat atggaaaaag tttgatttgt aatttcaata catattttaa atgtattgtg
     5641 tcttacgtag tttgtccccc cctttagcag ggattccttt ttaaagctat tttggctgga
     5701 atacaggtga cttttgtaaa
//
