LOCUS       NM_016422               4049 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 141 (RNF141), mRNA.
ACCESSION   NM_016422
VERSION     NM_016422.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4049)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4049)
  AUTHORS   Miyamoto,K., Uechi,A. and Saito,K.
  TITLE     The zinc finger domain of RING finger protein 141 reveals a unique
            RING fold
  JOURNAL   Protein Sci 26 (8), 1681-1686 (2017)
   PUBMED   28547869
  REMARK    GeneRIF: A germ cell-specific transcription factor RFP141 reveals a
            unique RING fold.
REFERENCE   3  (bases 1 to 4049)
  AUTHORS   Lee,Y.I., Giovinazzo,D., Kang,H.C., Lee,Y., Jeong,J.S.,
            Doulias,P.T., Xie,Z., Hu,J., Ghasemi,M., Ischiropoulos,H., Qian,J.,
            Zhu,H., Blackshaw,S., Dawson,V.L. and Dawson,T.M.
  TITLE     Protein microarray characterization of the S-nitrosoproteome
  JOURNAL   Mol Cell Proteomics 13 (1), 63-72 (2014)
   PUBMED   24105792
REFERENCE   4  (bases 1 to 4049)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   5  (bases 1 to 4049)
  AUTHORS   Qiu,W., Zhang,S., Xiao,C., Xu,W., Ma,Y., Liu,Y. and Wu,Q.
  TITLE     Molecular cloning and characterization of a mouse
            spermatogenesis-related ring finger gene znf230
  JOURNAL   Biochem Biophys Res Commun 306 (2), 347-353 (2003)
   PUBMED   12804569
  REMARK    GeneRIF: Analysis of the mouse counterpart.
REFERENCE   6  (bases 1 to 4049)
  AUTHORS   Zhang,S., Qiu,W., Wu,H., Zhang,G., Huang,M., Xiao,C., Yang,J.,
            Kamp,C., Huang,X., Huellen,K., Yue,Y., Pan,A., Lebo,R., Milunsky,A.
            and Vogt,P.H.
  TITLE     The shorter zinc finger protein ZNF230 gene message is transcribed
            in fertile male testes and may be related to human spermatogenesis
  JOURNAL   Biochem J 359 (Pt 3), 721-727 (2001)
   PUBMED   11672448
REFERENCE   7  (bases 1 to 4049)
  AUTHORS   Moore,G.P. and Sullivan,D.T.
  TITLE     The characterization of multiple forms of kynurenine formidase in
            Drosophila melanogaster
  JOURNAL   Biochim Biophys Acta 397 (2), 468-477 (1975)
   PUBMED   50862
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL598903.1, BC018104.1,
            BF970569.1, AL600289.1, BG108453.1, BQ229248.1, BU679024.1,
            CB956484.1, AI912940.1, AI356880.1 and AC021914.7.
            
            On Nov 22, 2018 this sequence version replaced NM_016422.3.
            
            Summary: The protein encoded by this gene contains a RING finger, a
            motif known to be involved in protein-DNA and protein-protein
            interactions. Abundant expression of this gene was found in the
            testicular tissue of fertile men, but was not detected in
            azoospermic patients. Studies of the mouse counterpart suggest that
            this gene may function as a testis specific transcription factor
            during spermatogenesis. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.60761.1,
                                           SRR1660809.49586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265981.7/ ENSP00000265981.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AL598903.1         49-413
            366-980             BC018104.1         396-1010
            981-1142            BF970569.1         329-490
            1143-1439           AL600289.1         307-603
            1440-1958           BG108453.1         73-591
            1959-2232           BQ229248.1         438-711
            2233-2902           BU679024.1         31-700
            2903-3593           CB956484.1         14-704
            3594-3939           AI912940.1         3-348               c
            3940-4044           AI356880.1         1-105               c
            4045-4049           AC021914.7         41805-41809
FEATURES             Location/Qualifiers
     source          1..4049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4049
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="ring finger protein 141"
                     /db_xref="GeneID:50862"
                     /db_xref="HGNC:HGNC:21159"
                     /db_xref="MIM:616641"
     exon            1..66
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            67..256
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..806
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="C3HC4-like zinc finger protein; zinc finger protein
                     230"
                     /codon_start=1
                     /product="RING finger protein 141"
                     /protein_id="NP_057506.2"
                     /db_xref="CCDS:CCDS7803.1"
                     /db_xref="GeneID:50862"
                     /db_xref="HGNC:HGNC:21159"
                     /db_xref="MIM:616641"
                     /translation="MGQQISDQTQLVINKLPEKVAKHVTLVRESGSLTYEEFLGRVAE
                     LNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQ
                     FIQLYKDITSQAAGVLAQSSTSEEPDENSSSVTSCQASLWMGRVKQLTDEEECCICMD
                     GRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYIL
                     NMADEAGQPHRP"
     exon            257..365
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            366..547
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            548..655
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            656..4049
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="hexamer: AATAAA"
     regulatory      3771..3776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="hexamer: AATAAT"
     polyA_site      3789
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="major polyA site"
     polyA_site      3799
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
     regulatory      3953..3958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="hexamer: AATATA"
     polyA_site      3987
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
     regulatory      4029..4034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
                     /note="hexamer: ATTAAA"
     polyA_site      4049
                     /gene="RNF141"
                     /gene_synonym="RFP141; ZFP26; ZNF230"
ORIGIN      
        1 aggtctgagc tgtgggctga ggcagcgcag ccgctgccgc agggtgcgcg atgccttgaa
       61 cctgggaaac tatgtgaagc aacactctgg attttgaaag acatcttttc atcatgggac
      121 agcaaatttc ggatcagaca cagttggtta ttaacaagtt accagaaaaa gtagcaaaac
      181 atgttacgtt ggttcgagag agtggctcct taacttatga agaatttctt gggagagtag
      241 ctgagcttaa tgatgtaacg gctaaagtgg cttctggcca ggaaaaacat cttctctttg
      301 aggtacaacc tgggtctgat tcctctgctt tttggaaagt ggttgtacgg gtggtctgta
      361 ccaagattaa caaaagcagt ggcattgtgg aggcatcacg gatcatgaat ttataccagt
      421 ttattcaact ttataaagat atcacaagtc aagcagcagg agtattggca cagagctcca
      481 cctctgaaga acctgatgaa aactcatcct ctgtaacatc ttgtcaggct agtctttgga
      541 tgggaagggt gaagcagctg accgatgagg aggagtgttg tatctgtatg gatgggcggg
      601 ctgacctcat cctgccttgt gctcacagct tttgtcagaa gtgtattgat aaatggagtg
      661 atcgacacag gaattgccct atttgtcgcc tacagatgac tggagcaaat gaatcttggg
      721 tggtatcaga tgcacccact gaagatgata tggctaacta tattcttaac atggctgatg
      781 aggcaggcca gccccacagg ccatgacctt gaagtgaaag tcttctgttg ctattgtggg
      841 ctcaaatatt tggtcatggg ggaagaatgt agggttgtgg cactggcaca gacacaggaa
      901 aatccatttt ccccactctt ttatttttgc tattctgatc atttgtcccc cttttaaaaa
      961 taaacttccc atgtcttcca tttgtggtac taaaatttgc tactgtttta gaccatattt
     1021 tcctattatt tatctgttca aatttgtatt attacaacta atagctcttg aattctttgc
     1081 taaaggtaac agcaacactt ccagaggctt ctaaaacact actgttttgc agggcaggag
     1141 tattctggaa tctttttact tagatataaa ataaacctcg aatattaaaa agttgtagcc
     1201 atctgagaga ggaaagttta agtgactgaa aatgtagaat acttcaacgt gcatgttact
     1261 acttaaaact agtctttctg ctggaatcta aggagtatat atatatatgc ccccttgtgg
     1321 ttaattattg ctcctttaat aatttttact tgaaatgatc cacaattatt tcataacttt
     1381 agcagtgtgt tttggaacta ctgtacttaa aggtttgttt gtttgttttt gccatactgt
     1441 ataatttggg tgaggtctac aaaattgggt gtgactttcc tttgcaaatg gatttctcct
     1501 ggggaatttt cttggctgtt ctggaaatgc tttcccacag ctgggtaact gttctaaatg
     1561 gctttgataa tgctcacaca tcttggagtt tcagaaggaa attattctgc atcacaaata
     1621 ctaaatttta tatttctaaa ttactatagg tcatttaata ttggtttatg gtgcttttat
     1681 ttccttaact tgaaaacatc tttctgagat ttcagagtcc tcaaatttct tagattaaga
     1741 gacaagaggc cagtgcagtg gttcacacct gtaatcccag cactttggga ggccgaggtg
     1801 ggtggatcat ttgaggttag gagtttgaga ccagcctggc caacatggcg aaatcctctc
     1861 tctactaaaa tacaaaaatt agctgggcat ggtggcaggt gcctgtaatc tcagctactc
     1921 gggaggctga ggcagaattg cttgaaccca ggaggtggag gttgcagtga gccgagatca
     1981 caccactgca ctccagcctg ggagacagaa cgagactcct aatcaaaaaa aaaacacaag
     2041 aaaatagagt gaggcttttt taccgtatat acataaaata cttatgaaaa ttagaagata
     2101 atttggcatt cctactgttt cactgtactt ccattgaaat actctttcca ttaaaatatt
     2161 ctgaaacaat atagtaataa tggaattgtg atcttcagtt gcacctcaac catttttttt
     2221 gcttatgaac taaaatttct aacattaaca tttcggcatg taataaaaca agggcctatc
     2281 tcctttaaaa tttaacattc catgtaactt ttctgactta tcattcataa gttgcaaata
     2341 ttactatttt cctaaaccag ggtacacaat ttaagttgcc acttattgat gacagaattt
     2401 ctggatagta ggattttaat aggcgagcaa ataaaattca aatcaatttc aaggaaaaac
     2461 atctggccag gggtagcttg atttcgcccc caaaaatact gaagactaat ccattgacat
     2521 tcataatggg acagctaagt accaaatagc taactactcc ctatggaggt ttatgcaagc
     2581 agagtaccag gggttccatc atatcaacct ggcaatgcac ttggtggttg tgtgaccttg
     2641 agaaagtctc ttactcttgt ttatgtgttc ttactttaga aactgagact ttatttgtgg
     2701 ttttcacact atttcagcag caaaaacttt ttcaaggaaa atcttacaga acctttaaac
     2761 acgtgtgcat acacacatac cctatacccc actatataaa agtcatatta ttataaattt
     2821 ccttattata taaactttat atactataaa tgtgattaag tcaatgaata aaaacattaa
     2881 tgcattggtg atatccagca tgtttgaatt tggtgagtaa cacacatata gtgggagtcg
     2941 ttttttttaa aaaaattttt taattaaatt caagtcaaat ttgcagaacc ctgtatctcc
     3001 tccatagatt cttagtattc catggaacat attttgaaaa ccttgggata gatgatccac
     3061 tgaaatcttt tccagctcta agattttaaa ttgtcctttt agattagact tgctgagttt
     3121 aattcagatt acctaatttt aaaatgtttc tgaaaagtga acagagttac cttacagagt
     3181 tttggatctt tccagggata gccaatgatt ttatccccca gaatccttca cctttcaagg
     3241 agttatttaa caatgagccc agtgactcaa tagggcccaa acctttttat tttacaatat
     3301 gagctccaag acacttactg atctactgtg aatataaaat gttattagcc ttatcaaata
     3361 aataaatgag cacagctctt tgttcgctct attgaactgg gtgataatta tttagatgtg
     3421 aatgttaggt cagttctact gtaataacta atcgtaaaag ttgtaaattt gtttaatgga
     3481 tgaaatgtac actttttgta ttctgtacag ctttgtcttt tttaaatatg aagtacttaa
     3541 atgtacttac tatgatagga aatataatgt gtgccttcta ggatttgtga agtggtttca
     3601 tgaactctaa ggaatttgtt ttccctatcc taactcagta acagagggtt tactccgatt
     3661 atgtatagaa ccttagtttg agaaaatgaa ttttactatg tactgaattt agaggttgag
     3721 aataatagga tctgtgttat tcttagtacc cactgataaa ttgtgcaata aataatcttt
     3781 cgcaagtgat tttagctaat tgaagagatt attttcctat gtaatttcac attctaatat
     3841 actaaatgtt tatattcctt agagaactat tttatattgt gcgctggggg cttgtgatgt
     3901 ttgtgtgctg ttttaaaatt catttcaaat tggactcgat ttccttatat ctaatatata
     3961 tctgggagaa aaggctgctt gaaaatatct tttgattcag tgatttttaa cattgggaag
     4021 ttgagtttat taaaaggtag tctgaagaa
//
