LOCUS       NM_004290               4170 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ring finger protein 14 (RNF14), transcript variant 1,
            mRNA.
ACCESSION   NM_004290
VERSION     NM_004290.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Zhao,S., Cordes,J., Caban,K.M., Gotz,M.J., Mackens-Kiani,T.,
            Veltri,A.J., Sinha,N.K., Weickert,P., Kaya,S., Hewitt,G.,
            Nedialkova,D.D., Frohlich,T., Beckmann,R., Buskirk,A.R., Green,R.
            and Stingele,J.
  TITLE     RNF14-dependent atypical ubiquitylation promotes
            translation-coupled resolution of RNA-protein crosslinks
  JOURNAL   Mol Cell 83 (23), 4290-4303 (2023)
   PUBMED   37951216
  REMARK    GeneRIF: RNF14-dependent atypical ubiquitylation promotes
            translation-coupled resolution of RNA-protein crosslinks.
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Suryo Rahmanto,A., Blum,C.J., Scalera,C., Heidelberger,J.B.,
            Mesitov,M., Horn-Ghetko,D., Graf,J.F., Mikicic,I., Hobrecht,R.,
            Orekhova,A., Ostermaier,M., Ebersberger,S., Mockel,M.M.,
            Krapoth,N., Da Silva Fernandes,N., Mizi,A., Zhu,Y., Chen,J.X.,
            Choudhary,C., Papantonis,A., Ulrich,H.D., Schulman,B.A., Konig,J.
            and Beli,P.
  TITLE     K6-linked ubiquitylation marks formaldehyde-induced RNA-protein
            crosslinks for resolution
  JOURNAL   Mol Cell 83 (23), 4272-4289 (2023)
   PUBMED   37951215
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Gurzeler,L.A., Link,M., Ibig,Y., Schmidt,I., Galuba,O.,
            Schoenbett,J., Gasser-Didierlaurant,C., Parker,C.N., Mao,X.,
            Bitsch,F., Schirle,M., Couttet,P., Sigoillot,F., Ziegelmuller,J.,
            Uldry,A.C., Teodorowicz,W., Schmiedeberg,N., Muhlemann,O. and
            Reinhardt,J.
  TITLE     Drug-induced eRF1 degradation promotes readthrough and reveals a
            new branch of ribosome quality control
  JOURNAL   Cell Rep 42 (9), 113056 (2023)
   PUBMED   37651229
  REMARK    Erratum:[Cell Rep. 2023 Sep 26;42(9):113159. doi:
            10.1016/j.celrep.2023.113159.. PMID: 37708027]
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Oltion,K., Carelli,J.D., Yang,T., See,S.K., Wang,H.Y., Kampmann,M.
            and Taunton,J.
  TITLE     An E3 ligase network engages GCN1 to promote the degradation of
            translation factors on stalled ribosomes
  JOURNAL   Cell 186 (2), 346-362 (2023)
   PUBMED   36638793
REFERENCE   5  (bases 1 to 4170)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 4170)
  AUTHORS   Miyamoto,H., Rahman,M., Takatera,H., Kang,H.Y., Yeh,S., Chang,H.C.,
            Nishimura,K., Fujimoto,N. and Chang,C.
  TITLE     A dominant-negative mutant of androgen receptor coregulator ARA54
            inhibits androgen receptor-mediated prostate cancer growth
  JOURNAL   J Biol Chem 277 (7), 4609-4617 (2002)
   PUBMED   11673464
  REMARK    GeneRIF: dominant-negative AR coregulator can suppress AR
            transactivation and cell proliferation in prostate cancer cells
REFERENCE   7  (bases 1 to 4170)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
REFERENCE   8  (bases 1 to 4170)
  AUTHORS   Ueki,N., Seki,N., Yano,K., Masuho,Y., Saito,T. and Muramatsu,M.
  TITLE     Isolation and characterization of a novel human gene (HFB30) which
            encodes a protein with a RING finger motif
  JOURNAL   Biochim Biophys Acta 1445 (2), 232-236 (1999)
   PUBMED   10320776
REFERENCE   9  (bases 1 to 4170)
  AUTHORS   Kang,H.Y., Yeh,S., Fujimoto,N. and Chang,C.
  TITLE     Cloning and characterization of human prostate coactivator ARA54, a
            novel protein that associates with the androgen receptor
  JOURNAL   J Biol Chem 274 (13), 8570-8576 (1999)
   PUBMED   10085091
REFERENCE   10 (bases 1 to 4170)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC402536.1, AF060544.1,
            AC005740.1 and BE042895.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004290.4.
            
            Summary: The protein encoded by this gene contains a RING zinc
            finger, a motif known to be involved in protein-protein
            interactions. This protein interacts with androgen receptor (AR)
            and may function as a coactivator that induces AR target gene
            expression in prostate. A dominant negative mutant of this gene has
            been demonstrated to inhibit the AR-mediated growth of prostate
            cancer. This protein also interacts with class III
            ubiquitin-conjugating enzymes (E2s) and may act as a
            ubiquitin-ligase (E3) in the ubiquitination of certain nuclear
            proteins. Six alternatively spliced transcript variants encoding
            two distinct isoforms have been reported. [provided by RefSeq, Jan
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.229101.1,
                                           SRR1660807.228946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394520.7/ ENSP00000378028.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               DC402536.1         223-557
            336-1905            AF060544.1         132-1701
            1906-3778           AC005740.1         78899-80771         c
            3779-4169           BE042895.1         8-398               c
            4170-4170           AC005740.1         78507-78507         c
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..4170
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:9604"
                     /db_xref="HGNC:HGNC:10058"
                     /db_xref="MIM:605675"
     exon            1..63
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..237
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..397
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1668
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /EC_number="2.3.2.31"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen receptor associated protein 54; E3
                     ubiquitin-protein ligase RNF14"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform 1"
                     /protein_id="NP_004281.1"
                     /db_xref="CCDS:CCDS4270.1"
                     /db_xref="GeneID:9604"
                     /db_xref="HGNC:HGNC:10058"
                     /db_xref="MIM:605675"
                     /translation="MSSEDREAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQ
                     ASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLF
                     LCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATP
                     GQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNF
                     AFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEME
                     SKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHFNDPG
                     SPCFNRLFYAVDVDDDIWEDEVED"
     exon            398..549
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1077
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1306
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1479
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1610
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..4170
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="hexamer: ATTAAA"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="hexamer: ATTATA"
     polyA_site      1917
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="major polyA site"
     polyA_site      1930
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="major polyA site"
     regulatory      3037..3042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="hexamer: AATAAA"
     polyA_site      3067
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="hexamer: ATTAAA"
     polyA_site      3651
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
                     /note="hexamer: AATAAA"
     polyA_site      4170
                     /gene="RNF14"
                     /gene_synonym="ARA54; HFB30; HRIHFB2038; TRIAD2"
ORIGIN      
        1 gagaacggaa gaggcggcgc gccggttgag cagggcgtct ctaggcctgg tcggctggcg
       61 gcgatggcag gattttcata atatatgtag tatgagttcc acatcttggc ctcttaccca
      121 gcttcagcag tctcagctcc accagttaga gaataaatgg gatttgcatg aactccactc
      181 tgagctgaaa tacagactgc ggtgttaata tccttttctt ctgattgtta ttaacaggtc
      241 cttatgtcgt cagaagatcg agaagctcag gaggatgaat tgctggccct ggcaagtatt
      301 tacgatggag atgaatttag aaaagcagag tctgtccaag gtggagaaac caggatctat
      361 ttggatttgc cacagaattt caagatattt gtgagcggca attcaaatga gtgtctccag
      421 aatagtggct ttgaatacac catttgcttt ctgcctccac ttgtgctgaa ctttgaactg
      481 ccaccagatt atccatcctc ttccccacct tcattcacac ttagtggcaa atggctgtca
      541 ccaactcagc tatctgctct atgcaagcac ttagacaacc tatgggaaga acaccgtggc
      601 agcgtggtcc tgtttgcctg gatgcaattt cttaaggaag agaccctagc atacttgaat
      661 attgtctctc cttttgagct caagattggt tctcagaaaa aagtgcagag aaggacagct
      721 caagcttctc ccaacacaga gctagatttt ggaggagctg ctggatctga tgtagaccaa
      781 gaggaaattg tggatgagag agcagtgcag gatgtggaat cactgtcaaa tctgatccag
      841 gaaatcttgg actttgatca agctcagcag ataaaatgct ttaatagtaa attgttcctg
      901 tgcagtatct gtttctgtga gaagctgggt agtgaatgca tgtacttctt ggagtgcagg
      961 catgtgtact gcaaagcctg tctgaaggac tactttgaaa tccagatcag agatggccag
     1021 gttcaatgcc tcaactgccc agaaccaaag tgcccttcgg tggccactcc tggtcaggtc
     1081 aaagagttag tggaagcaga gttatttgcc cgttatgacc gccttctcct ccagtcctcc
     1141 ttggacctga tggcagatgt ggtgtactgc ccccggccgt gctgccagct gcctgtgatg
     1201 caggaacctg gctgcaccat gggtatctgc tccagctgca attttgcctt ctgtactttg
     1261 tgcaggttga cctaccatgg ggtctcccca tgtaaggtga ctgcagagaa attaatggac
     1321 ttacgaaatg aatacctgca agcggatgag gctaataaaa gacttttgga tcaaaggtat
     1381 ggtaagagag tgattcagaa ggcactggaa gagatggaaa gtaaggagtg gctagagaag
     1441 aactcaaaga gctgcccatg ttgtggaact cccatagaga aattagacgg atgtaacaag
     1501 atgacatgta ctggctgtat gcaatatttc tgttggattt gcatgggttc tctctctaga
     1561 gcaaaccctt acaaacattt caatgaccct ggttcaccat gttttaaccg gctgttttat
     1621 gctgtggatg ttgacgacga tatttgggaa gatgaggtag aagactagtt aactactgct
     1681 caagatatgg aagtggattg tttttcccta atcttccgtc aagtacacaa agtaactttg
     1741 cgggatattt agggtactat tcattcactc ttcctgcgta gaagatatgg aagaacgagg
     1801 tttatatttt catgtggtac tactgaagaa ggtgcattga tacattttta aatgtaagtt
     1861 gagaaaaatt tataagccaa aggttcagaa aattaaacta cagaatatta aatattataa
     1921 tgtgcccaaa gctctgaata gttaaaaatt aaatatttat tttcttcccc aagctttagg
     1981 taaggagaag aggggtcaag agttaaactt agagaccctt tgtctctgag aagcatcctt
     2041 ctaagacatt ctgttggagt tccctcagta ctattcctta caactggagt gggtagaagc
     2101 cttatgaaaa ttatactgag aacctgatct cgtttactcc atgttaatca cattcctacc
     2161 aacctaaatt tctgccaagt cagttctctt tggaggaagc ccattactcc gtaactgact
     2221 ggatggtcca gtgtcatttt gatctgcttt tcagaatgga aatttataat ataaatatat
     2281 gttttaatac cacaaacact gtggggcact tgatatttat tagtggtgta tatggtccac
     2341 tggtttcagg ccaaatctag aatttagtga tactggctca gaagaattta agttctattc
     2401 agccttcctg ggtgttagaa cctagattca aaatggcttg tctttgctac ttttgttcca
     2461 cattctctct ctttaccttt gccctacctt ctgtttgtaa ggatgatttt aatattaatt
     2521 ccaggaacac atgtttttat ttcctctgct ggaataggag aaagcttaat atattcccaa
     2581 gctgaatgtt cttgaattat atctgcattt accactgtat atgcatatag tgacagtata
     2641 acctgtctat actacagtag ttccagtcct aactttctga attattttta aagatcttct
     2701 ctaacaagct atgggaattt ggcttcatac tctttctttg caacagcagt gttctgggtg
     2761 ataattttga attgatacct gttccttttt ctgggttttg ttggcttttt gaaaaattgt
     2821 ctttccttat cattggtggg aggcttggta gcaaagtaac attttttgga aaagaggaca
     2881 gaaaaattga actacagctt gagaacgtat tctttttttc ctactttgtt attgcaaatt
     2941 gaggaatcac ttttaactgt tttaggtgtg tgtgtccaga gtgagcaagg attatgtttt
     3001 tggattgtca aagaggatgc ttagtcttaa aataaaaata aatttaaaaa tcatcttata
     3061 attagaacag agttgctgct atttgttctg tcaccaaggc aactaatcac attttaaaac
     3121 tgttcggcat ataacatatt cttaaagtaa gaaaaaaaag gtcacagaat agcatctctt
     3181 ttacctgggc ttgtgactga gcttaggttt tagggcccat attttgttta aaccagatag
     3241 tttcatggtc ttccattcag gacattttgt gtaaaaattg aggttaattt gctgggcaca
     3301 gtggctcacg cctgtaatcc cagcactttg ggaggcctag gcgggcggat cacgaggtca
     3361 ggagttcgag accatcatgg ctaacacggt gaaaccccgt ctctactaaa aatacaaaaa
     3421 attagctggg catggtggca ggcgcctgta gtcccagcta ctcaggaggc tgaggcagga
     3481 gaatggcatg aacctgggag gtggagcttg cagtgagccg agatagcgcc actgcactcc
     3541 agcctgagcg acagagcgag actccttctc aaaaaaaaaa aaaaaaaaaa ttgaggttaa
     3601 agaataaatt aaagataaga aatggaaatt aaaatgattt gttctacagt atatacctga
     3661 gaagagtgat ttctgtgatc aaagagttca attcagattt attcagaaag agctactcag
     3721 aagctctata gttcgtgagc tacttgatat tttctagaga tcattttatg ttaagctgtt
     3781 atacattgtt gatgatgtca tagaagtagg aaagaagcct ttataataca gttttatgaa
     3841 agaaatggga gccttttttc ccatttatga tattaaaaac aacacaggta tttggtgttt
     3901 agtctcaaaa atttgtttgg tcaccttagt gattcttagg tacaaagtct tcatcactca
     3961 attttaacaa agaaaatagg gcttataaag ttatactttt gaagcatgag ttatgagcta
     4021 attttaagat gtatagtttt ggtagagtac ttttgtctca gtaaaatgaa agatttgggt
     4081 aactccccaa atgccctgta aaacaaatgg gtttgtggaa ggttgtggtg tcagcaaaat
     4141 atatgataga ataaagagtt ttgtacctac
//
