LOCUS       NM_007218               3199 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ring finger protein 139 (RNF139), mRNA.
ACCESSION   NM_007218
VERSION     NM_007218.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3199)
  AUTHORS   Chen,X., Kuang,W., Zhu,Y., Zhou,B., Li,X., Zhang,X., Li,B., Li,L.
            and Zou,S.
  TITLE     An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in
            Glioma
  JOURNAL   J Mol Neurosci 71 (8), 1664-1673 (2021)
   PUBMED   34106407
  REMARK    GeneRIF: An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor
            in Glioma.
REFERENCE   2  (bases 1 to 3199)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3199)
  AUTHORS   Zhang,Y., Lu,J., Ma,J. and Liu,X.
  TITLE     Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by
            degrading Gag via activity of the ubiquitin ligase TRC8
  JOURNAL   J Biol Chem 294 (6), 2046-2059 (2019)
   PUBMED   30563842
  REMARK    GeneRIF: INSIG1 coordinated with another ligase, translocation in
            renal carcinoma chromosome 8 (TRC8), and promoted Gag degradation
            through the lysosome pathway.
REFERENCE   4  (bases 1 to 3199)
  AUTHORS   Stefanovic-Barrett,S., Dickson,A.S., Burr,S.P., Williamson,J.C.,
            Lobb,I.T., van den Boomen,D.J., Lehner,P.J. and Nathan,J.A.
  TITLE     MARCH6 and TRC8 facilitate the quality control of cytosolic and
            tail-anchored proteins
  JOURNAL   EMBO Rep 19 (5) (2018)
   PUBMED   29519897
  REMARK    GeneRIF: TRC8 and MARCH6 depletion altered the turnover of the
            tail-anchored protein heme oxygenase-1.
REFERENCE   5  (bases 1 to 3199)
  AUTHORS   Wang,L., Yin,W. and Shi,C.
  TITLE     E3 ubiquitin ligase, RNF139, inhibits the progression of tongue
            cancer
  JOURNAL   BMC Cancer 17 (1), 452 (2017)
   PUBMED   28662643
  REMARK    GeneRIF: Low RNF139 expression is associated with progression of
            tongue cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3199)
  AUTHORS   Poland,K.S., Azim,M., Folsom,M., Goldfarb,R., Naeem,R., Korch,C.,
            Drabkin,H.A., Gemmill,R.M. and Plon,S.E.
  TITLE     A constitutional balanced t(3;8)(p14;q24.1) translocation results
            in disruption of the TRC8 gene and predisposition to clear cell
            renal cell carcinoma
  JOURNAL   Genes Chromosomes Cancer 46 (9), 805-812 (2007)
   PUBMED   17539022
  REMARK    GeneRIF: The presence of diploid and tetraploid tumor cells with
            and without TRC8 deletions on the nontranslocated chromosome
            suggest that loss of the remaining normal allele of TRC8 may
            contribute to tumor development at later stages.
REFERENCE   7  (bases 1 to 3199)
  AUTHORS   Brauweiler,A., Lorick,K.L., Lee,J.P., Tsai,Y.C., Chan,D.,
            Weissman,A.M., Drabkin,H.A. and Gemmill,R.M.
  TITLE     RING-dependent tumor suppression and G2/M arrest induced by the
            TRC8 hereditary kidney cancer gene
  JOURNAL   Oncogene 26 (16), 2263-2271 (2007)
   PUBMED   17016439
  REMARK    GeneRIF: TRC8 modulation of sterol response element binding protein
            activity comprises a novel regulatory link between growth control
            and the cholesterol/lipid homeostasis pathway.
REFERENCE   8  (bases 1 to 3199)
  AUTHORS   Gemmill,R.M., Bemis,L.T., Lee,J.P., Sozen,M.A., Baron,A., Zeng,C.,
            Erickson,P.F., Hooper,J.E. and Drabkin,H.A.
  TITLE     The TRC8 hereditary kidney cancer gene suppresses growth and
            functions with VHL in a common pathway
  JOURNAL   Oncogene 21 (22), 3507-3516 (2002)
   PUBMED   12032852
REFERENCE   9  (bases 1 to 3199)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   10 (bases 1 to 3199)
  AUTHORS   Gemmill,R.M., West,J.D., Boldog,F., Tanaka,N., Robinson,L.J.,
            Smith,D.I., Li,F. and Drabkin,H.A.
  TITLE     The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to
            a patched-related gene, TRC8
  JOURNAL   Proc Natl Acad Sci U S A 95 (16), 9572-9577 (1998)
   PUBMED   9689122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD171728.1, BC021571.1,
            BM804626.1, AA455970.1 and BM677460.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_007218.3.
            
            Summary: The protein encoded by this gene is a multi-membrane
            spanning protein containing a RING-H2 finger. This protein is
            located in the endoplasmic reticulum, and has been shown to possess
            ubiquitin ligase activity. This gene was found to be interrupted by
            a t(3:8) translocation in a family with hereditary renal and
            non-medulary thyroid cancer. Studies of the Drosophila counterpart
            suggested that this protein may interact with tumor suppressor
            protein VHL, as well as with  COPS5/JAB1, a protein responsible for
            the degradation of tumor suppressor CDKN1B/P27KIP. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064636.1, AF064801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303545.4/ ENSP00000304051.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               CD171728.1         139-706
            569-886             BC021571.1         553-870
            887-888             BM804626.1         827-828
            889-2483            BC021571.1         873-2467
            2484-2667           AA455970.1         7-190               c
            2668-3199           BM677460.1         99-630              c
FEATURES             Location/Qualifiers
     source          1..3199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..3199
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /note="ring finger protein 139"
                     /db_xref="GeneID:11236"
                     /db_xref="HGNC:HGNC:17023"
                     /db_xref="MIM:603046"
     exon            1..411
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2225
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /EC_number="2.3.2.27"
                     /note="patched related protein translocated in renal
                     cancer; multiple membrane spanning receptor TRC8;
                     translocation in renal carcinoma on chromosome 8 protein;
                     RING-type E3 ubiquitin transferase RNF139; translocation
                     in renal carcinoma, chromosome 8"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF139"
                     /protein_id="NP_009149.2"
                     /db_xref="CCDS:CCDS6350.1"
                     /db_xref="GeneID:11236"
                     /db_xref="HGNC:HGNC:17023"
                     /db_xref="MIM:603046"
                     /translation="MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDS
                     SQSRFCIVLQIFLRLFGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLH
                     IDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILDLL
                     VPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRI
                     YGLQLLMEDTWKRIRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDL
                     ICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFIL
                     ALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPV
                     LFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYY
                     NVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNI
                     YLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHY
                     FHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAE
                     SDRELNEDDSTDCDDDVQRERNGVIQHTGAAAEEFNDDTD"
     exon            412..3199
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2453..2458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /note="major polyA site"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /note="hexamer: AATGAA"
     polyA_site      2570
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /note="hexamer: AATAAA"
     polyA_site      2670
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
                     /note="hexamer: ACTAAA"
     polyA_site      2843
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
     polyA_site      3122
                     /gene="RNF139"
                     /gene_synonym="HRCA1; RCA1; TRC8"
ORIGIN      
        1 agagacctcc tggggagccg ccgccgccgc cctctcggcc atcgctgcct ccgccgcctg
       61 ctccacctcg agggacgcga gcgggcggcg gggctggccg tgagagagac aggagaggaa
      121 ggagggcagg ggcggagttg cccgccttag cccccgcccc cggccgcggc cccgggccct
      181 gccccgcgcg gccctgcccg gcccaccgag ccctggtgtg gcagcggctc atggcggccg
      241 tggggccccc gcagcagcag gtgcggatgg cccatcagca ggtctgggcg gcgctcgaag
      301 tggcgctccg ggtgccctgc ctttacatca tcgacgccat cttcaactcc tacccggatt
      361 ccagccaaag ccggttctgc atcgtgctcc agatcttcct ccggctcttt ggtgtatttg
      421 catccagtat tgttctgatc ttgtcacaac gatcactttt caagttttac acgtacagct
      481 cagcctttct gttagctgca acttcagtgt tggtgaatta ttatgcttct ttgcacattg
      541 acttctatgg tgcctacaac acgtcagctt ttggaattga gctgcttcct cgaaaaggtc
      601 cctcgctgtg gatggcactt atcgttctac agctaacatt tggaattgga tacgttacac
      661 tactccagat tcattccatc tattcacaat taattatttt ggatctcttg gttcctgtaa
      721 taggcttaat cacagagcta ccattacaca tcagagagac tttactgttt acttcttcct
      781 tgattctcac attaaataca gtgtttgtcc tggcagtgaa actgaagtgg ttttattatt
      841 ccacacgata tgtttatctt ttggtgaggc acatgtatcg aatttacgga ttacagttat
      901 tgatggagga cacatggaag aggattcgtt tcccagacat actacgagtc ttttggctaa
      961 caagagttac agctcaggct acagtgttaa tgtacatctt aaggatggca aatgaaactg
     1021 attccttctt tatttcttgg gatgattttt gggacctcat ttgcaatctt ataattagtg
     1081 ggtgcgattc tacactaact gtactgggca tgagtgctgt aatttcctca gtagcccatt
     1141 atttggggct tggaatattg gcctttattg gatcaactga ggaagatgac aggcgtcttg
     1201 gctttgttgc acctgtttta ttttttattt tggctcttca gactgggtta agtgggctaa
     1261 gaccagaaga gagacttatt cgcttaagta gaaacatgtg ccttttatta actgcagtcc
     1321 tgcattttat ccatggaatg acagaccctg tattaatgtc tctcagtgcc tctcatgtgt
     1381 catcttttcg tagacatttt cctgtgctgt ttgtctctgc ttgcctgttt attcttcctg
     1441 tcttactcag ttatgttctt tggcatcact atgcactaaa tacatggttg tttgcagtta
     1501 cagcattttg tgtggaactg tgcttaaaag taattgtttc tctcactgtt tatacgttat
     1561 tcatgattga tggctactat aatgtcctct gggaaaagct tgacgattat gtctactacg
     1621 ttcgttcaac aggcagtatt attgaattta tatttggagt tgtaatgttt ggaaatgggg
     1681 cttacactat gatgtttgag tcgggaagta aaattcgggc ttttatgatg tgcctacatg
     1741 catattttaa catctactta caagccaaaa atggctggaa gacatttatg aatcgtagga
     1801 ctgctgtgaa gaaaattaat tcacttcctg aaataaaagg gagccgctta caagaaataa
     1861 atgatgtatg tgcaatctgc tatcatgagt ttacaacatc tgctcgtatt acaccgtgta
     1921 atcattattt ccatgcactt tgccttcgga aatggctgta cattcaagat acttgtccaa
     1981 tgtgccatca gaaagtatac atcgaagatg atatcaagga taattcaaat gtatctaaca
     2041 acaatggatt tattccaccc aatgaaactc cagaggaagc tgtaagagaa gctgctgctg
     2101 aatctgacag ggaattgaac gaagatgaca gtacagattg tgatgatgat gttcaaagag
     2161 aaagaaatgg agtgattcag cacacaggcg cagcagctga agaatttaat gatgatactg
     2221 actgatgaaa atagcattta ttaatgattg aggtatttgt ttaaaattca gttcatccaa
     2281 aatggagtaa tatccttcac cttcagtgtg taaccaagca caaaaacagt atcaatgttg
     2341 aatctgtgaa tggttttccg tttactgtga tgtgctactg taaatatacc tctttaatta
     2401 cttctggtct ctttggtgac ctgtttaaat ttgtgtacat tattgtacat agaataaaat
     2461 gttttcacat ttttatgaca aaatttgaac aaatagcttt ttaatagatg taatgatcat
     2521 atggtgcgtc acctgtgcca aatattcttc aatgaaatta tataatgtaa ctttggacct
     2581 cagtttttct ttagaaatgg gtgggagaat gaaaatgcaa atcaggaaac cacattaaag
     2641 tcaaggaaat aaaataattt gaccagagga taaaggacat gagagagtat tttaaaacta
     2701 aagaaaaaat tagctgccag aagcaactga ggaccttttt tgaaacttga gtagcagtgt
     2761 aattgagctg agtttgaaag tcctgattca gagagagact gagggttgac aaataaactg
     2821 tatcaactaa actttgatat aaaccagaat gtgctaaatg ttttttatgt aaaattgtat
     2881 atttgttagc cattctgtgt ctgcagtatt gtcataaaat tgtcctttca ttcttttgaa
     2941 gatattacaa aacaaaaata gtttttttta aattgtttta aactaagata ctcaatgata
     3001 taaaaacatc ctgatctgat tttacgagaa aaagaagggg aatggtgggg aatggtgtgt
     3061 accgatatat agtatttctt tagacaactt gcagataatt tctttattga aactatcagg
     3121 aagttttact atgaaatttt acatacatga tggaaagtgg aagacatata ccaattatat
     3181 tccaggaaaa aatacttta
//
