LOCUS       NM_016271               3551 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens ring finger protein 138 (RNF138), transcript variant
            1, mRNA.
ACCESSION   NM_016271
VERSION     NM_016271.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3551)
  AUTHORS   Singh,A.K., Upadhyay,V., Sethi,A., Chowdhury,S., Mishra,S.,
            Verma,S.P., Bhatt,M.L.B. and Trivedi,A.K.
  TITLE     Ring finger protein 138 inhibits transcription factor C/EBPalpha
            protein turnover leading to differentiation arrest in acute myeloid
            leukemia
  JOURNAL   Biochem J 481 (10), 653-666 (2024)
   PUBMED   38666590
  REMARK    GeneRIF: Ring finger protein 138 inhibits transcription factor
            C/EBPalpha protein turnover leading to differentiation arrest in
            acute myeloid leukemia.
REFERENCE   2  (bases 1 to 3551)
  AUTHORS   Locke,A.J., Abou Farraj,R., Tran,C., Zeinali,E., Mashayekhi,F.,
            Ali,J.Y.H., Glover,J.N.M. and Ismail,I.H.
  TITLE     The role of RNF138 in DNA end resection is regulated by
            ubiquitylation and CDK phosphorylation
  JOURNAL   J Biol Chem 300 (3), 105709 (2024)
   PUBMED   38309501
  REMARK    GeneRIF: The role of RNF138 in DNA end resection is regulated by
            ubiquitylation and CDK phosphorylation.
REFERENCE   3  (bases 1 to 3551)
  AUTHORS   Liu,W., Wang,Z., Liu,S., Zhang,X., Cao,X. and Jiang,M.
  TITLE     RNF138 inhibits late inflammatory gene transcription through
            degradation of SMARCC1 of the SWI/SNF complex
  JOURNAL   Cell Rep 42 (2), 112097 (2023)
   PUBMED   36800290
  REMARK    GeneRIF: RNF138 inhibits late inflammatory gene transcription
            through degradation of SMARCC1 of the SWI/SNF complex.
REFERENCE   4  (bases 1 to 3551)
  AUTHORS   Averbeck,N.B., Barent,C., Jakob,B., Syzonenko,T., Durante,M. and
            Taucher-Scholz,G.
  TITLE     The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate
            Resection of Complex DNA Double-Strand Breaks in Human G1-Phase
            Cells
  JOURNAL   Cells 11 (16), 2561 (2022)
   PUBMED   36010636
  REMARK    GeneRIF: The Ubiquitin Ligase RNF138 Cooperates with CtIP to
            Stimulate Resection of Complex DNA Double-Strand Breaks in Human
            G1-Phase Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3551)
  AUTHORS   Lu,Y., Huang,R., Ying,J., Li,X., Jiao,T., Guo,L., Zhou,H., Wang,H.,
            Tuersuntuoheti,A., Liu,J., Chen,Q., Wang,Y., Su,L., Guo,C., Xu,F.,
            Wang,Z., Lu,Y., Li,K., Liang,J., Huang,Z., Chen,X., Yao,J., Hu,H.,
            Cheng,X., Wan,Y., Chen,X., Zhang,N., Miao,S., Cai,J., Wang,L.,
            Liu,C., Song,W. and Zhao,H.
  TITLE     RING finger 138 deregulation distorts NF-small ka, CyrillicB
            signaling and facilities colitis switch to aggressive malignancy
  JOURNAL   Signal Transduct Target Ther 7 (1), 185 (2022)
   PUBMED   35697692
  REMARK    GeneRIF: RING finger 138 deregulation distorts NF-small ka,
            CyrillicB signaling and facilities colitis switch to aggressive
            malignancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3551)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 3551)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   8  (bases 1 to 3551)
  AUTHORS   Yamada,M., Ohnishi,J., Ohkawara,B., Iemura,S., Satoh,K.,
            Hyodo-Miura,J., Kawachi,K., Natsume,T. and Shibuya,H.
  TITLE     NARF, an nemo-like kinase (NLK)-associated ring finger protein
            regulates the ubiquitylation and degradation of T cell
            factor/lymphoid enhancer factor (TCF/LEF)
  JOURNAL   J Biol Chem 281 (30), 20749-20760 (2006)
   PUBMED   16714285
  REMARK    GeneRIF: NARF functions as a novel ubiquitin-ligase to regulate
            ubiquitylation and degradation of T cell factor/lymphoid enhancer
            factor
REFERENCE   9  (bases 1 to 3551)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 3551)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB452430.1, AC011825.13 and
            BC018107.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016271.4.
            
            Summary: The protein encoded by this gene contains a RING finger, a
            motif present in a variety of functionally distinct proteins and
            known to be involved in protein-DNA and protein-protein
            interactions. Alternatively spliced transcript variants encoding
            distinct isoforms have been observed. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 3 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018107.1, SRR1803611.134661.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261593.8/ ENSP00000261593.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB452430.1         20-55
            37-362              AC011825.13        50566-50891
            363-549             AC011825.13        51356-51542
            550-715             AC011825.13        70410-70575
            716-831             AC011825.13        72401-72516
            832-888             AC011825.13        82174-82230
            889-1000            AC011825.13        83390-83501
            1001-1108           AC011825.13        85349-85456
            1109-2688           AC011825.13        87775-89354
            2689-3551           BC018107.1         2349-3211
FEATURES             Location/Qualifiers
     source          1..3551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3551
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /note="ring finger protein 138"
                     /db_xref="GeneID:51444"
                     /db_xref="HGNC:HGNC:17765"
                     /db_xref="MIM:616319"
     exon            1..362
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            363..549
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1177
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Nemo-like kinase-associated RING finger protein; E3
                     ubiquitin-protein ligase RNF138; NLK-associated RING
                     finger protein; testicular tissue protein Li 165;
                     nemo-like kinase associated ring finger protein; ring
                     finger protein 138, E3 ubiquitin protein ligase; RING-type
                     E3 ubiquitin transferase RNF138"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF138 isoform 1"
                     /protein_id="NP_057355.2"
                     /db_xref="CCDS:CCDS11903.1"
                     /db_xref="GeneID:51444"
                     /db_xref="HGNC:HGNC:17765"
                     /db_xref="MIM:616319"
                     /translation="MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFL
                     TAMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHY
                     KSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCP
                     LCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFD
                     YGEFVNLQLDEETQYQTAVEESFQVNI"
     exon            550..715
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            716..831
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            832..888
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1000
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1108
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..3551
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /note="hexamer: ATTAAA"
     polyA_site      3551
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /note="major polyA site"
ORIGIN      
        1 gccgtgcgcc ggttgctata caggccgcac ttcacacccc gtgcctcccc gcctctcctg
       61 gctcctccgc ccagatcccc ggcgctcccg cgttcggtga cggccgggta ggctgtaggc
      121 agcgcaatgc caagacagag ctgctggcgg cggcgggcga atctccctgc accatgagcc
      181 tcggctccgg ccccgttagg ggccgataag cacagcgcac gccgccctcc atttgccccg
      241 gggcctcggc tgcgaagata gcggcggccg gacaggaagc tcgaggaaag cgctgggccg
      301 ggtctctacg aacacgtgaa ggaaaagcag ctccgtccac aacgccgctt cggggctcct
      361 agggagtcgg gccccgggcc gccaccgtca cctcggccgc tgccgctgtc gccatcgcct
      421 tgtttcccca tcccccgcca tggccgagga cctctctgcg gccacgtcct acaccgaaga
      481 tgatttctac tgccccgtct gtcaggaggt gctcaaaacg cccgtgcgga ccacggcctg
      541 tcagcacgtt ttctgtagaa aatgtttcct gactgcaatg agggaaagcg gagcacattg
      601 tcccctatgt cgtggaaatg tgactagaag agagagagca tgtcctgaac gggccttaga
      661 ccttgaaaat ataatgagga agttttctgg tagctgcaga tgctgtgcaa aacagattaa
      721 attctatcgc atgagacatc attacaaatc ttgtaagaag tatcaggatg aatatggtgt
      781 ttcttctatc attccaaact ttcagatctc tcaagattca gtagggaaca gcaataggag
      841 tgaaacatcc acatctgata acacagaaac ttaccaagag aatacaagtt cttctggtca
      901 tcctactttt aagtgtcccc tgtgtcaaga atcaaatttt accagacagc gtttactgga
      961 tcactgtaac agtaatcacc tatttcagat agttcctgtg acatgtccta tttgtgtgtc
     1021 tcttccttgg ggagatccta gccagattac cagaaatttc gttagtcatc taaatcagag
     1081 acatcaattt gattatggag aatttgtgaa tcttcagcta gatgaagaaa cccaatacca
     1141 aactgctgtt gaagaatctt ttcaagtaaa catctgaagg ctgtagacat ctctgcatct
     1201 ttgtacctgc aagtgccatc tttaaggggg aaactacatg aagtcaccgt tacagtaact
     1261 tgatgtgtat attaataaaa gtaattcagt cattttagtt tttgattgaa aataaaggta
     1321 gggcttctaa aaacttcatc atcttgataa gttaaaaaat gaaagttatg acattagctt
     1381 taaaggtgta aaaaagatgt ttcactaatg taacggtgaa agagaatccc tgttgtactt
     1441 tatctttttg taatattatt tttgaatttt tcattattat gttgcttttg aaatttgatg
     1501 cattcctccc atttacttta ttattgtaca catttaacac acagtagcaa attttgaacg
     1561 atgtgattga tataacctaa caaatctgag ccagttatta ttagagttgc agaatagaaa
     1621 cttgaagtgc taaatggaat aatccaaagg aaatttttta aatgcaggtt ctagctgaaa
     1681 aattcaacta taagaaaatt gtatttatat aacatttact atttttgaag actagtgaga
     1741 tttctgtaat aattttaatt ctttaaaaag tgaaagcttg ttgtaaagat attttctttt
     1801 tgttattaga aggaaataca aagagaaaaa tttctttctt tcatgggcat ttgataattt
     1861 cagtctttga ctgatttgta agcctagaat atactaagct gaataacagc tctttggcct
     1921 cagaattttc agtagccagt atttctgatt aactaagttg aaactcttat tagaaacttt
     1981 cagttggtga tattgtattc tagaagatat aaatgagagg tttggcttca tctcagttta
     2041 gaaatttatt caaagctaaa gatgtatata tacatatact tttgtgtgta tatatacaca
     2101 tatgtgtgta tgcagtttgt caggttatat atagaatttc tattaaggat tttttaaatg
     2161 gacaagcaat agggggttga agtgtttatc tgatttgttt aaaattttgt atatcaccaa
     2221 atttttaaaa agtgatagtc acagtgctaa gttatctagt tggctactat tacaccttaa
     2281 aaattgagtt tacacacaca caattacctg tttatatggt gctcatttgt tattctcaaa
     2341 tataatgtgt gaccgtgata tagtgagaaa gattctacca accactgttt cactactttt
     2401 tagttaaaat tgggtatgtt cttaatattc attagtgaga atcacaaagt attttgtaga
     2461 aggcccaaat cacagaataa aggactaaga gtggatttgc tgacattcca tactaatata
     2521 cattgtttat gctttcttta aaataactag aagaacataa aagaaagaga atctcagaag
     2581 tagtttgctg ctaatatata catatattgt ataaaaaggt atattttggt tttgttaaaa
     2641 cccttgttga cttttctaca ctgaacattt tttttaactt gatttaataa aaatgttaat
     2701 tttggaagtg cagttttgta aaaacctttt tcagtcaaac agtaaagact ttatttatgg
     2761 attgtaataa caaccacaag aaaagccata catcttaatg aacatacgcc tttgttctgt
     2821 cattttaaag agtggtgttt actatgtgtg tgcttgagca ttttctttca gttacatggg
     2881 tgtaatttaa aaaacagctc ctttttaaga cttttgacca tagtgttttc cagtttaaag
     2941 caataacttt catagtttct ttcaaagttt aatacatcca atatgtcaag ttaaaccatt
     3001 ctgggatttg caaagtttaa tacatccaat atgtcaagtt aaaccattct gggatttgca
     3061 aagtttaata catccaatat gtcaagttaa accattctgg gatttgggaa cttctttaaa
     3121 ggaaaattgt agtagaggtc atcttgatgg aattgtgttt taaagttttg tgaatgagtt
     3181 aaatatcatt gatagtcttg tgtgtctcac atatcagctt tttcataagg aaaatacttt
     3241 atttgctttt atctgagaat ttctcagtat gaaaatgatt gtttaaaatt tcccctcttt
     3301 ttgtcagtgc attgggaata gggatagact ttacagattt atggaaatta aatttatggg
     3361 gaaaagttta tttttaatat tacttatagc tgagtcagaa ttaaaggagg gaattgtatt
     3421 gatactccaa tacctaaatt tcacaatacc acttaggaaa gctatttcaa caaattacag
     3481 ttttattgtt aaaacagagt cttatttgag atgtattgct ttatttttca attaaaagtg
     3541 gttttctcct a
//
