LOCUS       NM_001191324            3201 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens ring finger protein 138 (RNF138), transcript variant
            3, mRNA.
ACCESSION   NM_001191324
VERSION     NM_001191324.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Singh,A.K., Upadhyay,V., Sethi,A., Chowdhury,S., Mishra,S.,
            Verma,S.P., Bhatt,M.L.B. and Trivedi,A.K.
  TITLE     Ring finger protein 138 inhibits transcription factor C/EBPalpha
            protein turnover leading to differentiation arrest in acute myeloid
            leukemia
  JOURNAL   Biochem J 481 (10), 653-666 (2024)
   PUBMED   38666590
  REMARK    GeneRIF: Ring finger protein 138 inhibits transcription factor
            C/EBPalpha protein turnover leading to differentiation arrest in
            acute myeloid leukemia.
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Locke,A.J., Abou Farraj,R., Tran,C., Zeinali,E., Mashayekhi,F.,
            Ali,J.Y.H., Glover,J.N.M. and Ismail,I.H.
  TITLE     The role of RNF138 in DNA end resection is regulated by
            ubiquitylation and CDK phosphorylation
  JOURNAL   J Biol Chem 300 (3), 105709 (2024)
   PUBMED   38309501
  REMARK    GeneRIF: The role of RNF138 in DNA end resection is regulated by
            ubiquitylation and CDK phosphorylation.
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Liu,W., Wang,Z., Liu,S., Zhang,X., Cao,X. and Jiang,M.
  TITLE     RNF138 inhibits late inflammatory gene transcription through
            degradation of SMARCC1 of the SWI/SNF complex
  JOURNAL   Cell Rep 42 (2), 112097 (2023)
   PUBMED   36800290
  REMARK    GeneRIF: RNF138 inhibits late inflammatory gene transcription
            through degradation of SMARCC1 of the SWI/SNF complex.
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Averbeck,N.B., Barent,C., Jakob,B., Syzonenko,T., Durante,M. and
            Taucher-Scholz,G.
  TITLE     The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate
            Resection of Complex DNA Double-Strand Breaks in Human G1-Phase
            Cells
  JOURNAL   Cells 11 (16), 2561 (2022)
   PUBMED   36010636
  REMARK    GeneRIF: The Ubiquitin Ligase RNF138 Cooperates with CtIP to
            Stimulate Resection of Complex DNA Double-Strand Breaks in Human
            G1-Phase Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   Lu,Y., Huang,R., Ying,J., Li,X., Jiao,T., Guo,L., Zhou,H., Wang,H.,
            Tuersuntuoheti,A., Liu,J., Chen,Q., Wang,Y., Su,L., Guo,C., Xu,F.,
            Wang,Z., Lu,Y., Li,K., Liang,J., Huang,Z., Chen,X., Yao,J., Hu,H.,
            Cheng,X., Wan,Y., Chen,X., Zhang,N., Miao,S., Cai,J., Wang,L.,
            Liu,C., Song,W. and Zhao,H.
  TITLE     RING finger 138 deregulation distorts NF-small ka, CyrillicB
            signaling and facilities colitis switch to aggressive malignancy
  JOURNAL   Signal Transduct Target Ther 7 (1), 185 (2022)
   PUBMED   35697692
  REMARK    GeneRIF: RING finger 138 deregulation distorts NF-small ka,
            CyrillicB signaling and facilities colitis switch to aggressive
            malignancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Yamada,M., Ohnishi,J., Ohkawara,B., Iemura,S., Satoh,K.,
            Hyodo-Miura,J., Kawachi,K., Natsume,T. and Shibuya,H.
  TITLE     NARF, an nemo-like kinase (NLK)-associated ring finger protein
            regulates the ubiquitylation and degradation of T cell
            factor/lymphoid enhancer factor (TCF/LEF)
  JOURNAL   J Biol Chem 281 (30), 20749-20760 (2006)
   PUBMED   16714285
  REMARK    GeneRIF: NARF functions as a novel ubiquitin-ligase to regulate
            ubiquitylation and degradation of T cell factor/lymphoid enhancer
            factor
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA752192.1, AK023579.1 and
            BC018107.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001191324.1.
            
            Summary: The protein encoded by this gene contains a RING finger, a
            motif present in a variety of functionally distinct proteins and
            known to be involved in protein-DNA and protein-protein
            interactions. Alternatively spliced transcript variants encoding
            distinct isoforms have been observed. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.112954.1,
                                           SRR18074968.1814161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               DA752192.1         24-577
            555-2325            AK023579.1         273-2043
            2326-3201           BC018107.1         2336-3211
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3201
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /note="ring finger protein 138"
                     /db_xref="GeneID:51444"
                     /db_xref="HGNC:HGNC:17765"
                     /db_xref="MIM:616319"
     exon            1..199
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..827
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 3;
                     Nemo-like kinase-associated RING finger protein; E3
                     ubiquitin-protein ligase RNF138; NLK-associated RING
                     finger protein; testicular tissue protein Li 165;
                     nemo-like kinase associated ring finger protein; ring
                     finger protein 138, E3 ubiquitin protein ligase; RING-type
                     E3 ubiquitin transferase RNF138"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF138 isoform 1"
                     /protein_id="NP_001178253.2"
                     /db_xref="CCDS:CCDS11903.1"
                     /db_xref="GeneID:51444"
                     /db_xref="HGNC:HGNC:17765"
                     /db_xref="MIM:616319"
                     /translation="MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFL
                     TAMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHY
                     KSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCP
                     LCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFD
                     YGEFVNLQLDEETQYQTAVEESFQVNI"
     exon            200..365
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            366..481
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            482..538
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            539..650
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            651..758
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            759..3201
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3181..3186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /note="hexamer: ATTAAA"
     polyA_site      3201
                     /gene="RNF138"
                     /gene_synonym="hNARF; HSD-4; NARF; STRIN"
                     /note="major polyA site"
ORIGIN      
        1 gggttcatgt agggagtcgg gccccgggcc gccaccgtca cctcggccgc tgccgctgtc
       61 gccatcgcct tgtttcccca tcccccgcca tggccgagga cctctctgcg gccacgtcct
      121 acaccgaaga tgatttctac tgccccgtct gtcaggaggt gctcaaaacg cccgtgcgga
      181 ccacggcctg tcagcacgtt ttctgtagaa aatgtttcct gactgcaatg agggaaagcg
      241 gagcacattg tcccctatgt cgtggaaatg tgactagaag agagagagca tgtcctgaac
      301 gggccttaga ccttgaaaat ataatgagga agttttctgg tagctgcaga tgctgtgcaa
      361 aacagattaa attctatcgc atgagacatc attacaaatc ttgtaagaag tatcaggatg
      421 aatatggtgt ttcttctatc attccaaact ttcagatctc tcaagattca gtagggaaca
      481 gcaataggag tgaaacatcc acatctgata acacagaaac ttaccaagag aatacaagtt
      541 cttctggtca tcctactttt aagtgtcccc tgtgtcaaga atcaaatttt accagacagc
      601 gtttactgga tcactgtaac agtaatcacc tatttcagat agttcctgtg acatgtccta
      661 tttgtgtgtc tcttccttgg ggagatccta gccagattac cagaaatttc gttagtcatc
      721 taaatcagag acatcaattt gattatggag aatttgtgaa tcttcagcta gatgaagaaa
      781 cccaatacca aactgctgtt gaagaatctt ttcaagtaaa catctgaagg ctgtagacat
      841 ctctgcatct ttgtacctgc aagtgccatc tttaaggggg aaactacatg aagtcaccgt
      901 tacagtaact tgatgtgtat attaataaaa gtaattcagt cattttagtt tttgattgaa
      961 aataaaggta gggcttctaa aaacttcatc atcttgataa gttaaaaaat gaaagttatg
     1021 acattagctt taaaggtgta aaaaagatgt ttcactaatg taacggtgaa agagaatccc
     1081 tgttgtactt tatctttttg taatattatt tttgaatttt tcattattat gttgcttttg
     1141 aaatttgatg cattcctccc atttacttta ttattgtaca catttaacac acagtagcaa
     1201 attttgaacg atgtgattga tataacctaa caaatctgag ccagttatta ttagagttgc
     1261 agaatagaaa cttgaagtgc taaatggaat aatccaaagg aaatttttta aatgcaggtt
     1321 ctagctgaaa aattcaacta taagaaaatt gtatttatat aacatttact atttttgaag
     1381 actagtgaga tttctgtaat aattttaatt ctttaaaaag tgaaagcttg ttgtaaagat
     1441 attttctttt tgttattaga aggaaataca aagagaaaaa tttctttctt tcatgggcat
     1501 ttgataattt cagtctttga ctgatttgta agcctagaat atactaagct gaataacagc
     1561 tctttggcct cagaattttc agtagccagt atttctgatt aactaagttg aaactcttat
     1621 tagaaacttt cagttggtga tattgtattc tagaagatat aaatgagagg tttggcttca
     1681 tctcagttta gaaatttatt caaagctaaa gatgtatata tacatatact tttgtgtgta
     1741 tatatacaca tatgtgtgta tgcagtttgt caggttatat atagaatttc tattaaggat
     1801 tttttaaatg gacaagcaat agggggttga agtgtttatc tgatttgttt aaaattttgt
     1861 atatcaccaa atttttaaaa agtgatagtc acagtgctaa gttatctagt tggctactat
     1921 tacaccttaa aaattgagtt tacacacaca caattacctg tttatatggt gctcatttgt
     1981 tattctcaaa tataatgtgt gaccgtgata tagtgagaaa gattctacca accactgttt
     2041 cactactttt tagttaaaat tgggtatgtt cttaatattc attagtgaga atcacaaagt
     2101 attttgtaga aggcccaaat cacagaataa aggactaaga gtggatttgc tgacattcca
     2161 tactaatata cattgtttat gctttcttta aaataactag aagaacataa aagaaagaga
     2221 atctcagaag tagtttgctg ctaatatata catatattgt ataaaaaggt atattttggt
     2281 tttgttaaaa cccttgttga cttttctaca ctgaacattt tttttaactt gatttaataa
     2341 aaatgttaat tttggaagtg cagttttgta aaaacctttt tcagtcaaac agtaaagact
     2401 ttatttatgg attgtaataa caaccacaag aaaagccata catcttaatg aacatacgcc
     2461 tttgttctgt cattttaaag agtggtgttt actatgtgtg tgcttgagca ttttctttca
     2521 gttacatggg tgtaatttaa aaaacagctc ctttttaaga cttttgacca tagtgttttc
     2581 cagtttaaag caataacttt catagtttct ttcaaagttt aatacatcca atatgtcaag
     2641 ttaaaccatt ctgggatttg caaagtttaa tacatccaat atgtcaagtt aaaccattct
     2701 gggatttgca aagtttaata catccaatat gtcaagttaa accattctgg gatttgggaa
     2761 cttctttaaa ggaaaattgt agtagaggtc atcttgatgg aattgtgttt taaagttttg
     2821 tgaatgagtt aaatatcatt gatagtcttg tgtgtctcac atatcagctt tttcataagg
     2881 aaaatacttt atttgctttt atctgagaat ttctcagtat gaaaatgatt gtttaaaatt
     2941 tcccctcttt ttgtcagtgc attgggaata gggatagact ttacagattt atggaaatta
     3001 aatttatggg gaaaagttta tttttaatat tacttatagc tgagtcagaa ttaaaggagg
     3061 gaattgtatt gatactccaa tacctaaatt tcacaatacc acttaggaaa gctatttcaa
     3121 caaattacag ttttattgtt aaaacagagt cttatttgag atgtattgct ttatttttca
     3181 attaaaagtg gttttctcct a
//
