LOCUS       NM_032322               2054 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens ring finger protein 135 (RNF135), transcript variant
            1, mRNA.
ACCESSION   NM_032322
VERSION     NM_032322.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Zhao,Y., Zhao,L., Jin,H., Xie,Y., Chen,L., Zhang,W., Dong,L.,
            Zhang,L., Huang,Y., Wan,K., Yang,Q. and Wang,S.
  TITLE     Plasma methylated GNB4 and Riplet as a novel dual-marker panel for
            the detection of hepatocellular carcinoma
  JOURNAL   Epigenetics 19 (1), 2299044 (2024)
   PUBMED   38154055
  REMARK    GeneRIF: Plasma methylated GNB4 and Riplet as a novel dual-marker
            panel for the detection of hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Chen,B., Zhang,Y., Song,G. and Wei,X.
  TITLE     RNF135 Promotes Human Osteosarcoma Cell Growth and Inhibits
            Apoptosis by Upregulating the PI3K/AKT Pathway
  JOURNAL   Cancer Rep (Hoboken) 7 (8), e2159 (2024)
   PUBMED   39118262
  REMARK    GeneRIF: RNF135 Promotes Human Osteosarcoma Cell Growth and
            Inhibits Apoptosis by Upregulating the PI3K/AKT Pathway.
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Zhuang,L., Shi,G. and Sun,Y.
  TITLE     RNF135 promotes cell proliferation and autophagy in lung
            adenocarcinoma by promoting the phosphorylation of ULK1
  JOURNAL   Allergol Immunopathol (Madr) 52 (2), 3-9 (2024)
   PUBMED   38459884
  REMARK    GeneRIF: RNF135 promotes cell proliferation and autophagy in lung
            adenocarcinoma by promoting the phosphorylation of ULK1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Qiu,Z., He,S., Lu,B., Sun,Y., Zhang,T., Lv,W. and Shen,D.
  TITLE     The E3 ubiquitin ligase RNF135 modulates chemotherapy resistance to
            oxaliplatin for colorectal cancer by modulating autophagy
  JOURNAL   Tissue Cell 86, 102282 (2024)
   PUBMED   38056362
  REMARK    GeneRIF: The E3 ubiquitin ligase RNF135 modulates chemotherapy
            resistance to oxaliplatin for colorectal cancer by modulating
            autophagy.
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Yao,Y., Gong,G., Guo,Z. and Zhang,D.
  TITLE     A pan-cancer analysis of ring finger protein 135 and its
            relationship to triple-negative breast cancer proliferation and
            metastasis
  JOURNAL   Aging (Albany NY) 14 (23), 9758-9772 (2022)
   PUBMED   36495591
  REMARK    GeneRIF: A pan-cancer analysis of ring finger protein 135 and its
            relationship to triple-negative breast cancer proliferation and
            metastasis.
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Gack,M.U., Shin,Y.C., Joo,C.H., Urano,T., Liang,C., Sun,L.,
            Takeuchi,O., Akira,S., Chen,Z., Inoue,S. and Jung,J.U.
  TITLE     TRIM25 RING-finger E3 ubiquitin ligase is essential for
            RIG-I-mediated antiviral activity
  JOURNAL   Nature 446 (7138), 916-920 (2007)
   PUBMED   17392790
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Jenne,D.E., Tinschert,S., Reimann,H., Lasinger,W., Thiel,G.,
            Hameister,H. and Kehrer-Sawatzki,H.
  TITLE     Molecular characterization and gene content of breakpoint
            boundaries in patients with neurofibromatosis type 1 with 17q11.2
            microdeletions
  JOURNAL   Am J Hum Genet 69 (3), 516-527 (2001)
   PUBMED   11468690
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Chaudhary,P.M., Eby,M.T., Jasmin,A., Kumar,A., Liu,L. and Hood,L.
  TITLE     Activation of the NF-kappaB pathway by caspase 8 and its homologs
  JOURNAL   Oncogene 19 (39), 4451-4460 (2000)
   PUBMED   11002417
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ496729.1, BC005084.1 and
            AC138207.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_032322.3.
            
            Summary: The protein encoded by this gene contains a RING finger
            domain, a motif present in a variety of functionally distinct
            proteins and known to be involved in protein-protein and
            protein-DNA interactions. This gene is located in a chromosomal
            region known to be frequently deleted in patients with
            neurofibromatosis. Alternatively spliced transcript variants
            encoding distinct isoforms have been reported. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.331075.1,
                                           SRR3476690.577511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328381.10/ ENSP00000328340.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-855               AJ496729.1         17-871
            856-2052            BC005084.1         709-1905
            2053-2054           AC138207.3         120477-120478       c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..2054
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /note="ring finger protein 135"
                     /db_xref="GeneID:84282"
                     /db_xref="HGNC:HGNC:21158"
                     /db_xref="MIM:611358"
     exon            1..407
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1334
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF135; RIG-I E3 ubiquitin
                     ligase; RING-type E3 ubiquitin transferase RNF135; RING
                     finger protein leading to RIG-I activation"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF135 isoform 1"
                     /protein_id="NP_115698.3"
                     /db_xref="CCDS:CCDS11262.1"
                     /db_xref="GeneID:84282"
                     /db_xref="HGNC:HGNC:21158"
                     /db_xref="MIM:611358"
                     /translation="MAGLGLGSAVPVWLAEDDLGCIICQGLLDWPATLPCGHSFCRHC
                     LEALWGARDARRWACPTCRQGAAQQPHLRKNTLLQDLADKYRRAAREIQAGSDPAHCP
                     CPGSSSLSSAAARPRRRPELQRVAVEKSITEVAQELTELVEHLVDIVRSLQNQRPLSE
                     SGPDNELSILGKAFSSGVDLSMASPKLVTSDTAAGKIRDILHDLEEIQEKLQESVTWK
                     EAPEAQMQGELLEAPSSSSCPLPDQSHPALRRASRFAQWAIHPTFNLKSLSCSLEVSK
                     DSRTVTVSHRPQPYRWSCERFSTSQVLCSQALSSGKHYWEVDTRNCSHWAVGVASWEM
                     SRDQVLGRTMDSCCVEWKGTSQLSAWHMVKETVLGSDRPGVVGIWLNLEEGKLAFYSV
                     DNQEKLLYECTISASSPLYPAFWLYGLHPGNYLIIKQVKV"
     exon            408..551
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /inference="alignment:Splign:2.1.0"
     exon            552..714
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /inference="alignment:Splign:2.1.0"
     exon            715..804
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /inference="alignment:Splign:2.1.0"
     exon            805..2054
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="RNF135"
                     /gene_synonym="L13; MMFD; REUL; Riplet"
                     /note="major polyA site"
ORIGIN      
        1 aaccccgacg tccgcgcccc ggccgcctgt tggccatggc gggcctgggc ctgggctccg
       61 ccgttcccgt gtggctggcc gaggacgacc tcggctgcat catctgccag gggctgctgg
      121 actggcccgc cacgctgccc tgcggccaca gcttctgccg ccactgcctg gaggccctgt
      181 ggggcgcccg cgacgcccgc cgctgggcct gccccacttg ccgccagggc gccgcgcagc
      241 agccgcacct gcggaagaac acgctactgc aggacctggc cgacaagtac cgccgcgccg
      301 cacgcgagat acaggcgggc tccgaccctg cccactgccc ctgcccgggc tccagttccc
      361 tctccagcgc ggccgcgagg ccccggcgcc gcccggaact gcagcgggtg gcagtagaga
      421 agagcatcac agaagttgct caggagctga cagagctggt ggaacatctt gtagacattg
      481 tcagaagcct gcagaatcag aggcccctat cagaatctgg accagacaac gaactgagca
      541 tcctgggcaa ggctttttct tctggggtgg atctttccat ggcttctcca aagctggtga
      601 cttccgacac agctgcaggg aaaatcagag atattctcca tgacctagaa gaaattcagg
      661 aaaaattaca agaaagcgtc acctggaaag aggctcctga agcacaaatg cagggagaac
      721 tcctggaagc cccgtcttcc tcctcatgcc cattgcctga ccagagccac cctgcactca
      781 ggagagcttc tcggtttgct cagtgggcca tccatccaac ctttaacttg aagagccttt
      841 cctgcagcct ggaggtgtcc aaggattccc gtacagtgac tgtgtctcac cgcccacaac
      901 cctatcgctg gagctgtgag aggttttcta ccagccaggt cttatgttcc caggccctgt
      961 cttctggaaa gcattactgg gaagtggaca ctaggaattg cagccactgg gcagttgggg
     1021 tggcttcctg ggagatgagc cgcgaccagg tcctgggaag gactatggac tcttgttgtg
     1081 tggaatggaa ggggactagc cagctctctg catggcacat ggtcaaggaa actgtccttg
     1141 gctcagacag acctggggtg gtgggcatct ggctgaacct tgaggaggga aagcttgcct
     1201 tctattcagt ggacaatcag gagaagcttc tgtatgagtg taccatctct gcctcctctc
     1261 ctttgtaccc tgccttctgg ctgtatggct tacatcctgg aaattacctg ataataaagc
     1321 aagtaaaggt gtaaggtttc ctaagggatt acaacacagt ggtttcctgg tctctctccc
     1381 tgtcatcaat cagggtagta acttgactta agaataccac tttttagaaa aattacgata
     1441 gagatgggat ctcactaggt tgcccaggct ggtgtcgaat tcctggtctc aagcagtcct
     1501 cccacctcag cctcccaagg tgctgggatt acaggtgtga gccaccacac ctggccaaga
     1561 ataccacttt tgaagttaat ccttttgtgt gatacaggat gaacttggga tgtttgaacc
     1621 ctggacattc caaataaaga ataggcccct gcctggctcc tgggagataa cctctaagcc
     1681 attagaatat cttgcctgat aagagtgttt ttgtttacct gtgggccttg ggccatgcag
     1741 tatcagcttg accttgcaag gtcaagctga ggagactaag ttagccatgt gggcagtgaa
     1801 gcatgccaat gtgatcaatc cctagtaaaa gccctggaca cctaggcatg ggtgagctac
     1861 tctggttggt aatactctgt gcacacatca ttgtagccac acatcattgc tgggagaatt
     1921 aagcattatc ctgaagactc tgccaggaga ggataattgg aagttctctt ggaccttacc
     1981 ttatgtgcct ttcttcattg ctgattttaa tctgtatcct ttcactgtaa taaactgtaa
     2041 ctatgagtgc aaca
//
