LOCUS       NM_139175               1383 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 133 (RNF133), mRNA.
ACCESSION   NM_139175
VERSION     NM_139175.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022038.2.
            
            On May 17, 2019 this sequence version replaced NM_139175.1.
            
            Summary: The protein encoded by this gene contains a RING finger
            domain, a motif present in a variety of functionally distinct
            proteins and known to be involved in protein-protein and
            protein-DNA interactions. This gene has no intron. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189667.275395.1, BC022038.2
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340112.3/ ENSP00000344489.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1383              BC022038.2         17-1399
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..1383
                     /gene="RNF133"
                     /note="ring finger protein 133"
                     /db_xref="GeneID:168433"
                     /db_xref="HGNC:HGNC:21154"
                     /db_xref="MIM:620556"
     exon            1..1383
                     /gene="RNF133"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1330
                     /gene="RNF133"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF133"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF133"
                     /protein_id="NP_631914.1"
                     /db_xref="CCDS:CCDS5784.1"
                     /db_xref="GeneID:168433"
                     /db_xref="HGNC:HGNC:21154"
                     /db_xref="MIM:620556"
                     /translation="MHLLKVGTWRNNTASSWLMKFSVLWLVSQNCCRASVVWMAYMNI
                     SFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNTIFSRSKYSETWL
                     ALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFEDVVVVMIGNLKG
                     TEIFHLIKKGVLITAVVEVGRKHIIWMNHYLVSFVIVTTATLAYFIFYHIHRLCLARI
                     QNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICFERYKPNDIVRILTCKH
                     FFHKNCIDPWILPHGTCPICKCDILKVLGIQVVVENGTEPLQVLMSNELPETLSPSEE
                     ETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF133"
                     /note="hexamer: ATTAAA"
     polyA_site      1383
                     /gene="RNF133"
                     /note="major polyA site"
ORIGIN      
        1 aatctaaagt ttttcacctc tctctagtaa gacatctgaa actcataagc catctttaag
       61 aatttcttac aaaaacatgc tggaagacag tggatcttgt ttgtatcctg aagatttttt
      121 tctcttcgtt attttaaatt aattgtcaac agatgtgcaa ctgttaggtt ggttcttaag
      181 tcactcggag aagagagaga tgcatctact caaggttggc acttggagaa acaacactgc
      241 ctcttcctgg cttatgaagt tcagtgttct ttggcttgtt agtcagaact gttgcagagc
      301 aagtgttgtt tggatggctt atatgaacat atcatttcat gttgggaatc atgtgttgtc
      361 agagttggga gagactggag tctttggaag aagctccact ttgaagagag tggcaggagt
      421 tatagtgcca ccagagggaa aaatccaaaa tgcatgtaat cccaatacca ttttcagccg
      481 atcaaagtac tcagagacct ggcttgcact tattgaacgg ggaggttgta ccttcacaca
      541 gaaaattaaa gtggcaactg agaagggagc cagtggagtg atcatctata acgttccagg
      601 tactggcaac caggtgttcc ccatgtttca tcaggcattt gaagatgtcg ttgtggttat
      661 gattggtaac ttaaaaggca cggaaatttt ccatttaatt aagaagggag ttctcattac
      721 agccgtggtt gaggtgggga gaaagcacat catctggatg aatcactatt tggtctcttt
      781 tgtgattgtc acaactgcta ccttagcata tttcatcttt tatcacattc atagactttg
      841 tttagcaagg attcagaacc ggagatggca gcgattaaca acagatcttc agaacacatt
      901 tggacaactc caacttcgag tagtaaaaga gggggatgaa gaaataaatc caaatgggga
      961 tagctgcgta atttgctttg aacgctataa gcctaatgac atagttcgta ttctgacttg
     1021 taaacatttt ttccacaaga attgcattga cccctggatt ttaccccatg ggacatgccc
     1081 catttgcaaa tgtgatattc ttaaagtttt ggggattcaa gtggttgttg aaaatggaac
     1141 agaacctttg caagttctaa tgtcaaatga actgcctgaa accttatcac ctagtgaaga
     1201 ggagacaaat aatgaagttt ctcctgcagg aacctcagat aaagtaatcc atgtggagga
     1261 gaaccctact tctcagaata atgacatcca gcctcattca gtagtggaag atgttcatcc
     1321 ttcaccttga tggcatgact tttgaggaag tgtattaaac ctgtatgtga aatcaggtcc
     1381 taa
//
