LOCUS       NM_018434               1904 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 130 (RNF130), transcript variant
            1, mRNA.
ACCESSION   NM_018434
VERSION     NM_018434.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1904)
  AUTHORS   Zhang,J., Chen,W., Du,J., Chu,L., Zhou,Z., Zhong,W., Liu,D.,
            Huang,H., Huang,Y., Qiao,Y., Meng,X., Zou,F., Cai,S. and Dong,H.
  TITLE     RNF130 protects against pulmonary fibrosis through suppressing
            aerobic glycolysis by mediating c-myc ubiquitination
  JOURNAL   Int Immunopharmacol 117, 109985 (2023)
   PUBMED   36893517
  REMARK    GeneRIF: RNF130 protects against pulmonary fibrosis through
            suppressing aerobic glycolysis by mediating c-myc ubiquitination.
REFERENCE   2  (bases 1 to 1904)
  AUTHORS   Li,Z., Wong,K.Y., Calin,G.A., Chng,W.J., Chan,G.C. and Chim,C.S.
  TITLE     Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms
            and prognostic impact
  JOURNAL   Clin Epigenetics 11 (1), 71 (2019)
   PUBMED   31064412
  REMARK    GeneRIF: In myeloma cell lines but not normal plasma cells, DNA
            methylation correlated inversely with the expression of both
            miR-340 and RNF130. RNF130/miR-340 methylation at diagnosis was
            associated with inferior overall survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1904)
  AUTHORS   Kim,S.J., Lee,S.Y., Lee,C., Kim,I., An,H.J., Kim,J.Y., Baek,K.H.,
            Kim,E.J., Kim,J.M., Lee,J.B., Lee,J.W., Jung,W.W., Chun,T. and
            Oh,Y.K.
  TITLE     Differential expression profiling of genes in a complete
            hydatidiform mole using cDNA microarray analysis
  JOURNAL   Gynecol Oncol 103 (2), 654-660 (2006)
   PUBMED   16797685
REFERENCE   4  (bases 1 to 1904)
  AUTHORS   Guais,A., Siegrist,S., Solhonne,B., Jouault,H., Guellaen,G. and
            Bulle,F.
  TITLE     h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed
            in human leukocytes
  JOURNAL   Gene 374, 112-120 (2006)
   PUBMED   16549277
  REMARK    GeneRIF: GOLIATH, a paralog of GRAIL, is a new E3 ligase protein,
            expressed in leukocytes.
REFERENCE   5  (bases 1 to 1904)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   6  (bases 1 to 1904)
  AUTHORS   Guais,A., Solhonne,B., Melaine,N., Guellaen,G. and Bulle,F.
  TITLE     Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing
            hormone/human chorionic gonadotropin in rat leydig cells
  JOURNAL   Biol Reprod 70 (1), 204-213 (2004)
   PUBMED   13679316
  REMARK    GeneRIF: Cloning and functional analysis of the rat counterpart.
REFERENCE   7  (bases 1 to 1904)
  AUTHORS   Baker,S.J. and Reddy,E.P.
  TITLE     Cloning of murine G1RP, a novel gene related to Drosophila
            melanogaster g1
  JOURNAL   Gene 248 (1-2), 33-40 (2000)
   PUBMED   10806348
  REMARK    GeneRIF: Cloning and functional analysis of the mouse counterpart.
REFERENCE   8  (bases 1 to 1904)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB209800.1, AK313089.1,
            BC017100.1, BP390145.1, DB572650.2 and AA339219.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018434.5.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif and is similar to g1, a Drosophila zinc-finger protein that
            is expressed in mesoderm and involved in embryonic development. The
            expression of the mouse counterpart was found to be upregulated in
            myeloblastic cells following IL3 deprivation, suggesting that this
            gene may regulate growth factor withdrawal-induced apoptosis of
            myeloid precursor cells. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.114642.1,
                                           SRR1660807.217301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521389.6/ ENSP00000430237.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AB209800.1         343-502
            161-1317            AK313089.1         3-1159
            1318-1491           BC017100.1         1259-1432
            1492-1518           BP390145.1         473-499
            1519-1741           DB572650.2         303-525
            1742-1742           AA339219.1         229-229
            1743-1904           DB572650.2         527-688
FEATURES             Location/Qualifiers
     source          1..1904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1904
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /note="ring finger protein 130"
                     /db_xref="GeneID:55819"
                     /db_xref="HGNC:HGNC:18280"
                     /db_xref="MIM:619163"
     exon            1..304
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1317
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; g1-related zinc finger protein; goliath
                     homolog; E3 ubiquitin-protein ligase RNF130; RING-type E3
                     ubiquitin transferase RNF130"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF130 isoform 1
                     precursor"
                     /protein_id="NP_060904.2"
                     /db_xref="CCDS:CCDS4451.1"
                     /db_xref="GeneID:55819"
                     /db_xref="HGNC:HGNC:18280"
                     /db_xref="MIM:619163"
                     /translation="MSCAGRAGPARLAALALLTCSLWPARADNASQEYYTALINVTVQ
                     EPGRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCDPQTRFFVPPNIK
                     QWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPGTGDIIAVMITEL
                     RGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFI
                     QKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDV
                     VRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALGIVPNLPCTDNVAFDMERLTRT
                     QAVNRRSALGDLAGDNSLGLEPLRTSGISPLPQDGELTPRTGEINIAVTKEWFIIASF
                     GLLSALTLCYMIIRATASLNANEVEWF"
     exon            305..499
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            500..750
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            751..822
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            823..905
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1002
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1207
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1301
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1904
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /note="hexamer: AATAAA"
     polyA_site      1491
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /note="major polyA site"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
                     /note="hexamer: AATAAA"
     polyA_site      1904
                     /gene="RNF130"
                     /gene_synonym="G1RP; G1RZFP; GOLIATH; GP"
ORIGIN      
        1 ctctaggcgc cggccccgga gcccggtccg cgagcagcgg cggctgccgg agggacgatg
       61 agctgcgcgg ggcgggcggg ccctgcccgg ctcgccgcgc tcgccctgct gacctgcagc
      121 ctgtggccgg cacgggcaga caacgcgagc caggagtact acacggcgct catcaacgtg
      181 acggtgcagg agcccggccg cggcgccccg ctcacgtttc gcatcgaccg cgggcgctac
      241 gggcttgact cccccaaggc cgaggtccgc ggccaggtgc tggcgccgct gcccctccac
      301 ggagttgctg atcatctggg ctgtgatcca caaacccggt tctttgtccc tcctaatatc
      361 aaacagtgga ttgccttgct gcagagggga aactgcacgt ttaaagagaa aatatcacgg
      421 gccgctttcc acaatgcagt tgctgtagtc atctacaata ataaatccaa agaggagcca
      481 gttaccatga ctcatccagg cactggagat attattgctg tcatgataac agaattgagg
      541 ggtaaggata ttttgagtta tctggagaaa aacatctctg tacaaatgac aatagctgtt
      601 ggaactcgaa tgccaccgaa gaacttcagc cgtggctctc tagtcttcgt gtcaatatcc
      661 tttattgttt tgatgattat ttcttcagca tggctcatat tctacttcat tcagaagatc
      721 aggtacacaa atgcacgcga caggaaccag cgtcgtctcg gagatgcagc caagaaagcc
      781 atcagtaaat tgacaaccag gacagtaaag aagggtgaca aggaaactga cccagacttt
      841 gatcattgtg cagtctgcat agagagctat aagcagaatg atgtcgtccg aattctcccc
      901 tgcaagcatg ttttccacaa atcctgcgtg gatccctggc ttagtgaaca ttgtacctgt
      961 cctatgtgca aacttaatat attgaaggcc ctgggaattg tgccgaattt gccatgtact
     1021 gataacgtag cattcgatat ggaaaggctc accagaaccc aagctgttaa ccgaagatca
     1081 gccctcggcg acctcgccgg cgacaactcc cttggccttg agccacttcg aacttcgggg
     1141 atctcacctc ttcctcagga tggggagctc actccgagaa caggagaaat caacattgca
     1201 gtaacaaaag aatggtttat tattgccagt tttggcctcc tcagtgccct cacactctgc
     1261 tacatgatca tcagagccac agctagcttg aatgctaatg aggtagaatg gttttgaaga
     1321 agaaaaaacc tgctttctga ctgattttgc cttgaaggaa aaaagaacct atttttgtgc
     1381 atcatttacc aatcatgcca cacaagcatt tatttttagt acattttatt ttttcataaa
     1441 attgctaatg ccaaagcttt gtattaaaag aaataaataa taaaataaaa agtctgtgct
     1501 gttgagtctt attaaccaga cctgtgtttt gagggctgat ttgaagctcg cagacccaga
     1561 ttgcatttgt ttgtgtttca gagacagaat gtgctcctgg ctcccgtgag aggaacaggg
     1621 attgacactt actattggtg tcttcacatt ggctcctacc cacatagggc gcaagagcgg
     1681 ggacatcctg ctggtgatgc cgcttaggat ggtcagttga tttactcatt cttcaagggg
     1741 gacattcact ctgtgataat ttcttctctg tggttgatca gcctccacca gagctgcagc
     1801 acccccagca gcagggactt gtaacatttg ctccccactg tgcccctgca cccaacagag
     1861 tgctttgcac atcgtaagtg ctcaataaat atttgtggaa tgaa
//
