LOCUS       NM_194460               1631 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ring finger protein 126 (RNF126), transcript variant
            1, mRNA.
ACCESSION   NM_194460
VERSION     NM_194460.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Liu,W., Zheng,M., Zhang,R., Jiang,Q., Du,G., Wu,Y., Yang,C., Li,F.,
            Li,W., Wang,L., Wu,J., Shi,L., Li,W., Zhang,K., Zhou,Z., Liu,R.,
            Gao,Y., Huang,X., Fan,S., Zhi,X., Jiang,D. and Chen,C.
  TITLE     RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage
            Response and Confers Resistance of Triple-Negative Breast Cancer to
            Radiotherapy
  JOURNAL   Adv Sci (Weinh) 10 (5), e2203884 (2023)
   PUBMED   36563124
  REMARK    GeneRIF: RNF126-Mediated MRE11 Ubiquitination Activates the DNA
            Damage Response and Confers Resistance of Triple-Negative Breast
            Cancer to Radiotherapy.
            Erratum:[Adv Sci (Weinh). 2025 Jan 30:e2417701. doi:
            10.1002/advs.202417701.. PMID: 39888281]
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Pan,Y., Yang,Y., Huang,R., Yang,H., Huang,Q., Ji,Y., Dai,J.,
            Qiao,K., Tang,W., Xie,L., Yin,M., Ouyang,J., Ning,S. and Su,D.
  TITLE     Ring finger protein 126 promotes breast cancer metastasis and
            serves as a potential target to improve the therapeutic sensitivity
            of ATR inhibitors
  JOURNAL   Breast Cancer Res 24 (1), 92 (2022)
   PUBMED   36539893
  REMARK    GeneRIF: Ring finger protein 126 promotes breast cancer metastasis
            and serves as a potential target to improve the therapeutic
            sensitivity of ATR inhibitors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Huang,J., Li,Y., Zheng,M., He,H., Xu,D. and Tian,D.
  TITLE     RNF126 contributes to stem cell-like properties and metastasis in
            hepatocellular carcinoma through ubiquitination and degradation of
            LKB1
  JOURNAL   Hum Cell 35 (6), 1869-1884 (2022)
   PUBMED   36068398
  REMARK    GeneRIF: RNF126 contributes to stem cell-like properties and
            metastasis in hepatocellular carcinoma through ubiquitination and
            degradation of LKB1.
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Sun,Z., Liu,X., Chen,M., Zhang,H. and Zeng,X.
  TITLE     Overexpression of RNF126 is associated with poor prognosis and
            contributes to the progression of lung adenocarcinoma
  JOURNAL   Biomark Med 15 (15), 1345-1355 (2021)
   PUBMED   34533052
  REMARK    GeneRIF: Overexpression of RNF126 is associated with poor prognosis
            and contributes to the progression of lung adenocarcinoma.
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Delker,R.K., Zhou,Y., Strikoudis,A., Stebbins,C.E. and
            Papavasiliou,F.N.
  TITLE     Solubility-based genetic screen identifies RING finger protein 126
            as an E3 ligase for activation-induced cytidine deaminase
  JOURNAL   Proc Natl Acad Sci U S A 110 (3), 1029-1034 (2013)
   PUBMED   23277564
  REMARK    GeneRIF: identify a unique cofactor, RING finger protein 126
            (RNF126), verify its interaction by traditional techniques, and
            show that it has functional consequences as RNF126 is able to
            ubiquitylate activation-induced cytidine deaminase
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Zhi,X., Zhao,D., Wang,Z., Zhou,Z., Wang,C., Chen,W., Liu,R. and
            Chen,C.
  TITLE     E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by
            targeting the tumor suppressor p21 for ubiquitin-mediated
            degradation
  JOURNAL   Cancer Res 73 (1), 385-394 (2013)
   PUBMED   23026136
  REMARK    GeneRIF: These findings suggest that RNF126 promotes cancer cell
            proliferation by targeting p21 for ubiquitin-mediated degradation
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289616.1, AC004156.1,
            AC004449.1 and BG773910.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_194460.2.
            
            Summary: The protein encoded by this gene contains a RING finger
            domain, a motif present in a variety of functionally distinct
            proteins and known to be involved in protein-protein and
            protein-DNA interactions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289616.1, AK000559.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292363.10/ ENSP00000292363.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK289616.1         20-24
            6-168               AC004156.1         18464-18626         c
            169-227             AC004156.1         8243-8301           c
            228-291             AC004156.1         7650-7713           c
            292-536             AC004156.1         7028-7272           c
            537-599             AC004156.1         5651-5713           c
            600-669             AC004156.1         5096-5165           c
            670-763             AC004449.1         37946-38039         c
            764-879             AC004449.1         37436-37551         c
            880-1601            AC004449.1         36620-37341         c
            1602-1631           BG773910.1         386-415
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1631
                     /gene="RNF126"
                     /note="ring finger protein 126"
                     /db_xref="GeneID:55658"
                     /db_xref="HGNC:HGNC:21151"
                     /db_xref="MIM:615177"
     exon            1..168
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1029
                     /gene="RNF126"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF126"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF126 isoform 1"
                     /protein_id="NP_919442.1"
                     /db_xref="CCDS:CCDS12039.1"
                     /db_xref="GeneID:55658"
                     /db_xref="HGNC:HGNC:21151"
                     /db_xref="MIM:615177"
                     /translation="MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEET
                     RSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQA
                     DDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITP
                     ATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPV
                     TEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQ
                     NTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS"
     exon            169..227
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            228..291
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            292..536
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            537..599
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            600..669
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            670..763
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            764..879
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1631
                     /gene="RNF126"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF126"
                     /note="hexamer: AATAAA"
     polyA_site      1347
                     /gene="RNF126"
                     /note="major polyA site"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF126"
                     /note="hexamer: AATACA"
     polyA_site      1631
                     /gene="RNF126"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcgggc gcgtcggccg gcgagggagc agcaaacggc cggcggcggg tgccgcgcgg
       61 ggggcgggcg gcgcggagta ggtggcggcg gccatggccg aggcgtcgcc gcatcccgga
      121 cggtacttct gccactgctg ctccgtggag atcgtcccgc gcctgccgga ttatatctgt
      181 ccaagatgcg agtctggttt tatcgaggag cttccggaag agaccaggag cacagaaaat
      241 ggttctgccc cctccacagc tcccacagac cagagccggc caccgttgga gcacgtggac
      301 cagcacctgt tcacgctgcc gcagggctac ggacagtttg ctttcggcat cttcgatgac
      361 agcttcgaga tccccacgtt ccctcctggg gcgcaggctg acgacggcag ggaccctgag
      421 agccggcggg agagagacca tccgtcccgg caccggtacg gcgcccgaca gccccgcgcc
      481 cgcctcacca cgcggcgggc caccggccgg cacgaaggcg tccccacgct ggaagggatc
      541 atccagcagc tcgtcaacgg catcatcacg cccgccacca tccccagcct gggcccctgg
      601 ggagtcctgc actcaaaccc tatggactac gcctgggggg ccaacggcct ggatgccatc
      661 atcacacagc tcctcaatca gtttgaaaac acaggccccc caccggcaga taaagagaaa
      721 atccaggccc tccccaccgt ccccgtcact gaggagcacg taggctccgg gctcgagtgc
      781 cctgtgtgca aggacgacta cgcgctgggt gagcgtgtgc ggcagctgcc ctgcaaccac
      841 ctgttccacg acggctgcat cgtgccctgg ctggagcagc acgacagctg ccccgtctgc
      901 cgaaaaagcc tcacgggaca gaacacggcc acgaaccccc ctggcctcac tggggtgagc
      961 ttctcctcct cgtcgtcatc gtcctcctcc agctcgccca gcaacgagaa cgccacaagc
     1021 aactcgtgag cccacgtcgg ccgtcgggaa agcacggggc ctttcccacc caccctcagc
     1081 cagcgccaca cggcacccac agactgggtg ccccggcggc gccacgcttg gctggtcagc
     1141 gctgcaggtc ccgcctgttc cagggcagga cccgggcccg gcccaccggc cccctggctt
     1201 gggaaggcgt gggccacatg gtcccctctg gggcgtcccc agcctccccg tcctctgtct
     1261 aacctcaccc tctaaacgtt cagcggtgga aagattttta taattttaaa ttattactgc
     1321 tttgaaataa acggacgttt gagctcacgt ggcggccatg catggtttgt ggcggaagac
     1381 ggggcccagc ggctccccca gcgctgaagc acggggttca gcggctcccc cagtgctgca
     1441 ggtgccgcca ggacgggcca cgtgggcccc cagcctcccc ctcggccgcc tccacgaccc
     1501 ggagtagggg ggctcgggac catgaggatg accagcaaaa ttcaagaaca aaactgctcc
     1561 aacagacttt tttaaaggaa aaaatatgtg tatcttgaaa gctatttaaa atacactact
     1621 tacaaagaga a
//
