LOCUS       NM_017831               5573 bp    mRNA    linear   PRI 24-MAR-2025
DEFINITION  Homo sapiens ring finger protein 125 (RNF125), transcript variant
            1, mRNA.
ACCESSION   NM_017831
VERSION     NM_017831.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5573)
  AUTHORS   Feng,Z., Ke,S., Wang,C., Lu,S., Xu,Y., Yu,H., Li,Z., Yin,B., Li,X.,
            Hua,Y., Qian,B., Bai,M., Fu,Y., Zhang,Y., Wu,Y. and Ma,Y.
  TITLE     RNF125 attenuates hepatocellular carcinoma progression by
            downregulating SRSF1-ERK pathway
  JOURNAL   Oncogene 42 (24), 2017-2030 (2023)
   PUBMED   37142680
  REMARK    GeneRIF: RNF125 attenuates hepatocellular carcinoma progression by
            downregulating SRSF1-ERK pathway.
REFERENCE   2  (bases 1 to 5573)
  AUTHORS   Jiang,C., He,L., Xiao,S., Wu,W., Zhao,Q. and Liu,F.
  TITLE     E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and
            Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression
  JOURNAL   Mol Biotechnol 65 (6), 891-903 (2023)
   PUBMED   36344734
  REMARK    GeneRIF: E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in
            Head and Neck Squamous Cell Carcinoma by Regulating PD-L1
            Expression.
REFERENCE   3  (bases 1 to 5573)
  AUTHORS   Yang,W., Ru,Y., Ren,J., Bai,J., Wei,J., Fu,S., Liu,X., Li,D. and
            Zheng,H.
  TITLE     G3BP1 inhibits RNA virus replication by positively regulating
            RIG-I-mediated cellular antiviral response
  JOURNAL   Cell Death Dis 10 (12), 946 (2019)
   PUBMED   31827077
  REMARK    GeneRIF: G3BP1 inhibits RNA virus replication by positively
            regulating RIG-I-mediated cellular antiviral response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5573)
  AUTHORS   Saha,S.S., Caviness,G., Yi,G., Raymond,E.L., Mbow,M.L. and Kao,C.C.
  TITLE     E3 Ubiquitin Ligase RNF125 Activates Interleukin-36 Receptor
            Signaling and Contributes to Its Turnover
  JOURNAL   J Innate Immun 10 (1), 56-69 (2018)
   PUBMED   29176319
  REMARK    GeneRIF: this study shows that RNF125 activates Interleukin-36
            receptor signaling and contributes to its turnover
REFERENCE   5  (bases 1 to 5573)
  AUTHORS   Liu,Z.Y., Cao,J., Zhang,J.T., Xu,G.L., Li,X.P., Wang,F.T.,
            Ansari,K.H., Mohamed,H. and Fan,Y.Z.
  TITLE     Ring finger protein 125, as a potential highly aggressive and
            unfavorable prognostic biomarker, promotes the invasion and
            metastasis of human gallbladder cancers via activating the TGF-
            beta1-SMAD3-ID1 signaling pathway
  JOURNAL   Oncotarget 8 (30), 49897-49914 (2017)
   PUBMED   28611292
  REMARK    GeneRIF: high RNF125 expression is related with aggressive
            characteristics and unfavorable prognosis of GBC patients; RNF125
            promotes the invasion and metastasis of human GBCs via activating
            the TGF-beta1-SMAD3-ID1 signaling pathway.
REFERENCE   6  (bases 1 to 5573)
  AUTHORS   Shoji-Kawata,S., Zhong,Q., Kameoka,M., Iwabu,Y., Sapsutthipas,S.,
            Luftig,R.B. and Ikuta,K.
  TITLE     The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1
            replication in primary human peripheral blood mononuclear cells
  JOURNAL   Virology 368 (1), 191-204 (2007)
   PUBMED   17643463
  REMARK    GeneRIF: These results suggest that RNF125/TRAC-1 could function to
            recruit host factor(s) controlling HIV-1 transcription to the
            ubiquitin-proteasome pathway.
REFERENCE   7  (bases 1 to 5573)
  AUTHORS   Arimoto,K., Takahashi,H., Hishiki,T., Konishi,H., Fujita,T. and
            Shimotohno,K.
  TITLE     Negative regulation of the RIG-I signaling by the ubiquitin ligase
            RNF125
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7500-7505 (2007)
   PUBMED   17460044
REFERENCE   8  (bases 1 to 5573)
  AUTHORS   Zhao,H., Li,C.C., Pardo,J., Chu,P.C., Liao,C.X., Huang,J.,
            Dong,J.G., Zhou,X., Huang,Q., Huang,B., Bennett,M.K.,
            Molineaux,S.M., Lu,H., Daniel-Issakani,S., Payan,D.G. and
            Masuda,E.S.
  TITLE     A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell
            activation
  JOURNAL   J Immunol 174 (9), 5288-5297 (2005)
   PUBMED   15843525
REFERENCE   9  (bases 1 to 5573)
  AUTHORS   Chu,P., Pardo,J., Zhao,H., Li,C.C., Pali,E., Shen,M.M., Qu,K.,
            Yu,S.X., Huang,B.C., Yu,P., Masuda,E.S., Molineaux,S.M.,
            Kolbinger,F., Aversa,G., de Vries,J., Payan,D.G. and Liao,X.C.
  TITLE     Systematic identification of regulatory proteins critical for
            T-cell activation
  JOURNAL   J Biol 2 (3), 21 (2003)
   PUBMED   12974981
REFERENCE   10 (bases 1 to 5573)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI666910.1, BC012021.1,
            AK000463.1 and AC011825.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017831.3.
            
            Summary: This gene encodes a novel E3 ubiquitin ligase that
            contains a RING finger domain in the N-terminus and three
            zinc-binding and one ubiquitin-interacting motif in the C-terminus.
            As a result of myristoylation, this protein associates with
            membranes and is primarily localized to intracellular membrane
            systems. The encoded protein may function as a positive regulator
            in the T-cell receptor signaling pathway. [provided by RefSeq, Mar
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.373170.1,
                                           SRR1660809.78201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217740.4/ ENSP00000217740.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BI666910.1         459-653
            196-352             BC012021.1         170-326
            353-593             AK000463.1         696-936
            594-731             BC012021.1         568-705
            732-5545            AC011825.13        27034-31847
            5546-5573           AC011825.13        31848-31875
FEATURES             Location/Qualifiers
     source          1..5573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5573
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /note="ring finger protein 125"
                     /db_xref="GeneID:54941"
                     /db_xref="HGNC:HGNC:21150"
                     /db_xref="MIM:610432"
     exon            1..203
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..738
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell ring protein identified in activation screen; ring
                     finger protein 125, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF125 isoform 1"
                     /protein_id="NP_060301.2"
                     /db_xref="CCDS:CCDS11902.1"
                     /db_xref="GeneID:54941"
                     /db_xref="HGNC:HGNC:21150"
                     /db_xref="MIM:610432"
                     /translation="MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVL
                     HQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAE
                     CDTLVCLSEMRAHIRTCQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITH
                     HRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVL
                     DRSLLEYVNHSNTT"
     exon            204..357
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..452
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..543
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..651
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..5573
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5510..5515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /note="hexamer: AATAAA"
     regulatory      5538..5543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /note="hexamer: ATTAAA"
     polyA_site      5544
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
                     /note="major polyA site"
     polyA_site      5573
                     /gene="RNF125"
                     /gene_synonym="TNORS; TRAC-1; TRAC1"
ORIGIN      
        1 actgagtgct tcgcagctgt ctgggcgaga ggcacagcga tgggctccgt gctgagcacc
       61 gacagcggca aatcggcgcc cgcctctgcc accgcgcggg ccctggagcg caggagggac
      121 ccggagttgc ccgtcacgtc cttcgactgc gccgtgtgcc ttgaggtgtt acaccagcct
      181 gtccggaccc gctgtggcca cgtattctgc cgttcctgta ttgctaccag tctaaagaac
      241 aacaagtgga cctgtcctta ttgccgggca tatcttcctt cagaaggagt tccagcaact
      301 gatgtagcca aaagaatgaa atcagagtat aagaactgcg ctgagtgtga caccctggtt
      361 tgcctcagtg aaatgagggc acatattcgg acttgtcaga agtacataga taagtatgga
      421 ccactacaag aacttgagga gacagcagca aggtgtgtat gtcccttttg tcagagggaa
      481 ctgtatgaag acagcttgct ggatcattgt attactcatc acagatcgga acggaggcct
      541 gtgttctgtc cactttgccg tttaataccc gatgagaatc caagcagctt cagtggcagt
      601 ttaataagac atctgcaagt tagtcacact ttgttttatg atgatttcat agattttaat
      661 ataattgagg aagctcttat ccgaagagtc ttagaccggt cacttcttga atatgtgaat
      721 cactcgaaca ccacataatt ttattaaaac gaagggaaaa gggaccactg aattgcacca
      781 tttaagatgc tgcttgaaca aatgggaggg aagttgtcaa tgattgatgg gcaaaaatgt
      841 acaacacagt tatgtgtttg tccatgttta ttgttatagt gcatttaaaa actgctttaa
      901 ttttaatggt ttaaatctgt tttacatcct tgagattctt acacatctaa caacaaaaaa
      961 aattatctac atcagtcatt gttacatgga aaagacaggt ggtaggcaag taggtggagg
     1021 atctcggttt gcaaattaga taatactctg tgtataatgc tacatatcaa taactaccat
     1081 catggttagg cacgataact aatctttgtt ctgtgtaaaa aaatatggag agtgaaacaa
     1141 agtgcagaca ttcaaagaaa taagaaatct gctccaatgc tcttgttcta atctctaata
     1201 ggttaacgtt aataatcttg tatgggagtt ggaaaggaaa attttggaag tcaagaaagt
     1261 ccatttaggc cggacgcggt ggcttacgct tgtaatccca gcactttggg aggctgaagc
     1321 aggcggatca caaggtcagg agttcgagac cagcctggcc aacactggtc tctgtgaaac
     1381 tccgtctcta ctaaaaatac aaaaattagc tggacgtgtt ggcgggcatc tgtaatacca
     1441 gctacttggg aggctgaggc agaagaatca cttgaacccg ggaggcagag gttacagtga
     1501 gctgagatcg caccagtaca ctccagcctg ggtaacagag ctagactcca tctcaaaaaa
     1561 aaaaaaaaaa aaaatccatt taaccaaatt gtcttacata atactgtaac aaaacaaatt
     1621 ttgtgttaga aaagtatact taattctttg actttttata actgcataca taagaattca
     1681 atatttttca aatatttata gcttatttag aaatatttct ataatataag caatttctta
     1741 aaaaccatca gatgatactt acagtataag tattcacatc cagacttttt agtagaaaac
     1801 cctaagggct ttgatatctt ttttgattgt aacattttaa aaattatgaa ataaaagtac
     1861 tgaaaaccag acacaaaatt tatagctgaa tgccttatta taaggaaata ctcttttagg
     1921 actcagccag tcaccccacg tgtccttttt gtgtcctgtc acaattacaa ccccacaaaa
     1981 gtaactgcta gactgattta aatggtaatc actttgttgc atttgattac tgctgccaca
     2041 cctaaatgca tatatctata ttttaatatt atcaatttaa agttgttatt aaatgtatat
     2101 tttattttac atctcttttt taatctagaa gttcctcctt ctttccagtt ccttaaaatt
     2161 tacctggtga agaacctgat cctaggacct atagagtttc ccatactttg tattttgctg
     2221 attgcacact catggcacgg ttcagcacat tgccctgtcc tctcgatatt agcacacagt
     2281 gcaggttcag gcacattgaa tttgagaaga cttaggttca gtcctttggc aagactgtaa
     2341 atcacggtgt ctttctttcc ttcctccttc ttctctctct ctctctctct ctctttcctt
     2401 ttctttctct ttttttcaga gttgcactct gttgcccagg ctggagtaca gtggcacgat
     2461 ctcgactcac tgcaacctcc atctcccggg ttcaagcagt tctcctgttt cagcctccca
     2521 agtagctggg actacaggtg cacgccacca tgcccggcta atttttgtat ttttagtaga
     2581 ggggtttcac cataatggtc aggctggtct tgaactcctg aactcaagtg atccaccagc
     2641 cttggcctcc caaaatgctg ggattacagg catgagccac catgcccagc taatttttgt
     2701 atttttagta gagacagggt ttcaccataa tagccaggct ggtctcaaac tccttacctt
     2761 gtgatccgcc cacctcagcc ttccaaagtg ctgggattat aggcgtgagc cactgtgccc
     2821 ggcctacagg gtttttatct aacctttctg ttacaactgt acctctcctt ctgtactgaa
     2881 agtcctggtt ttcaagaaca cagggcacga tagaattaga acatcccaca attactcatt
     2941 tcttttattt atcttacact tacagctgtc tcagaataac aatagaaata caaccacaaa
     3001 taatatggca attgaaacaa ttaaaaagtt ttcatttgct tttctcattc tttcccaatt
     3061 tttttttttt tttgagatgg agtctcgcgc tcttgttgcc caggctggag tgcaatggca
     3121 cgatctcggc tcactgcaac ctctgcctcc tggattcaag caattctcct gcctcagctt
     3181 cccgagtagc tgggattata ggcatgcgcc accacgccct gctaattttg tatttttagt
     3241 agagtcagga tttctccaca ttggtcaggc tggcctcaaa ctctcgacct caggtgatcc
     3301 gcctgcctcg gcctcccaaa gtgctgggat tacaggtgtg agccactgcg cccgacatcc
     3361 caatttttaa aatagttata ctatgtcaac attttcagaa catactggta tagcatactg
     3421 tactttcttc cttttatccc ccatttattc ttagttcttc aactatatat ttaacacttg
     3481 cccccagttt tgttttgttt tgttttgagg aggaatcttg ctctgttgcc caggctggag
     3541 tgcagtggtg tgatcttggc tcactgcaac ctccgcctcc cgggttcaag tgattctcct
     3601 gcctcagcct ctcgagtagc tgggattaca agtgggcacc accacacccg gctaattgtt
     3661 gtatttttag tagagatggg ttttgccatg ttggccaggc tggttttgaa ctcctgacct
     3721 caagtgatcc acctgtgttg gcctcctaaa gtactgggat tacaggtgtg tgccaccgcg
     3781 ccaggcaatt gcccccagtt tttatttgat ggctctgact gtttctcata tctgactctt
     3841 taattatgaa tccagggcat agattagtat ctccatcttg taaggatgca aagaagccat
     3901 gaaaataagt aatatcaact cctgaggata aaacgttact tgactagagt tagcttttta
     3961 attgtaatca tttataaact tctttgttcc ttacatataa gcatagtcat aaccatggta
     4021 cccaaaattt tctataagtt attgtaactc cttaaaggtc ttgctacagt tcttttatcc
     4081 agtacaaata attgggaaaa tgtaaagctg aatgaaatct agtgagcctc atatcctccc
     4141 ttttagatat tgattttaag tttgcttttc acagctgcta aaaagtaaca actgattttt
     4201 agttccacaa cctctctttc ttcaatttag atggatcata caataaagca aaatctggct
     4261 ggttacagtg gctcacacct ataatcccag cactttggga ggctgaggtg gagggtctca
     4321 tgagcccagg agttcaagac caacctgggc aatatagtga gactctttct atttaaacaa
     4381 aaacaaaaac aaacaaacaa acaaacaaaa agctgggcat gatgcacacc tttagtttca
     4441 gctactaagg aggctgaggt tggaggatca cttgagccta ggaggtcaac actgcagtga
     4501 gctatgatca tgctactgcc ctccagcctg ggcaacagag caagaccctg tctccaaaaa
     4561 cataaataat taaatataaa taaaaataaa gcaaaatctg ttgggaaacg agaaaaagga
     4621 gaggaatttt tcaggaataa tcataaaaag aaatgatcat cagactgaaa gtccagagcc
     4681 tgagaaatga aaacatattt ttaagcattg gtgttgacca tgcagacaaa cttttgttaa
     4741 ttcagagcga tacaaaaggc actttgaatc tataaaactt gaaaaagtta aaaattgtat
     4801 gtcggataaa gctttaagtc atctgtcact attaacctca gtgcagcaat tctgactcct
     4861 gtgcctggat tccttttatg ataattttgc cacctacagg acagattagg tgctggtcgc
     4921 ctgaattatt ttgtgttctg aattattttg agctctaaaa tggtaaagta caaatactca
     4981 ttgttttact gtgcctttgg ccttttataa aaaggtattt ataattcgtt gataaaaacc
     5041 aatatttgaa gctgttgatt accaacaaaa aagtttcact ctctttatag tgcttcagga
     5101 tacaactttt tcagggcctt attagagaaa aactgattca catgttattc ttctaaagct
     5161 aaattattaa aatgtaggtt gaaagattgg attgattgtg aatctacact aaagatatgg
     5221 ttccaggcag acctccttag agacctccag gcagacctcc ttactgtctt cagtgatgtt
     5281 taatttcatt actgttactg ggtgccaagt gtctttcatt tggaagtgaa cttactccag
     5341 ttattgaatg tttatcatat cataatttgc atttttccaa cattgaaggt attttaaaaa
     5401 gtcactaaga gattcattct tttattattc aactacaaaa aaatagtgta atgatcagaa
     5461 tttaaaatgt gtgattcttt ttcttctgta agtatgtatt gctatgataa ataaaaaatg
     5521 gcaggaccat tgtttttatt aaaatatcta ctgtgtctat tcttaaacat taa
//
