LOCUS       NM_022064               4255 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ring finger protein 123 (RNF123), transcript variant
            1, mRNA.
ACCESSION   NM_022064
VERSION     NM_022064.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Gulei,D., Drula,R., Ghiaur,G., Buzoianu,A.D.,
            Kravtsova-Ivantsiv,Y., Tomuleasa,C. and Ciechanover,A.
  TITLE     The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From
            Cell-Cycle Control to NF-kappaB Regulator
  JOURNAL   Cancer Res 83 (11), 1762-1767 (2023)
   PUBMED   36880841
  REMARK    GeneRIF: The Tumor Suppressor Functions of Ubiquitin Ligase KPC1:
            From Cell-Cycle Control to NF-kappaB Regulator.
            Review article
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Goldhirsh,G., Kravtsova-Ivantsiv,Y., Satish,G., Ziv,T., Brik,A. and
            Ciechanover,A.
  TITLE     A short binding site in the KPC1 ubiquitin ligase mediates
            processing of NF-kappaB1 p105 to p50: A potential for a
            tumor-suppressive PROTAC
  JOURNAL   Proc Natl Acad Sci U S A 118 (49) (2021)
   PUBMED   34873064
  REMARK    GeneRIF: A short binding site in the KPC1 ubiquitin ligase mediates
            processing of NF-kappaB1 p105 to p50: A potential for a
            tumor-suppressive PROTAC.
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Rahman,M.S., Winsvold,B.S., Chavez Chavez,S.O., Borte,S.,
            Tsepilov,Y.A., Sharapov,S.Z., Aulchenko,Y.S., Hagen,K., Fors,E.A.,
            Hveem,K., Zwart,J.A., van Meurs,J.B., Freidin,M.B. and
            Williams,F.M.
  CONSRTM   HUNT All-In Pain
  TITLE     Genome-wide association study identifies RNF123 locus as associated
            with chronic widespread musculoskeletal pain
  JOURNAL   Ann Rheum Dis 80 (9), 1227-1235 (2021)
   PUBMED   33926923
  REMARK    GeneRIF: Genome-wide association study identifies RNF123 locus as
            associated with chronic widespread musculoskeletal pain.
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Kravtsova-Ivantsiv,Y., Goldhirsh,G., Ivantsiv,A., Ben Itzhak,O.,
            Kwon,Y.T., Pikarsky,E. and Ciechanover,A.
  TITLE     Excess of the NF-kB p50 subunit generated by the ubiquitin ligase
            KPC1 suppresses tumors via PD-L1- and chemokines-mediated
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 117 (47), 29823-29831 (2020)
   PUBMED   33168738
  REMARK    GeneRIF: Excess of the NF-kB p50 subunit generated by the ubiquitin
            ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated
            mechanisms.
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Kotoshiba,S., Kamura,T., Hara,T., Ishida,N. and Nakayama,K.I.
  TITLE     Molecular dissection of the interaction between p27 and Kip1
            ubiquitylation-promoting complex, the ubiquitin ligase that
            regulates proteolysis of p27 in G1 phase
  JOURNAL   J Biol Chem 280 (18), 17694-17700 (2005)
   PUBMED   15746103
  REMARK    GeneRIF: Free p27 is recognized by the amino-terminal region of
            KPC1, which also associates with KPC2, and p27 is then
            polyubiquitylated by the carboxy-terminal RING-finger domain of
            KPC1.
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Kamura,T., Hara,T., Matsumoto,M., Ishida,N., Okumura,F.,
            Hatakeyama,S., Yoshida,M., Nakayama,K. and Nakayama,K.I.
  TITLE     Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1)
            at G1 phase
  JOURNAL   Nat Cell Biol 6 (12), 1229-1235 (2004)
   PUBMED   15531880
  REMARK    GeneRIF: KPC thus probably controls degradation of p27(Kip1) in G1
            phase after export of the latter from the nucleus
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI596589.1, BC130632.1,
            AC099668.2 and BC088801.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022064.4.
            
            Summary: The protein encoded by this gene contains a C-terminal
            RING finger domain, a motif present in a variety of functionally
            distinct proteins and known to be involved in protein-protein and
            protein-DNA interactions, and an N-terminal SPRY domain. This
            protein displays E3 ubiquitin ligase activity toward the
            cyclin-dependent kinase inhibitor 1B which is also known as p27 or
            KIP1. Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832034.1, AL832344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327697.11/ ENSP00000328287.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BI596589.1         60-60
            2-2646              BC130632.1         1-2645
            2647-2647           AC099668.2         23730-23730         c
            2648-4080           BC130632.1         2647-4079
            4081-4255           BC088801.1         2400-2574
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4255
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /note="ring finger protein 123"
                     /db_xref="GeneID:63891"
                     /db_xref="HGNC:HGNC:21148"
                     /db_xref="MIM:614472"
     exon            1..50
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..168
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..4031
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /EC_number="2.3.2.27"
                     /note="kip1 ubiquitination-promoting complex protein 1;
                     Kip1 ubiquitination-promoting complex subunit 1; RING-type
                     E3 ubiquitin transferase RNF123"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF123"
                     /protein_id="NP_071347.2"
                     /db_xref="CCDS:CCDS33758.1"
                     /db_xref="GeneID:63891"
                     /db_xref="HGNC:HGNC:21148"
                     /db_xref="MIM:614472"
                     /translation="MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFS
                     SSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGF
                     EGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQ
                     EEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSL
                     GTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQ
                     RLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLV
                     EAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFS
                     PIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQ
                     ELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQIL
                     KLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALR
                     YYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKA
                     NIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRAN
                     RFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQ
                     PLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRK
                     DILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTG
                     SLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIV
                     GTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVR
                     LWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFL
                     NSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMT
                     ITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHY
                     PILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPA
                     PDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPI
                     SAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA"
     exon            169..253
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..333
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..428
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..483
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..569
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..656
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..724
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..850
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..965
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1070
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1196
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1289
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1363
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1481
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1581
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1643
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1715
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1836
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1938
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2045
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2244
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2390
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2474
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2582
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2760
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2835
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2923
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3011
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3096
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3236
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3425
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3501
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3586
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3729
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3824
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3910
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4255
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4235..4240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /note="hexamer: ATTAAA"
     polyA_site      4255
                     /gene="RNF123"
                     /gene_synonym="FP1477; KPC1"
                     /note="major polyA site"
ORIGIN      
        1 aagaggttgg gcggatgttg tgagccgggt cgctgcggcc gaggctccgg cccccaggac
       61 cactggctgc ccatgagaga tgaaggatgg catccaaggg ggccggcatg tctttctccc
      121 gcaagagcta taggctgacc tcagatgctg agaaatccag ggtcacaggc attgtgcagg
      181 agaagctgct gaatgactac ctgaaccgca tcttttcctc ttctgaacat gcacccccag
      241 cagccaccag caggaaaccc ctgaacttcc agaacctgcc agaacatttg gaccagttgc
      301 tacaggtgga caatgaggag gaggaaagcc agggacaggt tgaagggcgg cttggcccat
      361 ccactgtggt cctggaccac acaggcggct ttgaggggct tctcctggtg gatgatgacc
      421 tgctgggggt gattggacac agcaactttg gcaccatccg ctctaccaca tgcgtgtaca
      481 aagggaaatg gctctacgag gtcctcatct cctcccaggg gctcatgcag atcggctggt
      541 gcaccatcag ctgccgcttc aaccaggagg agggggttgg agatacacac aactcctatg
      601 cctatgatgg caaccgcgtg cgcaagtgga atgtgaccac aacgaattat ggcaaggcgt
      661 gggcagcggg ggacatcgtg agctgcctga ttgacctgga tgatggcact ctgtccttct
      721 gcctgaacgg tgtatcactg ggcactgcct ttgagaacct gtccaggggc ctgggtatgg
      781 cctacttccc agccatcagc ctctctttca aggagtccgt ggccttcaac tttggcagcc
      841 gtcctctgcg ctacccagtg gcaggctacc ggcccctgca ggacccaccg agtgctgacc
      901 tggtgcgggc acagaggttg ctgggctgct tccgggcagt gctgagtgtg gagctggacc
      961 ctgtggaggg gcggctgttg gacaaggaga gctccaagtg gcggttgcgg ggccagccca
     1021 ccgtcctcct cacactggcc cacatcttcc atcactttgc accgcttctg cgcaaggtgt
     1081 atctggtgga ggctgtgctc atgagcttct tgctgggcat cgtggagaag ggcacaccca
     1141 cacaggcaca gtccgtggtg caccaggtcc tggacctctt gtggctcttc atggaggact
     1201 acgaggtaca agattgcctc aagcagttga tgatgtctct gcttcggctg taccgattct
     1261 cacccattgt cccagacctg ggcctacaga tccattacct gcggctcact atcgccatcc
     1321 tgaggcatga gaagtcccgc aagtttctgc ttagcaatgt cctcttcgac gtgctccgct
     1381 ccgtcgtctt cttttacatc aagagccccc tgcgtgtgga ggaggccggc ctgcaggagc
     1441 tcattcccac cacctggtgg ccccactgct ccagtaggga gggcaaagag agcacggaga
     1501 tgaaggagga gaccgcagag gagcggctgc ggcggcgagc ctacgaacgg ggctgtcagc
     1561 ggctcaggaa gcgcatcgaa gtggtggaag aactacaggt ccagatcctg aagctgctgc
     1621 tggacaataa agatgacaat gggggtgaag cttctaggta tatcttcctg accaagtttc
     1681 gcaagtttct gcaggagaac gccagtggcc gggggaacat gcccatgctc tgcccccctg
     1741 agtacatggt ctgcttctta caccggctga tctctgccct gcgctactat tgggatgaat
     1801 acaaggcttc caatcctcat gcttccttca gtgaggaggc ctacatcccg ccccaggtct
     1861 tctataatgg caaggtggac tactttgacc tgcagcgcct ggggggcctc ctctcgcacc
     1921 tgcggaagac cctcaaagat gaccttgctt ccaaagccaa cattgtgatc gacccactgg
     1981 agctccagtc aaccgccatg gatgacctag atgaggatga ggagccagcc ccagctatgg
     2041 cccagcgccc catgcaggcc ctggctgttg gggggccact gcccctgccc cggcccggct
     2101 ggctcagttc tccaactttg ggccgagcca accgcttcct cagcacagcg gctgtgagcc
     2161 tcatgacccc acggcggcct ctgagcacct cggagaaagt gaaggtccgc acgctgagcg
     2221 tggagcagag gacccgtgag gacattgaag gcagccactg gaatgagggc ttgctgctgg
     2281 ggcggccccc cgaggagcct gagcagcccc tcaccgagaa ctcgctgctg gaagtcctgg
     2341 atggggcggt catgatgtac aacctcagcg tacaccagca gctgggcaag atggtgggtg
     2401 tctccgatga tgtcaatgaa tacgctatgg ctctgaggga cacagaggac aagctccgcc
     2461 ggtgccccaa gaggaggaag gacatccttg cagagttgac caagagccag aaggttttct
     2521 cagaaaagct ggaccacctg agccgccgtc ttgcctgggt ccatgccact gtctactccc
     2581 aggagaagat gctggacatc tactggctgc tgcgcgtctg cctgcggacc attgagcacg
     2641 gtgatcgcac agggtctctc tttgccttca tgcccgagtt ctacctgagc gtggccatca
     2701 acagctacag tgctctcaag aattactttg gtcccgtgca cagcatggag gagctcccag
     2761 gctatgaaga gaccctgacc cgcctggctg ccattctcgc caaacacttt gccgacgcac
     2821 gcattgtggg cactgacatc cgagactcac tgatgcaggc cctggccagc tacgtgtgct
     2881 acccacactc cctgcgggct gtggagcgaa tccccgagga gcagcgtatc gccatggtga
     2941 ggaacctcct ggcgccctat gagcagcggc cctgggccca gaccaactgg atcctggtgc
     3001 ggctctggag gggctgtggc ttcgggtacc gctatacacg gctgccacat ctgctgaaaa
     3061 ccaaacttga ggacgccaat ttgcccagcc tccagaagcc ctgcccttcc accctgctgc
     3121 agcagcacat ggcggacctc ctacagcagg gtcctgatgt ggcacccagc ttcctcaaca
     3181 gcgtcctcaa tcagctcaac tgggccttct ctgaattcat tggcatgatc caagagatcc
     3241 agcaggctgc tgagcgcctg gagcggaact ttgtggacag ccggcagctc aaggtatgtg
     3301 ccacctgctt tgacctctcg gtcagcctgc tgcgtgtctt ggagatgact atcacactgg
     3361 tgcctgagat attccttgac tggacccggc ctacctctga gatgctgctg cggcgtcttg
     3421 cacagctgct aaaccaggtg ctgaaccggg tgacagctga gaggaacctg tttgatcgtg
     3481 tggtcaccct acggctgcct ggcctagaga gcgtggacca ctatcccatt ctggtggcag
     3541 tgacgggcat cctggtgcag ctcctggtgc gtggcccagc ctcagagaga gagcaagcca
     3601 catcagtgct cctggcagat ccctgcttcc agctacgctc aatatgctat ctcctgggac
     3661 agccagagcc cccagcacct ggcactgctc tgccagcccc tgaccggaag cgcttctccc
     3721 tgcagagcta tgcggattat atcagtgccg atgagctggc ccaagtggaa cagatgctgg
     3781 cgcacctgac ctctgcatct gcccaggcag cagctgcctc cctgcccacc agtgaggagg
     3841 acctctgccc catctgctat gcccacccca tctctgctgt gttccagccc tgtggccaca
     3901 agtcctgcaa agcctgtatc aaccagcacc tgatgaacaa caaggactgc ttcttctgca
     3961 aaaccaccat cgtgtctgta gaggactggg agaagggagc caatacgagt actacctcct
     4021 cagctgccta gccctcacag cctgtgccat cctggaacct ccacctttga acccagagcc
     4081 aggctgggcc ctatttatga gctccctttg cccttctcct gtatcccaca ccaccacatc
     4141 caacctcctt gcctgcctgt atcctcattg gtgggagccc agccatggcc ctaattgtgc
     4201 ctgagcttga ctttcagtca gggccacagt gagcattaaa ttattattcc ataca
//
