LOCUS       NM_024787               1872 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens ring finger protein 122 (RNF122), mRNA.
ACCESSION   NM_024787
VERSION     NM_024787.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Xiao,Q., Xue,K., Li,L., Zhu,K., Fu,R. and Xiong,Z.
  TITLE     RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc
            signaling Axis
  JOURNAL   CNS Neurosci Ther 30 (9), e70017 (2024)
   PUBMED   39218810
  REMARK    GeneRIF: RNF122 promotes glioblastoma growth via the
            JAK2/STAT3/c-Myc signaling Axis.
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Garcia-Martinez,I., Sanchez-Mora,C., Soler Artigas,M., Rovira,P.,
            Pagerols,M., Corrales,M., Calvo-Sanchez,E., Richarte,V.,
            Bustamante,M., Sunyer,J., Cormand,B., Casas,M., Ramos-Quiroga,J.A.
            and Ribases,M.
  TITLE     Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a
            Novel Susceptibility Gene for Attention Deficit Hyperactivity
            Disorder
  JOURNAL   Sci Rep 7 (1), 5407 (2017)
   PUBMED   28710364
  REMARK    GeneRIF: Findings indicate genetic association between E3 ubiquitin
            ligase RNF122 and Attention Deficit Disorders with Hyperactivity
            (ADHD).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Peng,Z., Shi,T. and Ma,D.
  TITLE     RNF122: a novel ubiquitin ligase associated with calcium-modulating
            cyclophilin ligand
  JOURNAL   BMC Cell Biol 11, 41 (2010)
   PUBMED   20553626
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Wang,L., Gao,X., Gao,P., Deng,W., Yu,P., Ma,J., Guo,J., Wang,X.,
            Cheng,H., Zhang,C., Yu,C., Ma,X., Lv,B., Lu,Y., Shi,T. and Ma,D.
  TITLE     Cell-based screening and validation of human novel genes associated
            with cell viability
  JOURNAL   J Biomol Screen 11 (4), 369-376 (2006)
   PUBMED   16751333
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Koyama,K., Sudo,K. and Nakamura,Y.
  TITLE     Isolation of 115 human chromosome 8-specific expressed-sequence
            tags by exon amplification
  JOURNAL   Genomics 26 (2), 245-253 (1995)
   PUBMED   7601449
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA610129.1, DA904646.1,
            BC093884.1 and AC013603.17.
            
            On Jul 19, 2013 this sequence version replaced NM_024787.2.
            
            Summary: The encoded protein contains a RING finger, a motif
            present in a variety of functionally distinct proteins and known to
            be involved in protein-protein and protein-DNA interactions. The
            encoded protein is localized to the endoplasmic reticulum and golgi
            apparatus, and may be associated with cell viability. [provided by
            RefSeq, Jul 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022588.1, BC093884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267760 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256257.2/ ENSP00000256257.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA610129.1         1-2
            3-382               DA904646.1         1-380
            383-896             BC093884.1         1-514
            897-1872            AC013603.17        37158-38133         c
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..1872
                     /gene="RNF122"
                     /note="ring finger protein 122"
                     /db_xref="GeneID:79845"
                     /db_xref="HGNC:HGNC:21147"
                     /db_xref="MIM:620523"
     exon            1..430
                     /gene="RNF122"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..873
                     /gene="RNF122"
                     /codon_start=1
                     /product="RING finger protein 122"
                     /protein_id="NP_079063.2"
                     /db_xref="CCDS:CCDS6091.1"
                     /db_xref="GeneID:79845"
                     /db_xref="HGNC:HGNC:21147"
                     /db_xref="MIM:620523"
                     /translation="MHPFQWCNGCFCGLGLVSTNKSCSMPPISFQDLPLNIYMVIFGT
                     GIFVFMLSLIFCCYFISKLRNQAQSERYGYKEVVLKGDAKKLQLYGQTCAVCLEDFKG
                     KDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPIASPSEATQNIGILLDELV"
     exon            431..587
                     /gene="RNF122"
                     /inference="alignment:Splign:2.1.0"
     exon            588..633
                     /gene="RNF122"
                     /inference="alignment:Splign:2.1.0"
     exon            634..675
                     /gene="RNF122"
                     /inference="alignment:Splign:2.1.0"
     exon            676..758
                     /gene="RNF122"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1872
                     /gene="RNF122"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF122"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="RNF122"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtttcg gaaccccagc cagctcacct ctgcgccgct gaacccgatc cgagcctccg
       61 gcaaaggttt ttccctcctc ccccggccga gggcttctgc agcccgggca cccccgcccc
      121 gcggcgcccc acattccccc agcccggggc ccttggcgcg tgcgctccgt gcggctgtgc
      181 tccgcgggac tttgtttgtt tcctcctcgt ccctctttgt tgggctgaac accagcctcg
      241 tcaaagcccc ccactccgga gggagttcgg cttctccagc agggcggctg cagcgcgctg
      301 ccccgacccc gcctgcggcc cctcacgccg ctagtgctcc caccccgccc tcctggcacc
      361 ccgcctgcgt ccgttcgccc gaggaagcca accgcgactt cattgatgca cccattccag
      421 tggtgtaacg ggtgtttctg tggcctggga ctggttagca ccaacaagtc ctgctcgatg
      481 ccacccatca gtttccagga ccttccgctc aacatctata tggtcatctt cggcacaggc
      541 atctttgtct tcatgctcag ccttatcttc tgctgctatt ttatcagcaa actgcggaac
      601 caggcacaga gtgagcgata cggatataag gaggtggtgc ttaaaggtga tgccaagaag
      661 ttacaattat atgggcagac ctgcgcagtc tgtctggaag acttcaaggg gaaggatgag
      721 ttaggcgtgc tcccgtgcca acacgccttt caccgcaagt gtctggtgaa atggctggaa
      781 gttcgctgtg tctgccccat gtgtaacaag cccattgcta gtccctcaga ggccacgcag
      841 aacattggga ttctattgga tgagctggtg tgagtgctgc cgctacaccg agacctggag
      901 aagacctctt gcctcatgga tgtctggtcc ctctgcacag ctccaaccaa caggactgta
      961 gggtgatgac gatcactttc ccagtgatga gaagggtggt ctaggactgg gcttctaccc
     1021 tcagtgcaag accagtgcca gatgtgcccc cacttcctgc ctcctgaagc cttcttccct
     1081 gctactccat gctggtggcc tcacccatca agaccactgt ctcctggtac tggactatct
     1141 acctgccttg tccctgttct gggggaaggt gtccaccccg atcaagaaca tggagaaagt
     1201 cctctttcaa ggctcccatt aggaggatga gctgccttga cccagaaggg atgagacggg
     1261 ctcttacctc tctacaacct tccctcccct tcccactcct tccggagtaa ggttagaagg
     1321 gaaggaagga aagatcaagg aaccaagcgc ctccacggga ggcgagggag gctctgtatg
     1381 aaacagaaga gcagggacat aaaggaaaat gtcagtgttt acatgggacc tatggaaaca
     1441 aaggctggcg ggcgccagct gactccagag taagagaggg cccttcccct gccaggaccc
     1501 acggtgctat ccattcagtc tcttcctcag ttaatctcgg agcttcctat tccatgttga
     1561 ggtttgtggg cccctctaga ggagggctag ttctatactt aaattgattc ccaggggcct
     1621 tttttttttt tttttttttt tttttgatca aaaggggtgt ggggatgggg gtgtctacgg
     1681 ttaagcaaca gatacctcct tccctttgta aatagtattt ttatacttca tcctcgcctc
     1741 tcaggcttta gatacgaaat ctccagaatg gaagggggtg gggattttct gttcctccct
     1801 ggagtgggtg agggtgggag aaagttacat atttaaagaa aaataaattt aataacaagt
     1861 ttctctaacc ta
//
