LOCUS       NM_018683               2447 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ring finger protein 114 (RNF114), mRNA.
ACCESSION   NM_018683
VERSION     NM_018683.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2447)
  AUTHORS   Liu,S.C., Gong,L.L., Huang,F.C., Xu,N., Yang,K.X., Liu,X.H. and
            Li,W.L.
  TITLE     RNF114 facilitates the proliferation, stemness, and metastasis of
            colorectal cancer
  JOURNAL   Pathol Res Pract 248, 154716 (2023)
   PUBMED   37523804
  REMARK    GeneRIF: RNF114 facilitates the proliferation, stemness, and
            metastasis of colorectal cancer.
REFERENCE   2  (bases 1 to 2447)
  AUTHORS   Han,W., Chen,Q., Cui,J., Zhao,Y., Li,M. and Li,X.
  TITLE     E3 ubiquitin ligase RNF114 promotes vesicular stomatitis virus
            replication via inhibiting type I interferon production
  JOURNAL   Microb Pathog 167, 105569 (2022)
   PUBMED   35545202
  REMARK    GeneRIF: E3 ubiquitin ligase RNF114 promotes vesicular stomatitis
            virus replication via inhibiting type I interferon production.
REFERENCE   3  (bases 1 to 2447)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2447)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2447)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2447)
  AUTHORS   Capon,F., Bijlmakers,M.J., Wolf,N., Quaranta,M., Huffmeier,U.,
            Allen,M., Timms,K., Abkevich,V., Gutin,A., Smith,R., Warren,R.B.,
            Young,H.S., Worthington,J., Burden,A.D., Griffiths,C.E., Hayday,A.,
            Nestle,F.O., Reis,A., Lanchbury,J., Barker,J.N. and Trembath,R.C.
  TITLE     Identification of ZNF313/RNF114 as a novel psoriasis susceptibility
            gene
  JOURNAL   Hum Mol Genet 17 (13), 1938-1945 (2008)
   PUBMED   18364390
  REMARK    GeneRIF: ZNF313 is a novel psoriasis susceptibility gene.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2447)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 2447)
  AUTHORS   Ma,Y.X., Zhang,S.Z., Hou,Y.P., Huang,X.L., Wu,Q.Q. and Sun,Y.
  TITLE     Identification of a novel human zinc finger protein gene ZNF313
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35 (3),
            230-237 (2003)
   PUBMED   12621547
REFERENCE   9  (bases 1 to 2447)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 2447)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091976.1, BM830132.1, BC013695.1 and AF131742.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018683.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066919.1, BX640603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244061.6/ ENSP00000244061.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK091976.1         21-22
            3-529               BM830132.1         21-547
            530-2442            BC013695.1         519-2431
            2443-2447           AF131742.1         1823-1827
FEATURES             Location/Qualifiers
     source          1..2447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..2447
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /note="ring finger protein 114"
                     /db_xref="GeneID:55905"
                     /db_xref="HGNC:HGNC:13094"
                     /db_xref="MIM:612451"
     exon            1..156
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..703
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 313; zinc finger protein 228;
                     RING-type E3 ubiquitin transferase RNF114"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF114"
                     /protein_id="NP_061153.1"
                     /db_xref="CCDS:CCDS33482.1"
                     /db_xref="GeneID:55905"
                     /db_xref="HGNC:HGNC:13094"
                     /db_xref="MIM:612451"
                     /translation="MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPC
                     GHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSK
                     IRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHC
                     KLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMN
                     QVLQRSIIDQ"
     exon            157..307
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /inference="alignment:Splign:2.1.0"
     exon            308..414
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /inference="alignment:Splign:2.1.0"
     exon            415..529
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /inference="alignment:Splign:2.1.0"
     exon            530..637
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /inference="alignment:Splign:2.1.0"
     exon            638..2447
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /inference="alignment:Splign:2.1.0"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /note="hexamer: ATTAAA"
     polyA_site      773
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /note="major polyA site"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="RNF114"
                     /gene_synonym="PSORS12; ZNF313"
ORIGIN      
        1 gcagagcggc agcaagatgg cggcgcaaca gcgggactgc gggggtgctg cgcagctggc
       61 ggggccggcg gcggaggctg accccctagg acgcttcacg tgtcccgtgt gcttagaggt
      121 gtacgagaag ccggtacagg tgccctgcgg acacgtcttt tgctctgcat gcctgcagga
      181 atgtctgaag ccgaagaagc ctgtctgtgg ggtgtgtcgc agcgctctgg cacctggcgt
      241 ccgagccgtg gagctcgagc ggcagatcga gagcacagag acttcttgcc atggctgccg
      301 taagaatttc ttcctgtcca agatccggtc ccacgtggct acttgttcca aataccagaa
      361 ttacatcatg gaaggtgtga aggccaccat taaggatgca tctcttcagc caaggaatgt
      421 tccaaaccgt tacacctttc cttgtcctta ctgtcctgag aagaactttg atcaggaagg
      481 acttgtggaa cactgcaaat tattccatag cacggatacc aaatctgtgg tttgtccgat
      541 atgtgcctcg atgccctggg gagaccccaa ctaccgcagc gccaacttca gagagcacat
      601 ccagcgccgg caccggtttt cttatgacac ttttgtggat tatgatgttg atgaagagga
      661 catgatgaat caggtgttgc agcgctccat catcgaccag tgagcagagt ccgtgcttgc
      721 tatctgtctc atgttacaga gcttccatta catattaaac gtgaaatcta tgactcctgt
      781 accttacctg ttcaacagac ctgaaaatga gccatggcat tgggacaggg tcacttctga
      841 caggggaagt gggtccccag gtcagccctt ctcttccctt tgggctcttg ccaaagctgt
      901 cttcccctac tgttaacctt gtttgtcaca cggtcgagtt cgtattggtt ctcggctact
      961 tcctggagct tctgccgcct cctgtggaag ataatctagc ttctccacct cttgtttcac
     1021 actcattcct cccatccagt gtttgtctct cgggtccttc aagccagcca ggaccttttc
     1081 tgggtcatga atagcacaat gaagcaagtg tctcctttcc ttgtccccaa ggtgtgcaga
     1141 ctttggcagc cgtgcacctg accagagctg aagctcccgc tgggctgtgg ggttgccaga
     1201 agctggggtt gccatcccgg ggtacatgtc accagtcctc ttggggtttt gtaccatctg
     1261 atgctggaag ttttgattag tgatattttc tactactaca tatttagagt tcactggttc
     1321 agtcttaaat gcctgcatgg tgccttttta ggataaggta taaccataca tttttggtgg
     1381 aagtgtttct gggttaggga agttaaagtc tgtttatccg taagtgggga ggagggtcag
     1441 ctaagagaag tgggagggcc agagcttttt ggttctgatt tacaaattaa tgaagtagtt
     1501 tcaaacaacg cggtcatgtt tacctctcca tttgggagcc tgcctacatt cttgttctag
     1561 aagcacaaaa aatcctcaga tgaattagaa gaaagaggtt tggggactca gcggatacta
     1621 gttcttttac cttctgcttg gtaacttaga ttaaactgag cattgttttt ctgtcacaaa
     1681 tgttttcctt atgacactgg tttcgacatg taaaatgtgt ttgaaaacct gctttgtaga
     1741 tgcagagaga agctatagga aacccagtac cacccctggt ctgttctgac gagacatcgt
     1801 tcataaggca cagcacatcg caagatgaac agttgttaat aaaagctgtt gctggaaact
     1861 tgctttagga acagctcaag aaccttggag ttcatatttc acaaatatta ataaatataa
     1921 gtccaagagc tgtcagccta atctgtagga gcagaacctc tgattgacca aaaggcatat
     1981 gggtttaggt tggttttttg atgtcatatg tctctgatgg ggctgcaagt gctacctcgc
     2041 gcttgtacac tgctgctgtg gggctccgcg cctgccggtg aagagctgca gatgccgaga
     2101 agccagcaaa cacagggccc actggaaaaa aatagttttt tcattagtat ttctcgggag
     2161 gacccaaaag ttaaggtcag cttgttcact gtaatttctg gaagaagttc actcagacct
     2221 tcctgaattc agatcatctc agaagtctgg agggaaatct ggcgaaacct tcgtttgagg
     2281 gactgatgtg agtgtatgtc cacctcactg gtggcaccga gaaacttact tccttgtatt
     2341 aagtgcactt cttgtatttc taataagatg actttccaga aagtgagatt tgttatgttc
     2401 tggcttttaa aaggtaaaat ataaataaat ttcataactt aatctaa
//
