LOCUS       NM_178861               1380 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens ring finger protein 113B (RNF113B), mRNA.
ACCESSION   NM_178861
VERSION     NM_178861.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136300.22, BC017585.2 and AI935007.1.
            
            On May 17, 2019 this sequence version replaced NM_178861.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.168162.1, AF539427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267291.7/ ENSP00000267291.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL136300.22        133754-133755       c
            3-348               AL136300.22        133408-133753       c
            349-1158            BC017585.2         347-1156
            1159-1380           AI935007.1         4-225               c
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.2"
     gene            1..1380
                     /gene="RNF113B"
                     /gene_synonym="bA10G5.1; RNF161; ZNF183L1"
                     /note="ring finger protein 113B"
                     /db_xref="GeneID:140432"
                     /db_xref="HGNC:HGNC:17267"
     exon            1..988
                     /gene="RNF113B"
                     /gene_synonym="bA10G5.1; RNF161; ZNF183L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1002
                     /gene="RNF113B"
                     /gene_synonym="bA10G5.1; RNF161; ZNF183L1"
                     /note="zinc finger protein 183-like 1"
                     /codon_start=1
                     /product="RING finger protein 113B"
                     /protein_id="NP_849192.1"
                     /db_xref="CCDS:CCDS9486.1"
                     /db_xref="GeneID:140432"
                     /db_xref="HGNC:HGNC:17267"
                     /translation="MAAPPSPGRTADQADQVCTFLFKKPGRKGAAGLRKRPACDPEHG
                     ESSSSGDEGDTVAQPPRVAPRPRGLHSWQKAAHGDRRGEEAAPESLDVVYRSTRSAKP
                     VGPEDMGATADFEQDTEKEHHTPTILKCSQRVQEALRGREHDHIYRGIHSYLRYLKPK
                     DTSMGNSSSGMARKGPIRAPGHLRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRS
                     DYKLGWEIERELEEGRYCICEDENHEVGSEEEEIPFRCFICRQAFQNPVVTKCRHYFC
                     ESCALEHFRATPRCYICDQPTGGIFNPAKELMAKLQKLQAAEGKKR"
     exon            989..1380
                     /gene="RNF113B"
                     /gene_synonym="bA10G5.1; RNF161; ZNF183L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1360..1365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF113B"
                     /gene_synonym="bA10G5.1; RNF161; ZNF183L1"
                     /note="hexamer: AATAAA"
     polyA_site      1380
                     /gene="RNF113B"
                     /gene_synonym="bA10G5.1; RNF161; ZNF183L1"
                     /note="major polyA site"
ORIGIN      
        1 acgccacggc cgttgggagc ctgagactca aacatggcag cgccaccttc tccaggaagg
       61 acggccgacc aagcagacca ggtatgcacc ttcctcttca aaaagcctgg acggaaaggg
      121 gctgcaggcc tcagaaagcg cccggcctgc gaccccgagc acggagagag cagcagcagc
      181 ggggacgagg gcgacacagt ggctcagccc ccgcgggtgg caccgaggcc ccggggcctc
      241 cacagctggc agaaggcggc tcacggcgac aggaggggcg aggaggcggc gcctgagagc
      301 ctcgacgtgg tgtacaggtc cacccgctcg gcgaagcctg tggggccaga ggacatgggg
      361 gccaccgctg acttcgagca ggacaccgag aaggagcacc atacgccgac catcctcaag
      421 tgcagccagc gggtccagga ggcactgcgg ggtcgggagc acgaccacat ctaccgggga
      481 atccacagct acctgaggta cctgaagccc aaggacacgt ccatgggcaa ctcctcctcg
      541 gggatggcga ggaagggccc catacgtgcg ccagggcatc tgcgcgccac tgtgcgctgg
      601 gattaccagc ctgacatctg caaggactac aaggagactg gcttctgtgg cttcggggac
      661 agctgcaaat tcctccacga ccgttccgat tacaagctcg ggtgggagat tgaacgggag
      721 cttgaagagg gtcgctactg tatctgcgag gacgaaaacc atgaagtggg aagcgaggaa
      781 gaggaaatac cattcaggtg tttcatatgt cgccaggcct tccaaaaccc agtcgtcacc
      841 aagtgcaggc attatttctg cgagagctgc gcgctggagc acttccgggc caccccgcgc
      901 tgctacatct gtgaccagcc aaccggcggc atctttaacc ccgccaaaga actgatggcg
      961 aaactgcaaa agcttcaggc tgcagaagga aaaaagagat aagaaagact caagtctgta
     1021 tgtacactgg ggagaagcag cctgttgagt aagatgagag agatgacagt cttcctgcaa
     1081 tcccatgcct gagtatgtaa ccaaaagaat tgaaatccgg atctcaaaga ggtatgtgca
     1141 ctcccatgtt cactgcagaa ttatttgcaa aagccaagag gtgtaaacaa cccaagtgtc
     1201 catggatgga tgaatggaca aacaaaatgc gatacacaca cacaatggaa tgctattaag
     1261 ccttaacggg aaggaaatcc ttttaaagat ttaaactgat ccttttaagg atcacatgct
     1321 acaactagaa tgaaccttga agacgacact gctaagtgaa ataaactagt cacaaaatga
//
