LOCUS       NM_006978               1259 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein 113A (RNF113A), mRNA.
ACCESSION   NM_006978
VERSION     NM_006978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1259)
  AUTHORS   Zhang,Q., Song,J., Cao,L., Sun,M., Xu,T., Yang,S., Li,S., Wang,H.
            and Fu,X.
  TITLE     RNF113A targeted by miR-197 promotes proliferation and inhibits
            autophagy via CXCR4/CXCL12/AKT/ERK/Beclin1 axis in cervical cancer
  JOURNAL   Exp Cell Res 428 (1), 113632 (2023)
   PUBMED   37164050
  REMARK    GeneRIF: RNF113A targeted by miR-197 promotes proliferation and
            inhibits autophagy via CXCR4/CXCL12/AKT/ERK/Beclin1 axis in
            cervical cancer.
REFERENCE   2  (bases 1 to 1259)
  AUTHORS   Lukinovic,V., Hausmann,S., Roth,G.S., Oyeniran,C., Ahmad,T.,
            Tsao,N., Brickner,J.R., Casanova,A.G., Chuffart,F., Benitez,A.M.,
            Vayr,J., Rodell,R., Tardif,M., Jansen,P.W.T.C., Coute,Y.,
            Vermeulen,M., Hainaut,P., Mazur,P.K., Mosammaparast,N. and
            Reynoird,N.
  TITLE     SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation
            Damage through RNF113A Methylation-Phosphorylation Cross-talk
  JOURNAL   Cancer Discov 12 (9), 2158-2179 (2022)
   PUBMED   35819319
  REMARK    GeneRIF: SMYD3 Impedes Small Cell Lung Cancer Sensitivity to
            Alkylation Damage through RNF113A Methylation-Phosphorylation
            Cross-talk.
REFERENCE   3  (bases 1 to 1259)
  AUTHORS   Mattioni,A., Boldt,K., Auciello,G., Komada,M., Rappoport,J.Z.,
            Ueffing,M., Castagnoli,L., Cesareni,G. and Santonico,E.
  TITLE     Ring Finger Protein 11 acts on ligand-activated EGFR via the direct
            interaction with the UIM region of ANKRD13 protein family
  JOURNAL   FEBS J 287 (16), 3526-3550 (2020)
   PUBMED   31985874
  REMARK    GeneRIF: Ring Finger Protein 11 acts on ligand-activated EGFR via
            the direct interaction with the UIM region of ANKRD13 protein
            family.
REFERENCE   4  (bases 1 to 1259)
  AUTHORS   Shostak,K., Jiang,Z., Charloteaux,B., Mayer,A., Habraken,Y.,
            Tharun,L., Klein,S., Xu,X., Duong,H.Q., Vislovukh,A., Close,P.,
            Florin,A., Rambow,F., Marine,J.C., Buttner,R. and Chariot,A.
  TITLE     The X-linked trichothiodystrophy-causing gene RNF113A links the
            spliceosome to cell survival upon DNA damage
  JOURNAL   Nat Commun 11 (1), 1270 (2020)
   PUBMED   32152280
  REMARK    GeneRIF: RNF113A deficiency circumvents the resistance to Cisplatin
            and to BCL-2 inhibitors through the destabilization of MCL-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1259)
  AUTHORS   Mendelsohn,B.A., Beleford,D.T., Abu-El-Haija,A., Alsaleh,N.S.,
            Rahbeeni,Z., Martin,P.M., Rego,S., Huang,A., Capodanno,G.,
            Shieh,J.T., Van Ziffle,J., Risch,N., Alkuraya,F.S. and
            Slavotinek,A.M.
  TITLE     A novel truncating variant in ring finger protein 113A (RNF113A)
            confirms the association of this gene with X-linked
            trichothiodystrophy
  JOURNAL   Am J Med Genet A 182 (3), 513-520 (2020)
   PUBMED   31880405
  REMARK    GeneRIF: A novel truncating variant in ring finger protein 113A
            (RNF113A) confirms the association of this gene with X-linked
            trichothiodystrophy.
REFERENCE   6  (bases 1 to 1259)
  AUTHORS   Corbett,M.A., Dudding-Byth,T., Crock,P.A., Botta,E., Christie,L.M.,
            Nardo,T., Caligiuri,G., Hobson,L., Boyle,J., Mansour,A.,
            Friend,K.L., Crawford,J., Jackson,G., Vandeleur,L., Hackett,A.,
            Tarpey,P., Stratton,M.R., Turner,G., Gecz,J. and Field,M.
  TITLE     A novel X-linked trichothiodystrophy associated with a nonsense
            mutation in RNF113A
  JOURNAL   J Med Genet 52 (4), 269-274 (2015)
   PUBMED   25612912
  REMARK    GeneRIF: A mutation that resulted in significant reduction of
            RNF113A protein was implicated in a non-photosensitive form of
            trichothiodystrophy.  Lymphoblastoid cell lines from patients with
            the mutation in RNF113A had normal DNA damage responses on exposure
            to mitomycin C, diepoxybutane (DEB), bromodeoxyuridine (BrdU) and
            irradiation with ultraviolet light.
REFERENCE   7  (bases 1 to 1259)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (bases 1 to 1259)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   9  (bases 1 to 1259)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 1259)
  AUTHORS   Frattini,A., Faranda,S., Bagnasco,L., Patrosso,C., Nulli,P.,
            Zucchi,I. and Vezzoni,P.
  TITLE     Identification of a new member (ZNF183) of the Ring finger gene
            family in Xq24-25
  JOURNAL   Gene 192 (2), 291-298 (1997)
   PUBMED   9224902
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW001915.1, BC020556.1 and
            AC002477.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006978.2.
            
            Summary: This intronless gene encodes a protein which contains a
            C3H1-type zinc finger domain and a C3HC4 Ring-type (Really
            Interesting New Gene-type) zinc finger domain. The Ring-type zinc
            finger domain is identified in various tumor suppressors, DNA
            repair genes and cytokine receptor-associated molecules, and is
            probably involved in mediating protein-protein interactions.
            [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X98253.1, BC020556.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371442.4/ ENSP00000360497.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AW001915.1         96-494
            400-1202            BC020556.1         381-1183
            1203-1259           AC002477.1         47000-47056         c
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..1259
                     /gene="RNF113A"
                     /gene_synonym="Cwc24; RNF113; TTD5; ZNF183"
                     /note="ring finger protein 113A"
                     /db_xref="GeneID:7737"
                     /db_xref="HGNC:HGNC:12974"
                     /db_xref="MIM:300951"
     exon            1..1259
                     /gene="RNF113A"
                     /gene_synonym="Cwc24; RNF113; TTD5; ZNF183"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1152
                     /gene="RNF113A"
                     /gene_synonym="Cwc24; RNF113; TTD5; ZNF183"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 183 (RING finger, C3HC4 type);
                     cwc24 homolog"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF113A"
                     /protein_id="NP_008909.1"
                     /db_xref="CCDS:CCDS14589.1"
                     /db_xref="GeneID:7737"
                     /db_xref="HGNC:HGNC:12974"
                     /db_xref="MIM:300951"
                     /translation="MAEQLSPGKAVDQVCTFLFKKPGRKGAAGRRKRPACDPEPGESG
                     SSSDEGCTVVRPEKKRVTHNPMIQKTRDSGKQKAAYGDLSSEEEEENEPESLGVVYKS
                     TRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRGKEDDKIYRGINNYQ
                     KYMKPKDTSMGNASSGMVRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFGDSCK
                     FLHDRSDYKHGWQIERELDEGRYGVYEDENYEVGSDDEEIPFKCFICRQSFQNPVVTK
                     CRHYFCESCALQHFRTTPRCYVCDQQTNGVFNPAKELIAKLEKHRATGEGGASDLPED
                     PDEDAIPIT"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF113A"
                     /gene_synonym="Cwc24; RNF113; TTD5; ZNF183"
                     /note="hexamer: AATAAA"
     polyA_site      1202
                     /gene="RNF113A"
                     /gene_synonym="Cwc24; RNF113; TTD5; ZNF183"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcttc cgtcagtgtc ttttgcttcg actcccggcg gagcgcgcaa cgtggagtga
       61 cgtgcagggg ccaagtgcaa cccaggcagc cacggctgtt tcggagctca ggactctaaa
      121 atggcagagc agctttctcc aggaaaggcg gtggatcagg tgtgcacctt ccttttcaaa
      181 aagcctgggc ggaaaggggc tgctggacgc agaaagcgcc cggcctgcga cccagagccc
      241 ggagaaagcg gcagcagtag cgacgaaggc tgcactgtgg ttcgaccgga aaagaagcgg
      301 gtgacccaca atccaatgat acagaagacc cgtgacagtg gtaaacagaa ggcggcttac
      361 ggcgacttga gcagcgaaga ggaagaggaa aatgagcccg agagtctcgg cgtggtttat
      421 aaatccaccc gttcggcgaa acccgtggga ccagaggata tgggagcgac agctgtctat
      481 gagctggaca cagagaaaga gcgcgatgca caagccatct ttgagcgcag ccagaagatc
      541 caggaggagc tgaggggcaa ggaggatgac aagatctatc ggggaatcaa caattatcag
      601 aaatacatga agcccaagga tacgtctatg ggcaatgcct cttccgggat ggtgaggaag
      661 ggccccatcc gagcgcccga gcatctacgt gccaccgtgc gctgggatta ccagcccgac
      721 atctgtaagg actacaaaga gactggcttc tgcggcttcg gagacagctg caaattcctc
      781 catgaccgtt cagattacaa gcatgggtgg cagatcgaac gtgagcttga tgagggtcgc
      841 tatggtgtct atgaggatga aaactatgaa gtgggaagcg atgatgagga aataccattc
      901 aagtgtttca tctgtcgcca gagcttccaa aacccagttg tcaccaagtg caggcattat
      961 ttctgcgaga gctgtgcact gcagcatttc cgcaccaccc cgcgctgcta tgtctgtgac
     1021 cagcagacca atggcgtctt caatccagcg aaagaattga ttgctaaact agagaagcat
     1081 cgagctacag gagagggtgg tgcttccgac ttgccagaag accccgatga ggatgcaatt
     1141 cccattactt aggtttccca taattcttaa atttaaaaaa taaacgtttt gttcttttgg
     1201 aagtcttact tcgtgtcctt cctttgtaga gaaagtgaca gagcaggcgg gtggtgaag
//
