LOCUS       NM_007148               3174 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ring finger protein 112 (RNF112), mRNA.
ACCESSION   NM_007148
VERSION     NM_007148.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Zhang,S., Wang,J., Hu,W., He,L., Tang,Q., Li,J., Jie,M., Li,X.,
            Liu,C., Ouyang,Q., Yang,S. and Hu,C.
  TITLE     RNF112-mediated FOXM1 ubiquitination suppresses the proliferation
            and invasion of gastric cancer
  JOURNAL   JCI Insight 8 (11), e166698 (2023)
   PUBMED   37288663
  REMARK    GeneRIF: RNF112-mediated FOXM1 ubiquitination suppresses the
            proliferation and invasion of gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Lee,K.H., Chen,C.L., Lee,Y.C., Kao,T.J., Chen,K.Y., Fang,C.Y.,
            Chang,W.C., Chiang,Y.H. and Huang,C.C.
  TITLE     Znf179 induces differentiation and growth arrest of human primary
            glioblastoma multiforme in a p53-dependent cell cycle pathway
  JOURNAL   Sci Rep 7 (1), 4787 (2017)
   PUBMED   28684796
  REMARK    GeneRIF: Znf179 can reprogram glioblastoma multiforme cells into a
            more-differentiated phenotype and prevent the progression of
            gliomas to a more-malignant state through p53-mediated cell-cycle
            signaling pathways.
            Erratum:[Sci Rep. 2018 Sep 3;8(1):13375. doi:
            10.1038/s41598-018-30081-w.. PMID: 30177766]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Lomash,R.M., Gu,X., Youle,R.J., Lu,W. and Roche,K.W.
  TITLE     Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses
            and Spine Density
  JOURNAL   Cell Rep 12 (5), 743-751 (2015)
   PUBMED   26212327
REFERENCE   5  (bases 1 to 3174)
  AUTHORS   Lin,D.Y., Huang,C.C., Hsieh,Y.T., Lin,H.C., Pao,P.C., Tsou,J.H.,
            Lai,C.Y., Hung,L.Y., Wang,J.M., Chang,W.C. and Lee,Y.C.
  TITLE     Analysis of the interaction between Zinc finger protein 179
            (Znf179) and promyelocytic leukemia zinc finger (Plzf)
  JOURNAL   J Biomed Sci 20 (1), 98 (2013)
   PUBMED   24359566
  REMARK    GeneRIF: Plzf was identified as a specific interacting protein of
            Znf179; the region containing the first two zinc fingers is
            critical for its interaction with Znf179.  Cellular localization of
            Znf179 changed from cytoplasm to nucleus when Plzf was
            co-expressed.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3174)
  AUTHORS   Seki,N., Hattori,A., Muramatsu,M. and Saito,T.
  TITLE     cDNA cloning of a human brain finger protein, BFP/ZNF179, a member
            of the RING finger protein family
  JOURNAL   DNA Res 6 (5), 353-356 (1999)
   PUBMED   10574464
REFERENCE   7  (bases 1 to 3174)
  AUTHORS   Orimo,A., Inoue,S., Ikeda,K., Sato,M., Kato,A., Tominaga,N.,
            Suzuki,M., Noda,T., Watanabe,M. and Muramatsu,M.
  TITLE     Molecular cloning, localization, and developmental expression of
            mouse brain finger protein (Bfp)/ZNF179: distribution of bfp mRNA
            partially coincides with the affected areas of Smith-Magenis
            syndrome
  JOURNAL   Genomics 54 (1), 59-69 (1998)
   PUBMED   9806830
REFERENCE   8  (bases 1 to 3174)
  AUTHORS   Kimura,T., Arakawa,Y., Inoue,S., Fukushima,Y., Kondo,I., Koyama,K.,
            Hosoi,T., Orimo,A., Muramatsu,M., Nakamura,Y., Abe,T. and
            Inazawa,J.
  TITLE     The brain finger protein gene (ZNF179), a member of the RING finger
            family, maps within the Smith-Magenis syndrome region at 17p11.2
  JOURNAL   Am J Med Genet 69 (3), 320-324 (1997)
   PUBMED   9096764
REFERENCE   9  (bases 1 to 3174)
  AUTHORS   Matsuda,Y., Inoue,S., Seki,N., Hosoi,T., Orimo,A., Muramatsu,M. and
            Hori,T.
  TITLE     Chromosome mapping of human (ZNF179), mouse, and rat genes for
            brain finger protein (bfp), a member of the RING finger family
  JOURNAL   Genomics 33 (2), 325-327 (1996)
   PUBMED   8660987
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE297851.1 and BC053989.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007148.4.
            
            Summary: This gene encodes a member of the RING finger protein
            family of transcription factors. The protein is primarily expressed
            in brain. The gene is located within the Smith-Magenis syndrome
            region on chromosome 17. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053989.1, SRR3476690.472598.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000461366.2/ ENSP00000454919.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BE297851.1         46-112
            68-3174             BC053989.1         37-3143
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..3174
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /note="ring finger protein 112"
                     /db_xref="GeneID:7732"
                     /db_xref="HGNC:HGNC:12968"
                     /db_xref="MIM:601237"
     exon            1..231
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2073
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 179; brain finger protein;
                     neurolastin"
                     /codon_start=1
                     /product="RING finger protein 112"
                     /protein_id="NP_009079.2"
                     /db_xref="CCDS:CCDS58529.1"
                     /db_xref="GeneID:7732"
                     /db_xref="HGNC:HGNC:12968"
                     /db_xref="MIM:601237"
                     /translation="MPRPALSVTSFCHRLGKRERKQSFMGNSGNSWSHTPFPKLELGL
                     GPQPMAPRELPTCSICLERLRDPISLDCGHDFCIRCFSTHRLPGCEPPCCPECRKICK
                     QKRGLRSLGEKMKLLPQRPLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLK
                     HPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESGEGGRPRGGEASLQGCRWGA
                     NGLARGIWMWSHPFLLGKEGKKVAVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQI
                     LSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHPNKAGQGHVGNI
                     FQRLSGRYPKVQELLQGKRARCCLLPAPGRRRMNQGHASPGDTDDDFRHLLGAYVSDV
                     LSAAPQHAKSRCQGYWNEGRAVARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDE
                     MAAQLHDLRKVEAAKREFEEYVRQQDVATKRIFSALRVLPDTMRNLLSTQKDAILARH
                     GVALLCKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVV
                     GAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERLLEGDR
                     EPLLQEE"
     exon            232..272
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            273..558
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            559..765
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            766..897
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1002
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1053
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1110
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1185
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1303
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1473
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1527
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1602
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3174
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /note="hexamer: AATAAA"
     polyA_site      3174
                     /gene="RNF112"
                     /gene_synonym="BFP; ZNF179"
                     /note="major polyA site"
ORIGIN      
        1 acatttcttt tccagctctg accgggagtc agctcctcgg ggataccatc ccccgacctc
       61 accttctacc taccgcagcc tgctagcctt tccgggagaa aaggcatcct tacctctggt
      121 tgaaggtctc ggggcctccc cctctgcatc cggaccctct ccccatccca gcctcccatg
      181 ccaaggcccg ccttgtcagt cacttccttt tgtcatcggc ttggcaaacg ggagagaaaa
      241 cagagcttca tgggaaacag cggcaacagt tggtcccata cacctttccc caagttggag
      301 ctaggcctgg ggccccagcc catggcgccc cgggagctcc ctacctgctc catctgcctg
      361 gagaggttgc gcgaccccat ctcgctggac tgtggccacg acttctgcat acggtgcttc
      421 agcacacacc gtctcccggg ctgtgagccg ccctgctgtc ctgagtgccg gaagatatgc
      481 aagcagaaga ggggcctccg gagcctgggc gagaagatga agctcctgcc gcagcggccg
      541 ctgccccctg cactgcagga gacgtgtcct gtgagggcgg agccgctgct gctggttcgc
      601 atcaatgcct ctgggggcct catccttagg atgggggcca tcaaccgctg cctgaagcac
      661 cctctggcca gggacacccc agtctgcctc ctcgctgtcc tgggggagca gcactcaggg
      721 aagtccttcc tcctcaacca tttgcttcag ggcttgccgg gcctggagtc tggtgagggc
      781 ggccggccaa gaggaggaga ggcatccctg cagggctgca ggtggggcgc caatggcctc
      841 gccaggggca tatggatgtg gagccacccc ttcttgctgg ggaaagaagg gaagaaggtg
      901 gcggtgttcc tggtggacac aggggatgcc atgagccctg agctgagcag ggaaacaagg
      961 atcaagctct gtgctctcac cacgatgctg agctcctacc agatcctcag cacctcccag
     1021 gagctgaagg atacagacct ggactatctg gagatgtttg tccacgtggc cgaggtgatg
     1081 ggcaagcatt atgggatggt gccaatccag catctggacc tcttagttcg tgactcatcc
     1141 caccccaaca aggcagggca ggggcatgta ggcaacatct tccagagatt gtctggcaga
     1201 taccccaagg tgcaggagct gctgcaaggg aagcgagccc gttgctgcct cttgcctgcc
     1261 ccagggaggc ggcggatgaa ccaaggccat gcaagccctg gtgacacaga tgatgacttc
     1321 cgccaccttc tgggggccta cgtctcagat gtgctgagtg cggcccccca gcacgctaag
     1381 agccgctgcc aggggtactg gaacgagggg cgcgccgtgg ccagggggga cagacgccta
     1441 ctcacggggc agcagctagc tcaggaaatc aagaacctct caggatggat ggggaggaca
     1501 gggcccggtt tcacctctcc ggatgagatg gctgctcagc tgcacgacct gaggaaggtg
     1561 gaagctgcca agagggagtt cgaggagtat gtgaggcagc aggacgtagc caccaagcgc
     1621 atattctctg cgctgcgggt cctgccagac accatgcgga acctcctctc cacccagaaa
     1681 gatgccattc tggcccgcca tggtgtggcc ttactctgca aggggagaga tcagaccttg
     1741 gaggcactgg aagctgagct gcaggccacg gccaaggcct tcatggactc ctacacgatg
     1801 cgcttctgtg gccacctagc tgctgtgggg ggtgctgtgg gggccgggct catgggcctg
     1861 gcagggggcg tggtgggtgc tggcatggca gcagctgcac tggctgcaga ggctgggatg
     1921 gtggctgctg gagctgccgt gggggccaca ggggccgctg tggttggggg tggcgtgggt
     1981 gctgggttgg ctgccacagt gggctgcatg gagaaggagg aggatgagag gcttctggaa
     2041 ggggaccgag agccccttct ccaggaagag taacagcccc aggaggtatt gaaggacagg
     2101 agagatgtca ggtggggatg aagaagaggg gcaggtcggg ggagggtgat gccagggatt
     2161 ccaaggcacc gccatgtact gcactgccct ggtcgaatgc tcggtgtctg ggtggcagct
     2221 gagctgggac tcaaggtggc tcttggaacc tgggaggcag catctggggg cagtggatag
     2281 aacacccggc ctgtttctgg ttgcagatgg ttgccgatct gcccttgtca cagataggct
     2341 acatcccagg gtttctggct gcaagtgaga ctccaccctc cccacctggc tcatttcccc
     2401 gatgaccctg gattgtagga aagttaagca ggcaccatcc tggaagtcta cccctaggtg
     2461 gtcgagagac ctgttctttc acagatgtga gaagccccag gatgattgac catggtgttc
     2521 aggagcgggg agcactgatg aggtgctggg gatgacagga aggaaggaac actgggcaga
     2581 accagagaga tgggacatgg tagactgtgg cccagacccc agagcagaga aacttgttcc
     2641 catgaccctt cccaaatctg ctccagcagg actaaggtgg ctttcccact cctggcccac
     2701 agccccagag agcctgtctg tgcatcctga accactcttt gctgggcctc cgcaagggcc
     2761 tctcttgggt ctgtgtcctt tttcaagcct gtttagatgg gggagtgccc atgccctctg
     2821 tgaagtgccc aaatgcgaaa gaataacacc ttttcttgca ttctgagcta agccagacag
     2881 cctttatact agattctatc aaaatcttgc aaaggaaaac aaaatgaaca acttctaccc
     2941 ttaaacacat cctttctccc ctgggcttgt aagaagatgc agcttgatgc agctcctcaa
     3001 acaccaggcc ccctgggaac tgggggtgcg ggagttctcc ctctggggga cagaaaatct
     3061 gactactagg aagacttcta ggctatgaaa ctgacttcta ggctatgaaa cttacagggt
     3121 atgggtgggc acattatcct ttattttatg aaaaataaaa tgtgtgtatg tgaa
//
