LOCUS       NM_014372               3074 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens ring finger protein 11 (RNF11), mRNA.
ACCESSION   NM_014372
VERSION     NM_014372.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Chen,S., Xu,K., Kong,D., Wu,L., Chen,Q., Ma,X., Ma,S., Li,T.,
            Xie,Q., Liu,H. and Luo,L.
  TITLE     Ubiquitin ligase OsRINGzf1 regulates drought resistance by
            controlling the turnover of OsPIP2;1
  JOURNAL   Plant Biotechnol J 20 (9), 1743-1755 (2022)
   PUBMED   35587579
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Deng,W., Long,T. and Du,Y.
  TITLE     [Mechanism of ring finger protein 11 regulating Akt signaling
            pathway to promote osteogenic differentiation of bone marrow
            mesenchymal stem cells]
  JOURNAL   Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 36 (1), 102-110 (2022)
   PUBMED   35038807
  REMARK    GeneRIF: [Mechanism of ring finger protein 11 regulating Akt
            signaling pathway to promote osteogenic differentiation of bone
            marrow mesenchymal stem cells].
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Subramaniam,V., Li,H., Wong,M., Kitching,R., Attisano,L., Wrana,J.,
            Zubovits,J., Burger,A.M. and Seth,A.
  TITLE     The RING-H2 protein RNF11 is overexpressed in breast cancer and is
            a target of Smurf2 E3 ligase
  JOURNAL   Br J Cancer 89 (8), 1538-1544 (2003)
   PUBMED   14562029
  REMARK    GeneRIF: overexpression of RNF11, through its interaction with
            Smurf2, can restore TGFbeta responsiveness in transfected tumor
            cells
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Kitching,R., Wong,M.J., Koehler,D., Burger,A.M., Landberg,G.,
            Gish,G. and Seth,A.
  TITLE     The RING-H2 protein RNF11 is differentially expressed in breast
            tumours and interacts with HECT-type E3 ligases
  JOURNAL   Biochim Biophys Acta 1639 (2), 104-112 (2003)
   PUBMED   14559117
REFERENCE   8  (bases 1 to 3074)
  AUTHORS   Watanabe,T., Ichihara,M., Hashimoto,M., Shimono,K., Shimoyama,Y.,
            Nagasaka,T., Murakumo,Y., Murakami,H., Sugiura,H., Iwata,H.,
            Ishiguro,N. and Takahashi,M.
  TITLE     Characterization of gene expression induced by RET with MEN2A or
            MEN2B mutation
  JOURNAL   Am J Pathol 161 (1), 249-256 (2002)
   PUBMED   12107109
REFERENCE   9  (bases 1 to 3074)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   10 (bases 1 to 3074)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Sasaki,M., Suzuki,Y.,
            Sugano,S., Muramatsu,M.A. and Saito,T.
  TITLE     Cloning and expression profile of mouse and human genes,
            Rnf11/RNF11, encoding a novel RING-H2 finger protein
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 421-427 (1999)
   PUBMED   10673045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB265274.1, BC047654.1,
            BC036670.1, BC020964.2, DB564333.1 and AA224090.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014372.4.
            
            Summary: The protein encoded by this gene contains a RING-H2 finger
            motif, which is known to be important for protein-protein
            interactions. The expression of this gene has been shown to be
            induced by mutant RET proteins (MEN2A/MEN2B). The germline
            mutations in RET gene are known to be responsible for the
            development of multiple endocrine neoplasia (MEN). [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.213058.1,
                                           SRR1660803.151881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242719.4/ ENSP00000242719.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DB265274.1         16-45
            31-196              BC047654.1         1-166
            197-239             BC036670.1         176-218
            240-405             BC036670.1         220-385
            406-2451            BC020964.2         1-2046
            2452-2749           BC047654.1         2420-2717
            2750-3070           DB564333.1         117-437
            3071-3074           AA224090.1         9-12                c
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3074
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /note="ring finger protein 11"
                     /db_xref="GeneID:26994"
                     /db_xref="HGNC:HGNC:10056"
                     /db_xref="MIM:612598"
     exon            1..607
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..949
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /codon_start=1
                     /product="RING finger protein 11"
                     /protein_id="NP_055187.1"
                     /db_xref="CCDS:CCDS556.1"
                     /db_xref="GeneID:26994"
                     /db_xref="HGNC:HGNC:10056"
                     /db_xref="MIM:612598"
                     /translation="MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQV
                     PVPVYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVIC
                     MMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN"
     exon            608..777
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /inference="alignment:Splign:2.1.0"
     exon            778..3074
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /note="hexamer: CATAAA"
     polyA_site      2732
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /note="major polyA site"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /note="hexamer: AATGAA"
     polyA_site      2883
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
     regulatory      3050..3055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
                     /note="hexamer: AATAAA"
     polyA_site      3074
                     /gene="RNF11"
                     /gene_synonym="CGI-123; SID1669"
ORIGIN      
        1 agtgcccgag ccggcctcgt tctggctgcc gccgtctcgc tgaggcggag taggatgagg
       61 cccgcggccg tggctccggc gtcggcgggg gcagcagcag ctgaggcagc agctgaggca
      121 gccgcgacgg ccgcgccccc ccccgctgac ctggattagg cccagcagct ccgtggccgc
      181 cgccgccccg cgggggggcg gggtggggaa gtgcttcgtc tccccgcccc ccccccccca
      241 tcgctgcctc gcaggaggcg aacgccgcga ccccagcgga gcccgcggcc cagccttgat
      301 cccccaaccc cgggggctgg catgagcggc ccctcggcgg caccgtgggg cggtggagtc
      361 gcctccgcct gatccccggc ctgtcgcccg accccacctc gccaaccgag gcggaccgcg
      421 gagtgtgcga acgaccccac cgctgctttc tcctccccca gatcacgcac cccagctccg
      481 gaagatgggg aactgcctca aatcccccac ctcggatgac atctccctgc ttcacgagtc
      541 tcagtccgac cgggctagct ttggcgaggg gacggagccg gatcaggagc cgccgccgcc
      601 atatcaggaa caagttccag ttccagtcta ccacccaaca cctagccaga ctcggctagc
      661 aactcagctg actgaagagg aacaaattag gatagctcaa agaataggtc ttatacaaca
      721 tctgcctaaa ggagtttatg accctggaag agatggatca gaaaaaaaga tccgggagtg
      781 tgtgatctgt atgatggact ttgtttatgg ggacccaatt cgatttctgc cgtgcatgca
      841 catctatcac ctggactgta tagatgactg gttgatgaga tccttcacgt gcccctcctg
      901 catggagcca gttgatgcag cactgctttc atcctatgag actaattgag ccagggtctc
      961 ttatctgact tcaagtgaac caccattttg gtggttttga tcttttgtca ctgagcccaa
     1021 agagccaggg attaggaatt aagatcgtgc acaaaagttt ccttaaaatt cctggatggc
     1081 tgcagatgtt gggggaaaaa gtacgtgata ttttagaaac ttagtgggaa aagtaggatg
     1141 gtatttttat gtaaagcctt gacccaatgt ttaaaaatat aattgtattt agatcttgtt
     1201 attgctccag tacataggaa ttgtgtaaag tgttaacagc agctgtattt gtttaaattg
     1261 tgtgtattga agattaggaa aaagatagta gttatttttc ctaaatgaaa taactttctt
     1321 ctcttcccct tccccacccg aattcttttc tgaagttgct ggcatttggg tcaaggtttt
     1381 attaaaagct acattttata acactggcac acacaaaaaa gtagttttaa gcttgtttgc
     1441 acagttcttt ttttccattg gaaatggaat tcattgcctt aggtcttttt aaatagtgta
     1501 ttattatcgt tggggctggc tctatgcttg aaaaccagtt tatttataac ctgttataag
     1561 tgctatattc tgtttgcagt taggaaatgc agaattcaaa gtgatctcct agcttgtaag
     1621 caaactgaga tgcactatcc cttttctata aaaaataagt taatgtgtca agaaaccaac
     1681 tctattaagg tggggtttaa tattaccctt tcctatgtgt tttatctaat tattttggtt
     1741 gttaatatgg tgataatgga aagtcaagtt aaattttaaa tattaagaat tctgatttat
     1801 tgagattgaa ttatgccacc acgtttatgt aaaaatgaag gtggcaccgt ggtgagacct
     1861 aatgagaaat agttactcag ttgtaaaaat tttgatttat tctctttctt ctgacctcct
     1921 tgcctcttgt cttgaaccat agcaaaagga tactgcatct ctcattactg tagtgctgag
     1981 gttattgaag ttatacaaaa cacatctcag tctctgtttc ttggaaaggt atctattaca
     2041 tcctgctagc tgactgacaa aactaagcag ggagaataaa gataattgta ttttatgttt
     2101 tgcacacaaa cgcagaattt gtataaccat atgacttcat agttgtgatc tcaaaaaaga
     2161 aggaatttct cctttgtttc ttgcagttaa tgtaagaata ctttaaatct ctaagcttct
     2221 gaagtgttag aggtagagat ggtctagtaa agatgtagta gtaatgtttt atccatttag
     2281 catgtgttta ttttttcata tgtactcaaa ggtgacttat tggttcacct cagtgatatt
     2341 acagctaaaa aaatcattca ttagcaaaag gaaaagtggt ctcaacctaa catcagaagt
     2401 gtttcttatt attattttat attgagttga atattgaact ctaacagttt tctacataca
     2461 aaacacagtg tcatgaaggt tattcataat tgcattatag aggaatgtag tatgtcataa
     2521 gtactttgta aagatttgac attcaactgt agtatccata tgttgcttaa atttccttat
     2581 gagccccatg atggaaagac ttaaagatga atttgagaaa aattgaaaga aattagatta
     2641 tcaggttctg ttaaattgtt acatgtatct tgcttaaatt tctgtttatt aatttatatc
     2701 cacccaagta cataaagcaa atttggagga aacaactgaa gttgtgcaat attttctgat
     2761 aattgctttt tttattcttg tgttttctac ttaaacataa tgtctgtgtc atcaagtatt
     2821 atagtcagac ttttcttttt ttctagattg ttaaaattgg caaatgaact tttttaaaaa
     2881 tcatcttcca tgttgcagtt agtctttctt ttcattacaa gtctttcaca gaagtttggt
     2941 ggtaatattg aaagaactag cattgggcag aatgtgtctt ttttaggcac tttatattct
     3001 caacatacaa tgttaagaac catcaatttt gacttttact aagttgttaa ataaagttat
     3061 aatacagctg tgaa
//
